{"id":10312,"date":"2019-11-13T09:21:03","date_gmt":"2019-11-13T00:21:03","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=10312"},"modified":"2020-01-10T08:41:58","modified_gmt":"2020-01-09T23:41:58","slug":"post-10312","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=10312","title":{"rendered":"\u98df\u3079\u308b\u9806\u756a\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u52b9\u679c\u306f\uff1f"},"content":{"rendered":"<p>\u5148\u65e5\u3001\u6b21\u306e\u3088\u3046\u306a\u8a18\u4e8b\u304c\u51fa\u3066\u3044\u307e\u3057\u305f\u3002\u300c\u98df\u3079\u308b\u9806\u756a\u3067\u91cd\u70b9\u6307\u5c0e\u3001\u4f53\u91cd\u6e1b\u5c11\u306b\u52b9\u679c\u300d\uff08\u305d\u306e\u8a18\u4e8b\u306f<a href=\"https:\/\/www.asahi.com\/articles\/ASMBS5H50MBSOHGB00Q.html\" target=\"_blank\" rel=\"noopener 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data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/a66a3030bff5e8ed1dd263a3f8b788ff.jpg?fit=300%2C129&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/a66a3030bff5e8ed1dd263a3f8b788ff.jpg?fit=640%2C276&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/a66a3030bff5e8ed1dd263a3f8b788ff.jpg?fit=680%2C294\" alt=\"\" class=\"wp-image-10330\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/a66a3030bff5e8ed1dd263a3f8b788ff.jpg?w=1277&amp;ssl=1 1277w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/a66a3030bff5e8ed1dd263a3f8b788ff.jpg?resize=300%2C129&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/a66a3030bff5e8ed1dd263a3f8b788ff.jpg?resize=768%2C331&amp;ssl=1 768w, 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class=\"wp-block-image\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"221\" data-attachment-id=\"10317\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=10317\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?fit=2006%2C692&amp;ssl=1\" data-orig-size=\"2006,692\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u98df\u3079\u308b\u9806\u30c0\u30a4\u30a8\u30c3\u30c8\u52b9\u679c\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?fit=300%2C103&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?fit=640%2C221&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?resize=640%2C221\" alt=\"\" class=\"wp-image-10317\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?resize=1024%2C353&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?resize=300%2C103&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?resize=768%2C265&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?resize=320%2C110&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?w=2006&amp;ssl=1 2006w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?w=1280 1280w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/11\/201575060ed192059eadace8955d93db-1.png?w=1920 1920w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure>\n<p><\/p>\n<p><\/p>\n<p>\u305d\u308c\u3067\u3069\u3046\u306a\u3063\u305f\u304b\uff1f\u30b0\u30eb\u30fc\u30d7A\u306b\u5bfe\u3057\u3066\u3001\u30b0\u30eb\u30fc\u30d7B\u3067\u306fBMI\u3068\u4f53\u91cd\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\u2026\uff08\uff1f\uff09\u5177\u4f53\u7684\u306b\u306f\u30b0\u30eb\u30fc\u30d7A\u3067\u306f6\u304b\u6708\u3067BMI\u304c0.3\u5897\u52a0\u3057\u3001\u4f53\u91cd\u30820.9\u338f\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u53c2\u52a0\u8005\u305f\u3061\u306f\u305f\u3063\u305f6\u304b\u6708\u30670.9\u338f\u4f53\u91cd\u304c\u5897\u52a0\u3059\u308b\u98df\u4e8b\u3092\u6442\u3063\u3066\u3044\u308b\u307f\u305f\u3044\u3067\u3059\u30021\u5e74\u30671.8\u338f\u30015\u5e74\u30679\u338f\u2026\u3055\u3059\u304c\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u3059\u306d\u3002\u6700\u521d\u306e\u56f3\u3067\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u304c1,800\uff5e1,900kcal\u7a0b\u5ea6\u3068\u3044\u3046\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u81ea\u5df1\u7533\u544a\u306e\u6442\u53d6\u30a8\u30cd\u30eb\u30ae\u30fc\u91cf\u306f\u904e\u5c11\u7533\u544a\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u3088\u3046\u306a\u3069\u3093\u3069\u3093\u80a5\u6e80\u5316\u3059\u308b\u5f93\u6765\u306e\u98df\u4e8b\u3068\u6bd4\u8f03\u3057\u3066\u3001\u98df\u3079\u308b\u9806\u306e\u30b0\u30eb\u30fc\u30d7B\u3067\u306fBMI\u3067\uff0d0.1\uff17\u3001\u4f53\u91cd\u3067\uff0d0.5\u338f\u6e1b\u5c11\u3067\u3059\u3002\u7d20\u6674\u3089\u3057\u3044\uff08\uff1f\uff096\u304b\u6708\u3067\u305f\u3063\u305f0.5\u338f\u3057\u304b\u6e1b\u3089\u306a\u3044\u306e\u3067\u3059\u3002\u304a\u3057\u3063\u3053\u3084\u3046\u3093\u3053\u3092\u3057\u305f\u3060\u3051\u3067\u3082200\uff5e300g\u306f\u6e1b\u5c11\u3059\u308b\u3067\u3057\u3087\u3046\u3002\u8aa4\u5dee\u7bc4\u56f2\u7a0b\u5ea6\u306e\u6e1b\u5c11\u306b\u3059\u304e\u307e\u305b\u3093\u30026\u304b\u6708\u3042\u308c\u3070\u7cd6\u8cea\u5236\u9650\u3067\u306f10\u338f\u3050\u3089\u3044\u306f\u6e1b\u3063\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3002\u6804\u990a\u30d0\u30e9\u30f3\u30b9\u306e\u30b0\u30eb\u30fc\u30d7C\u3067\u306f\u6709\u610f\u5dee\u306f\u7121\u304b\u3063\u305f\u3088\u3046\u3067\u3059\u304c\u3001\u540c\u69d8\u306bBMI\u30670.2\u3001\u4f53\u91cd\u30670.58\u338f\u306e\u6e1b\u5c11\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>VFA\uff08\u5185\u81d3\u8102\u80aa\uff09\u3001WC\uff08\u8179\u56f2\uff09\u306f\u3059\u3079\u3066\u306e\u7fa4\u3067\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3059\u3002\u4e0d\u601d\u8b70\u306a\u3053\u3068\u306b\u4f53\u91cd\u306e\u5897\u52a0\u3057\u305f\u30b0\u30eb\u30fc\u30d7A\u3067\u3082\u5185\u81d3\u8102\u80aa\u304c\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u98df\u4e8b\u3060\u3051\u3067\u306a\u304f\u904b\u52d5\u306e\u6307\u5c0e\u3082\u53d7\u3051\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u306e\u52b9\u679c\u304c\u3042\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1fGLP-1\u3084GIP\u306e\u5909\u5316\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30b0\u30eb\u30ab\u30b4\u30f3\u306f\u30b0\u30eb\u30fc\u30d7C\u3067\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>FPG\uff08\u7a7a\u8179\u6642\u8840\u7cd6\u5024\uff09\u306f\u3059\u3079\u3066\u306e\u7fa4\u3067\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3059\u3002\u30b0\u30eb\u30fc\u30d7B\u3067\u306f6\u4ee5\u4e0a\u306e\u6e1b\u5c11\u3067\u3059\u3002\u3057\u304b\u3057HbA1c\u306b\u95a2\u3057\u3066\u306f\u5909\u5316\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u7a7a\u8179\u6642\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u95a2\u3057\u3066\u306f\u30b0\u30eb\u30fc\u30d7B\u30671\u8fd1\u304f\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u8868\u3059HOMA-IR\u3082\u5909\u5316\u306a\u3057\uff5e\u3084\u3084\u5897\u52a0\u3067\u3059\u3002HOMA-IR\u306f2.5\u4ee5\u4e0a\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3042\u308a\u3068\u5224\u65ad\u3055\u308c\u307e\u3059\u304c\u30016\u304b\u6708\u5f8c\u306e\u30b0\u30eb\u30fc\u30d7B\u3067\u306f2.5\u3092\u8d85\u3048\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\uff01<\/p>\n<p><\/p>\n<p><\/p>\n<p>HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u3069\u306e\u30b0\u30eb\u30fc\u30d7\u3082\u5909\u5316\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u4e2d\u6027\u8102\u80aa\uff08Triglycerides\uff09\u306f\u30b0\u30eb\u30fc\u30d7A\u3067\u306f\u7d0445\u3001\u30b0\u30eb\u30fc\u30d7B\u3067\u306f\u7d0428\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u5358\u7d14\u306b\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u3092\u8a08\u7b97\u3059\u308b\u3068\u3001\u30b0\u30eb\u30fc\u30d7A\u30672.5\u21923.2\u3001\u30b0\u30eb\u30fc\u30d7B\u30673.5\u21924.1\u3001\u30b0\u30eb\u30fc\u30d7C\u30673.0\u21922.9\u3067\u3059\u3002\u30b0\u30eb\u30fc\u30d7C\u4ee5\u5916\u3067\u306f\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u304c\u60aa\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a rel=\"noreferrer noopener\" aria-label=\"\u7cd6\u8cea\u5236\u9650\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607 (opens in a new tab)\" href=\"http:\/\/promea2014.com\/blog\/?p=1101\" target=\"_blank\">\u7cd6\u8cea\u5236\u9650\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607<\/a>\u300d\u300c<a rel=\"noreferrer noopener\" aria-label=\"\u4e2d\u6027\u8102\u80aa\u304c\u4f4e\u304fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u3068\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044 (opens in a new tab)\" href=\"http:\/\/promea2014.com\/blog\/?p=4044\" target=\"_blank\">\u4e2d\u6027\u8102\u80aa\u304c\u4f4e\u304fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u3068\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044<\/a>\u300d\u306a\u3069\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u306f\u91cd\u8981\u3067\u3042\u308a\u3001\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u304f\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u65b9\u304c\u6709\u76ca\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u79c1\u306f\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u306f1.3\u4ee5\u4e0b\u3092\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u304c4\u3088\u308a\u5927\u304d\u3044\u3053\u3068\u304c\u3001\u51a0\u52d5\u8108\u75be\u60a3\u767a\u75c7\u306e\u6700\u3082\u5f37\u529b\u306a\u72ec\u7acb\u3057\u305f\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5ca1\u5c71\u5927\u5b66\u306e\u7814\u7a76\u3067\u306f\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u304c3.03\u4ee5\u4e0a\u3067\u306f\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3092\u60f9\u8d77\u3057\u3084\u3059\u3044\u51a0\u52d5\u8108\u306e\u30cf\u30a4\u30ea\u30b9\u30af\u30d7\u30e9\u30fc\u30af\u304c\u6709\u610f\u306b\u5897\u52a0\u3059\u308b\u305d\u3046\u3067\u3059\u3002\u98df\u3079\u308b\u9806\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u304c4\u3092\u8d85\u3048\u3066\u3057\u307e\u3063\u3066\u3044\u308b\u3067\u306f\u306a\u3044\u3067\u3059\u304b\uff01<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3055\u3066\u3001\u3053\u306e\u8ad6\u6587\u306e\u7d50\u8ad6\u306f\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p><\/p>\n<p><\/p>\n<p class=\"has-text-color has-vivid-cyan-blue-color\">\u300cThe group receiving health guidance with dietary instructions focusing on meal sequence exhibited similar adherence and greater reduction in body weight than the group receiving conventional health guidance.\u300d<\/p>\n<p><\/p>\n<p><\/p>\n<p class=\"has-text-color has-vivid-cyan-blue-color\">\u300c\u98df\u4e8b\u306e\u9806\u5e8f\u306b\u7126\u70b9\u3092\u5408\u308f\u305b\u305f\u98df\u4e8b\u6307\u5c0e\u3092\u4f34\u3046\u5065\u5eb7\u6307\u5c0e\u3092\u53d7\u3051\u305f\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5f93\u6765\u306e\u5065\u5eb7\u6307\u5c0e\u3092\u53d7\u3051\u305f\u30b0\u30eb\u30fc\u30d7\u3068\u540c\u69d8\u306e\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u3092\u793a\u3057\u5f93\u6765\u306e\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u4f53\u91cd\u306e\u5927\u5e45\u306a\u6e1b\u5c11\u3092\u793a\u3057\u305f\u3002\u300d<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3055\u3089\u306b\u3053\u306e\u7814\u7a76\u3092\u884c\u3063\u305f\u5927\u5b66\u306e\u6559\u6388\u306f<\/p>\n<p><\/p>\n<p><\/p>\n<p class=\"has-text-color has-vivid-cyan-blue-color\">\u300c\u98df\u3079\u308b\u9806\u756a\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u305f\u98df\u4e8b\u7642\u6cd5\u306f\u30c0\u30a4\u30a8\u30c3\u30c8\u3001\u5065\u5eb7\u5897\u9032\u306b\u3064\u306a\u304c\u308b\u3002\u7d99\u7d9a\u3082\u3057\u3084\u3059\u3044\u306e\u3067\u3001\u6307\u5c0e\u3092\u547c\u3073\u304b\u3051\u305f\u3044\u300d<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3068\u8a9e\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u7d99\u7d9a\u306f\u3057\u3084\u3059\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u5065\u5eb7\u5897\u9032\u306b\u306f\u5168\u304f\u3064\u306a\u304c\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3001\u4e2d\u6027\u8102\u80aa\/HDL\u6bd4\u3067\u898b\u308b\u3068\u5065\u5eb7\u304c\u60aa\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3053\u306e\u8ad6\u6587\u306e\u5229\u76ca\u76f8\u53cd\u3092\u898b\u3066\u307f\u308b\u3068<\/p>\n<p><\/p>\n<p>\u300cD. Yabe received consulting or speaker fees from <span style=\"color: #ff0000;\">MSD K.K.<\/span>,<span style=\"color: #ff0000;\"> Novo Nordisk Pharma Ltd<\/span>. and <span style=\"color: #ff0000;\">Nippon Boehringer Ingelheim Co., Ltd<\/span>. D. Yabe also received clinical commissioned\/joint research grants from <span style=\"color: #ff0000;\">Nippon Boehringer Ingelheim Co., Ltd<\/span>., <span style=\"color: #ff0000;\">Eli Lilly<\/span> and Company, <span style=\"color: #ff0000;\">Taisho Toyama Pharmaceutical Co. Ltd<\/span>., <span style=\"color: #ff0000;\">MSD K.K<\/span>., <span style=\"color: #ff0000;\">Ono Pharmaceutical Co. Ltd<\/span>., <span style=\"color: #ff0000;\">Novo Nordisk Pharma Ltd<\/span>., <span style=\"color: #ff0000;\">Arklay Co. Ltd<\/span>., <span style=\"color: #ff0000;\">Sanofi K.K.<\/span>, <span style=\"color: #ff0000;\">Astellas Pharma Inc<\/span>. and <span style=\"color: #ff0000;\">Takeda Pharmaceutical Company Limited<\/span>. Y. Hamamoto received consulting or speaker fees from Novo Nordisk Pharma Ltd. T. Kurose received consulting or speaker fees from Sanofi K.K. T. Kurose also received clinical commissioned\/joint research grants from the Japan Vascular Disease Research Foundation. Yut. Seino received consulting or speaker fees from Eli Lilly Japan K.K., Sanofi K.K., Novo Nordisk Pharma Inc., Glaxo-Smith-Kline, Taisho Pharmaceutical Co., Ltd., Taisho Toyama Pharmaceutical Co., Ltd., Astellas Pharma Inc., BD, Nippon Boehringer Ingelheim Co., Ltd., Johnson &amp; Johnson and Takeda Pharmaceutical Company Limited. Yut. Seino also received clinical commissioned\/joint research grants from Nippon Boehringer Ingelheim Co., Ltd., Eli Lilly and Company, Taisho Toyama Pharmaceutical Co. Ltd., MSD K.K., Ono Pharmaceutical Co. Ltd., Novo Nordisk Pharma Ltd., and Arklay Co. Ltd. H. Kuwata, Y. Fujiwara, K. Murotani, M. Sakaguchi, S. Moyama, N. Makabe, Yus. Seino, H. Asano, S. Ito and H. Mishima report no conflict of interest relevant to this study. H. Takase and N. Oota are employees of Kao Corporation.\u300d<\/p>\n<p><\/p>\n<p>\u7b2c\u4e00\u8457\u8005\u306e\u5206\u3060\u3051\u88fd\u85ac\u4f1a\u793e\u3092\u8d64\u6587\u5b57\u306b\u3057\u307e\u3057\u305f\u3002\u98df\u3079\u308b\u9806\u756a\u30c0\u30a4\u30a8\u30c3\u30c8\u3092\u63a8\u5968\u3057\u3066\u3001\u307b\u3093\u306e\u308f\u305a\u304b\u306a\u8aa4\u5dee\u7bc4\u56f2\u3068\u3067\u3082\u601d\u308f\u308c\u308b\u3088\u3046\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u5f37\u8abf\u3057\u3066\u3001\u88cf\u306b\u96a0\u308c\u3066\u3044\u308b\u6709\u5bb3\u6027\u3092\u96a0\u3057\u3066\u3001\u3069\u306e\u65b9\u5411\u306b\u8a98\u5c0e\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u98df\u3079\u308b\u9806\u756a\u3060\u3051\u3092\u5f37\u8abf\u3057\u3066\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u3084\u3081\u3055\u305b\u306a\u3044\u306e\u3067\u3059\u3002\u76f4\u63a5\u85ac\u306e\u5ba3\u4f1d\u3092\u3057\u3066\u3044\u306a\u3044\u306b\u3057\u3066\u3082\u3001\u3053\u308c\u3067\u533b\u5e2b\u3082\u88fd\u85ac\u4f1a\u793e\u3082Win\uff0dWin\u3067\u3059\u306d\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\uff08\u3053\u306e\u7814\u7a76\u306e\u6982\u8981\u306e\u308f\u304b\u308a\u3084\u3059\u3044\u65e5\u672c\u8a9e\u306e\u6587\u7ae0\u306f<a 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href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S105687271930621X\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"\u3053\u3053 (opens in a new tab)\">\u3053\u3053<\/a>\uff09<\/p>\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5148\u65e5\u3001\u6b21\u306e\u3088\u3046\u306a\u8a18\u4e8b\u304c\u51fa\u3066\u3044\u307e\u3057\u305f\u3002\u300c\u98df\u3079\u308b\u9806\u756a\u3067\u91cd\u70b9\u6307\u5c0e\u3001\u4f53\u91cd\u6e1b\u5c11\u306b\u52b9\u679c\u300d\uff08\u305d\u306e\u8a18\u4e8b\u306f\u3053\u3053\uff09 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