{"id":10684,"date":"2019-12-19T08:51:06","date_gmt":"2019-12-18T23:51:06","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=10684"},"modified":"2020-01-10T08:39:08","modified_gmt":"2020-01-09T23:39:08","slug":"post-10684","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=10684","title":{"rendered":"\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u304b\u3089\u8003\u3048\u308b\u3000\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u539f\u56e0\u3067\u306f\u306a\u3044\u3000\u305d\u306e7\u3000LDL\u3088\u308a\u3082\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u91cd\u8981\u306a\u3082\u306e"},"content":{"rendered":"

\u300c\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u304b\u3089\u8003\u3048\u308b\u3000\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u539f\u56e0\u3067\u306f\u306a\u3044\u300d\u30b7\u30ea\u30fc\u30ba\u306e\u4e45\u3005\u306e\u8a18\u4e8b\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u300c\u305d\u306e1<\/a>\u300d\uff5e\u300c\u305d\u306e6<\/a>\u300d\u307e\u3067\u66f8\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff08FH\uff09\u3068\u3044\u3046\u75be\u60a3\u306f\u3001\u907a\u4f1d\u7684\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u975e\u5e38\u306b\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001FH\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e3b\u306a\u539f\u56e0\u3068\u3057\u3066\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u306b\u3064\u3044\u3066\u306e\u7591\u554f\u3092\u793a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u7a0b\u5ea6\u306f LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u95a2\u9023\u3057\u3066\u3044\u306a\u3044\u3067\u3059\u3057\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u4f34\u308f\u306a\u3044FH\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u540c\u3058\u5e74\u9f62\u306eFH\u3068\u307b\u307c\u540c\u3058\u304f\u3089\u3044\u9ad8\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306fFH\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u306e\u60a3\u8005\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u30d8\u30c6\u30ed\u306f500\u4eba\u306b1\u4eba\u4ee5\u4e0a\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u30d8\u30c6\u30ed\u3068\u306f\u7236\u89aa\u7531\u6765\u3068\u6bcd\u89aa\u7531\u6765\u306e2\u3064\u304c\u4e00\u7d44\u306b\u306a\u3063\u305f\u907a\u4f1d\u5b50\u306e\u3046\u3061\u3069\u3061\u3089\u304b\u7247\u65b9\u306b\u7570\u5e38\u304c\u3042\u308b\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\n

14,283\u4eba\u306e\u60a3\u8005\u306e\u3046\u3061\u3001\u5408\u8a081,310\u4eba\uff089.2\uff05\uff09\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u30a4\u30d9\u30f3\u30c8\u3092\u7d4c\u9a13\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5358\u5909\u91cf\u89e3\u6790\u3067\u306f\u3001\u7537\u6027\u306e\u6027\u5225\u3001\u5e74\u9f62\u306e\u5897\u52a0\u3001BMI\u306e\u5897\u52a0\u3001\u55ab\u7159\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u4e2d\u6027\u8102\u80aa\u5024\u304c\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3068\u53cd\u6bd4\u4f8b\u3057\u307e\u3057\u305f\u3002\u591a\u5909\u91cf\u89e3\u6790\u3067\u306f\u3001\u7537\u6027\u306e\u6027\u5225\u3001\u5e74\u9f62\u306e\u5897\u52a0\u3001BMI\u306e\u5897\u52a0\u3001\u55ab\u7159\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u72ec\u7acb\u3057\u305f\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

FH\uff08\u30d8\u30c6\u30ed\uff09\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u56e0\u5b50<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/th>\n\u5358\u5909\u91cf\u89e3\u6790<\/th>\n\u591a\u5909\u91cf\u89e3\u6790<\/th>\n<\/tr>\n
OR<\/th>\n95\uff05CI<\/th>\np<\/em>\u5024<\/th>\nOR<\/th>\n95\uff05CI<\/th>\np<\/em>\u5024<\/th>\n<\/tr>\n<\/thead>\n
\u7537\u6027\u306e\u6027\u5225<\/td>\n1.72<\/td>\n1.53\u20131.92<\/td>\n<0.001<\/td>\n2.44<\/td>\n2.07\u20132.88<\/td>\n<0.001<\/td>\n<\/tr>\n
\u5e74\u9f62<\/td>\n1.08<\/td>\n1.08\u20131.09<\/td>\n<0.001<\/td>\n1.08<\/td>\n1.08\u20131.09<\/td>\n<0.001<\/td>\n<\/tr>\n
BMI<\/td>\n1.13<\/td>\n1.12\u20131.15<\/td>\n<0.001<\/td>\n1.04<\/td>\n1.03\u20131.06<\/td>\n<0.001<\/td>\n<\/tr>\n
\u55ab\u7159<\/td>\n1.70<\/td>\n1.50\u20131.94<\/td>\n<0.001<\/td>\n1.59<\/td>\n1.36\u20131.86<\/td>\n<0.001<\/td>\n<\/tr>\n
\u9ad8\u8840\u5727<\/td>\n8.02<\/td>\n7.08\u301c9.07<\/td>\n<0.001<\/td>\n2.38<\/td>\n2.01\u20132.82<\/td>\n<0.001<\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5<\/td>\n6.40<\/td>\n5.21\u20137.86<\/td>\n<0.001<\/td>\n1.37<\/td>\n1.03\u20131.82<\/td>\n0.03<\/td>\n<\/tr>\n
HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n0.55<\/td>\n0.46\u20130.65<\/td>\n<0.001<\/td>\n0.61<\/td>\n0.48\u20130.77<\/td>\n<0.001<\/td>\n<\/tr>\n
LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n1.16<\/td>\n1.13\u20131.19<\/td>\n<0.001<\/td>\n1.08<\/td>\n1.04\u20131.12<\/td>\n<0.001<\/td>\n<\/tr>\n
\u4e2d\u6027\u8102\u80aa<\/td>\n1.76<\/td>\n1.59\u20131.94<\/td>\n<0.001<\/td>\n\u2013<\/td>\n\u2013<\/td>\n\u2013<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6027\u5225\u306f\u5927\u304d\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3059\u3002\u3064\u307e\u308a\u5973\u6027\u3088\u308a\u3082\u7537\u6027\u306e\u65b9\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u306e\u3067\u3059\u3002\u305d\u308c\u306f\u5973\u6027\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u52d5\u8108\u786c\u5316\u6291\u5236\u4f5c\u7528\u306b\u3088\u3063\u3066\u5b88\u3089\u308c\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002\u305d\u308c\u306f\u5225\u3068\u3057\u3066\u3001\u5358\u5909\u91cf\u89e3\u6790\u3067\u898b\u308c\u3070\u3001\u6700\u3082\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u308b\u306e\u306f\u3001\u9ad8\u8840\u5727\u3084\u7cd6\u5c3f\u75c5\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u3002\u3055\u3089\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u4e2d\u6027\u8102\u80aa\u306e\u9ad8\u3055\u3084HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4f4e\u3055\u306e\u65b9\u304c\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3082\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u4e2d\u6027\u8102\u80aa\u5024\u306f\u5897\u52a0\u3057\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u4f4e\u4e0b\u3059\u308b\u306e\u3067\u3001\u7cd6\u8cea\u904e\u5270\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u591a\u5909\u91cf\u89e3\u6790\u3067\u306f\u3055\u3089\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u95a2\u9023\u306f\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30aa\u30c3\u30ba\u6bd4\u304c1\u4ee5\u4e0a\u306a\u306e\u3067\u95a2\u9023\u304c\u306a\u3044\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001BMI\u306b\u7d9a\u3044\u30662\u756a\u76ee\u306b\u4f4e\u3044\u30ea\u30b9\u30af\u56e0\u5b50\u306a\u306e\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u5c0f\u3055\u306a\u5371\u967a\u306aLDL\uff08sdLDL\uff09\u3084\u9178\u5316LDL\u304c\u5897\u52a0\u3059\u308c\u3070\u3001\u5f53\u7136LDL\u3068\u306e\u95a2\u9023\u306f\u8a8d\u3081\u3089\u308c\u308b\u3067\u3057\u3087\u3046\u3002LDL\u306f\u8cea\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n

LDL\u3088\u308a\u3082\u9ad8\u8840\u5727\u3084\u7cd6\u5c3f\u75c5\u3001\u55ab\u7159\u3001\u4e2d\u6027\u8102\u80aa\u3001HDL\u306e\u65b9\u304c\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u91cd\u8981\u306a\u306e\u3067\u3059\u3002<\/p>\n

\u305d\u3046\u3059\u308b\u3068\u3001\u7cd6\u8cea\u5236\u9650\u3092\u3057\u3066\u3044\u3066\u3001\u55ab\u7159\u3057\u306a\u3044\u5973\u6027\u306eFH\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6050\u308c\u308b\u5fc5\u8981\u306a\u3093\u3066\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u539f\u56e0\u304cLDL\u306b\u3042\u308b\u3068\u3059\u308c\u3070\u3001LDL\u304c\u9ad8\u3051\u308c\u3070\u9ad8\u3044\u307b\u3069\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001FH\u3067\u3082\u3068\u3093\u3067\u3082\u306a\u3044\u307b\u3069\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306b\u95a2\u9023\u3059\u308b\u30a4\u30d9\u30f3\u30c8\u304c\u8d77\u304d\u306a\u3051\u308c\u3070\u304a\u304b\u3057\u3044\u3067\u3059\u3002\u3057\u304b\u3057\u3001FH\u3067\u3055\u3048LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u306e\u95a2\u9023\u306f\u5e0c\u8584\u3067\u3059\u3002FH\u3067\u306f\u306a\u3044\u4eba\u3067\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6570\u5024\u81ea\u4f53\u306f\u3042\u307e\u308a\u610f\u5473\u304c\u306a\u3044\u3067\u3057\u3087\u3046\u3002HDL\u304c\u9ad8\u304f\u3001\u4e2d\u6027\u8102\u80aa\u304c\u4f4e\u3051\u308c\u3070\u3001LDL\u306f\u554f\u984c\u3092\u8d77\u3053\u3055\u306a\u3044\u512a\u826f\u306aLDL\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u8840\u4e2d\u306eLDL\u304c\u9ad8\u3051\u308c\u3070\u3001\u672c\u5f53\u306b\u8840\u7ba1\u58c1\u3092\u901a\u308a\u629c\u3051\u3066\u5185\u819c\u306b\u5165\u308a\u3001\u8840\u7ba1\u306e\u5185\u8154\u3092\u72ed\u304f\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u8840\u7ba1\u306e\u5185\u76ae\u7d30\u80de\u306f\u305d\u3093\u306a\u306b\u30b9\u30ab\u30b9\u30ab\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u8840\u7ba1\u306e\u30d0\u30ea\u30a2\u304c\u305d\u3093\u306a\u306b\u5f31\u3051\u308c\u3070\u8840\u4e2d\u306e\u6c34\u5206\u306f\u6f0f\u308c\u6f0f\u308c\u306b\u306a\u308a\u3001\u4eba\u9593\u306f\u3059\u3050\u306b\u6b7b\u3093\u3067\u3057\u307e\u3046\u3067\u3057\u3087\u3046\u3002<\/p>\n

 <\/p>\n<\/div>\n

\u300cSevere heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers\u300d<\/span><\/p>\n

\u300c\u91cd\u5ea6\u306e\u30d8\u30c6\u30ed\u63a5\u5408\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\uff1a14,000\u4eba\u306e\u7a81\u7136\u5909\u7570\u30ad\u30e3\u30ea\u30a2\u306e\u30b3\u30db\u30fc\u30c8\u306e\u7814\u7a76\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

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