{"id":11262,"date":"2020-02-14T00:16:39","date_gmt":"2020-02-13T15:16:39","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=11262"},"modified":"2020-02-14T00:16:39","modified_gmt":"2020-02-13T15:16:39","slug":"post-11262","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=11262","title":{"rendered":"\u8840\u6db2\u4e2d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2"},"content":{"rendered":"<p>\u5148\u65e5\u306e\u8a18\u4e8b\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=11348\" target=\"_blank\" rel=\"noopener noreferrer\">\u30c9\u30af\u30bf\u30fc\u30b7\u30df\u30ba\u306e\u30a6\u30eb\u30c8\u30e9\u30e9\u30f3\u30ca\u30fc\u3078\u306e\u9053\u30002020\u6625\u3078\u306e\u6e96\u5099<\/a>\u300d\u3067\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u958b\u59cb\u3057\u305f\u3053\u3068\u3092\u66f8\u304d\u307e\u3057\u305f\u3002\u6700\u521d\u306b\u305d\u306e\u30b9\u30bf\u30b8\u30aa\u306e\u30a4\u30f3\u30b9\u30c8\u30e9\u30af\u30bf\u30fc\u306e\u65b9\u304c\u8272\u3005\u3068\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u3066\u304f\u308c\u305f\u306e\u3067\u3059\u304c\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u30e1\u30ea\u30c3\u30c8\u3068\u3057\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u3092\u5897\u3084\u3059\u3068\u3044\u3046\u3053\u3068\u3092\u8a00\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u306f\u8d64\u8840\u7403\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3001\u4f4e\u9178\u7d20\u306b\u5fdc\u7b54\u3057\u3066\u7523\u751f\u3055\u308c\u3001\u9020\u8840\u7d30\u80de\u306b\u50cd\u3044\u3066\u8d64\u8840\u7403\u7523\u751f\u3092\u523a\u6fc0\u3057\u307e\u3059\u3002<\/p>\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3054\u5b58\u3058\u306e\u3088\u3046\u306b\u7d30\u80de\u5185\u306b\u5b58\u5728\u3057\u3001\u96fb\u5b50\u4f1d\u9054\u7cfb\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u306eATP\u3092\u4f5c\u308a\u51fa\u3059\u5de5\u5834\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u771f\u6838\u7d30\u80de\u306b\u5171\u751f\u3057\u305f\u3053\u3068\u3067\u3001\u73fe\u5728\u306e\u3088\u3046\u306a\u751f\u7269\u304c\u8a95\u751f\u3067\u304d\u305f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u3001\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u6d3b\u6027\u5316\u3057\u5897\u3048\u308c\u3070\u3001\u9178\u7d20\u3092\u904b\u3076\u8d64\u8840\u7403\u304c\u5897\u52a0\u3057\u30a8\u30cd\u30eb\u30ae\u30fc\u3082\u5897\u52a0\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>\u3053\u3053\u307e\u3067\u306f\u826f\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u4e2d\u306f\u6c34\u3092\u5341\u5206\u306b\u88dc\u7d66\u3057\u3066\u304f\u3060\u3055\u3044\u3001\u3068\u8a00\u308f\u308c\u307e\u3057\u305f\u3002\u6c57\u304c\u305f\u304f\u3055\u3093\u51fa\u308b\u304b\u3089\u3001\u3068\u3044\u3046\u306e\u3067\u306f\u306a\u304f\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u8840\u4e2d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u5897\u3048\u3066\u8840\u6db2\u304c\u30c9\u30ed\u30c9\u30ed\u306b\u306a\u308b\u3001\u3068\u3044\u3046\u3088\u3046\u306a\u4e3b\u65e8\u306e\u8aac\u660e\u3092\u3055\u308c\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u305d\u306e\u6642\u79c1\u306f\u300c\uff1f\u300d\u3068\u601d\u3044\u307e\u3057\u305f\u3002\u8840\u4e2d\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff1f\u3057\u304b\u3082\u305d\u3093\u306a\u6025\u306b\u5897\u52a0\u3059\u308b\uff1f\u79c1\u306e\u305d\u306e\u6642\u306e\u8a8d\u8b58\u3067\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u5185\u306b\u5b58\u5728\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u7d30\u80de\u304c\u58ca\u308c\u3066\u3001\u6a5f\u80fd\u3057\u3066\u3044\u306a\u3044\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u8840\u4e2d\u306b\u51fa\u308b\u3053\u3068\u306f\u3042\u3063\u3066\u3082\u3001\u6b63\u5e38\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u8840\u4e2d\u306b\u3042\u308b\u3068\u306f\u601d\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3060\u304b\u3089\u3001\u6b63\u76f4\u300c\u4f55\u3092\u8a00\u3063\u3066\u3044\u308b\u3093\u3060\u304b\uff1f\u300d\u3068\u601d\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30bb\u30eb\u30d5\u30ea\u30fcDNA (cfDNA)\u307e\u305f\u306f\u7121\u7d30\u80deDNA\u3068\u3044\u3046\u3001\u7d30\u80de\u6b7b\u306b\u3088\u3063\u3066\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u305f\u904a\u96e2DNA\u306f\u8ab0\u306b\u3067\u3082\u5b58\u5728\u3057\u3001\u7279\u306b\u6700\u8fd1\u306f\u708e\u75c7\u3084\u7d30\u80de\u6b7b\u304c\u8d77\u3053\u308b\u3068cfDNA\u304c\u5897\u52a0\u3059\u308b\u306e\u3067\u3001\u7cd6\u5c3f\u75c5\u3001\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u304c\u3093\u306a\u3069\u306e\u30de\u30fc\u30ab\u30fc\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u6700\u8fd1\u3001\u5065\u5eb7\u306a\u4eba\u306e\u8840\u4e2d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eDNA\u306e\u30b3\u30d4\u30fc\u6570\u304c\u6838\u306eDNA\u306e50,000\u500d\u3082\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u305d\u306e\u8ad6\u6587\u306f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30914716\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/p>\n<p>\u3053\u3093\u306a\u306b\u3082\u591a\u304f\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eDNA\u304c\u5065\u5eb7\u306a\u4eba\u306b\u3082\u5b58\u5728\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u306e\u306f\u3001\u306a\u305c\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306f\u79c1\u306b\u306f\u975e\u5e38\u306b\u96e3\u3057\u3044\u306e\u3067\u3059\u304c\u3001\u975e\u5e38\u306b\u8208\u5473\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u5065\u5eb7\u306a\u4eba\u306e\u8840\u6db2\u3092\u8abf\u3079\u3066\u307f\u308b\u3068\u3001\u7121\u50b7\u3067\u6a5f\u80fd\u304c\u3042\u308b\uff08\u547c\u5438\u80fd\u529b\u3001\u3064\u307e\u308a\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4f5c\u308a\u51fa\u305b\u308b\uff09\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u5b58\u5728\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u3002\u6211\u3005\u306e\u4f53\u3067\u306f\u8840\u6db2\u306e\u6d41\u308c\u306b\u4e57\u3063\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6f02\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u8840\u4e2d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f79\u5272\u306f\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u91cd\u8981\u306a\u751f\u7269\u5b66\u7684\u304a\u3088\u3073\u751f\u7406\u5b66\u7684\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u305f\u65b9\u304c\u59a5\u5f53\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u4e00\u90e8\u306e\u5668\u5b98\u3068\u306a\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5b9f\u969b\u306f\u305d\u3046\u3067\u306f\u306a\u304f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u3057\u3066\u5358\u72ec\u3067\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u307e\u305f\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6210\u5206\u306e\u7d30\u80de\u5916\u7a7a\u9593\u3001\u8840\u4e2d\u3078\u306e\u653e\u51fa\u306f\u5f37\u529b\u306a\u708e\u75c7\u8a98\u767a\u6027\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u4e00\u3064\u306e\u7d30\u80de\u306b\u7559\u307e\u3063\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u9593\u3067\u6c34\u5e73\u306b\u79fb\u52d5\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\uff08\u305d\u306e\u8ad6\u6587\u306f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27734015\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09\u6a5f\u80fd\u969c\u5bb3\u306b\u306a\u3063\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u6301\u3064\u7d30\u80de\u306b\u3001\u6b63\u5e38\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u79fb\u52d5\u3057\u3066\u6551\u6e08\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3082\u3057\u304b\u3057\u305f\u3089\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u5e38\u306b\u8840\u4e2d\u3092\u6f02\u3044\u306a\u304c\u3089\u3001\u554f\u984c\u304c\u3042\u308b\u7d30\u80de\u3001\u640d\u50b7\u3057\u305f\u7d30\u80de\u3092\u898b\u3064\u3051\u308b\u3068\u3001\u305d\u306e\u7d30\u80de\u306e\u4e2d\u306b\u5165\u3063\u3066\u884c\u3063\u3066\u4f55\u3068\u304b\u305d\u306e\u7d30\u80de\u304c\u56de\u5fa9\u3067\u304d\u308b\u3088\u3046\u306b\u52a9\u3051\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u8840\u4e2d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3001\u514d\u75ab\u3001\u708e\u75c7\u306a\u3069\u69d8\u3005\u306a\u3053\u3068\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u30a4\u30f3\u30b9\u30c8\u30e9\u30af\u30bf\u30fc\u306e\u65b9\u306f\u3001\u3082\u3046\u3059\u3067\u306b\u3053\u306e\u3088\u3046\u306a\u77e5\u8b58\u3092\u6301\u3063\u3066\u3044\u3066\u3001\u4f4e\u9178\u7d20\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3068\u3001\u3044\u304f\u3064\u304b\u306e\u7d30\u80de\u306f\u82e6\u3057\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u3001\u305d\u308c\u3092\u52a9\u3051\u308b\u305f\u3081\u306b\u8840\u4e2d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u5897\u52a0\u3057\u3066\u305d\u306e\u82e6\u3057\u3044\u7d30\u80de\u3092\u52a9\u3051\u308b\u306e\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3092\u8a00\u3044\u305f\u304b\u3063\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u79c1\u306f\u307e\u3060\u307e\u3060\u77e5\u3089\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u306d\u3002\u30a4\u30f3\u30b9\u30c8\u30e9\u30af\u30bf\u30fc\u306e\u65b9\u3001\u7533\u3057\u8a33\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6050\u308c\u5165\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u300cBlood contains circulating cell-free respiratory competent mitochondria\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u8840\u6db2\u306b\u306f\u3001\u5faa\u74b0\u3059\u308b\u7121\u7d30\u80de\u3067\u547c\u5438\u80fd\u529b\u306e\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31957088\" target=\"_blank\" rel=\"noopener 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