{"id":11441,"date":"2020-02-10T08:53:46","date_gmt":"2020-02-09T23:53:46","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=11441"},"modified":"2020-02-10T08:53:46","modified_gmt":"2020-02-09T23:53:46","slug":"post-11441","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=11441","title":{"rendered":"\u7cd6\u8cea\u5236\u9650\u3067\u306f\u3069\u3046\u3057\u3066HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u304b\uff1f\u3000\u305d\u306e2"},"content":{"rendered":"

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u7cd6\u8cea\u5236\u9650\u3067\u306f\u3069\u3046\u3057\u3066HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u304b\uff1f\u3000\u305d\u306e1<\/a>\u300d\u3067\u306f\u8840\u6f3f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30a8\u30b9\u30c6\u30eb\u8ee2\u9001\u86cb\u767d(CETP)\u306e\u4f5c\u7528\u3084\u4e2d\u6027\u8102\u80aa\u4f4e\u4e0b\u306b\u3088\u308bHDL\u5897\u52a0\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8003\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u4eca\u56de\u306f\u524d\u56de\u3088\u308a\u3082\u3063\u3068\u96e3\u3057\u3044\u5185\u5bb9\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u304f\u3089\u3044\u8907\u96d1\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u4eba\u9593\u3092\u306f\u3058\u3081\u751f\u7269\u306b\u306f\u5b58\u5728\u3057\u3001\u81ea\u5206\u3067\u306f\u308f\u304b\u3089\u306a\u3044\u3046\u3061\u306b\u69d8\u3005\u306a\u73fe\u8c61\u304c\u8d77\u304d\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u9032\u5316\u306e\u904e\u7a0b\u3067\u4f5c\u3089\u308c\u3066\u304d\u305f\u3082\u306e\u3067\u3059\u3002\u4eba\u9593\u306e\u9032\u5316\u3092\u7121\u8996\u3059\u308c\u3070\u4f53\u306b\u4e0d\u5177\u5408\u304c\u8d77\u304d\u308b\u306e\u3082\u5f53\u7136\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u7d30\u80de\u5185\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30ec\u30d9\u30eb\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u7d30\u80de\u304c\u751f\u304d\u3066\u3044\u304f\u305f\u3081\u306b\u53b3\u5bc6\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b\u30b9\u30c6\u30ed\u30fc\u30eb\u8abf\u7bc0\u914d\u5217\u7d50\u5408\u30bf\u30f3\u30d1\u30af\uff08SRTEBP\uff09\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308a\u3001SREBP\u306b\u306f1\u30682\u304c\u3042\u308a\u307e\u3059\u3002SREBP-1\u306f\u8102\u80aa\u9178\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0\u3001\u3064\u307e\u308a\u4e2d\u6027\u8102\u80aa\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3001SREBP-2\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002SREBP-2\u306f\u7d30\u80de\u5185\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u3092\u611f\u77e5\u3057\u3066\u3001\u7d30\u80de\u304c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0d\u8db3\u306b\u306a\u308b\u3053\u3068\u3092\u9632\u3050\u50cd\u304d\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u4e00\u65b9\u3001HDL\u306e\u5f62\u6210\u306b\u306f\u7d30\u80de\u819c\u306b\u5b58\u5728\u3059\u308bATP\u7d50\u5408\u30ab\u30bb\u30c3\u30c8\u8f38\u9001\u4f53A1\uff08ABCA1\uff09\u304c\u5fc5\u9808\u3067\u3059\u3002SREBP-2\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u3084\u53d6\u308a\u8fbc\u307f\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3092\u4fc3\u9032\u3057\u3001\u307e\u305f\u672b\u68a2\u306e\u7d30\u80de\u306b\u304a\u3044\u3066\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5f15\u304d\u629c\u304d\u306b\u95a2\u308f\u308bABCA1\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306bSREBP\u306b\u5185\u5728\u3059\u308b\u30de\u30a4\u30af\u30edRNA\u306emiR-33\u3068\u3044\u3046\u3082\u306e\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u307e\u3059\u3002\u30de\u30a6\u30b9\u306b\u306f\u4eba\u9593\u306b\u306fmiR-33a\u3057\u304b\u5b58\u5728\u3057\u307e\u305b\u3093\u304c\u3001\u4eba\u9593\u306b\u306fmiR-33a\u3068miR-33b\u304c\u3042\u308a\u307e\u3059\u3002SREBP-1\u306b\u306fmiR-33b\u3001SREBP-2\u306b\u306fmiR-33a\u304c\u5b58\u5728\u3057\u3001\u5171\u8ee2\u5199\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u4e0a\u306e\u56f3\u306f\u3053\u3053<\/a>\u3088\u308a\uff09<\/p>\n

\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5fc5\u8981\u306a\u7d30\u80de\u3067\u306f\u3001SREBP-\uff12\u3067\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5408\u6210\u3068\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3057\u3001miR33a\u306b\u3088\u308a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5f15\u304d\u629c\u304d\u306b\u95a2\u308f\u308bABCA\uff11\u306b\u3088\u308bHDL\u7523\u751f\u3092\u6291\u3048\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u653e\u51fa\u3092\u6291\u3048\u3001\u307e\u305f\u8102\u80aa\u9178\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u3092\u6291\u5236\u3059\u308b\u3001\u3068\u3044\u3046\u53cd\u5fdc\u304c\u540c\u6642\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7cd6\u8cea\u5236\u9650\u3067\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6442\u53d6\u91cf\u3082\u591a\u3044\u306e\u3067SREBP-2\u304a\u3088\u3073miR33a\u306f\u6291\u5236\u3055\u308c\u3001HDL\u304c\u5897\u52a0\u3057\u3001\u8102\u80aa\u9178\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u306e\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306fSREBP-1\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3057\u3001miR-33b\u3082\u5897\u52a0\u3055\u305b\u307e\u3059\u3002miR-33b\u3082ABCA1\u306b\u3088\u308aHDL\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8102\u80aa\u9178\u306e\u9178\u5316\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u307e\u305f\u3001SREBP-1\u306f\u8102\u80aa\u9178\u306e\u5408\u6210\u3092\u4fc3\u9032\u3057\u3001\u4e2d\u6027\u8102\u80aa\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306b\u3088\u308aHDL\u306e\u4f4e\u4e0b\u3068\u4e2d\u6027\u8102\u80aa\u306e\u5897\u52a0\u304c\u8d77\u3053\u308b\u306e\u3067\u3059\u3002\u9006\u306b\u8a00\u3048\u3070\u7cd6\u8cea\u5236\u9650\u3067\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u5c11\u306a\u3044\u306e\u3067\u3001SREBP-1\u3082miR-33b\u3082\u5897\u52a0\u3057\u307e\u305b\u3093\u3002\u305d\u308c\u306b\u3088\u308aHDL\u5897\u52a0\u3068\u4e2d\u6027\u8102\u80aa\u4f4e\u4e0b\u3068\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u30d6\u30c9\u30a6\u7cd6\u304c\u809d\u81d3\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3066\u3001\u4e2d\u6027\u8102\u80aa\u306b\u5909\u5316\u3059\u308b\u307e\u3067\u306e\u69d8\u3005\u306a\u4ee3\u8b1d\u3092\u8868\u3057\u305f\u3082\u306e\u3067\u3059\u3002\uff08\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09\u8d64\u3044\u56db\u89d2\u3067\u56f2\u307e\u308c\u305f\u3082\u306e\u306f\u73fe\u5728\u308f\u304b\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u3059\u3079\u3066SREBP-1\u304c\u304b\u304b\u308f\u3063\u3066\u3044\u3066\u3001\u8272\u4ed8\u304d\u306e\u8d64\u3044\u56db\u89d2\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u30d6\u30c9\u30a6\u7cd6\u304c\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002\u9ad8\u7cd6\u8cea\u306e\u98df\u4e8b\u3067\u3053\u308c\u3089\u306e\u53cd\u5fdc\u3001\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u30d6\u30c9\u30a6\u7cd6\u304c\u4e2d\u6027\u8102\u80aa\u306b\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u975e\u5e38\u306b\u96e3\u3057\u3044\u8a71\u3067\u306f\u3042\u308b\u306e\u3067\u3001\u4e00\u3064\u3060\u3051\u899a\u3048\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u4e2d\u6027\u8102\u80aa\u3092\u5897\u52a0\u3055\u305b\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u7cd6\u8cea\u5236\u9650\u3067\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u975e\u5e38\u306b\u5c11\u306a\u304f\u306a\u308b\u306e\u3067\u3001\u5f53\u7136HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

HDL\u3092\u5897\u3084\u3059\u306b\u306f\u3069\u3046\u3057\u305f\u3089\u3044\u3044\u304b\uff1f\u7c21\u5358\u3067\u3059\u306d\u3002\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002<\/p>\n

SREBP\u3092\u8003\u3048\u308b\u3068\u7cd6\u8cea\u5236\u9650\u3067LDL\u304c\u5897\u52a0\u3059\u308b\u7406\u7531\u306e\u4e00\u90e8\u3082\u8aac\u660e\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u308c\u306b\u3064\u3044\u3066\u306f\u6b21\u56de\u4ee5\u964d\u3067\u3002<\/p>\n

 <\/p>\n

\u300cMicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo\u300d<\/span><\/p>\n

\u300c\u30b9\u30c6\u30ed\u30fc\u30eb\u8abf\u7bc0\u914d\u5217\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea2\uff08Srebp2\uff09\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u3088\u3063\u3066\u30a8\u30f3\u30b3\u30fc\u30c9\u3055\u308c\u305fMicroRNA-33\u306fin vivo\u3067HDL\u3092\u8abf\u7bc0\u3059\u308b\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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