{"id":11449,"date":"2020-02-26T12:26:07","date_gmt":"2020-02-26T03:26:07","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=11449"},"modified":"2020-02-26T12:26:07","modified_gmt":"2020-02-26T03:26:07","slug":"post-11449","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=11449","title":{"rendered":"\u30b9\u30bf\u30c1\u30f3\u304cHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u73cd\u3057\u304f\u306a\u3044"},"content":{"rendered":"<p>\u30b9\u30bf\u30c1\u30f3\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5408\u6210\u3092\u6291\u5236\u3059\u308b\u306e\u3067\u3001\u901a\u5e38\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u4e00\u65b9\u3067HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=11441\" target=\"_blank\" rel=\"noopener noreferrer\">\u7cd6\u8cea\u5236\u9650\u3067\u306f\u3069\u3046\u3057\u3066HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u304b\uff1f\u3000\u305d\u306e2<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u306f\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5408\u6210\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7d30\u80de\u3067\u306fSREBP-\uff12\u304c\u5897\u52a0\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5408\u6210\u3068\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3057\u3088\u3046\u3068\u3057\u307e\u3059\u3057\u3001miR33a\u306b\u3088\u308a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5f15\u304d\u629c\u304d\u306b\u95a2\u308f\u308bABCA\uff11\u306b\u3088\u308bHDL\u7523\u751f\u3092\u6291\u3048\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u306fHDL\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u5b9f\u969b\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n<p><a 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data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?fit=300%2C298&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?fit=640%2C636&amp;ssl=1\" class=\"alignnone size-medium wp-image-11481\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?resize=300%2C298\" alt=\"\" width=\"300\" height=\"298\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?resize=300%2C298&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?resize=100%2C100&amp;ssl=1 100w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?resize=320%2C318&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/884726cdc51973774a90b619495d6fd5.jpg?w=705&amp;ssl=1 705w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" 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href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"11452\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=11452\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?fit=774%2C590&amp;ssl=1\" data-orig-size=\"774,590\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u30b9\u30bf\u30c1\u30f3HDL\u4f4e\u4e0b40261_2015_372_Fig2_HTML\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?fit=300%2C229&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?fit=640%2C488&amp;ssl=1\" class=\"alignnone size-medium wp-image-11452\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?resize=300%2C229\" alt=\"\" width=\"300\" height=\"229\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?resize=300%2C229&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?resize=768%2C585&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?resize=320%2C244&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/7e1fd760687778ff0a4d8a49de3feda8-1.jpg?w=774&amp;ssl=1 774w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u70b9\u7dda\u304cHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6e1b\u5c11\u3057\u305f\u4eba\u3001\u5b9f\u7dda\u304cHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u5316\u304c\u306a\u304b\u3063\u305f\u4eba\u3067\u3059\u3002\u7e26\u8ef8\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u30a4\u30d9\u30f3\u30c8\uff08\u865a\u8840\u6027\u8133\u5352\u4e2d\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u6b7b\uff09\u306e\u767a\u751f\u7387\u3067\u3059\u3002HDL\u306e\u5909\u5316\u304c\u306a\u304b\u3063\u305f\u4eba\u3088\u308a\u3082HDL\u304c\u6e1b\u5c11\u3057\u305f\u4eba\u306e\u65b9\u304c\u30ea\u30b9\u30af\u304c56\uff05\u3082\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u3092\u98f2\u3093\u3067HDL\u304c\u6e1b\u5c11\u3059\u308b\u5834\u5408\u306f\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u308f\u306a\u3044\u65b9\u304c\u826f\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=11441\" target=\"_blank\" rel=\"noopener noreferrer\">\u7cd6\u8cea\u5236\u9650\u3067\u306f\u3069\u3046\u3057\u3066HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u304b\uff1f\u3000\u305d\u306e2<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5897\u52a0\u3059\u308c\u3070HDL\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u3046\u304b\u3069\u3046\u304b\u3068\u3044\u3046\u3088\u308a\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u3044\u304b\u306b\u6e1b\u3089\u3059\u304b\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u30b9\u30bf\u30c1\u30f3\u306b\u306f\u69d8\u3005\u306a\u6709\u5bb3\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\uff08\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=4336\" target=\"_blank\" rel=\"noopener noreferrer\">\u30b9\u30bf\u30c1\u30f3\u306f\u3042\u306a\u305f\u306e\u4f53\u306e\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n<p>\u3042\u306a\u305f\u306e\u305d\u306e\u30b9\u30bf\u30c1\u30f3\u306f\u672c\u5f53\u306b\u5fc5\u8981\u3067\u3059\u304b\uff1f<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u300cEffect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300cHDL-C\u306b\u5bfe\u3059\u308b\u30b9\u30bf\u30c1\u30f3\u306e\u5f71\u97ff\uff1aLDL-C\u306e\u5909\u66f4\u3068\u306f\u7121\u95a2\u4fc2\u306e\u8907\u96d1\u306a\u30d7\u30ed\u30bb\u30b9\uff1aVOYAGER\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u5206\u6790\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19965573\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300cAssociation Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u30d7\u30e9\u30a4\u30de\u30ea\u30b1\u30a2\u8a2d\u5b9a\u3067\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u958b\u59cb\u3057\u305f\u60a3\u8005\u306b\u304a\u3051\u308b\u9006\u8aac\u7684HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6e1b\u5c11\u3068\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26718960\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30b9\u30bf\u30c1\u30f3\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5408\u6210\u3092\u6291\u5236\u3059\u308b\u306e\u3067\u3001\u901a\u5e38\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u4e00\u65b9\u3067HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f 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