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href=\"http:\/\/promea2014.com\/blog\/?p=11441\" target=\"_blank\" rel=\"noopener noreferrer\">\u7cd6\u8cea\u5236\u9650\u3067\u306f\u3069\u3046\u3057\u3066HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u304b\uff1f\u3000\u305d\u306e2<\/a>\u300d\u3067\u51fa\u3066\u304d\u305f\u3001\u30b9\u30c6\u30ed\u30fc\u30eb\u8abf\u7bc0\u914d\u5217\u7d50\u5408\u30bf\u30f3\u30d1\u30af\uff08SRTEBP\uff09\u306b\u95a2\u9023\u3057\u305f\u3053\u3068\u3092\u8003\u3048\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>SREBP-1\u306f\u8102\u80aa\u9178\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0\u3001\u3064\u307e\u308a\u4e2d\u6027\u8102\u80aa\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3001SREBP-2\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001SREBP-2\u306fLDL\u53d7\u5bb9\u4f53\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002LDL\u53d7\u5bb9\u4f53\u304c\u5897\u52a0\u3059\u308b\u3068\u8840\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u6e1b\u5c11\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u8c4a\u5bcc\u3067\u3042\u308b\u3068\u8ca0\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u304c\u8d77\u3053\u308a\u3001SREBP-2\u306f\u4f4e\u4e0b\u3057\u3001LDL\u53d7\u5bb9\u4f53\u3082\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u7cd6\u8cea\u5236\u9650\u98df\u306f\u901a\u5e38\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u591a\u304f\u6442\u53d6\u3057\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068SREBP-2\u306f\u4f4e\u4e0b\u3057\u3001LDL\u53d7\u5bb9\u4f53\u306f\u4f4e\u4e0b\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u53d6\u308a\u8fbc\u307f\u304c\u5c11\u306a\u304f\u306a\u308b\u306e\u3067\u3001\u8840\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5897\u52a0\u3057\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001SREBP-1\u306fLDL\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u306fSREBP-1\u3092\u5897\u52a0\u3055\u305b\u308b\u306e\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5897\u52a0\u306f\u8840\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306b\u306a\u3063\u3066\u3044\u306a\u3051\u308c\u3070\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u4e0b\u3052\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u9006\u306b\u8003\u3048\u308c\u3070\u7cd6\u8cea\u5236\u9650\u3067\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306f\u4f4e\u4e0b\u3059\u308b\u306e\u3067SREBP-1\u306f\u4f4e\u4e0b\u3057\u3001LDL\u53d7\u5bb9\u4f53\u3092\u5c11\u306a\u304f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3082\u7cd6\u8cea\u5236\u9650\u3067\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\uff08\u305f\u3060\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4f5c\u7528\u304cLDL\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u3068\u3057\u3066\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304cPCSK9\u3092\u8a98\u5c0e\u3059\u308b\u80fd\u529b\u306b\u3088\u308aLDL\u53d7\u5bb9\u4f53\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3068LDL\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u306f\u3082\u3063\u3068\u8907\u96d1\u3067\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\uff09<\/p>\n<p>SREBP\u306f\u30a2\u30bb\u30c1\u30ebCoA\u304b\u3089\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f5c\u308b\u304b\u3001\u8102\u80aa\u9178\u304a\u3088\u3073\u4e2d\u6027\u8102\u80aa\u3092\u4f5c\u308b\u304b\u306e\u30b9\u30a4\u30c3\u30c1\u306e\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u5236\u9650\u3067\u306f\u8102\u80aa\u9178\u306e\u6442\u53d6\u91cf\u306f\u5897\u52a0\u3057\u3066\u3044\u3066\u3001\u8102\u80aa\u9178\u3082SREBP-1\u3092\u6291\u5236\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4f4e\u4e0b\u306a\u3069\u306b\u3088\u308a\u7cd6\u8cea\u5236\u9650\u3067\u975e\u5e38\u306b\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u8003\u3048\u308c\u3070\u3001SREBP-2\u306b\u3088\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5408\u6210\u3059\u308b\u65b9\u5411\u304c\u4fc3\u9032\u3057\u3084\u3059\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u542b\u307e\u306a\u3044\u98df\u4e8b\u3092\u6442\u308c\u3070\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u304c\u5bb9\u6613\u306b\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002\u3055\u3089\u306bSREBP-2\u3067LDL\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3082\u5897\u52a0\u3059\u308b\u306e\u3067\u8840\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u305d\u3053\u307e\u3067\u5897\u52a0\u3057\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3064\u3044\u3066\u306f\u4ee3\u8b1d\u304c\u3069\u306e\u3088\u3046\u306a\u30d0\u30e9\u30f3\u30b9\u306b\u306a\u308b\u304b\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u4f55\u3068\u3082\u8a00\u3048\u307e\u305b\u3093\u304c\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6442\u53d6\u91cf\u304c\u5897\u52a0\u3059\u308c\u3070\u3001SREBP-2\u3082\u6291\u5236\u3055\u308c\u3066\u3001LDL\u53d7\u5bb9\u4f53\u306f\u6e1b\u5c11\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u4e0a\u6607\u3057\u3066\u3057\u307e\u3046\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u7cd6\u8cea\u5236\u9650\u3092\u7de9\u3081\u308b\u3068\u305d\u306e\u5206\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3082\u591a\u304f\u306a\u308b\u305f\u3081\u3001\u30a2\u30bb\u30c1\u30ebCoA\u304b\u3089\u4e2d\u6027\u8102\u80aa\u3092\u4f5c\u308bSREBP-1\u5074\u306e\u4ee3\u8b1d\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3057\u3001LDL\u53d7\u5bb9\u4f53\u3082\u5897\u52a0\u3057\u307e\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u6e1b\u5c11\u3057\u3001\u4e2d\u6027\u8102\u80aa\u306f\u5897\u52a0\u3057\u3001HDL\u306f\u6e1b\u5c11\u3057\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u3001\u4e2d\u6027\u8102\u80aa\u5024\u3084HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u898b\u308c\u3070\u3042\u308b\u7a0b\u5ea6\u3001\u3069\u306e\u7a0b\u5ea6\u306e\u7cd6\u8cea\u5236\u9650\u3092\u884c\u3063\u3066\u3044\u308b\u304b\u304c\u63a8\u6e2c\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u7cd6\u8cea\u5236\u9650\u3092\u7de9\u3081\u308b\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u7406\u7531\u306b\u3001\u7cd6\u8cea\u5236\u9650\u53cd\u5bfe\u6d3e\u304c\u300c\u7cd6\u8cea\u5236\u9650\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0a\u6607\u3055\u305b\u308b\u304b\u3089\u5371\u967a\u3060\u300d\u3068\u5426\u5b9a\u3057\u305f\u308a\u3001\u300c\u3042\u308b\u7a0b\u5ea6\u306e\u7cd6\u8cea\u306f\u5fc5\u8981\u3060\u300d\u3068\u3044\u3046\u3053\u3068\u306e\u8ad6\u62e0\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057LDL\u306f\u8cea\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u4eba\u306b\u3088\u3063\u3066\u306f\u7cd6\u8cea\u5236\u9650\u3092\u3057\u3066\u3044\u3066\u3082\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6442\u53d6\u91cf\u306e\u5897\u52a0\u304c\u30a2\u30bb\u30c1\u30ebCoA\u304b\u3089\u4e2d\u6027\u8102\u80aa\u3092\u4f5c\u308bSREBP-1\u306e\u6291\u5236\u3092\u7de9\u3081\u3066\u3001\u4e2d\u6027\u8102\u80aa\u3092\u4f5c\u308b\u91cf\u304c\u3061\u3087\u3063\u3068\u591a\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3053\u308c\u304c\u3082\u3057\u304b\u3057\u305f\u3089\u5375\u6442\u53d6\u3067\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u306e\u539f\u56e0\u3067\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u7cd6\u8cea\u5236\u9650\u3067\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u306e\u500b\u4eba\u5dee\u306f\u3053\u308c\u3089\u306e\u4ee3\u8b1d\u304c\u3069\u306e\u3088\u3046\u306a\u30d0\u30e9\u30f3\u30b9\u3067\u50cd\u304f\u304b\u306e\u9055\u3044\u3067\u8d77\u304d\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u7cd6\u8cea\u5236\u9650\u3067\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u73cd\u3057\u304f\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7cd6\u8cea\u5236\u9650\u3092\u884c\u3063\u3066\u3044\u308b\u5834\u5408\u3067\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u306f\u8cea\u306e\u826f\u3044LDL\u306e\u5897\u52a0\u3067\u3042\u308a\u3001\u5168\u304f\u554f\u984c\u306a\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u300cThe SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300cSREBP\u7d4c\u8def\uff1a\u819c\u7d50\u5408\u8ee2\u5199\u56e0\u5b50\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306b\u3088\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306e\u8abf\u7bc0\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9150132\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u3092\u8a8d\u3081\u308b\u3053\u3068\u304c\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u79c1\u81ea\u8eab\u3082LDL\u306f\u57fa\u6e96\u5024\u3092\u5927\u304d\u304f\u306f\u307f\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u7cd6\u8cea\u5236\u9650\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u306b\u3064\u3044\u3066\u69d8\u3005\u306a\u8003\u5bdf\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u8a18\u4e8b\u306e\u30b7\u30ea\u30fc\u30ba<\/p>\n","protected":false},"author":1,"featured_media":11509,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[145,8,146,144,10,161],"tags":[24,19],"class_list":["post-11466","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ldl","category-8","category-hdl","category-cholesterol","category-10","category-ketone","tag-cholesterol","tag-toushitsuseigen","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/02\/06bef2312fa82957f807d9a08a67e826_s.jpg?fit=640%2C425&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-2YW","jetpack-related-posts":[{"id":5889,"url":"https:\/\/promea2014.com\/blog\/?p=5889","url_meta":{"origin":11466,"position":0},"title":"\u7cd6\u8cea\u5236\u9650\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u3000\u305d\u306e8\u3000\u904b\u52d5\u306b\u3088\u308b\u4e0a\u6607\u2461","author":"Dr.Shimizu","date":"2018\u5e7410\u670824\u65e5","format":false,"excerpt":"\u524d\u56de\u306e\u300c\u7cd6\u8cea\u5236\u9650\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u3000\u305d\u306e7\u300d\u3067\u3001\u30b1\u30c8\u30f3\u4f53\u8cea\u306e\u30a2\u30b9\u30ea\u30fc\u30c8\u304c\u975e\u5e38\u306b\u5065\u5eb7\u7684\u306a\u5909\u5316\u3092\u2026","rel":"","context":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","block_context":{"text":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","link":"https:\/\/promea2014.com\/blog\/?cat=145"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/10\/17b83e34d1905055baba174ffa6f6ff4_s.jpg?fit=427%2C640&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":24687,"url":"https:\/\/promea2014.com\/blog\/?p=24687","url_meta":{"origin":11466,"position":1},"title":"\u7cd6\u8cea\u5236\u9650\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4e0a\u6607\u3057\u3084\u3059\u3044\u4eba\u306fT3\u3068BMI\u304c\u4f4e\u3044","author":"Dr.Shimizu","date":"2023\u5e7412\u670828\u65e5","format":false,"excerpt":"\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306eT3\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002T3\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 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