{"id":1219,"date":"2017-04-03T13:12:29","date_gmt":"2017-04-03T04:12:29","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=1219"},"modified":"2020-01-10T08:45:26","modified_gmt":"2020-01-09T23:45:26","slug":"post-1219","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=1219","title":{"rendered":"\u8102\u8cea\u7570\u5e38\u75c7\u306e\u6cbb\u7642\u85ac\u3001PCSK9\u963b\u5bb3\u85ac\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff08\u30ec\u30d1\u30fc\u30b5\uff09\u306f\u672c\u5f53\u306b\u5fc5\u8981\u304b\uff1f\u4e00\u4eba\u6551\u3046\u306e\u306b2\u5104\u5186\u304b\u304b\u308a\u307e\u3059\uff01"},"content":{"rendered":"<p>\u8102\u8cea\u7570\u5e38\u75c7\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306e\u8a66\u9a13<span style=\"color: #000000;\">\uff08FOURIER\u8a66\u9a13\uff09<\/span>\u304c\u884c\u308f\u308c\u3001\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u539f\u6587\u306f<a href=\"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1615664\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\u3067\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u3060\u3051\u3067\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u4e0d\u826f\u306e\u65b9\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u3044\u3046\u5185\u5bb9\u3067\u3059\u304c\u3001\u79c1\u306b\u306f\u3001\u3069\u3046\u3057\u3066\u3082\u3053\u306e\u85ac\u306e\u30e1\u30ea\u30c3\u30c8\u304c\u7406\u89e3\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u307e\u305a\u3001\uff2c\uff24\uff2c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3044\u307e\u3060\u306b\u60aa\u7389\u3068\u3044\u3046\u524d\u63d0\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u975e\u5e38\u306b\u4eba\u9593\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u3082\u306e\u3067\u3042\u308b\u306e\u306b\u3001\u3053\u3093\u306a\u306b\u4f4e\u4e0b\u3055\u305b\u3066\u5927\u4e08\u592b\u306a\u3093\u3067\u3057\u3087\u3046\u304b\uff1f\uff2c\uff24\uff2c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c20\u3068\u304b30\u3067\u672c\u5f53\u306b\u5927\u4e08\u592b\u306a\u3093\u3067\u3057\u3087\u3046\u304b\uff1f\u3053\u306e\u8a66\u9a13\u3067\u306f\u8ffd\u8de1\u671f\u9593\u304c\u305f\u3063\u305f2.2\u5e74\u306a\u306e\u3067\u3001\u9577\u671f\u306b\u6295\u4e0e\u3055\u308c\u308b\u3068\u3069\u3046\u306a\u308b\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff08<span 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data-image-title=\"\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u8a66\u9a13\u306e\u30b0\u30e9\u30d5\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/04\/5cfc93e9d70bab00861cf14ae1e09161.jpg?fit=300%2C247&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/04\/5cfc93e9d70bab00861cf14ae1e09161.jpg?fit=634%2C521&amp;ssl=1\" class=\"alignnone size-medium wp-image-1220\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/04\/5cfc93e9d70bab00861cf14ae1e09161.jpg?resize=300%2C247\" alt=\"\" width=\"300\" height=\"247\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/04\/5cfc93e9d70bab00861cf14ae1e09161.jpg?resize=300%2C247&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/04\/5cfc93e9d70bab00861cf14ae1e09161.jpg?w=634&amp;ssl=1 634w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u629c\u7c8b\uff09<\/span><\/p>\n<p>\u4e00\u65b9\u3001<span style=\"color: #000000;\">\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u56e0\u6b7b\u4ea1\u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3092\u5408\u308f\u305b\u308b\u30681.5\uff05\u306e\u5dee\u304c\u3064\u304f\u3051\u3069\u3001\u5b9f\u969b\u306e\u5fc3\u8840\u7ba1\u6b7b\u306f\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u3064\u307e\u308a\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u5dee\u304c\u51fa\u308b\u3088\u3046\u306b\u9805\u76ee\u3092\u64cd\u4f5c\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u306e\u3067\u3059\u3002<\/span><\/p>\n<p>\u3082\u3063\u3068\u3082\u602a\u3057\u3044\u6c17\u6301\u3061\u306b\u3055\u305b\u308b\u306e\u306f\u3001\u3053\u306e\u8a66\u9a13\u81ea\u4f53\u304c\u958b\u767a\u5143\u306e<span style=\"color: #ff0000;\">Amgen\u793e\u306e\u52a9\u6210\u306b\u3088\u308b<\/span>\u8a66\u9a13\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305d\u306e\u3053\u3068\u3092\u5dee\u3057\u5f15\u3044\u3066\u8003\u3048\u305f\u3089\u5168\u304f\u52b9\u679c\u306e\u306a\u3044\u85ac\u3060\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u8457\u8005\u306f\u300c\u5fc3\u8840\u7ba1\u7cfb\u306e\u6b7b\u4ea1\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u307e\u305f\u306f\u8133\u5352\u4e2d\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u300174\u4eba\u306e\u60a3\u8005\u30922\u5e74\u9593\u306b\u308f\u305f\u3063\u3066\u6cbb\u7642\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u300d\u3064\u307e\u308a\u3001\uff2e\uff2e\uff34\uff08\u6cbb\u7642\u5fc5\u8981\u6570\uff09\u306f\uff17\uff14\u3067\u3059\u3002<\/p>\n<p>\u30b3\u30b9\u30c8\u306f\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u3001\u5e74\u9593\u306e\u4f9b\u7d66\u3067\u306f\u60a3\u80051\u4eba\u5f53\u305f\u308a\u7d0414,350\u30c9\u30eb\u3001\u307e\u305f\u306f\u6708\u306b\u7d041,200\u30c9\u30eb\u304b\u304b\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u30672\u5e74\u9593\u6cbb\u7642\u3057\u305f74\u4eba\u306e\u60a3\u8005\u306e\u63a8\u5b9a\u8cbb\u7528\u306f2,123,800\u30c9\u30eb\u3067\u3059\u3002 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#000000;\">EBBINGHAUS\u00a0Study\u3082\u884c\u308f\u308c\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee\u304c\u306a\u3044\u3068\u306e\u7d50\u679c\u3060\u3063\u305f\u3088\u3046\u3067\u3059\u304c\u3001\u3053\u306e\u8a66\u9a13\u308220\u304b\u6708\u3057\u304b\u884c\u308f\u308c\u305a\u3001\u9577\u671f\u306b\u6295\u4e0e\u3057\u305f\u5834\u5408\u306e\u5f71\u97ff\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/span><\/p>\n<p>74\u4eba\u30922\u5e74\u9593\u6cbb\u7642\u3057\u3066\u30012\u5104\u5186\u4ee5\u4e0a\u306e\u304a\u91d1\u3092\u304b\u3051\u3066\u3001\u4f55\u3082\u3057\u306a\u304b\u3063\u305f\u5834\u5408\u3068\u6bd4\u3079\u30661.5\uff05\u3060\u3051\u3057\u304b\u6709\u52b9\u6027\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u672c\u5f53\u306b\u3053\u306e\u85ac\u5fc5\u8981\u3067\u3059\u304b\uff1f\u30b3\u30b9\u30c8\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u4f4e\u3059\u304e\u307e\u305b\u3093\u304b\uff1f\u7cd6\u8cea\u5236\u9650\u3092\u3057\u305f\u307b\u3046\u304c\u6050\u3089\u304f\u6709\u52b9\u6027\u306f\u3082\u3063\u3068\u9ad8\u304f\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u304a\u91d1\u3082\u304b\u304b\u308a\u307e\u305b\u3093\u3057\u3002\u3053\u3093\u306a\u85ac\u3092\u4fdd\u967a\u3067\u8cc4\u3063\u3066\u3044\u305f\u3089\u65e5\u672c\u306e\u533b\u7642\u4fdd\u967a\u306f\u3059\u3050\u306b\u7834\u7dbb\u3057\u307e\u3059\u3002\u4eca\u3067\u3082\u5371\u3046\u3044\u306e\u3067\u3059\u304b\u3089\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"color: #0000ff;\">\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u8ffd\u52a0\u3067\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u4f4e\u6e1b\uff0fNEJM<\/span><\/h2>\n<p><span style=\"color: #0000ff;\">2017\/04\/03\u3000\u30b1\u30a2\u30cd\u30c3\u30c8\u00a0\u3088\u308a\u3000<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u524d\u99c6\u30bf\u30f3\u30d1\u30af\u8cea\u8ee2\u63db\u9175\u7d20\u30b5\u30d6\u30c1\u30ea\u30b7\u30f3\/\u30b1\u30ad\u30b7\u30f39\u578b\uff08PCSK9\uff09\u963b\u5bb3\u85ac\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff08\u5546\u54c1\u540d\uff1a\u30ec\u30d1\u30fc\u30b5\uff09\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u4e0d\u826f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306eLDL-C\u5024\u309230mg\/dL\u307e\u3067\u4f4e\u4e0b\u3055\u305b\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u3001\u7c73\u56fd\u30fb\u30d6\u30ea\u30ac\u30e0\uff06\u30a6\u30a3\u30e1\u30f3\u30ba\u75c5\u9662\u306eMarc S Sabatine\u6c0f\u3089\u304c\u884c\u3063\u305fFOURIER\u8a66\u9a13\u3067\u793a\u3055\u308c\u305f\u3002\u7814\u7a76\u306e\u6210\u679c\u306f\u3001NEJM\u8a8c\u30aa\u30f3\u30e9\u30a4\u30f3\u72482017\u5e743\u670817\u65e5\u53f7\u306b\u63b2\u8f09\u3055\u308c\u305f\u3002\u672c\u85ac\u306f\u5358\u5264\u3067LDL-C\u5024\u3092\u7d0460\uff05\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u4e88\u9632\u3059\u308b\u304b\u306f\u4e0d\u660e\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">2\u4e077,564\u4f8b\u3092\u5bfe\u8c61\u3068\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7121\u4f5c\u70ba\u5316\u8a66\u9a13<\/span><br \/>\n<span style=\"color: #0000ff;\"> \u3000FOURIER\u8a66\u9a13\u306f\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u306e\u30b9\u30bf\u30c1\u30f3\u3078\u306e\u4e0a\u4e57\u305b\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u9632\u306e\u6539\u5584\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u56fd\u969b\u7684\u306a\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\uff08<span style=\"color: #ff0000;\">Amgen\u793e\u306e\u52a9\u6210\u306b\u3088\u308b<\/span>\uff09\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u5bfe\u8c61\u306f\u3001\u5e74\u9f6240\uff5e85\u6b73\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3067\u30b9\u30bf\u30c1\u30f3\u306e\u6295\u4e0e\u3092\u53d7\u3051\u3066\u3044\u308b\u304c\u3001LDL-C\u5024\u304c\u226770mg\/dL\u306e\u60a3\u8005\u3067\u3042\u3063\u305f\u3002\u88ab\u9a13\u8005\u306f\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff08\u60a3\u8005\u306e\u597d\u307f\u3067\u30012\u9031\u3054\u3068\u306b140mg\u307e\u305f\u306f1\u30f5\u6708\u3054\u3068\u306b420mg\u304b\u3089\u9078\u629e\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306e\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u3063\u305f\u3002\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u306e\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u30002013\u5e742\u6708\uff5e2015\u5e746\u6708\u306b\u300149\u30f5\u56fd1,242\u65bd\u8a2d\u30672\u4e077,564\u4f8b\u304c\u767b\u9332\u3055\u308c\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306b1\u4e073,784\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u306f1\u4e073,780\u4f8b\u304c\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f2.2\u5e74\u3060\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">LDL-C\u5024\u304c59\uff05\u4f4e\u4e0b\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u304c15\uff05\u6539\u5584<\/span><br \/>\n<span style=\"color: #0000ff;\"> \u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5168\u4f53\u306e\u5e73\u5747\u5e74\u9f62\u306f63\u6b73\u3001\u5973\u6027\u304c24.6\uff05\u542b\u307e\u308c\u305f\u3002\u5fc3\u7b4b\u6897\u585e\u306e\u65e2\u5f80\u304c81.1\uff05\u3001\u975e\u51fa\u8840\u6027\u8133\u5352\u4e2d\u306e\u65e2\u5f80\u304c19.4\uff05\u3001\u75c7\u5019\u6027\u672b\u68a2\u52d5\u8108\u75be\u60a3\u304c13.2\uff05\u306b\u8a8d\u3081\u3089\u308c\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306f\u3001ACC\/AHA\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306ehigh-intensity\u304c69.3\uff05\u3001moderate-intensity\u304c30.4\uff05\u306b\u884c\u308f\u308c\u30015.2\uff05\u306b\u306f\u30a8\u30bc\u30c1\u30df\u30d6\u3082\u6295\u4e0e\u3055\u308c\u3066\u3044\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u5024\u4e2d\u592e\u5024\u306f92mg\/dL\uff08IQR\uff1a80\uff5e109\uff09\u3067\u3042\u3063\u305f\u300248\u9031\u6642\u306b\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306eLDL-C\u5024\u4e2d\u592e\u5024\u306f30mg\/dL\uff08IQR\uff1a19\uff5e46\uff09\u306b\u4f4e\u4e0b\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u7d76\u5bfe\u5dee\u306f56mg\/dL\uff0895\uff05\u4fe1\u983c\u533a\u9593[CI]\uff1a55\uff5e57\uff09\u3067\u3042\u3063\u305f\u3002LDL-C\u5024\u306e\u6e1b\u5c11\u7387\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5024\u306f59\uff05\uff0895\uff05CI\uff1a58\uff5e60\u3001p\uff1c0.001\uff09\u3067\u3042\u308a\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u304c\u6709\u610f\u306b\u826f\u597d\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u767a\u751f\u306f\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u304c9.8\uff05\uff081,344\u4f8b\uff09\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e11.3\uff05\uff081,563\u4f8b\uff09\u306b\u6bd4\u3079\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4[HR]\uff1a0.85\u300195\uff05CI\uff1a0.79\uff5e0.92\u3001p\uff1c0.001\uff09\u3002\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306e\u767a\u751f\u3082\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u304c\u6709\u610f\u306b\u826f\u597d\u3060\u3063\u305f\uff085.9\uff05[816\u4f8b] vs.7.4\uff05[1,013\u4f8b]\u3001HR\uff1a0.80\u300195\uff05CI\uff1a0.73\uff5e0.88\u3001p\uff1c0.001\uff09\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u307e\u305f\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u6bd4\u3057\u3001\u5fc3\u7b4b\u6897\u585e\uff083.4 vs.4.6\uff05\u3001HR\uff1a0.73\u300195\uff05CI\uff1a0.65\uff5e0.82\u3001p\uff1c0.001\uff09\u3001\u8133\u5352\u4e2d\uff081.5 vs.1.9\uff05\u30010.79\u30010.66\uff5e0.95\u3001p\uff1d0.01\uff09\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\uff085.5 vs.7.0\uff05\u30010.78\u30010.71\uff5e0.86\u3001p\uff1c0.001\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\/\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\uff081.7 vs.2.1\uff05\u30010.77\u30010.65\uff5e0.92\u3001p\uff1d0.003\uff09\u3092\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3002\u4e00\u65b9\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u56e0\u6b7b\u4ea1\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u3001\u5fc3\u8840\u7ba1\u6b7b\/\u5fc3\u4e0d\u5168\u306e\u5897\u60aa\u306b\u3088\u308b\u5165\u9662\u306b\u306f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306b\u95a2\u3059\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001\u5e74\u9f62\u3001\u6027\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u52d5\u8108\u786c\u5316\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30bf\u30a4\u30d7\u306a\u3069\u306e\u4e3b\u8981\u306a\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306e\u307b\u3068\u3093\u3069\u306b\u4e00\u8cab\u3057\u3066\u8a8d\u3081\u3089\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u5024\u306e\u6700\u9ad8\u56db\u5206\u4f4d\u7fa4\uff08\u4e2d\u592e\u5024\uff1a126mg\/dL\u3001IQR\uff1a116\uff5e143\uff09\u304b\u3089\u6700\u4f4e\u56db\u5206\u4f4d\u7fa4\uff0874mg\/dL\u300169\uff5e77\uff09\u307e\u3067\u3001\u4e00\u8cab\u3057\u3066\u307f\u3089\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3000\u6709\u5bb3\u4e8b\u8c61\uff0877.4 vs.77.4\uff05\uff09\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\uff0824.8 vs.24.7\uff05\uff09\u3001\u6cbb\u9a13\u85ac\u95a2\u9023\u3068\u8003\u3048\u3089\u308c\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u73fe\u304a\u3088\u3073\u6cbb\u9a13\u30ec\u30b8\u30e1\u30f3\u306e\u4e2d\u6b62\uff081.6 vs.1.5\uff05\uff09\u306f\u3001\u4e21\u7fa4\u306b\u6709\u610f\u306a\u5dee\u306f\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u7b4b\u95a2\u9023\u30a4\u30d9\u30f3\u30c8\uff085.0 vs.4.8\uff05\uff09\u3001\u767d\u5185\u969c\uff081.7 vs.1.8\uff05\uff09\u3001\u65b0\u898f\u7cd6\u5c3f\u75c5\uff088.1 vs.7.7\uff05\uff09\u3001\u795e\u7d4c\u8a8d\u77e5\u6709\u5bb3\u4e8b\u8c61\uff081.6 vs.1.5\uff05\uff09\u306b\u3082\u3001\u4e21\u7fa4\u306b\u5dee\u306f\u306a\u304b\u3063\u305f\u304c\u3001\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc\uff082.1 vs.1.6\uff05\u3001p\uff1c0.001\uff09\u306f\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u3067\u6709\u610f\u306b\u591a\u304f\u307f\u3089\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: 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