{"id":13025,"date":"2020-06-11T15:36:10","date_gmt":"2020-06-11T06:36:10","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=13025"},"modified":"2020-06-11T15:36:10","modified_gmt":"2020-06-11T06:36:10","slug":"post-13025","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=13025","title":{"rendered":"\u514d\u75ab\u6a5f\u80fd\u306f\u5973\u6027\u306e\u65b9\u304c\u9ad8\u3044"},"content":{"rendered":"<p>\u30bd\u30d5\u30c8\u30d0\u30f3\u30af\u30b0\u30eb\u30fc\u30d7\u304c\u5927\u898f\u6a21\u306a\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u6297\u4f53\u691c\u67fb\u306e\u7d50\u679c\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\uff08<a href=\"https:\/\/group.softbank\/system\/files\/pdf\/antibodytest.pdf\" target=\"_blank\" rel=\"noopener 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href=\"https:\/\/news.yahoo.co.jp\/articles\/51bfe2268093501de66d79168f4e089ffbd91b9e\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u3084\u3063\u3068\u521d\u3081\u3066\u306e\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u304c\u7b2c3\u76f8\u8a66\u9a13\u306e\u627f\u8a8d\u304c\u5f97\u3089\u308c\u305f\u3070\u304b\u308a\u3067\u3059\u3002\uff08<a href=\"https:\/\/news.yahoo.co.jp\/articles\/bd43803fd53a795c92a09247d2a886d8854aa303\" target=\"_blank\" rel=\"noopener 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href=\"http:\/\/promea2014.com\/blog\/?p=12411\" target=\"_blank\" rel=\"noopener 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data-image-title=\"Submitted to Hormones and Behavior on: XX May 2007\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?fit=300%2C251&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?fit=640%2C534&amp;ssl=1\" class=\"alignnone size-medium wp-image-13033\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?resize=300%2C251\" alt=\"\" width=\"300\" height=\"251\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?resize=300%2C251&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?resize=768%2C641&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?resize=320%2C267&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/06\/0c9f564a9ba48cedf67174690d4fa632.jpg?w=800&amp;ssl=1 800w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\uff08\u56f3\u306f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20417416\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09<\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3068\u7372\u5f97\u514d\u75ab\u5fdc\u7b54\u306e\u6027\u5dee\u3092\u793a\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u4e0a\u6bb5\u304c\u5973\u6027\u3001\u4e0b\u6bb5\u304c\u7537\u6027\u3067\u3059\u3002\u7d30\u304b\u3044\u8aac\u660e\u306f\u7701\u7565\u3057\u307e\u3059\u304c\u3001\u5973\u6027\u306e\u65b9\u304c\u514d\u75ab\u306e\u5fdc\u7b54\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eba\u4f53\u306f\u75c5\u539f\u4f53\u304c\u4f53\u306e\u4e2d\u306b\u5165\u3063\u3066\u304f\u308b\u3068\u3001\u307e\u305a\u306f\u81ea\u7136\u514d\u75ab\u3067\u5bfe\u5fdc\u3057\u307e\u3059\u3002\u81ea\u7136\u514d\u75ab\u306f\u3001\u611f\u67d3\u3057\u305f\u75c5\u539f\u4f53\u3092\u7279\u7570\u7684\u306b\u898b\u5206\u3051\u3066\u8a18\u61b6\u3059\u308b\u3053\u3068\u3067\u3001\u540c\u3058\u75c5\u539f\u4f53\u304c\u518d\u5ea6\u5165\u3063\u3066\u304d\u305f\u3068\u304d\u306b\u52b9\u679c\u7684\u306b\u75c5\u539f\u4f53\u3092\u6392\u9664\u3067\u304d\u308b\u7372\u5f97\u514d\u75ab\u3068\u9055\u3044\u3001\u7279\u5b9a\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u75c5\u539f\u4f53\u306b\u5171\u901a\u3057\u305f\u5206\u5b50\u3084\u69cb\u9020\u30d1\u30bf\u30fc\u30f3\u3092\u8a8d\u8b58\u3057\u3066\u653b\u6483\u3057\u307e\u3059\u3002<\/p>\n<p>\u75c5\u539f\u4f53\u306e\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\uff08PRR\uff09\u306e\u4e00\u3064\u3067\u3042\u308b\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u3078\u306e\u5fdc\u7b54\u306e\u9055\u3044\u3082\u7537\u5973\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u5973\u6027\u3088\u308a\u3082\u7537\u6027\u3067\u3001\u672b\u68a2\u8840\u5358\u6838\u7403\u306e\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u306eTLR7\u306b\u5fdc\u7b54\u3057\u305f\u6297\u30a6\u30a4\u30eb\u30b9\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306eIFN-\u03b1\u306e\u91cf\u304c\u5c11\u306a\u304f\u3001TLR8\u304a\u3088\u3073TLR9\u306b\u5fdc\u7b54\u3057\u305f\u514d\u75ab\u6291\u5236\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IL10\u306e\u91cf\u3082\u591a\u304f\u306a\u308a\u307e\u3057\u305f\u3002\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3387221\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u3064\u307e\u308a\u3001\u5973\u6027\u3088\u308a\u3082\u7537\u6027\u306e\u65b9\u304c\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u304c\u8d77\u304d\u305f\u3068\u304d\u306e\u653b\u6483\u304c\u5f31\u304f\u3001\u514d\u75ab\u3092\u6291\u5236\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3082\u5897\u52a0\u3059\u308b\u306e\u3067\u3059\u3002\u5973\u6027\u306e\u65b9\u304c\u81ea\u7136\u514d\u75ab\u306e\u53cd\u5fdc\u304c\u5927\u304d\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u5973\u6027\u306f\u611f\u67d3\u306b\u5f37\u3044\u306e\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u3053\u3068\u306f\u3001\u9006\u306b\u5973\u6027\u306e\u65b9\u304c\u30ef\u30af\u30c1\u30f3\u306e\u526f\u4f5c\u7528\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u304c\u591a\u304f\u306a\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3067\u306f\u81ea\u7136\u514d\u75ab\u304b\u3089\u7372\u5f97\u514d\u75ab\u306e\u6a4b\u6e21\u3057\u304c\u3046\u307e\u304f\u884c\u304b\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u5834\u5408\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u305d\u306e\u3053\u3068\u304c\u91cd\u75c7\u5316\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002IFN-\u03b1\/\u03b2\u3068\u3044\u3046I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c\u306e\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3060\u3051\u3067\u306a\u304f\u7372\u5f97\u514d\u75ab\u306e\u6d3b\u6027\u5316\u306b\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>\u524d\u56de\u306eSARS\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u975e\u30ea\u30f3\u30d1\u7cfb\u7d30\u80de\u306b\u304a\u3051\u308bI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u8a98\u5c0e\u3092\u52b9\u7387\u7684\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5b9f\u9a13\u4e0a\u3067\u306f\u5c11\u91cf\u306eIFN- \u03b1\u3067\u523a\u6fc0\u3057\u3066\u304a\u304f\u3068\u3001\u3053\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u3088\u308bI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u6291\u5236\u3092\u9632\u6b62\u3067\u304d\u308b\u3068\u3044\u3046\u7d50\u679c\u304c\u51fa\u3066\u3044\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19625461\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u304cI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u8a98\u5c0e\u3092\u3069\u3053\u307e\u3067\u6291\u5236\u3057\u3066\u3044\u308b\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u540c\u3058\u3088\u3046\u306a\u3053\u3068\u304c\u8d77\u304d\u3066\u3044\u3066\u3001\u81ea\u7136\u514d\u75ab\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3084\u7372\u5f97\u514d\u75ab\u306e\u9045\u308c\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3067\u306f\u3001\u524d\u56de\u306eSARS\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3092\u542b\u3080\u4ed6\u306e\u591a\u304f\u306e\u30d2\u30c8\u75c5\u539f\u6027\u30a6\u30a4\u30eb\u30b9\u3088\u308a\u3082I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32360182\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u3064\u307e\u308a\u3001\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306e\u6291\u5236\u306b\u306fI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u304c\u975e\u5e38\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u305d\u3046\u3059\u308b\u3068\u3001\u305f\u3068\u3048\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u304cI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u8a98\u5c0e\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u305f\u3068\u3057\u3066\u3082\u3001\u524d\u56de\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u307b\u3069\u3067\u306f\u306a\u304f\u3001\u81f4\u6b7b\u7387\u304c\u4f4e\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u3001I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u81ea\u7136\u514d\u75ab\u306e\u529b\u306e\u3061\u3087\u3063\u3068\u3057\u305f\u9055\u3044\u304c\u91cd\u75c7\u5316\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5206\u3051\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u305d\u3046\u3060\u3068\u3059\u308b\u3068\u3001\u5973\u6027\u3067\u306f\u7537\u6027\u3088\u308a\u3082IFN-\u03b1\u304c\u591a\u304f\u306a\u308a\u3001BCG\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u81ea\u7136\u514d\u75ab\u306e\u8a13\u7df4\u304c\u52b9\u679c\u3092\u4e0a\u3052\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u91cd\u75c7\u5316\u3092\u9632\u3052\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u9ad8\u9f62\u8005\u3001\u7cd6\u5c3f\u75c5\u3084\u80a5\u6e80\u3067\u306f\u514d\u75ab\u529b\u4f4e\u4e0b\u3092\u8d77\u3053\u3059\u306e\u3067\u3001\u81ea\u7136\u514d\u75ab\u306e\u9632\u5fa1\u529b\u304c\u5f31\u307e\u308a\u3001\u3055\u3089\u306b\u7372\u5f97\u514d\u75ab\u306e\u9045\u308c\u304c\u91cd\u75c7\u5316\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5b50\u4f9b\u3067\u306f\u3082\u3057\u304b\u3059\u308b\u3068\u80f8\u817a\u304c\u5927\u304d\u306a\u529b\u3092\u767a\u63ee\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u514d\u75ab\u529b\u3092\u4e0b\u3052\u306a\u3044\u3088\u3046\u306b\u3057\u3066\u3044\u308c\u3070\u3001\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306f\u5168\u304f\u6016\u3044\u3082\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u305d\u308c\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u300cSex-based differences in immune function and responses to vaccination\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u514d\u75ab\u6a5f\u80fd\u306e\u6027\u5225\u306b\u3088\u308b\u9055\u3044\u3068\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25573105\/\" target=\"_blank\" rel=\"noopener 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