{"id":1318,"date":"2017-04-28T23:00:30","date_gmt":"2017-04-28T14:00:30","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=1318"},"modified":"2017-04-28T23:00:30","modified_gmt":"2017-04-28T14:00:30","slug":"post-1318","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=1318","title":{"rendered":"\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u304c\u610f\u56f3\u7684\u306b\u6e1b\u91cf\u3059\u308b\u3068\u3001\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044"},"content":{"rendered":"<p>\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u304c\u610f\u56f3\u7684\u306b\u6e1b\u91cf\u3059\u308c\u3070\u3001\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u6e1b\u3089\u305b\u308b\u3068\u3044\u3046\u7814\u7a76\u306e\u8a18\u4e8b\u304c\u51fa\u307e\u3057\u305f\u3002\uff08\u8a18\u4e8b\u306e\u539f\u6587\u306f<a href=\"http:\/\/www.medscape.com\/viewarticle\/875429#vp_1\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09\uff08\u8ad6\u6587\u306e\u539f\u6587\u306f<a href=\"http:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2016.70.5822?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%3dpubmed\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u4ee5\u4e0b\u306f\u305d\u306e\u7814\u7a76\u306e\u8a18\u4e8b\u306b\u8981\u7d04\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>the Women&#8217;s Health Initiative (WHI)\u304b\u3089\u306e\u30c7\u30fc\u30bf\u306e\u5206\u6790\u306b\u3088\u308b\u3068\u3001\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306e\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306f\u3001\u610f\u56f3\u7684\u306b\u6e1b\u91cf\u3057\u305fBMI30\u4ee5\u4e0a\u306e\u80a5\u6e80\u5973\u6027\u306b\u304a\u3044\u3066\u6700\u3082\u5927\u304d\u304f\u3001\u610f\u56f3\u7684\u306b\u4f53\u91cd\u3092\u6e1b\u3089\u3059\u3053\u3068\u306f\u3001\u5b89\u5b9a\u3057\u305f\u4f53\u91cd\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u3068\u6bd4\u8f03\u3057\u306656\uff05\u3082\u30ea\u30b9\u30af\u304c\u6e1b\u5c11\u3057\u305f\u3057\u305f\u306e\u3067\u3059\u3002\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4[HR]\u30010.44; 95\uff05\u4fe1\u983c\u533a\u9593[CI]\u30010.25-0.78\uff09\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u4f53\u91cd\u3092\u6e1b\u3089\u3057\u305f\u3059\u3079\u3066\u306e\u5973\u6027\u306b\u304a\u3044\u3066\u3067\u3082\u300129\uff05\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u5bfe\u8c61\u306f50\uff5e79\u6b73\u306e\u9589\u7d4c\u5f8c\u306e\u5973\u602736,794\u4eba\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u767b\u9332\u6642\u30683\u5e74\u5f8c\u306b\u4f53\u91cd\u3092\u6e2c\u5b9a\u3057\u3001\u4f53\u91cd\u6e1b\u5c11\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u767b\u9332\u30683\u5e74\u5f8c\u306e\u4f53\u91cd\u306e5\uff05\u4ee5\u4e0a\u306e\u6e1b\u5c11\u3068\u5b9a\u7fa9\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4f53\u91cd\u6e1b\u5c11\u304c\u610f\u56f3\u7684\u3067\u3042\u3063\u305f\u304b\u3069\u3046\u304b\u3082\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u5f8c\u306e11.4\u5e74\u9593\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u671f\u9593\u4e2d\u3001566\u4eba\u304c\u5b50\u5bae\u4f53\u304c\u3093\u3092\u767a\u75c7\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7c73\u56fd\u306e\u5b50\u5bae\u4f53\u304c\u3093\u306e60\uff05\u8fd1\u304f\u304c\u904e\u5270\u306a\u4f53\u91cd\u306b\u8d77\u56e0\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>2016\u5e74\u306e\u5b50\u5bae\u4f53\u304c\u3093\u306e\u6b7b\u8005\u6570\u306f10,170\u306b\u9054\u3057\u30015\u5e74\u524d\u3068\u6bd4\u8f03\u3057\u306625\uff05\u306e\u5897\u52a0\u3068\u306a\u3063\u305f\u305d\u3046\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u4f53\u91cd\u6e1b\u5c11\u304c\u3001\u4eba\u751f\u306e\u5f8c\u534a\u3067\u3082\u3001\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u4eca\u56de\u306e\u8abf\u67fb\u7d50\u679c\u306f\u3001\u592a\u308a\u3059\u304e\u3084\u80a5\u6e80\u306e\u6210\u4eba\u306e\u304c\u3093\u4e88\u9632\u6226\u7565\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u6e1b\u91cf\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u958b\u767a\u3092\u652f\u63f4\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u7814\u7a76\u8005\u3089\u306f\u3001\u6210\u4eba\u671f\u306b\u81ea\u8a18\u5f0f\u306e\u4f53\u91cd\u6e1b\u5c11\u3068\u7d50\u3073\u3064\u3044\u305f\u4ed6\u306e4\u4ef6\u306e\u89b3\u5bdf\u7814\u7a76\u3067\u3001\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u7a0b\u5ea6\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u610f\u56f3\u7684\u3067\u306a\u3044\u3053\u3068\u306f\u91cd\u8981\u3067\u3059\u3002\u306a\u305c\u306a\u3089\u3001\u610f\u56f3\u7684\u3067\u306a\u3044\u4f53\u91cd\u6e1b\u5c11\u306f\u304c\u3093\u306e\u7f79\u60a3\u7387\u306e\u5897\u52a0\u3068\u9ad8\u5ea6\u306b\u76f8\u95a2\u3057\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n<p>\u5b50\u5bae\u4f53\u304c\u3093\u306f\u30a2\u30e1\u30ea\u30ab\u3067\u6700\u3082\u4e00\u822c\u7684\u306a\u5a66\u4eba\u79d1\u304c\u3093\u3067\u3042\u308a\u3001\u307b\u3068\u3093\u3069\u306e\u75c7\u4f8b\u306f\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u307f\u3089\u308c\u307e\u3059\u3002 \u5973\u6027\u306e\u7d042.8\uff05\u304c\u751f\u6daf\u306b\u308f\u305f\u3063\u3066\u5b50\u5bae\u4f53\u304c\u3093\u3068\u8a3a\u65ad\u3055\u308c\u308b\u305d\u3046\u3067\u3059\u3002\u305d\u306e\u751f\u6daf\u306e\u767a\u751f\u7387\u306f\u3001\u80a5\u6e80\u5973\u6027\u3067\u3088\u308a\u9ad8\u304f\u306a\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span id=\"result_box\" lang=\"ja\" tabindex=\"-1\"><span title=\"\u201cMany older adults think it\u2019s too late to benefit from weight loss or think that because they are overweight or obese, the damage has already been done.\">\u591a\u304f\u306e\u9ad8\u9f62\u8005\u306f\u4f53\u91cd\u6e1b\u5c11\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u306b\u306f\u9045\u3059\u304e\u308b\u3068\u601d\u3046\u3057\u3001\u4f53\u91cd\u304c\u904e\u4f53\u91cd\u307e\u305f\u306f\u80a5\u6e80\u3067\u3042\u308b\u305f\u3081\u3001\u3059\u3067\u306b\u30c0\u30e1\u30fc\u30b8\u304c\u751f\u3058\u3066\u3044\u308b\u3068\u8003\u3048\u308b\u3002<\/span><span title=\"But our findings show that\u2019s not true,\u201d said Dr Luo.\n\n\">\u3057\u304b\u3057\u3001\u3053\u306e\u767a\u898b\u306f\u305d\u308c\u304c\u771f\u5b9f\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/span><span title=\"&quot;The findings should also motivate women to lose weight,&quot; she added.\n\n\">\u3053\u306e\u8abf\u67fb\u7d50\u679c\u306f\u307e\u305f\u3001\u5973\u6027\u306b\u4f53\u91cd\u3092\u6e1b\u3089\u3059\u3088\u3046\u52d5\u6a5f\u3065\u3051\u308b\u306f\u305a\u3067\u3059\u3002<br \/>\n<\/span><span title=\"They were also more likely to have had no hormone therapy use, younger age at menarche, more term pregnancies, and younger age at first birth (all P &lt; .05).\n\n\"><br \/>\n<\/span><span title=\"The investigators also found that women who gained 10 pounds or more had a 26% higher risk for endometrial cancer than women whose weight was stable (HR, 1.26; 95% CI, 1.00 - 1.57).\n\n\">\u7814\u7a76\u8005\u3089\u306f\u300110\u30dd\u200b\u200b\u30f3\u30c9\uff08\u7d044.5kg\uff09\u4ee5\u4e0a\u4f53\u91cd\u304c\u5897\u52a0\u3057\u305f\u5973\u6027\u306f\u3001\u4f53\u91cd\u304c\u5b89\u5b9a\u3057\u3066\u3044\u308b\u5973\u6027\u3088\u308a\u3082\u5b50\u5bae\u4f53\u3060\u3093\u306e\u30ea\u30b9\u30af\u304c26\uff05\u9ad8\u3044\u3053\u3068\u3082\u767a\u898b\u3057\u307e\u3057\u305f\uff08HR\u30011.26; 95\uff05CI\u30011.00-1.57\uff09\u3002<\/span><span title=\"Notably, a second sensitivity analysis showed that women who intentionally lost weight and had a normal BMI at 3 years (ie, &lt;25 kg\/m2) had the same risk for endometrial cancer as women who maintained a stable normal BMI.\n\n\">\u610f\u56f3\u7684\u306b\u4f53\u91cd\u304c\u6e1b\u5c11\u3057\u30013\u5e74\u5f8c\u306b\u6b63\u5e38\u306aBMI\u300125\u672a\u6e80\u306e\u5973\u6027\u306f\u3001\u5b89\u5b9a\u3057\u305f\u6b63\u5e38BMI\u3092\u7dad\u6301\u3057\u305f\u5973\u6027\u3068\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u540c\u7a0b\u5ea6\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><\/span><span title=\"The authors also reported no significant difference in risk between hormone users and nonusers.\">\u30db\u30eb\u30e2\u30f3\u306e\u4f7f\u7528\u8005\u3068\u975e\u4f7f\u7528\u8005\u306e\u9593\u306b\u3082\u6709\u610f\u5dee\u306f\u306a\u3044\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><span title=\"This was important because endometrial cancer is known to be highly hormone related, they say.\n\n\">\u5b50\u5bae\u4f53\u304c\u3093\u306f\u9ad8\u3044\u30db\u30eb\u30e2\u30f3\u3068\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u306f\u91cd\u8981\u3067\u3057\u305f\u3002<\/p>\n<p><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u80a5\u6e80\u306f\u4e07\u75c5\u306e\u3082\u3068\uff01\u80a5\u6e80\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3067\u6700\u3082\u8d77\u3053\u308b\u3053\u3068\u3067\u3059\u3002\u6700\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5206\u6ccc\u3055\u308c\u308b\u306e\u306f\u7cd6\u8cea\u306e\u6442\u53d6\u3067\u3059\u3002\u305d\u308c\u304c\u308f\u304b\u308c\u3070\u3001\u75e9\u305b\u308b\u3053\u3068\u306f\u7c21\u5358\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u304c\u610f\u56f3\u7684\u306b\u6e1b\u91cf\u3059\u308c\u3070\u3001\u5b50\u5bae\u4f53\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u6e1b\u3089\u305b\u308b\u3068\u3044\u3046\u7814\u7a76\u306e\u8a18\u4e8b\u304c\u51fa\u307e\u3057\u305f\u3002\uff08\u8a18\u4e8b\u306e\u539f\u6587\u306f\u3053\u3053\uff09\uff08\u8ad6\u6587\u306e\u539f\u6587\u306f\u3053\u3053\uff09 &nbsp; \u4ee5\u4e0b\u306f\u305d\u306e\u7814\u7a76\u306e\u8a18\u4e8b\u306b\u8981\u7d04\u3067\u3059\u3002 &nbsp; the 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