{"id":1339,"date":"2017-05-08T21:21:09","date_gmt":"2017-05-08T12:21:09","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=1339"},"modified":"2017-05-08T21:21:09","modified_gmt":"2017-05-08T12:21:09","slug":"post-1339","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=1339","title":{"rendered":"\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u904b\u52d5\u306b\u3088\u308b\u52b9\u679c\u3092\u5f31\u3081\u3066\u3057\u307e\u3046"},"content":{"rendered":"<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u3067\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=1199\" target=\"_blank\" rel=\"noopener noreferrer\">\u9ad8\u9f62\u8005\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u6700\u3082\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u52b9\u679c\u7684<\/a>\u300d\u3068\u3044\u3046\u306e\u3092\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u30ad\u30fc\u30ef\u30fc\u30c9\u306f\u300c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u300d\u3067\u3057\u305f\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u5de5\u5834\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6570\u304c\u5897\u3048\u3001\u6a5f\u80fd\u304c\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u975e\u5e38\u306b\u5927\u5207\u3067\u3059\u3002\u904b\u52d5\u306f\u6700\u3082\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305b\u3063\u304b\u304f\u306e\u904b\u52d5\u3067\u3082\u3001\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u30d3\u30bf\u30df\u30f3C\u3084\u30d3\u30bf\u30df\u30f3E\u3092\u5927\u91cf\u306b\u98f2\u3093\u3067\u3044\u308b\u3068\u3001\u305d\u306e\u904b\u52d5\u306e\u52b9\u679c\u3092\u6253\u3061\u6d88\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u7279\u306b\u30de\u30e9\u30bd\u30f3\u306e\u3088\u3046\u306a\u6301\u4e45\u529b\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5f8c\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u4f7f\u7528\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=1244\" target=\"_blank\" rel=\"noopener noreferrer\">\u30d3\u30bf\u30df\u30f3\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u98f2\u3081\u3070\u826f\u3044\u3063\u3066\u3082\u3093\u3058\u3083\u306a\u3044\uff01\u672c\u5f53\u306b\u5fc5\u8981\u304b\u3001\u52b9\u679c\u306f\u3042\u308b\u306e\u304b\u306e\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5927\u5207\u304b\u3082<\/a>\uff1f\u300d\u3067\u3082\u89e6\u308c\u3001\u4e88\u544a\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u4eca\u65e5\u306f\u3044\u304f\u3064\u304b\u306e\u30b9\u30dd\u30fc\u30c4\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u3092\u3054\u7d39\u4ecb\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305a\u306f\u3001<\/p>\n<p><span style=\"color: #0000ff;\">Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial\u3000\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2013.267419\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u30d2\u30c8\u306e\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u5bfe\u3059\u308b\u7d30\u80de\u9069\u5fdc\u3092\u59a8\u3052\u308b\uff1a\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u30ad\u30fc\u30dd\u30a4\u30f3\u30c8<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"color: #0000ff;\">\u6700\u8fd1\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u6301\u4e45\u529b\u8a13\u7df4\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5408\u6210\u306a\u3069\u3001\u904b\u52d5\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u3092\u920d\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u30d2\u30c8\u306e\u7814\u7a76\u306f\u5c11\u306a\u304f\u3001\u7d50\u679c\u306f\u76f8\u53cd\u3057\u3066\u3044\u308b\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u5206\u96e2\u3055\u308c\u305f\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u904b\u52d5\u306b\u3088\u308b\u7d30\u80de\u304a\u3088\u3073\u751f\u7406\u5b66\u7684\u9069\u5fdc\u306b\u304a\u3051\u308b\u3053\u308c\u3089\u306e\u30d3\u30bf\u30df\u30f3\u306e\u59a8\u5bb3\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u306f\u3001\u5065\u5eb7\u76ee\u7684\u306e\u305f\u3081\u306b\u904b\u52d5\u3059\u308b\u4eba\u3005\u3084\u904b\u52d5\u9078\u624b\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3042\u308b\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u79c1\u305f\u3061\u306e\u7d50\u679c\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u3068E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u3001\u7b4b\u8089\u6301\u4e45\u529b\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u8a98\u767a\u3055\u308c\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30bf\u30f3\u30d1\u30af\u8cea\uff08COX4\uff09\u306e\u5897\u52a0\u3092\u920d\u3089\u305b\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\u306e\u5897\u5f37\u3068\u30e9\u30f3\u30cb\u30f3\u30b0\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306f\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u306a\u304b\u3063\u305f\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u3053\u306e\u7814\u7a76\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u304c\u30d2\u30c8\u306e\u904b\u52d5\u9069\u5fdc\u306b\u3069\u306e\u3088\u3046\u306b\u5e72\u6e09\u3059\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u3001\u305d\u306e\u7d50\u679c\u306f\u9ad8\u7528\u91cf\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u3092\u6ce8\u610f\u3057\u3066\u4f7f\u7528\u3059\u3079\u304d\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"color: #0000ff;\">\u8981\u7d04<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u3053\u306e\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u306f\u3001\u30d2\u30c8\u306e\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u9069\u5fdc\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3C\u3068E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5f71\u97ff\u3092\u8abf\u3079\u305f\u300254\u4eba\u306e\u82e5\u3044\u7537\u6027\u3068\u5973\u6027\u304c1000mg\u306e\u30d3\u30bf\u30df\u30f3C\u3068235mg\u306e\u30d3\u30bf\u30df\u30f3E\u306e\u3044\u305a\u308c\u304b\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u6bce\u65e511\u9031\u9593\u6295\u4e0e\u3055\u308c\u308b\u3088\u3046\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u670d\u7528\u306e\u9593\u3001\u53c2\u52a0\u8005\u306f\u9031\u306b3~4\u56de\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\uff08\u4e3b\u306b\u8d70\u3063\u3066\u3044\u308b\uff09\u304b\u3089\u306a\u308b\u8010\u4e45\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u5b8c\u4e86\u3057\u3001\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30bb\u30c3\u30b7\u30e7\u30f3[4-6\u00d74-6\u5206;<span class=\"Apple-converted-space\">\u00a0<\/span>&gt; 90\uff05\u306e\u6700\u5927\u5fc3\u62cd\u6570\uff08HR<span class=\"Apple-converted-space\">\u00a0<\/span><sub>max<\/sub>\uff09]\u304a\u3088\u3073\u5b9a\u5e38\u72b6\u614b\u306e\u9023\u7d9a\u30bb\u30c3\u30b7\u30e7\u30f3\uff0830-60\u5206; HR<span class=\"Apple-converted-space\">\u00a0<\/span><sub>max\u306e<\/sub><span class=\"Apple-converted-space\">\u00a0<\/span>70\u301c90\uff05\uff09\u3092\u884c\u3063\u305f\u3002\u4ecb\u5165\u306e\u524d\u5f8c\u3067\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\u3001\u6e96\u6700\u5927\u904b\u52d5\u91cf\u306e\u30e9\u30f3\u30cb\u30f3\u30b0\u304a\u3088\u307320m\u30b7\u30e3\u30c8\u30eb\u30e9\u30f3\u8a66\u9a13\u3092\u8a55\u4fa1\u3057\u3001\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u304a\u3088\u3073\u7b4b\u8089\u751f\u691c\u3092\u63a1\u53d6\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u7fa4\u306e\u53c2\u52a0\u8005\u306f\u3001\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\uff08\u5e73\u5747\u00b1\u00a0<span class=\"smallCaps\">SD<\/span>\uff1a8\u00b15\uff05\uff09\u306820m\u30b7\u30e3\u30c8\u30eb\u30e9\u30f3\u8a66\u9a13\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\uff0810\u00b111\uff05\uff09\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u540c\u7a0b\u5ea6\u306b\u5411\u4e0a\u3055\u305b\u305f\uff08\u5e73\u5747\u00b1\u00a0<span class=\"Apple-converted-space\">\u00a0<\/span><span class=\"smallCaps\">SD<\/span>\uff1a8 \u00b15\uff05\u304a\u3088\u307314\u00b117\uff05\uff09\u3002\u3057\u304b\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30b7\u30c8\u30af\u30ed\u30e0c\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8IV\uff08COX4\uff09\u304a\u3088\u3073\u7d30\u80de\u8cea\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53-\u03b3\u5171\u6d3b\u6027\u5316\u56e0\u5b501\u03b1\uff08PGC-1\u03b1\uff09\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u5916\u5074\u5e83\u7b4b\u3067\u5897\u52a0\u3057\u305f\u3002\uff08\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u7fa4\u3067\u306fCOX4\uff1a-13\u00b154\uff05\u3001PGC-1\u03b1\uff1a-13\u00b129\uff05\u3001<em>P<\/em><span class=\"Apple-converted-space\">\u00a0<\/span>\u00a0\u22660.03\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f59\u00b197\uff05\u300119\u00b151\uff05\uff09\u3002\u3055\u3089\u306b\u3001<em>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u7b4b\u8089\u306b\u304a\u3051\u308bCDC42\u3068\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc1\uff08MAPK1\uff09\u306emRNA\u30ec\u30d9\u30eb\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3082\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u7fa4\u3067\u4f4e\u304b\u3063\u305f\uff08 P\u00a0<\/em><span class=\"Apple-converted-space\">\u00a0<\/span>\u22660.05\uff09\u3002\u6bce\u65e5\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u88dc\u7d66\u306f\u3001\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u306e\u30de\u30fc\u30ab\u30fc\u306e\u5897\u52a0\u3092\u5f31\u3081\u308b\u3002\u3057\u304b\u3057\u3001\u6539\u5584\u3068\u30e9\u30f3\u30cb\u30f3\u30b0\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u3064\u3044\u3066\u660e\u78ba\u306a\u76f8\u4e92\u4f5c\u7528\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<span class=\"goog-text-highlight\">\u305d\u306e\u7d50\u679c\u3001\u30d3\u30bf\u30df\u30f3C\u3068E\u306e\u88dc\u7d66\u306f\u7b4b\u8089\u306e\u7d30\u80de\u9069\u5fdc\u3092\u59a8\u3052\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u672c\u8a66\u9a13\u3067\u4f7f\u7528\u3057\u305f\u6027\u80fd\u8a66\u9a13\u306b\u306f\u9069\u5408\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u6297\u9178\u5316\u7269\u8cea\u88dc\u7d66\u3068\u6301\u4e45\u529b\u904b\u52d5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3092\u691c\u8a0e\u3059\u308b\u969b\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/span>\u6bce\u65e5\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u88dc\u7d66\u306f\u3001\u6301\u4e45\u529b\u8a13\u7df4\u5f8c\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u306e\u30de\u30fc\u30ab\u30fc\u306e\u5897\u52a0\u3092\u5f31\u3081\u308b\u3002\u3057\u304b\u3057\u3001\u6539\u5584\u3068\u30e9\u30f3\u30cb\u30f3\u30b0\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u3064\u3044\u3066\u660e\u78ba\u306a\u76f8\u4e92\u4f5c\u7528\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30d3\u30bf\u30df\u30f3C\u3068E\u306e\u88dc\u7d66\u306f\u7b4b\u8089\u306e\u7d30\u80de\u9069\u5fdc\u3092\u59a8\u3052\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u672c\u8a66\u9a13\u3067\u4f7f\u7528\u3057\u305f\u6027\u80fd\u8a66\u9a13\u306b\u306f\u9069\u5408\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u6297\u9178\u5316\u7269\u8cea\u88dc\u7d66\u3068\u6301\u4e45\u529b\u904b\u52d5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3092\u691c\u8a0e\u3059\u308b\u969b\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u6bce\u65e5\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u88dc\u7d66\u306f\u3001\u6301\u4e45\u529b\u8a13\u7df4\u5f8c\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u306e\u30de\u30fc\u30ab\u30fc\u306e\u5897\u52a0\u3092\u5f31\u3081\u308b\u3002\u3057\u304b\u3057\u3001\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\u306e\u5411\u4e0a\u3068\u30e9\u30f3\u30cb\u30f3\u30b0\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u3064\u3044\u3066\u660e\u78ba\u306a\u76f8\u4e92\u4f5c\u7528\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30d3\u30bf\u30df\u30f3C\u3068E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u7b4b\u8089\u306e\u7d30\u80de\u9069\u5fdc\u3092\u59a8\u3052\u3066\u3044\u308b\u306e\u3067\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u6301\u4e45\u529b\u904b\u52d5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3092\u691c\u8a0e\u3059\u308b\u969b\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u6b21\u306b\u540c\u3058\u7814\u7a76\u8005\u306e\u8ad6\u6587\u3067\u3059\u304c\u3001<\/p>\n<p><span style=\"color: #0000ff;\">Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10\u00a0weeks of training\u3000\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2014.279950\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><br \/>\n<span style=\"color: #0000ff;\"> \u300c\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30bb\u30c3\u30b7\u30e7\u30f3\u5f8c\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5909\u5316\u3055\u305b\u308b\u304c\u300110\u9031\u9593\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u671f\u9593\u4e2d\u306e\u7b4b\u8089\u6210\u9577\u306f\u5909\u5316\u3055\u305b\u306a\u3044\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u30ad\u30fc\u30dd\u30a4\u30f3\u30c8<\/span><\/p>\n<ul>\n<li><span style=\"color: #0000ff;\">\u6297\u9178\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u4e00\u822c\u7684\u306b\u5065\u5eb7\u4e0a\u306e\u5229\u76ca\u3092\u3082\u305f\u3089\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u6700\u8fd1\u306e\u5b9f\u9a13\u3067\u306f\u3001\u6301\u4e45\u529b\u904b\u52d5\u3078\u306e\u9069\u5fdc\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u3053\u306e\u7814\u7a76\u306f\u3001\u9ad8\u7528\u91cf\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u304c\u30d2\u30c8\u306e\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u5bfe\u3059\u308b\u7d30\u80de\u6027\u304a\u3088\u3073\u751f\u7406\u5b66\u7684\u9069\u5fdc\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u6700\u521d\u306b\u8abf\u67fb\u3059\u308b\u7814\u7a76\u3067\u3042\u308b\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u3053\u3053\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\u5f8c\u3001p70S6\u30ad\u30ca\u30fc\u30bc\u304a\u3088\u3073\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcp38\u304a\u3088\u3073ERK1 \/ 2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7b4b\u8089\u7d30\u80de\u306b\u304a\u3051\u308b\u904b\u52d5\u8a98\u5c0e\u6027\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u59a8\u5bb3\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3059\u308b\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u300110\u9031\u9593\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u671f\u9593\u4e2d\u3001\u7b4b\u80a5\u5927\u3092\u8457\u3057\u304f\u920d\u3089\u305b\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u7b4b\u529b\u306e\u3044\u304f\u3064\u304b\u306e\u6e2c\u5b9a\u5024\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u7fa4\u306e\u5897\u52a0\u304c\u5c11\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/span><\/li>\n<li><span style=\"color: #0000ff;\">\u3053\u306e\u7814\u7a76\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3078\u306e\u9aa8\u683c\u7b4b\u306e\u9069\u5fdc\u3092\u8a98\u5c0e\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u9ad8\u7528\u91cf\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u3059\u308b\u5065\u5eb7\u3067\u82e5\u3044\u4eba\u305f\u3061\u304c\u304c\u670d\u7528\u3059\u308b\u3053\u3068\u3092\u56de\u907f\u3059\u308b\u3079\u304d\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #0000ff;\">\u8981\u7d04<\/span><br \/>\n<span style=\"color: #0000ff;\"> \u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u6025\u6027\u53cd\u5fdc\u304a\u3088\u3073\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3078\u306e\u9069\u5fdc\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8abf\u3079\u305f\u300232\u4eba\u306e\u5a2f\u697d\u3067\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u3057\u3066\u3044\u308b\u7537\u5973\u304c\u30e9\u30f3\u30c0\u30e0\u306b\u305d\u308c\u305e\u308c10\u9031\u9593\u306e\u9593\u3001\u30d3\u30bf\u30df\u30f3C(1000 mg\/\u65e5)\u3068\u30d3\u30bf\u30df\u30f3E\uff08235 mg\/\u65e5)\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u7fa4\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002\u3053\u306e\u671f\u9593\u4e2d\u3001\u53c2\u52a0\u8005\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u91cd\u8ca0\u8377\u62b5\u6297\u904b\u52d5\u3092\u9031\u306b4\u56de\u884c\u3063\u305f\u3002\u5916\u5074\u5e83\u7b4b\u306e\u7b4b\u751f\u691c\u3001\u6700\u5927\u7b49\u5c3a\u6027\u968f\u610f\u53ce\u7e2e\u529b\u3001\u4f53\u7d44\u6210\uff08\u4e8c\u91cd\u30a8\u30cd\u30eb\u30ae\u30fcX\u7dda\u5438\u53ce\u7387\uff09\u304a\u3088\u3073\u7b4b\u65ad\u9762\u7a4d\uff08MRI\uff09\u3092\u3001\u4ecb\u5165\u306e\u524d\u304a\u3088\u3073\u5f8c\u306b\u6e2c\u5b9a\u3057\u305f\u3002\u3055\u3089\u306b\u30011\u56de\u306e\u904b\u52d5\u30bb\u30c3\u30b7\u30e7\u30f3\u306b\u5bfe\u3059\u308b\u7d30\u80de\u5fdc\u7b54\u3092\u3001\u7b4b\u8089\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u753b\u5408\u6210\u901f\u5ea6\u304a\u3088\u3073\u3044\u304f\u3064\u304b\u306e\u80a5\u5927\u6027\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u306e\u6e2c\u5b9a\u306b\u3088\u3063\u3066\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u671f\u9593\u306e\u9014\u4e2d\u3067\u8a55\u4fa1\u3057\u305f\u3002\u5916\u5074\u5e83\u7b4b\u304b\u3089\u306e\u7b4b\u751f\u691c\u306f\u3001\u904b\u52d5\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\uff084\u00d78RM\u3001\u30ec\u30c3\u30b0\u30d7\u30ec\u30b9\u304a\u3088\u3073\u819d\u4f38\u5c55\uff09\u306e\u524d\u306b2\u56de\u3001\u304a\u3088\u3073\u30bb\u30c3\u30b7\u30e7\u30f3\u306e100\u5206\u5f8c\u304a\u3088\u3073150\u5206\u5f8c\u306b\u884c\u308f\u308c\u305f\u3002\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u670d\u7528\u306f\u3001\u7b4b\u8089\u91cf\u306e\u5897\u52a0\u307e\u305f\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306e\u6025\u6fc0\u306a\u5909\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u304b\u3063\u305f\u304c\u3001\u7279\u5b9a\u306e\u5f37\u5ea6\u5897\u52a0\uff08\u4e0a\u8155\u4e8c\u982d\u7b4b\u306e\u30ab\u30fc\u30eb\uff09\u3092\u59a8\u3052\u305f\u3002<span class=\"goog-text-highlight\">\u3055\u3089\u306b\u3001\u904b\u52d5\u5f8c\u306ep38\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u3001\u7d30\u80de\u5916\u30b7\u30b0\u30ca\u30eb\u8abf\u7bc0\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc1\u304a\u3088\u30732\u3001\u304a\u3088\u3073p70S6\u30ad\u30ca\u30fc\u30bc\u306e\u30ea\u30f3\u9178\u5316\u306e\u5897\u52a0\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u3063\u3066\u5f31\u307e\u3063\u305f\u3002<\/span>\u3057\u304b\u3057\u3001\u904b\u52d5\u30bb\u30c3\u30b7\u30e7\u30f3\u5f8c\u306e\u7dcf\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u30ec\u30d9\u30eb\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3082\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u7fa4\u306e\u65b9\u304c\u4f4e\u304b\u3063\u305f\u3002\u6211\u3005\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u91cd\u8ca0\u8377\u62b5\u6297\u904b\u52d5\u306b\u5bfe\u3059\u308b\u6025\u6027\u7d30\u80de\u5fdc\u7b54\u3092\u59a8\u3052\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3078\u306e\u9069\u5fdc\u306b\u5bfe\u3059\u308b\u9577\u671f\u7684\u306a\u8ca0\u306e\u52b9\u679c\u3092\u793a\u3057\u305f\u3068\u7d50\u8ad6\u3057\u305f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u540c\u69d8\u306a\u5185\u5bb9\u3067\u3059\u304c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u306e\u30de\u30fc\u30ab\u30fc\u306b\u5f71\u97ff\u306f\u3057\u306a\u3044\u3051\u308c\u3069\u3082\u3001\u7b4b\u8089\u306e\u9069\u5fdc\u3092\u6e1b\u5f31\u3055\u305b\u305f\u7814\u7a76\u3067\u3059\u3002<br \/>\n<span style=\"color: #0000ff;\">Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073\u30d3\u30bf\u30df\u30f3E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u4eba\u306b\u304a\u3044\u3066\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u7d30\u80de\u9069\u5fdc\u3092\u4e00\u90e8\u59a8\u3052\u308b\u300d\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584915010813\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u8981\u7d04<\/span><\/p>\n<p><span id=\"result_box\" lang=\"ja\" style=\"color: #0000ff;\" tabindex=\"-1\"><strong><span title=\"Background \">\u80cc\u666f\uff1a<\/span><\/strong><span title=\"It is clear that reactive oxygen species (ROS) produced during skeletal muscle contraction have a regulatory role in skeletal muscle adaptation to endurance exercise.\">\u9aa8\u683c\u7b4b\u53ce\u7e2e\u306e\u9593\u306b\u751f\u6210\u3055\u308c\u308b\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306f\u3001\u6301\u4e45\u529b\u904b\u52d5\u306b\u5bfe\u3059\u308b\u9aa8\u683c\u7b4b\u306e\u9069\u5fdc\u306b\u5236\u5fa1\u7684\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b\u3002<\/span><span title=\"However, there is much controversy in the literature regarding whether attenuation of ROS by antioxidant supplementation can prevent these cellular adaptations.\">\u3057\u304b\u3057\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308bROS\u306e\u6e1b\u5f31\u304c\u3053\u308c\u3089\u306e\u7d30\u80de\u9069\u5fdc\u3092\u59a8\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306b\u95a2\u3059\u308b\u6587\u732e\u306b\u306f\u591a\u304f\u306e\u8ad6\u4e89\u304c\u5b58\u5728\u3059\u308b\u3002<\/span><span title=\"Therefore, the aim of this study was to determine whether vitamin C and E supplementation attenuates performance and cellular adaptations following acute endurance exercise and endurance training. \">\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u3001\u6025\u6027\u6301\u4e45\u904b\u52d5\u304a\u3088\u3073\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304a\u3088\u3073\u7d30\u80de\u9069\u5fdc\u3092\u6e1b\u5f31\u3059\u308b\u304b\u5426\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002<\/span><\/span><\/p>\n<p><span style=\"color: #0000ff;\"><strong><span title=\"Methods \">\u65b9\u6cd5\uff1a<\/span><\/strong><span title=\"A double-blinded, placebo-controlled randomized control trial was conducted in eleven healthy young males.\">11\u4eba\u306e\u5065\u5e38\u306a\u82e5\u3044\u7537\u6027\u3067\u3001\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/span><span title=\"Participants were matched for peak oxygen consumption (VO2peak) and randomly allocated to placebo or antioxidant (vitamin C (2\u00d7500 mg\/day) and E (400 IU\/day)) groups.\">\u53c2\u52a0\u8005\u306f\u3001\u6700\u5927\u9178\u7d20\u6d88\u8cbb\u91cf\uff08VO2peak\uff09\u3068\u4e00\u81f4\u3055\u305b\u3001\u7121\u4f5c\u70ba\u306b\u30d7\u30e9\u30bb\u30dc\u307e\u305f\u306f\u6297\u9178\u5316\u5264\u3067\u3042\u308b\u30d3\u30bf\u30df\u30f3C\uff082\u00d7500mg \/\u65e5\uff09\u304a\u3088\u3073\u30d3\u30bf\u30df\u30f3E\uff08400IU \/\u65e5\uff09\u7fa4\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002 <\/span><span title=\"Following a four-week supplement loading period, participants completed acute exercise (10\u00d74 min cycling at 90% VO2peak, 2 min active recovery).\">4\u9031\u9593\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u8ca0\u8377\u671f\u9593\u306e\u5f8c\u3001\u53c2\u52a0\u8005\u306f\u6025\u6027\u904b\u52d5\u3092\u5b8c\u4e86\u3057\u305f\uff0890\uff05VO2peak\u306710\u00d74\u5206\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u30012\u5206\u9593\u306e\u80fd\u52d5\u7684\u56de\u5fa9\uff09\u3002 <\/span><span title=\"Vastus lateralis muscle samples were collected pre-, immediately-post- and 3 h-post-exercise.\">\u5916\u5074\u5e83\u7b4b\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u3001\u904b\u52d5\u524d\u3001\u76f4\u5f8c\u3001\u304a\u3088\u3073\u904b\u52d5\u5f8c3\u6642\u9593\u306b\u63a1\u53d6\u3057\u305f\u3002<\/span><span title=\"Participants then completed four weeks of training (3 days\/week) using the aforementioned exercise protocol while continuing supplementation.\">\u53c2\u52a0\u8005\u306f\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u670d\u7528\u3092\u7d9a\u3051\u306a\u304c\u3089\u3001\u524d\u8ff0\u306e\u904b\u52d5\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3092\u7528\u3044\u30664\u9031\u9593\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff083\u65e5\/\u9031\uff09\u3092\u5b8c\u4e86\u3057\u305f\u3002<\/span><span title=\"Following exercise training, participants again completed an acute exercise bout with muscle biopsies. \">\u904b\u52d5\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5f8c\u3001\u53c2\u52a0\u8005\u306f\u518d\u3073\u7b4b\u751f\u691c\u3092\u4f34\u3046\u6025\u6027\u904b\u52d5\u3092\u5b8c\u4e86\u3057\u305f\u3002<\/span><\/span><\/p>\n<p><span style=\"color: #0000ff;\"><strong><span title=\"Results \">\u7d50\u679c\uff1a<\/span><\/strong><span title=\"Acute exercise tended to increase skeletal muscle oxidative stress as measured by oxidized glutathione (GSSG) (P=0.058) and F2-isoprostanes (P=0.056), with no significant effect of supplementation.\">\u6025\u6027\u904b\u52d5\u306f\u3001\u9178\u5316\u578b\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\uff08GSSG\uff09\uff08P = 0.058\uff09\u304a\u3088\u3073F2-\u30a4\u30bd\u30d7\u30ed\u30b9\u30bf\u30f3\uff08P = 0.056\uff09\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u308b\u9aa8\u683c\u7b4b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5897\u52a0\u3055\u305b\u308b\u50be\u5411\u304c\u3042\u308a\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6709\u610f\u306a\u52b9\u679c\u306f\u306a\u304b\u3063\u305f\u3002<\/span><span title=\"Acute exercise significantly increased mRNA levels of peroxisome proliferator-activated receptor gamma coactivator 1\u03b1 (PGC-1\u03b1), mitochondrial transcription factor A (TFAM) and PGC related coactivator (PRC), with no effect of supplementation.\">\u6025\u6027\u904b\u52d5\u306f\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b3\u5171\u6d3b\u6027\u5316\u56e0\u5b501\u03b1\uff08PGC-1\u03b1\uff09\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8ee2\u5199\u56e0\u5b50A\uff08TFAM\uff09\u304a\u3088\u3073PGC\u95a2\u9023\u88dc\u56e0\u5b50\uff08PRC\uff09\u306emRNA\u30ec\u30d9\u30eb\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u305f\u3002<\/span><span title=\"Following endurance training, supplementation did not prevent significantly increased VO2peak, skeletal muscle levels of citrate synthase activity or mRNA or protein abundance of cytochrome oxidase subunit 4 (COX IV) (P&lt;0.05).\">\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5f8c\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001VO2peak\u3001\u9aa8\u683c\u7b4b\u30ec\u30d9\u30eb\u306e\u30af\u30a8\u30f3\u9178\u30b7\u30f3\u30bf\u30fc\u30bc\u6d3b\u6027\u307e\u305f\u306fmRNA\u307e\u305f\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5b58\u5728\u91cf\u306e\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u30c1\u30c8\u30af\u30ed\u30fc\u30e0\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u30b5\u30d6\u30e6\u30cb\u30c3\u30c84\uff08COX IV\uff09\u3092\u9632\u6b62\u3057\u306a\u304b\u3063\u305f\uff08P &lt;0.05\uff09\u3002<\/span><span title=\"However, following training, vitamin C and E supplementation significantly attenuated increased skeletal muscle superoxide dismutase (SOD) activity and protein abundance of SOD2 and TFAM. \">\u3057\u304b\u3057\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u9aa8\u683c\u7b4b\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\uff08SOD\uff09\u6d3b\u6027\u304a\u3088\u3073SOD2\u304a\u3088\u3073TFAM\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/span><\/span><\/p>\n<p><span style=\"color: #0000ff;\"><span title=\"Conclusion \"><strong>\u7d50\u8ad6\uff1a<\/strong>\u6025<\/span><span title=\"Following acute exercise, supplementation with vitamin C and E did not attenuate skeletal muscle oxidative stress or increased gene expression of mitochondrial biogenesis markers.\">\u6027\u904b\u52d5\u5f8c\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u9aa8\u683c\u7b4b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u307e\u305f\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u30de\u30fc\u30ab\u30fc\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5897\u52a0\u3092\u6e1b\u5f31\u3055\u305b\u306a\u304b\u3063\u305f\u3002<\/span><span title=\"However, supplementation attenuated some (SOD, TFAM) of the increased skeletal muscle adaptations following training in healthy young men.\">\u3057\u304b\u3057\u3001\u5065\u5e38\u306a\u82e5\u3044\u7537\u6027\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u9aa8\u683c\u7b4b\u306e\u9069\u5fdc\u306e\u5897\u52a0\u306e\u4e00\u90e8\uff08SOD\u3001TFAM\uff09\u3092\u6e1b\u5f31\u3055\u305b\u305f\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u6b21\u306f\u30d3\u30bf\u30df\u30f3C\u3060\u3051\u3067\u3059\u304c\u3001<\/p>\n<p><span style=\"color: #0000ff;\">Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance<a id=\"xref-aff-1-1\" class=\"xref-aff\" style=\"color: #0000ff;\" href=\"http:\/\/ajcn.nutrition.org\/content\/87\/1\/142.full#aff-1\"><\/a>\u3000\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"http:\/\/ajcn.nutrition.org\/content\/87\/1\/142.abstract\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><br \/>\n<span style=\"color: #0000ff;\"> \u300c\u30d3\u30bf\u30df\u30f3C\u306e\u7d4c\u53e3\u6295\u4e0e\u306f\u3001\u7b4b\u8089\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u3092\u6e1b\u5c11\u3055\u305b\u3001\u6301\u4e45\u529b\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u304a\u3044\u3066\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a98\u767a\u6027\u306e\u9069\u5fdc\u3092\u59a8\u3052\u308b\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u8981\u7d04<\/span><br \/>\n<span style=\"color: #0000ff;\"><strong>\u80cc\u666f\uff1a<\/strong>\u30b9\u30dd\u30fc\u30c4\u533b\u306f\u3057\u3070\u3057\u3070\u30d3\u30bf\u30df\u30f3C\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u670d\u7528\u3059\u308b\u3002\u305d\u308c\u306f\u7b4b\u8089\u3084\u8840\u4e2d\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u6fc3\u5ea6\u306e\u5909\u5316\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001DNA\u3001\u8102\u8cea\u904e\u9178\u5316\u306e\u5897\u52a0\u304c\u793a\u3059\u3088\u3046\u306b\u3001\u5f37\u3044\u7b4b\u8089\u53ce\u7e2e\u4f5c\u7528\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u30d3\u30bf\u30df\u30f3C\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6709\u76ca\u306a\u5065\u5eb7\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u3001\u304b\u306a\u308a\u306e\u8b70\u8ad6\u304c\u3042\u308b\u3002<\/span><br \/>\n<span style=\"color: #0000ff;\"> <strong>\u76ee\u7684\uff1a<\/strong>\u3053\u306e\u7814\u7a76\u306f\u3001\u30e9\u30c3\u30c8\u304a\u3088\u3073\u30d2\u30c8\u306b\u304a\u3051\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u7387\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3C\u306e\u5f71\u97ff\u3092\u7814\u7a76\u3059\u308b\u305f\u3081\u306b\u8003\u6848\u3055\u308c\u305f\u3002<\/span><br \/>\n<span style=\"color: #0000ff;\"> <strong>\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong>\u30d2\u30c8\u306e\u7814\u7a76\u306f\u4e8c\u91cd\u76f2\u691c\u3067\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u300214\u4eba\u306e\u7537\u6027\uff0827\u301c36\u6b73\uff09\u304c8\u9031\u9593\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u305f\u30025\u4eba\u306e\u7537\u6027\u306b\u30d3\u30bf\u30df\u30f3C\u30921g\u7d4c\u53e3\u6295\u4e0e\u3057\u305f\u3002\u52d5\u7269\u8a66\u9a13\u3067\u306f\u30013\u5339\u30686\u5339\u306e\u7570\u306a\u308b2\u3064\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306724\u5339\u306e\u96c4\u306eWistar\u30e9\u30c3\u30c8\u3092\u904b\u52d5\u3055\u305b\u305f\u300212\u5339\u306e\u30e9\u30c3\u30c8\u306b\u306f1\u65e51\u56de\u306e\u30d3\u30bf\u30df\u30f3C\uff080.24mg \/ cm<span class=\"Apple-converted-space\">\u00a0<\/span><sup>2<\/sup>\u4f53\u8868\u9762\u7a4d\uff09\u3092\u4e0e\u3048\u305f\u3002<\/span><br \/>\n<span style=\"color: #0000ff;\"> <strong>\u7d50\u679c\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3C\u306e\u6295\u4e0e\uff08<em>P<\/em><span class=\"Apple-converted-space\">\u00a0<\/span>= 0.014\uff09\u306f\u6301\u4e45\u529b\u3092\u59a8\u3052\u305f\u3002\u30d3\u30bf\u30df\u30f3C\u306e\u526f\u4f5c\u7528\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u306e\u904b\u52d5\u8a98\u767a\u6027\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u308b\u529b\u306b\u3088\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u56e0\u5b50\u306f\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u5171\u6d3b\u6027\u5316\u56e0\u5b501\u3001\u6838\u547c\u5438\u56e0\u5b501\u304a\u3088\u3073\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8ee2\u5199\u56e0\u5b50A\u3067\u3042\u308b\u3002\u307e\u305f<span id=\"result_box\" lang=\"ja\" tabindex=\"-1\">\u30d3\u30bf\u30df\u30f3C\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u542b\u6709\u91cf\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30b7\u30c8\u30af\u30ed\u30e0C\u304a\u3088\u3073\u6297\u9178\u5316\u9175\u7d20\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\u304a\u3088\u3073\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u306e\u904b\u52d5\u8a98\u767a\u6027\u306e\u767a\u73fe\u3092\u9632\u6b62\u3057\u305f\u3002<\/span><\/span><br \/>\n<span style=\"color: #0000ff;\"> <strong>\u7d50\u8ad6\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3C\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u3044\u304f\u3064\u304b\u904b\u52d5\u306b\u5bfe\u3059\u308b\u7d30\u80de\u9069\u5fdc\u3092\u9632\u3050\u306e\u3067\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u3055\u3089\u306b\u540c\u3058\u7814\u7a76\u8005\u3067\u3059\u304c\u3001<\/p>\n<p><span style=\"color: #0000ff;\">Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training\u3000\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584907001086\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u9069\u5ea6\u306a\u904b\u52d5\u306f\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308b\uff1a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b\u6297\u9178\u5316\u907a\u4f1d\u5b50\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u8981\u7d04<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u904b\u52d5\u306f\u3001\u6d88\u8017\u3057\u305f\u5834\u5408\u306b\u306e\u307f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u6fc0\u3057\u3044\u904b\u52d5\u306f\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u306e\u9178\u5316\u3001\u30b5\u30a4\u30c8\u30be\u30eb\u9175\u7d20\u306e\u653e\u51fa\u3001\u304a\u3088\u3073\u7d30\u80de\u640d\u50b7\u306e\u4ed6\u306e\u5fb4\u5019\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306f\u6bd2\u6027\u304c\u3042\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304a\u3088\u3073\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u8abf\u7bc0\u306b\u304a\u3044\u3066\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u30ad\u30b5\u30f3\u30c1\u30f3\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u306f\u3001\u6d88\u8017\u3059\u308b\u904b\u52d5\u306b\u4f34\u3046\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002 \u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\uff08\u3053\u306e\u9175\u7d20\u306e\u963b\u5bb3\u5264\uff09\u306f\u3001\u6d88\u8017\u3059\u308b\u904b\u52d5\u5f8c\u306e\u7b4b\u8089\u306e\u640d\u50b7\u3092\u9632\u3050\u304c\u3001\u30e9\u30c3\u30c8\u304a\u3088\u3073\u30d2\u30c8\u306e\u4e2d\u7b49\u5ea6\u304a\u3088\u3073\u6d88\u8017\u3059\u308b\u904b\u52d5\u306e\u4e21\u65b9\u306b\u95a2\u9023\u3059\u308b\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3082\u5909\u3048\u308b\u3002\u30e9\u30c3\u30c8\u306e\u8153\u8179\u7b4b\u306b\u304a\u3044\u3066\u3001\u904b\u52d5\u306fMAP\u30ad\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u3002\u3053\u308c\u306f\u3001NF-\u03baB\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u3001ROS\uff08\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\uff09\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u304a\u3088\u3073\u904b\u52d5\u9069\u5fdc\uff08eNOS\u304a\u3088\u3073iNOS\uff09\u306b\u95a2\u9023\u3059\u308b\u91cd\u8981\u306a\u9175\u7d20\u306e\u767a\u73fe\u3092\u6d3b\u6027\u5316\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5909\u5316\u306f\u3059\u3079\u3066\u3001ROS\u7523\u751f\u304c\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u306b\u3088\u3063\u3066\u9632\u6b62\u3055\u308c\u305f\u3068\u304d\u306b\u7121\u52b9\u3068\u306a\u3063\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001ROS\u306e\u5f62\u6210\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3001\u7d30\u80de\u306b\u304a\u3044\u3066\u6709\u7528\u306a\u9069\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u91cd\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u59a8\u3052\u308b\u306e\u3067\u3001ROS\u306f\u904b\u52d5\u306b\u304a\u3044\u3066\u30b7\u30b0\u30ca\u30eb\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u5f37\u529b\u306a\u6297\u9178\u5316\u9175\u7d20\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u3082\u305f\u3089\u3059\u306e\u3067\u3001\u904b\u52d5\u305d\u306e\u3082\u306e\u306f\u6297\u9178\u5316\u7269\u8cea\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u6211\u3005\u306f\u3001\u6297\u9178\u5316\u5264\u306b\u3088\u308b\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u4ee3\u8b1d\u306e\u59a8\u3052\u304c\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u6709\u7528\u306a\u9069\u5fdc\u3092\u59a8\u3052\u308b\u3053\u3068\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u3069\u308c\u3082\u3001\u6d3b\u6027\u9178\u7d20\u304c\u305f\u3060\u306e\u60aa\u8005\u3067\u306f\u306a\u304f\u3001\u904b\u52d5\u306b\u5bfe\u3057\u3066\u306f\u3042\u308b\u7a0b\u5ea6\u5fc5\u8981\u306a\u3082\u306e\u3060\u3068\u3044\u3046\u8003\u3048\u3067\u3059\u3002\u3067\u3059\u304b\u3089\u305d\u306e\u6d3b\u6027\u9178\u7d20\u3092\u6291\u3048\u3066\u3057\u307e\u3046\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u30d3\u30bf\u30df\u30f3C\u3084\u30d3\u30bf\u30df\u30f3E\u306f\u305b\u3063\u304b\u304f\u306e\u904b\u52d5\u306e\u52b9\u679c\u3092\u5f31\u3081\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u9ad8\u9f62\u8005\u3067\u3082\u4ee5\u524d\u306e\u8a18\u4e8b\u306b\u3082\u51fa\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u7b4b\u8089\u3092\u5897\u3084\u3059\u306e\u3092\u30d3\u30bf\u30df\u30f3C\u3068E\u306f\u59a8\u3052\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p><span style=\"color: #0000ff;\">Vitamin C and E supplementation blunts increases in total lean body mass in elderly men after strength training<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c<span id=\"result_box\" class=\"short_text\" lang=\"ja\" tabindex=\"-1\">\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u9ad8\u9f62\u7537\u6027\u306e\u5168\u8eab\u7684\u306a\u9664\u8102\u80aa\u4f53\u91cd\u306e\u5897\u52a0\u3092\u920d\u3089\u305b\u308b\u300d\u3000\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sms.12506\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u8981\u7d04<\/span><\/p>\n<p><span id=\"result_box\" lang=\"ja\" style=\"color: #0000ff;\" tabindex=\"-1\"><span title=\"The aim of this study was to investigate the effects of vitamin C and E supplementation on changes in muscle mass (lean mass and muscle thickness) and strength during 12 weeks of strength training in elderly men.\">\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u9ad8\u9f62\u8005\u306e\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u7b4b\u8089\u91cf\u304a\u3088\u3073\u7b4b\u8089\u539a\u3055\uff09\u304a\u3088\u3073\u7b4b\u529b\u306e\u5909\u5316\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002<\/span><span title=\"Thirty-four elderly males (60\u201381 years) were randomized to either an antioxidant group (500\u2009mg of vitamin C and 117.5\u2009mg vitamin E before and after training) or a placebo group following the same strength training program (three sessions per week)\">\u540c\u3058\u5f37\u5ea6\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\uff08\u90313\u56de\uff09\u306b\u7d9a\u3044\u3066\u3001\u8001\u9f62\u7537\u602734\u4eba\uff0860-81\u6b73\uff09\u3092\u6297\u9178\u5316\u7269\u8cea\u7fa4\uff08500 mg\u306e\u30d3\u30bf\u30df\u30f3C\u3068117.5 mg\u306e\u30d3\u30bf\u30df\u30f3E\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u3044\u305a\u308c\u304b\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f<\/span><span title=\".\">\u3002<\/span><span title=\"Body composition was assessed with dual-energy X-ray absorptiometry and muscle thickness by ultrasound imaging.\">\u4f53\u7d44\u6210\u306f\u3001\u4e8c\u91cd\u30a8\u30cd\u30eb\u30ae\u30fcX\u7dda\u5438\u5149\u5149\u5ea6\u6cd5\u304a\u3088\u3073\u8d85\u97f3\u6ce2\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308b\u7b4b\u8089\u539a\u3067\u8a55\u4fa1\u3057\u305f\u3002<\/span><span title=\"Muscle strength was measured as one-repetition maximum (1RM).\">\u7b4b\u529b\u306f\u6700\u5927\u6319\u4e0a\u91cd\u91cf\uff081RM\uff09\u3068\u3057\u3066\u6e2c\u5b9a\u3057\u305f\u3002<\/span><span title=\"Total lean mass increased by 3.9% (95% confidence intervals: 3.0, 5.2) and 1.4% (0, 5.4) in the placebo and antioxidant groups, respectively, revealing larger gains in the placebo group (P\u2009=\u20090.04).\">\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08P = 0.04\uff09\u306b\u304a\u3044\u3066\u306f\u3001\u5168\u9664\u8102\u80aa\u4f53\u91cd\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6297\u9178\u5316\u5264\u7fa4\u3067\u305d\u308c\u305e\u308c3.9\uff05\u30681.4\uff05\u5897\u52a0\u3057\u305f\u3002<\/span><span title=\"Similarly, the thickness of m.\">\u540c\u69d8\u306b\u3001\u5927\u817f\u76f4\u7b4b\u306e\u539a\u3055<\/span><span title=\"rectus femoris increased more in the placebo group [16.2% (12.8, 24.1)] than in the antioxidant group [10.9% (9.8, 13.5);\">\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff0816.2\uff05\uff09\u3067\u306f\u6297\u9178\u5316\u7fa4\u3088\u308a\u3082\u5897\u52a0\u3057\u305f\uff0810.9\uff05\uff1a<\/span><span title=\"P\u2009=\u20090.01].\">P = 0.01\uff09\u3002<\/span><span title=\"Increases of lean mass in trunk and arms, and muscle thickness of elbow flexors, did not differ significantly between groups.\">\u80f4\u4f53\u304a\u3088\u3073\u8155\u306e\u7b4b\u8089\u306e\u5897\u52a0\u3001\u304a\u3088\u3073\u8098\u5c48\u7b4b\u306e\u7b4b\u8089\u539a\u306e\u5897\u52a0\u306f\u3001\u7fa4\u9593\u3067\u6709\u610f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002\u7fa4\u9593\u3067\u5dee\u306f\u306a\u304f<\/span><span title=\"With no group differences, 1RM improved in the range of 15\u201321% (P\u2009&lt;\u20090.001).\">\u30011RM\u306f15-21\uff05\u306e\u7bc4\u56f2\u3067\u6539\u5584\u3057\u305f\uff08P &lt;0.001\uff09\u3002<\/span><span title=\"In conclusion, high-dosage vitamin C and E supplementation blunted certain muscular adaptations to strength training in elderly men.\">\u7d50\u8ad6\u3068\u3057\u3066\u3001\u9ad8\u7528\u91cf\u306e\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u9ad8\u9f62\u306e\u7537\u6027\u306e\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u4e00\u5b9a\u306e\u7b4b\u8089\u9069\u5fdc\u3092\u920d\u3089\u305b\u305f\u3002<\/span><\/span><\/p>\n<p>\u9aa8\u306b\u3082\u5f71\u97ff\u3057\u307e\u3059\u3002<\/p>\n<p><span style=\"color: #0000ff;\">High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly men<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c<span id=\"result_box\" class=\"short_text\" lang=\"ja\" tabindex=\"-1\">\u9ad8\u7528\u91cf\u306e\u30d3\u30bf\u30df\u30f3C + E\u306f\u3001\u9ad8\u9f62\u8005\u306e\u9aa8\u5bc6\u5ea6\u306e\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u8d77\u56e0\u3059\u308b\u6539\u5584\u3092\u8efd\u6e1b\u3059\u308b<\/span>\u300d\u3000\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s00421-017-3588-y\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p><span id=\"result_box\" lang=\"ja\" style=\"color: #0000ff;\" tabindex=\"-1\"><span title=\"Purpose \">\u8981\u7d04<\/span><\/span><\/p>\n<p><span id=\"result_box\" lang=\"ja\" style=\"color: #0000ff;\" tabindex=\"-1\"><span title=\"Purpose \"><strong>\u76ee\u7684\uff1a<\/strong><\/span><span title=\"Resistance training is beneficial for maintaining bone mass.\">\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u9aa8\u91cf\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u6709\u76ca\u3067\u3042\u308b\u3002<\/span><span title=\"We aimed to investigate the skeletal effects of high doses of antioxidants [vitamin C\u2009+\u2009E (\u03b1-tocopherol)] supplementation during 12-week supervised strength training in healthy, elderly men \">\u5065\u5eb7\u306a\u9ad8\u9f62\u7537\u6027\u306e12\u9031\u9593\u306e\u76e3\u7763\u4e0b\u3067\u306e\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9593\u306b\u3001\u9ad8\u7528\u91cf\u306e\u6297\u9178\u5316\u7269\u8cea\uff08\u30d3\u30bf\u30df\u30f3C + E\uff08\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\uff09\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9aa8\u683c\u3078\u306e\u52b9\u679c\u3092\u8abf\u3079\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002<br \/>\n<\/span><span title=\"Methods \"><strong>\u65b9\u6cd5\uff1a<\/strong><\/span><span title=\"Design: double-blinded randomized placebo-controlled study.\">\u8a2d\u8a08\uff1a\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u7814\u7a76\u3002<\/span><span title=\"Participants followed a supervised, undulating periodic exercise program with weekly adjusted load: 3 sessions\/week and 3\u201315 repetitions maximum (RM) sets\/exercise.\">\u53c2\u52a0\u8005\u306f\u3001\u6bce\u90313\u56de\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\u3068\u6700\u59273~15\u56de\u306e\u53cd\u5fa9\uff08RM\uff09\u30bb\u30c3\u30c8\u306e\u904b\u52d5\u3092\u9031\u3054\u3068\u306b\u9069\u5207\u306a\u8ca0\u8377\u3067\u7ba1\u7406\u3055\u308c\u305f\u5b9a\u671f\u7684\u306a\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u884c\u3063\u305f\u3002<\/span><span title=\"The control group (CG, n\u2009=\u200917, 67\u2009\u00b1\u20095 years) received placebo and the antioxidant group (AO, n\u2009=\u200916, 70\u2009\u00b1\u20097 years) 1000\u00a0mg vitamin C\u2009+\u2009235\u00a0mg vitamin E, daily.\">\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n = 17\u300167\u00b15\u6b73\uff09\u306b\u306f\u507d\u85ac\u3092\u3001\u6297\u9178\u5316\u7269\u8cea\u7fa4\uff08n = 16\u300170\u00b17\u6b73\uff09\u306b\u306f1000 mg\u30d3\u30bf\u30df\u30f3C \u3068235 mg\u30d3\u30bf\u30df\u30f3E\u3092\u6bce\u65e5\u6295\u4e0e\u3057\u305f\u3002<\/span><span title=\"Areal bone mineral density (aBMD) at whole body, lumbar spine (L1\u2013L4), total hip, and femoral neck were measured by dual energy X-ray absorptiometry and muscle strength by 1RM.\">\u4e8c\u91cd\u30a8\u30cd\u30eb\u30ae\u30fcX\u7dda\u5438\u5149\u5149\u5ea6\u6cd5\u3068\u7b4b\u8089\u5f37\u5ea6\u30921RM\u3067\u6e2c\u5b9a\u3057\u3001\u4f53\u5168\u4f53\u3001\u8170\u690e\uff08L1-L4\uff09\u3001\u5168\u80a1\u95a2\u7bc0\u304a\u3088\u3073\u5927\u817f\u9aa8\u9838\u90e8\u306b\u304a\u3051\u308b\u9aa8\u5bc6\u5ea6\uff08aBMD\uff09\u3092\u6e2c\u5b9a\u3057\u305f\u3002<\/span><span title=\"Serum analyses of bone-related factors and adipokines were performed. \">\u9aa8\u95a2\u9023\u56e0\u5b50\u304a\u3088\u3073\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306e\u8840\u6e05\u5206\u6790\u3092\u884c\u3063\u305f\u3002<br \/>\n<\/span><span title=\"Results \"><strong>\u7d50\u679c\uff1a<\/strong>\u30d7\u30e9\u30bb\u30dc\u7fa4<\/span><span title=\"In the CG, total hip aBMD increased by 1.0% (CI: 0.3\u20131.7) versus pretest and lumbar spine aBMD increased by 0.9% (CI: \u22120.2 to 2.0) compared to the AO.\">\u3067\u306f\u3001\u5168\u80a1\u95a2\u7bc0aBMD\u306f\u4e88\u5099\u691c\u67fb\u3068\u6bd4\u8f03\u3057\u30661.0\uff05\uff08CI\uff1a0.3-1.7\uff09\u5897\u52a0\u3057\u3001\u8170\u690eaBMD\u306f\u6297\u9178\u5316\u7269\u8cea\u7fa4\u3068\u6bd4\u8f03\u3057\u30660.9\uff05\uff08CI\uff1a-0.2\u301c2.0\uff09\u5897\u52a0\u3057\u305f\u3002 <\/span><span title=\"In the CG, there was an increase in serum concentrations of insulin-like growth factor 1 [+27.3% (CI: \u22120.3 to 54.9)] and leptin [+31.2% (CI: 9.8\u201352.6)) versus pretest, and a\">\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b501\uff08+ 27.3\uff05\uff08CI\uff1a-0.3\u301c54.9\uff09\uff09\u304a\u3088\u3073\u30ec\u30d7\u30c1\u30f3\uff08+ 31.2\uff05\uff08CI\uff1a9.8\u301c52.6\uff09\uff09\u306e\u8840\u6e05\u4e2d\u6fc3\u5ea6\u304c\u4e88\u5099\u691c\u67fb\u3088\u308a\u3082\u5897\u52a0\u3057\u3001<\/span><span title=\"decrease in sclerostin [\u22129.9% (CI: 4.4\u201315.3)] versus pretest and versus AO.\">\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u306f\u4e88\u5099\u691c\u67fb\u53ca\u3073\u6297\u9178\u5316\u7269\u8cea\u7fa4\u3088\u308a\u3082\u6e1b\u5c11[-9.9\uff05\uff08CI\uff1a4.4-15.3\uff09]\u3057\u305f\u3002<\/span><span title=\"Serum bone formation markers P1NP and osteocalcin increased in both groups, while the bone resorption marker CTX-1 remained unchanged. \">\u8840\u6e05\u9aa8\u5f62\u6210\u30de\u30fc\u30ab\u30fcP1NP\u304a\u3088\u3073\u30aa\u30b9\u30c6\u30aa\u30ab\u30eb\u30b7\u30f3\u306f\u4e21\u65b9\u306e\u7fa4\u3067\u5897\u52a0\u3057\u305f\u304c\u3001\u9aa8\u5438\u53ce\u30de\u30fc\u30ab\u30fcCTX-1\u306f\u5909\u5316\u3057\u306a\u304b\u3063\u305f\u3002<br \/>\n<\/span><span title=\"Conclusion \"><strong>\u7d50\u8ad6\uff1a<\/strong><\/span><span title=\"High doses of antioxidant supplementations may constrain the favorable skeletal benefits of 12 weeks of resistance exercise in healthy elderly men.\">\u9ad8\u7528\u91cf\u306e\u6297\u9178\u5316\u5264\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u5065\u5eb7\u306a\u9ad8\u9f62\u7537\u6027\u306b\u304a\u3044\u306612\u9031\u9593\u306e\u62b5\u6297\u904b\u52d5\u306e\u597d\u90fd\u5408\u306a\u9aa8\u683c\u306b\u5bfe\u3059\u308b\u6069\u6075\u3092\u5236\u9650\u3057\u5f97\u308b\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u7cd6\u8cea\u5236\u9650\u81ea\u4f53\u304c\u30b1\u30c8\u30f3\u4f53\u306b\u3088\u308a\u6297\u9178\u5316\u4f5c\u7528\u304c\u3042\u308b\u306e\u3067\u3001\u3053\u306e\u3088\u3046\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u9762\u3067\u306e\u52b9\u679c\u306e\u6e1b\u5f31\u304c\u3042\u308b\u306e\u304b\u306a\u3044\u306e\u304b\u304c\u7591\u554f\u3067\u3059\u3002\u8ab0\u304b\u308f\u304b\u308b\u65b9\u306f\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>\u4eba\u306f\u4e00\u65b9\u3067\u306f\u3001\u5065\u5eb7\u306e\u305f\u3081\u306b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u305f\u304f\u3055\u3093\u670d\u7528\u3057\u3001\u4e00\u65b9\u3067\u306f\u5065\u5eb7\u306e\u305f\u3081\u306b\u904b\u52d5\u3092\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u540c\u6642\u306b\u3084\u3063\u3066\u3057\u307e\u3063\u3066\u306f\u304a\u4e92\u3044\u304c\u52b9\u679c\u3092\u6253\u3061\u6d88\u3057\u3042\u3046\u3053\u3068\u3082\u3042\u308b\u306e\u3067\u3059\u3002\u81ea\u5206\u304c\u4f55\u3092\u3084\u3063\u3066\u3044\u3066\u3001\u3069\u306e\u3088\u3046\u306a\u52b9\u679c\u304c\u3042\u308b\u304b\u3001\u540c\u6642\u306b\u884c\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u76f8\u4e57\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u52b9\u679c\u304c\u6e1b\u5c11\u3057\u3066\u3057\u307e\u3046\u306e\u304b\u3001\u3044\u308d\u3044\u308d\u3068\u8003\u3048\u3066\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u305d\u3046\u3067\u3059\u3002\u8ab0\u304b\u6709\u540d\u306a\u4eba\u304c\u8a00\u3063\u3066\u3044\u308b\u304b\u3089\u4fe1\u7528\u3057\u3066\u3084\u3063\u3066\u308b\u3001\u3068\u3044\u3046\u4eba\u3082\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u305d\u308c\u3067\u305d\u306e\u65b9\u306e\u8003\u3048\u65b9\u3067\u3059\u3002\u7591\u554f\u306b\u601d\u3063\u305f\u308a\u3001\u7591\u3063\u3066\u307f\u305f\u308a\u3001\u81ea\u5206\u3067\u8a66\u3057\u305f\u308a\u304c\u5fc5\u8981\u3067\u3001\u5984\u4fe1\u306f\u5371\u967a\u306a\u3053\u3068\u3082\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3001\u591a\u5c11\u306e\u30b5\u30d7\u30ea\u3050\u3089\u3044\u3067\u306f\u4f53\u306b\u30ea\u30b9\u30af\u306f\u5c11\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u5b9f\u969b\u306b\u306f\u305d\u3053\u307e\u3067\u5fc5\u8981\u304c\u306a\u3044\u3068\u304b\u3001\u52b9\u679c\u304c\u7121\u3044\u304f\u3089\u3044\u306e\u3082\u306e\u3067\u3059\u3002\u5b89\u5fc3\u611f\u3067\u670d\u7528\u3068\u3044\u3046\u306e\u3082\u5927\u4e8b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u30d7\u30e9\u30bb\u30dc\u52b9\u679c\u306f\u99ac\u9e7f\u306b\u3067\u304d\u307e\u305b\u3093\u304b\u3089\u3002\u3057\u304b\u3057\u3001\u3042\u307e\u308a\u306b\u5927\u91cf\u306e\u30b5\u30d7\u30ea\u3092\u98f2\u3080\u3053\u3068\u306f\u3084\u306f\u308a\u554f\u984c\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002\u30d3\u30bf\u30df\u30f3\u3084\u30df\u30cd\u30e9\u30eb\u306b\u95a2\u3057\u3066\u306f\u6b20\u4e4f\u3057\u306a\u3044\u3053\u3068\u3092\u524d\u63d0\u306b\u3001\u98df\u4e8b\u3092\u57fa\u672c\u306b\u6442\u308a\u307e\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u3067\u300c\u9ad8\u9f62\u8005\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u6700\u3082\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u52b9\u679c\u7684\u300d\u3068\u3044\u3046\u306e\u3092\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u30ad\u30fc\u30ef\u30fc\u30c9\u306f\u300c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u300d\u3067\u3057\u305f\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u5de5\u5834\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6570\u304c\u5897<\/p>\n","protected":false},"author":1,"featured_media":1347,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[10,14],"tags":[],"class_list":["post-1339","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-10","category-14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