{"id":1366,"date":"2017-05-11T15:37:54","date_gmt":"2017-05-11T06:37:54","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=1366"},"modified":"2017-07-02T13:41:06","modified_gmt":"2017-07-02T04:41:06","slug":"post-1366","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=1366","title":{"rendered":"\u30d3\u30bf\u30df\u30f3\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u672c\u5f53\u306b\u6709\u76ca\u304b\uff1f\u6297\u9178\u5316\u7269\u8cea\u306e\u6697\u9ed2\u9762\u305d\u306e1\uff08\u52d5\u7269\u5b9f\u9a13\uff09"},"content":{"rendered":"<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u3067\u3001\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=1339\" target=\"_blank\" rel=\"noopener noreferrer\">\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u904b\u52d5\u306b\u3088\u308b\u52b9\u679c\u3092\u5f31\u3081\u3066\u3057\u307e\u3046<\/a>\u300d\u3068\u3044\u3046\u306e\u3092\u66f8\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306f2\u56de\u306b\u308f\u305f\u308a\u3001\u3082\u3046\u5c11\u3057\u96e3\u3057\u3044\u8aac\u660e\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u30d3\u30bf\u30df\u30f3\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6697\u9ed2\u9762\u3092\u898b\u3066\u3044\u304d\u307e\u3059\u3002\u307e\u305a\u306f\u52d5\u7269\u5b9f\u9a13\u3067\u306e\u8a71\u3067\u3059\u3002<\/p>\n<p>\u7814\u7a76\u8005\u3089\u306f\u3001\u6d3b\u6027\u9178\u7d20\uff08\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b5\u30a4\u30c9\uff09\u306a\u3069\u306e\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3068\u547c\u3070\u308c\u308b\u53cd\u5fdc\u6027\u306e\u9ad8\u3044\u5206\u5b50\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u308a\u3001\u7d30\u80de\u3092\u640d\u50b7\u3055\u305b\u3066\u8001\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7d44\u7e54\u3084\u5668\u5b98\u306e\u6a5f\u80fd\u3092\u640d\u306a\u3046\u3068\u8003\u3048\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n\u3057\u304b\u3057\u3001\u6700\u8fd1\u306e\u5b9f\u9a13\u3067\u306f\u3001\u30de\u30a6\u30b9\u304a\u3088\u3073\u7dda\u866b\u306b\u304a\u3044\u3066\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306e\u5897\u52a0\u304c\u3088\u308a\u9577\u3044\u5bff\u547d\u3068\u76f8\u95a2\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u5b9f\u969b\u306b\u3042\u308b\u72b6\u6cc1\u3067\u306f\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306f\u7d30\u80de\u4fee\u5fa9\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u30b7\u30b0\u30ca\u30eb\u3068\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<br \/>\n\u305d\u3046\u3060\u3068\u3059\u308b\u3068\u30d3\u30bf\u30df\u30f3\u3084\u305d\u306e\u4ed6\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6297\u9178\u5316\u7269\u8cea\u3092\u670d\u7528\u3059\u308b\u3053\u3068\u306f\u3001\u6709\u5bb3\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>2010\u5e74\u306e\u7dda\u866b\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u304c\u5bff\u547d\u3092\u7e2e\u3081\u308b\u53ef\u80fd\u6027\u3092\u5341\u5206\u306b\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u7814\u7a76\u306e\u539f\u6587\u306f<a href=\"http:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.1000556\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1367\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=1367\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg?fit=727%2C497&amp;ssl=1\" data-orig-size=\"727,497\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;\\u6e05\\u6c34\\u6cf0\\u884c&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;1494495916&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u7dda\u866b\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg?fit=300%2C205&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg?fit=640%2C438&amp;ssl=1\" class=\"alignnone size-medium wp-image-1367\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg?resize=300%2C205\" alt=\"\" width=\"300\" height=\"205\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg?resize=300%2C205&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/05\/a907450713269f6513437f67613b3f5d.jpg?w=727&amp;ssl=1 727w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\uff08\u30af\u30ea\u30c3\u30af\u3067\u62e1\u5927\u3001\u56f3\u306fThe Myth of Antioxidants \u3001Scientific American, February 2013\u3088\u308a\u629c\u7c8b\uff09<\/p>\n<p>\u56f3\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u9752\u3044\u7dda\u306f\u901a\u5e38\u306e\u72b6\u614b\u3067\u3059\u304c\u3001\u907a\u4f1d\u7684\u306b\u6539\u5909\u3057\u3066\u3001\u7279\u5b9a\u306e\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u7523\u751f\u3059\u308b\u3088\u3046\u306b\u3057\u307e\u3057\u305f\u7dda\u866b\uff08\u6fc3\u3044\u76ee\u306e\u8d64\u3044\u7dda\uff09\u306f\u3001\u9a5a\u3044\u305f\u3053\u3068\u306b\u901a\u5e38\u306e\u7dda\u866b\u3088\u308a\u3082\u5e73\u5747\u3057\u306632\uff05\u9577\u304f\u751f\u5b58\u3057\u3066\u3044\u307e\u3057\u305f\u3002 \u7814\u7a76\u8005\u304c\u5909\u7570\u7dda\u866b\u306b\u6297\u9178\u5316\u7269\u8cea\uff08\u30d3\u30bf\u30df\u30f3C\uff09\u3092\u4e0e\u3048\u305f\u3068\u304d\uff08\u8584\u3081\u306e\u8d64\u3044\u7dda\uff09\u3001\u305d\u306e\u9577\u5bff\u306e\u5229\u70b9\u306f\u6d88\u3048\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u305d\u306e\u5f8c\u306e\u7814\u7a76\u3067\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u7523\u751f\u3059\u308b\u9664\u8349\u5264\u3068\u3044\u3046\u6bd2\u7d20\u3092\u6d74\u3073\u305f\u7dda\u866b\u306f\u3001\u672a\u51e6\u7406\uff08\u9664\u8349\u5264\u3092\u6d74\u3073\u3066\u3044\u306a\u3044\uff09\u306e\u7dda\u866b\u3088\u308a\u308258\uff05\u9577\u304f\u751f\u304d\u3001\u3055\u3089\u306b\u3001\u7dda\u866b\u306b\u6297\u9178\u5316\u7269\u8cea\u3092\u4e0e\u3048\u308b\u3068\u3001\u6bd2\u7d20\u306e\u6709\u76ca\u5bff\u547d\u5ef6\u306a\u52b9\u679c\u304c\u6d88\u3048\u305f\u3068\u767a\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3082\u3046\u4e00\u3064\u30012006\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u30d6\u30bf\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u3059\u3002\uff08\u539f\u6587\u306f<a href=\"http:\/\/hyper.ahajournals.org\/content\/47\/3\/475\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/p>\n<p>\u3053\u306e\u30d6\u30bf\u306e\u7814\u7a76\u306f\u6b63\u5e38\u306a\u30d6\u30bf\u306b\u6162\u6027\u7684\u306b\u6297\u9178\u5316\u7269\u8cea\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u4e0e\u3048\u308b\u3068\u3069\u3046\u306a\u308b\u304b\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002\u5065\u5eb7\u306a\u30d6\u30bf\u306b\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u91781g \/\u65e5\u304a\u3088\u3073dl-\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ea\u30eb\u30a2\u30bb\u30c6\u30fc\u30c8100IU \/ kg \/\u65e5\uff09\u309212\u9031\u9593\u4e0e\u3048\u305f\u3068\u3053\u308d\u3001\u30d3\u30bf\u30df\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u4e0e\u3048\u3089\u308c\u3066\u3044\u306a\u3044\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306b\u6bd4\u3079\u3066\u3001\u5fc3\u7b4b\u8840\u6d41\u3068\u8840\u7ba1\u306e\u5185\u76ae\u6a5f\u80fd\u304c\u640d\u306a\u308f\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u7d50\u679c\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308b\u30d3\u30bf\u30df\u30f3\u306e\u4f5c\u7528\u306f\u3001\u305d\u3053\u306b\u3042\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u30ec\u30d9\u30eb\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u306f\u6297\u9178\u5316\u4f5c\u7528\u3092\u767a\u63ee\u3057\u3066\u5229\u76ca\u3092\u3082\u305f\u3089\u3059\u306e\u3067\u3059\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u4e0a\u6607\u304c\u4e0a\u6607\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u306b\u306f\u5229\u76ca\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u304b\u3001\u9006\u306b\u6709\u5bb3\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>1950\u5e74\u4ee3\u306b\u30c7\u30cb\u30b9\u30fb\u30cf\u30fc\u30de\u30f3\u304c\u5531\u3048\u305f\u3001\u9178\u5316\u7684\u640d\u50b7\u307e\u305f\u306f\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306b\u3088\u308b\u8001\u5316\u8aac\u306f\u3001\u305d\u306e\u8aac\u81ea\u4f53\u304c\u8001\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u30cf\u30fc\u30de\u30f3\u306f\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306f\u547c\u5438\u3068\u4ee3\u8b1d\u306b\u3088\u3063\u3066\u3067\u304d\u308b\u300c\u526f\u7523\u7269\u300d\u3067\u3042\u308a\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u4f53\u5185\u306b\u84c4\u7a4d\u3055\u308c\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u7d30\u80de\u306e\u640d\u50b7\u3068\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\u305f\u305f\u3081\u3001\u8001\u5316\u306e\u539f\u56e0\u3068\u306a\u308b\u3068\u306e\u4eee\u8aac\u3092\u8003\u3048\u307e\u3057\u305f\u3002\u30cf\u30fc\u30de\u30f3\u306f\u4eee\u8aac\u3092\u30c6\u30b9\u30c8\u3057\u3001\u6700\u521d\u306e\u5b9f\u9a13\u306e\u4e00\u3064\u3067\u3001\u5f7c\u306f\u30de\u30a6\u30b9\u306b\u6297\u9178\u5316\u7269\u8cea\u3092\u4e0e\u3048\u305f\u3068\u3053\u308d\u3001\u30de\u30a6\u30b9\u306f\u3088\u308a\u9577\u304f\u751f\u304d\u3066\u3044\u305f\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u9ad8\u6fc3\u5ea6\u3067\u306f\u6297\u9178\u5316\u7269\u8cea\u306b\u306f\u6709\u5bb3\u306a\u5f71\u97ff\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u8001\u5316\u8aac\u304c\u4e00\u822c\u7684\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u69d8\u3005\u306a\u52d5\u7269\u5b9f\u9a13\u3067\u4e0a\u306e\u3088\u3046\u306a\u77db\u76fe\u3057\u305f\u7d50\u679c\u304c\u51fa\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5927\u91cf\u306e\u9178\u5316\u7684\u640d\u50b7\u304c\u304c\u3093\u3084\u81d3\u5668\u306e\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308a\u3001\u9178\u5316\u7684\u640d\u50b7\u304c\u5fc3\u81d3\u75c5\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u6162\u6027\u75be\u60a3\u306e\u767a\u75c7\u306b\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u793a\u3059\u8a3c\u62e0\u306f\u305f\u304f\u3055\u3093\u3042\u308b\u306e\u3067\u3001\u9593\u9055\u3044\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001\u6297\u9178\u5316\u7269\u8cea\u306f\u3001\u4fdd\u8b77\u3059\u308b\u7269\u8cea\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u5c11\u306a\u3044\u91cf\u3067\u5b58\u5728\u3059\u308b\u5834\u5408\u3001\u9178\u5316\u7684\u640d\u50b7\u306b\u5bfe\u3057\u3066\u6709\u52b9\u306a\u7269\u8cea\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u308b\u3001\u3068\u300c<span class=\"cit-source\">Free Radicals in Biology and Medicine\u300d\uff08<\/span>Oxford Univ. Press,<span 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