{"id":13833,"date":"2020-08-25T20:26:42","date_gmt":"2020-08-25T11:26:42","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=13833"},"modified":"2020-08-25T20:29:44","modified_gmt":"2020-08-25T11:29:44","slug":"post-13833","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=13833","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5316\u3068\u7cd6\u8cea\u5236\u9650"},"content":{"rendered":"

\u76f8\u5909\u308f\u3089\u305a\u30de\u30b9\u30b3\u30df\u306f\u717d\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3067\u91cd\u75c7\u5316\u3059\u308b\u4eba\u306f\u5b9f\u969b\u306b\u306f\u304b\u306a\u308a\u5c11\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u5927\u962a\u5927\u5b66\u306e\u30c1\u30fc\u30e0\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u4ed5\u7d44\u307f\u3092\u89e3\u660e\u3057\u305f\u3001\u3068\u3044\u3046\u30cb\u30e5\u30fc\u30b9\u304c\u51fa\u307e\u3057\u305f\u304c\u3001\u306a\u3093\u3060\u304b\u306a\u3042\uff1f\u3068\u3044\u3046\u611f\u3058\u3067\u3059\u3002\u30a4\u30bd\u30b8\u30f3\u3092\u52e7\u3081\u305f\u77e5\u4e8b\u3068\u3044\u3044\u3001\u962a\u5927\u3068\u3044\u3044\u3001\u4f55\u304b\u5927\u962a\u304c\u304a\u304b\u3057\u304f\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u65b0\u578b\u30b3\u30ed\u30ca\u91cd\u75c7\u5316\u306e\u4ed5\u7d44\u307f\u89e3\u660e\u3000\u962a\u5927\u30c1\u30fc\u30e0<\/span><\/h2>\n

2020.8.24\u3000\u7523\u7d4c\u65b0\u805e\u3088\u308a\u3000\uff08\u8a18\u4e8b\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u4ed5\u7d44\u307f\u306e\u4e00\u90e8\u3092\u89e3\u660e\u3057\u305f\u3068\u3001\u5927\u962a\u5927\u306e\u5cb8\u672c\u5fe0\u4e09\u7279\u4efb\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c\uff12\uff14\u65e5\u3001\u767a\u8868\u3057\u305f\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u7a2e\u300c\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08\uff29\uff2c\uff09\uff16\u300d\u304c\u8840\u7ba1\u4e2d\u306b\u3001\u8840\u6813\u3092\u4f5c\u308b\u5225\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u300c\uff30\uff21\uff29\uff11\u300d\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u91cd\u75c7\u5316\u306b\u3064\u306a\u304c\u308b\u3002\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u6cbb\u7642\u85ac\u300c\u30a2\u30af\u30c6\u30e0\u30e9\u300d\u306e\u6709\u52b9\u6027\u304c\u671f\u5f85\u3067\u304d\u308b\u3068\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u3000\u6210\u679c\u306f\uff12\uff12\u65e5\u4ed8\u306e\u7c73\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981\u96fb\u5b50\u7248\u306b\u63b2\u8f09\u3055\u308c\u305f\u3002<\/span><\/p>\n

\u3000\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3059\u308b\u3068\u3001\u8840\u7ba1\u306e\u7d30\u80de\u304b\u3089\uff29\uff2c\uff16\u306a\u3069\u304c\u5206\u6ccc\u3055\u308c\u308b\u3002\uff29\uff2c\uff16\u306f\u904e\u5270\u306b\u5206\u6ccc\u3055\u308c\u308b\u3068\u3001\u514d\u75ab\u306e\u66b4\u8d70\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8840\u7ba1\u3084\u81d3\u5668\u3092\u50b7\u3064\u3051\u308b\u3002\u3053\u306e\u969b\u4f53\u5185\u3067\u8840\u6813\u304c\u3067\u304d\u3084\u3059\u3044\u72b6\u614b\u306b\u306a\u308b\u304c\u3001\u305d\u306e\u8a73\u3057\u3044\u4ed5\u7d44\u307f\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u3002<\/span><\/p>\n

\u3000\u30c1\u30fc\u30e0\u306f\u7814\u7a76\u3067\u3001\u8840\u7ba1\u306e\u7d30\u80de\u3092\uff29\uff2c\uff16\u3067\u523a\u6fc0\u3059\u308b\u3068\u3001\u7d30\u80de\u304b\u3089\u8840\u6db2\u51dd\u56fa\u3092\u4fc3\u3059\uff30\uff21\uff29\uff11\u304c\u591a\u304f\u653e\u51fa\u3055\u308c\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\uff30\uff21\uff29\uff11\u304c\u5897\u3048\u3066\u80ba\u306a\u3069\u306e\u81d3\u5668\u3067\u8840\u6813\u304c\u767a\u751f\u3059\u308c\u3070\u91cd\u75c7\u5316\u306b\u3064\u306a\u304c\u308b\u3068\u3055\u308c\u308b\u304c\u3001\uff29\uff2c\uff16\u306e\u50cd\u304d\u3092\u6291\u3048\u308b\u30a2\u30af\u30c6\u30e0\u30e9\u3092\u4f7f\u3046\u3068\uff30\uff21\uff29\uff11\u306e\u767a\u751f\u304c\u6291\u3048\u3089\u308c\u305f\u3068\u3044\u3046\u3002<\/span><\/p>\n

\u3000\u30a2\u30af\u30c6\u30e0\u30e9\u306f\u3001\u56fd\u5185\u5916\u3067\u91cd\u75c7\u30b3\u30ed\u30ca\u60a3\u8005\u306b\u5bfe\u3057\u3066\u6cbb\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

 <\/p>\n

\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30e1\u30a4\u30f3\u306f\u8840\u6813\u75c7\u3067\u3042\u308a\u3001\u8840\u6813\u75c7\u3067\u3042\u308c\u3070PAI-1\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u5341\u5206\u4e88\u60f3\u3067\u304d\u307e\u3059\u3002PAI-1\uff08plasminogen activator inhibitor-1\uff09\u306f\u30d7\u30e9\u30b9\u30df\u30f3\u3068\u3044\u3046\u7269\u8cea\u306e\u751f\u6210\u3092\u6291\u5236\u3057\u3001\u7dda\u6eb6\u4ea2\u9032\u306b\u3088\u308b\u51fa\u8840\u50be\u5411\u3092\u9632\u3050\u751f\u7406\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u901a\u5e38\u51dd\u56fa\u3057\u305f\u8840\u6db2\u3092\u6eb6\u304b\u3059\u7dda\u6eb6\u7cfb\u3092\u6291\u5236\u3059\u308b\u306e\u3067\u3059\u3002\u4f53\u306b\u708e\u75c7\u304c\u8d77\u3053\u308b\u3068\u3001PAI-1\u306f\u8457\u660e\u306b\u5897\u5f37\u3057\u3001\u904e\u5270\u306b\u306a\u308b\u3068\u7dda\u6eb6\u7cfb\u306e\u6291\u5236\u306b\u3088\u308a\u8840\u6813\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u3060\u304b\u3089\u3001\u4eca\u3055\u3089\u91cd\u75c7\u5316\u3092\u89e3\u660e\u3057\u305f\u306a\u3093\u3066\u5927\u3052\u3055\u306a\u8868\u73fe\u306b\u7591\u554f\u3092\u6301\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u300c\u30a2\u30af\u30c6\u30e0\u30e9\u300d\u306e\u5ba3\u4f1d\uff1f\u300c2017\u5e74\u5ea6\u7248\u30de\u30cd\u30fc\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<\/a>\u300d\u3067\u306f\u3001\u3053\u306e\u6559\u6388\u306f\u30a2\u30af\u30c6\u30e0\u30e9\u306e\u4e2d\u5916\u88fd\u85ac\u304b\u3089\u306f30\u4e07\u7a0b\u5ea6\u3057\u304b\u3082\u3089\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3002\uff082016\u5e74\u306f50\u4e07\u7a0b\u5ea6\u3067\u3059\u3002\u3053\u3053\u6700\u8fd1\u306f\u4e0d\u660e\u3067\u3059\u3002\uff09<\/p>\n

\u305d\u308c\u306f\u305d\u308c\u3068\u3057\u3066\u3001PAI-1\u306b\u95a2\u3059\u308b\u8ad6\u6587\u3092\u6f01\u3063\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u30fb\u300cRho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells\u300d<\/p>\n

\u300cRho-\u30ad\u30ca\u30fc\u30bc\u306f\u3001\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u9ad8\u8840\u7cd6\u8a98\u767a\u6027PAI-1<\/span>\u306e\u767a\u73fe\u3092\u4ef2\u4ecb\u3059\u308b\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

\u8981\u65e8\uff1a\u5185\u76ae\u7d30\u80de\u3092\u9ad8\u8840\u7cd6\u6761\u4ef6<\/span>\u306b\u66dd\u9732\u3059\u308b\u3068\u3001Rho\u30ad\u30ca\u30fc\u30bc\u6d3b\u6027\u3068PAI-1\u767a\u73fe\u304c\u5897\u52a0<\/span>\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\uff08\u30de\u30a6\u30b9\u3067\u3059\u304c\uff09<\/p>\n

\u30fb\u300cHyperglycemia modulates plasminogen activator inhibitor-1 expression and aortic diameter in experimental aortic aneurysm disease\u300d<\/p>\n

\u300c\u9ad8\u8840\u7cd6<\/span>\u306f\u5b9f\u9a13\u7684\u5927\u52d5\u8108\u7624\u75be\u60a3\u306b\u304a\u3044\u3066PAI-1\u306e\u767a\u73fe<\/span>\u3068\u5927\u52d5\u8108\u5f84\u3092\u8abf\u7bc0\u3059\u308b\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

\u8981\u65e8\uff1a\u9ad8\u8840\u7cd6<\/span>\u306f\u3001\u8179\u90e8\u5927\u52d5\u8108\u7624\u76f4\u5f84\u306e\u6e1b\u5c11\u3001PAI-1\u6fc3\u5ea6\u306e\u5897\u52a0<\/span>\u3001\u30d7\u30e9\u30b9\u30df\u30f3\u751f\u6210\u306e\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n

\u30fb\u300cInsulin resistance and thrombosis: a cardiologist\u2019s view\u300d<\/p>\n

\u300c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027<\/span>\u3068\u8840\u6813\u75c7<\/span>\uff1a\u5fc3\u81d3\u5c02\u9580\u533b\u306e\u898b\u89e3\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

\u8981\u65e8\uff1aPAI-1\u306e\u767a\u73fe\u306e\u5897\u52a0\u3001\u7d44\u7e54\u30d7\u30e9\u30b9\u30df\u30ce\u30fc\u30b2\u30f3\u6d3b\u6027\u5316\u56e0\u5b50\u306e\u767a\u73fe\u306e\u6e1b\u5c11\u3001\u307e\u305f\u306f\u305d\u306e\u4e21\u65b9\u306f\u3001\u7dda\u6eb6\u6d3b\u6027\u306e\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3057\u3001\u8840\u6813\u75c7\u306e\u7d20\u56e0\u3068\u306a\u308b\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\uff08\u304a\u3088\u3073\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\uff09\u306e\u6fc3\u5ea6\u304c\u5897\u52a0\u3059\u308b\u3068\u3001PAI-1\u304c\u5897\u52a0\u3059\u308b<\/span>\u3002<\/p>\n

\u30fb\u300cHyperinsulinemia, Hyperglycemia, and Impaired Hemostasis
\nThe Framingham Offspring Study\u300d<\/p>\n

\u300c\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7<\/span>\u3001\u9ad8\u8840\u7cd6\u75c7<\/span>\u3001\u304a\u3088\u3073\u6b62\u8840\u969c\u5bb3<\/span>\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

\u8981\u65e8\uff1a\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4e0a\u6607<\/span>\u306f\u3001\u6b63\u5e38\u306a\u8010\u7cd6\u80fd\u306e\u4eba\u3067\u3082\u8010\u7cd6\u80fd\u969c\u5bb3\u306e\u3042\u308b\u4eba\u3067\u3082\u3001PAI-1\u306e\u5897\u52a0<\/span>\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n

\u30fb\u300cInduction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects\u300d<\/p>\n

\u300c\u9ad8\u8840\u7cd6<\/span>\u304a\u3088\u3073\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3068\u7d44\u307f\u5408\u308f\u3055\u308c\u305f\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7<\/span>\u306e\u8a98\u767a\u306f\u3001\u6b63\u5e38\u306a\u30d2\u30c8\u88ab\u9a13\u8005\u306e\u8840\u6db2\u4e2d\u306ePAI-1\u3092\u5897\u52a0<\/span>\u3055\u305b\u308b\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

\u8981\u65e8\uff1a\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7<\/span>\u3001\u9ad8\u4e2d\u6027\u8102\u80aa<\/span>\u3001\u304a\u3088\u3073\u9ad8\u8840\u7cd6<\/span>\u306e\u8907\u5408\u304c\u3001\u6b63\u5e38\u306a\u4eba\u306ePAI-1\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u4e0a\u6607<\/span>\u3055\u305b\u308b\u3002<\/p>\n

\u300cPlasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies\u300d<\/p>\n

\u300cPAI-1\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5<\/span>\uff1a\u89b3\u5bdf\u7814\u7a76\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u304a\u3088\u3073\u30e1\u30bf\u5206\u6790\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

\u8981\u65e8\uff1a\u30e1\u30bf\u5206\u6790\u3067\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30012\u578b\u7cd6\u5c3f\u75c5<\/span>\u3067\u306fPAI-1\u30ec\u30d9\u30eb\u304c\u5927\u5e45\u306b\u4e0a\u6607<\/span>\u3057\u3066\u3044\u305f\u3002<\/p>\n

 <\/p>\n

\u63a2\u305b\u3070\u305f\u304f\u3055\u3093\u51fa\u3066\u304d\u307e\u3059\u3002PAI-1\u306f\u9ad8\u8840\u7cd6\u3001\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3001\u7cd6\u5c3f\u75c5\u3068\u5927\u304d\u304f\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067PAI-1\u306f\u5897\u52a0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002PAI-1\u5897\u52a0\u3092\u907f\u3051\u305f\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u307e\u305a\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3057\u3087\u3046\u3002<\/p>\n

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