{"id":14574,"date":"2020-11-23T09:33:32","date_gmt":"2020-11-23T00:33:32","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=14574"},"modified":"2020-11-23T09:33:32","modified_gmt":"2020-11-23T00:33:32","slug":"post-14574","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=14574","title":{"rendered":"\u8180\u80f1\u306e\u58c1\u306f\u5358\u306a\u308b\u58c1\u3067\u306f\u306a\u3044"},"content":{"rendered":"

\u524d\u56de\u306e\u8a18\u4e8b\u300c\u5c3f\u6f0f\u308c\u3059\u308b\u524d\u306b\u7cd6\u8cea\u5236\u9650<\/a>\u300d\u306b\u5bfe\u3057\u3066\u3001\u30b3\u30e1\u30f3\u30c8\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u5148\u751f\u3044\u3064\u3082\u60c5\u5831\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\uff01<\/span>
\n\u79c1\u3082\u7cd6\u5c3f\u75c5\u6027\u30b1\u30c8\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u3067\u5165\u9662\u3059\u308b1\u304b\u6708\u3050\u3089\u3044\u524d\u304b\u3089\u5c11\u91cf\u306e\u5c3f\u3082\u308c\u304c\u3042\u308a\u300c\u5e74\u9f62\u306e\u305b\u3044\uff1f\u307e\u3055\u304b\u306d\u2026\u307e\u306030\u4ee3\u306a\u306e\u306b\u300d\u3068\u601d\u3063\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u5165\u9662\u3057\u3066\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u3066\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u3068\u3059\u3050\u306b\u6b62\u307e\u3063\u305f\u3093\u3067\u3059\u3002<\/span><\/p>\n

\u305d\u3057\u3066\u300e\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u306f\u5c3f\u8def\u3001\u8180\u80f1\u306b\u591a\u304f\u306e\u7cd6\u304c\u4f55\u5ea6\u3082\u63a5\u3059\u308b\u3067\u3057\u3087\u3046\u3002\u305d\u3046\u3059\u308b\u3068\u8868\u9762\u306e\u7d30\u80de\u306f\u50b7\u5bb3\u3092\u53d7\u3051\u3066\u3001\u305d\u3053\u304b\u3089\u795e\u7d4c\u3084\u7b4b\u8089\u3078\u306e\u4fe1\u53f7\u4f1d\u9054\u304c\u4e0a\u624b\u304f\u3044\u304b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002\u300f\u3068\u306e\u3053\u308d\u3067\u3059\u304c\u3001SGLT2\u963b\u5bb3\u5264\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u65b9\u3067\u540c\u3058\u3088\u3046\u306a\u3053\u3068\u304c\u8d77\u304d\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/span><\/p>\n

\u5165\u9662\u3057\u3066\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u3068\u5c3f\u6f0f\u308c\u304c\u3059\u3050\u306b\u6b62\u307e\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u9ad8\u8840\u7cd6\u3084\u9ad8\u5c3f\u7cd6\u304c\u5927\u304d\u304f\u4f5c\u7528\u3057\u3066\u3044\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u306d\u3002\u8180\u80f1\u306e\u795e\u7d4c\u307e\u3067\u306f\u969c\u5bb3\u3055\u308c\u3066\u3044\u306a\u304f\u3066\u826f\u304b\u3063\u305f\u3067\u3059\u306d\u3002\u3068\u3053\u308d\u3067\u3001SGLT2\u963b\u5bb3\u5264\u3067\u306f\u5c3f\u7cd6\u304c\u5927\u304d\u304f\u5897\u52a0\u3059\u308b\u306e\u3067\u3001\u679c\u305f\u3057\u3066\u5c3f\u6f0f\u308c\u304c\u5897\u52a0\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/span><\/p>\n

\u7533\u3057\u8a33\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u305d\u306e\u7b54\u3048\u306f\u6301\u3063\u3066\u304a\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001SGLT2\u963b\u5bb3\u5264\u306f\u4eba\u306b\u3088\u3063\u3066\u3001\u8131\u6c34\u306b\u306a\u308b\u307b\u3069\u591a\u5c3f\u3001\u983b\u5c3f\u306b\u306a\u308a\u307e\u3059\u3057\u3001\u591c\u9593\u3082\u4f55\u5ea6\u3082\u304a\u3057\u3063\u3053\u306b\u8d77\u304d\u3066\u7761\u7720\u969c\u5bb3\u3092\u8d77\u3053\u3059\u65b9\u3082\u3044\u308b\u307b\u3069\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u591a\u5c3f\u306b\u3088\u308a\u3082\u3057\u304b\u3057\u305f\u3089\u5c3f\u6f0f\u308c\u3092\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u3082\u3068\u3082\u3068\u7cd6\u5c3f\u75c5\u306a\u306e\u3067\u3001\u3082\u3068\u3082\u3068\u5c3f\u6f0f\u308c\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u305f\u3081\u306b\u6c17\u4ed8\u304b\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002SGLT2\u963b\u5bb3\u5264\u3067\u306f\u5c3f\u8def\u611f\u67d3\u75c7\u3001\u8180\u80f1\u708e\u306a\u3069\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u708e\u75c7\u304c\u8180\u80f1\u306b\u60aa\u3055\u3092\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n

\u8180\u80f1\u306e\u58c1\u306f\u5358\u306a\u308b\u58c1\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u58c1\u306b\u306f\u795e\u7d4c\u3084\u69d8\u3005\u306a\u53d7\u5bb9\u4f53\u304c\u3042\u308a\u3001\u305d\u308c\u304c\u69d8\u3005\u306a\u4fe1\u53f7\u3092\u8133\u306b\u4f1d\u3048\u3001\u5c3f\u610f\u3092\u50ac\u3057\u305f\u308a\u3001\u6392\u5c3f\u3068\u3044\u3046\u8907\u96d1\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306a\u3069\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u8180\u80f1\u306e\u58c1\u306e\u8868\u9762\u306b\u306f\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\u3068\u547c\u3070\u308c\u308b\u5c64\uff08GAG\u5c64\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u8180\u80f1\u7c98\u819c\u306b\u7d30\u83cc\u306a\u3069\u304c\u304f\u3063\u4ed8\u304f\u306e\u3092\u9632\u3044\u3060\u308a\u3001\u5c3f\u304c\u6d78\u900f\u3059\u308b\u306e\u3092\u9632\u3044\u3060\u308a\u3059\u308b\u5f79\u5272\u3092\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306eGAG\u5c64\u304c\u4f55\u3089\u304b\u306e\u539f\u56e0\u3067\u969c\u5bb3\u3092\u53d7\u3051\u308b\u3068\u3001\u8180\u80f1\u306e\u7c98\u819c\u306e\u900f\u904e\u6027\u304c\u4ea2\u9032\u3057\u3066\u3057\u307e\u3044\u3001\u8180\u80f1\u306e\u58c1\u306f\u5c3f\u306e\u6210\u5206\u304c\u4fb5\u5165\u3059\u308b\u3053\u3068\u3092\u8a31\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3053\u306e\u3053\u3068\u304c\u5c40\u6240\u7684\u306a\u708e\u75c7\u3001\u795e\u7d4c\u523a\u6fc0\u3001\u305d\u308c\u306b\u7d9a\u304f\u75db\u307f\u3001\u983b\u5c3f\u3001\u6392\u5c3f\u306e\u5207\u8feb\u611f\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306eGAG\u5c64\u306e\u969c\u5bb3\u306e\u539f\u56e0\u306f\u73fe\u5728\u306e\u3068\u3053\u308d\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\u306a\u3069\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u3001\u8840\u7ba1\u306e\u5185\u76ae\u7d30\u80de\u306e\u8868\u9762\u306b\u3042\u308b\u30b0\u30ea\u30b3\u30ab\u30ea\u30c3\u30af\u30b9\u306f\u3001\u9ad8\u8840\u7cd6\u3067\u5927\u304d\u304f\u969c\u5bb3\u3055\u308c\u307e\u3059\u3002\u540c\u69d8\u306e\u3053\u3068\u304c\u8180\u80f1\u3067\u3082\u8d77\u304d\u3066\u3044\u3066\u3001\u9ad8\u8840\u7cd6\u3084\u9ad8\u5c3f\u7cd6\u3001\u708e\u75c7\u306b\u3088\u308a\u3053\u306eGAG\u5c64\u304c\u7834\u58ca\u3055\u308c\u3066\u3057\u307e\u3046\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002SGLT2\u963b\u5bb3\u5264\u306b\u3088\u308b\u8180\u80f1\u708e\u306a\u3069\u306fGAG\u5c64\u306b\u60aa\u5f71\u97ff\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3001SGLT2\u963b\u5bb3\u5264\u306b\u3088\u308a\u8840\u7cd6\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3084\u30b1\u30c8\u30f3\u4f53\u304c\u51fa\u308b\u3053\u3068\u3067\u60aa\u5f71\u97ff\u3092\u6253\u3061\u6d88\u3059\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u9ad8\u8840\u7cd6\u306b\u3088\u308b\u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u8180\u80f1\u306b\u6ce2\u53ca\u3057\u305f\u308a\u3001\u9ad8\u8840\u7cd6\u306b\u3088\u308bAGEs\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u306a\u3069\u306b\u3088\u308a\u8180\u80f1\u306e\u8868\u9762\u304c\u969c\u5bb3\u3092\u53d7\u3051\u308b\u3053\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u6b63\u5e38\u306a\u8180\u80f1\u58c1\u306b\u306f\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u53d6\u308a\u8fbc\u3080GLUT-1\u306f\u5b58\u5728\u3057\u306a\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8180\u80f1\u304c\u3093\u306e\u7d30\u80de\u306b\u306fGLUT-1\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u306f\u8180\u80f1\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u6642\u306bSGLT2\u963b\u5bb3\u5264\u306b\u3088\u308b\u5c3f\u7cd6\u306e\u6fc0\u5897\u306f\u679c\u305f\u3057\u3066\u554f\u984c\u306b\u306a\u3089\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u69d8\u3005\u306a\u6709\u76ca\u306a\u52b9\u679c\u3092\u8a8d\u3081\u3066\u3044\u308bSGLT2\u963b\u5bb3\u5264\u3067\u3059\u304c\u3001\u79c1\u306e\u52dd\u624b\u306a\u8003\u3048\u3067\u3059\u304c\u3001\u3084\u306f\u308a\u521d\u671f\u306e\u30b9\u30bf\u30c1\u30f3\u3068\u96f0\u56f2\u6c17\u304c\u3042\u308b\u3088\u3046\u306a\u6c17\u304c\u3057\u3066\u306a\u308a\u307e\u305b\u3093\u3002\u8180\u80f1\u3001\u5c3f\u8def\u306f\u9032\u5316\u306e\u904e\u7a0b\u3067\u306fSGLT2\u963b\u5bb3\u5264\u306b\u3088\u308b\u7269\u51c4\u3044\u91cf\u306e\u5c3f\u7cd6\u3092\u51e6\u7406\u3059\u308b\u3088\u3046\u306b\u306f\u8a2d\u8a08\u3055\u308c\u3066\u3044\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u3068\u3053\u308d\u3067\u3001\u9762\u767d\u3044\u3053\u3068\u306b\u8180\u80f1\u306e\u58c1\u306f\u5f93\u6765\u306f\u5c3f\u3092\u4fb5\u5165\u3055\u305b\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u3082\u3057\u304b\u3057\u305f\u3089\u5c3f\u3092\u518d\u5438\u53ce\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u5b9f\u969b\u306b\u306f\u30cd\u30ba\u30df\u3055\u3093\u3067\u306f\u8180\u80f1\u5185\u306e\u5c3f\u306e\u518d\u5438\u53ce\u3092\u8a8d\u3081\u3066\u3044\u307e\u3059\u3002\uff08\u3053\u3053<\/a>\u3068\u3053\u3053<\/a>\u53c2\u7167\uff09\u3069\u3046\u3084\u3089\u30a2\u30af\u30a2\u30dd\u30ea\u30f3\u3068\u3044\u3046\u5c0f\u3055\u306a\u7a74\u304c\u3042\u3044\u305f\u6c34\u306e\u30c8\u30f3\u30cd\u30eb\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

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\"\"<\/a><\/p>\n

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 <\/p>\n

\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4<\/span><\/p>\n

\u300cPeriodical measurement of urine volume in the bladder during sleep: Temporary volume reduction suggestive of absorption\u300d<\/span><\/p>\n

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