{"id":14821,"date":"2020-12-17T09:23:08","date_gmt":"2020-12-17T00:23:08","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=14821"},"modified":"2020-12-17T09:23:08","modified_gmt":"2020-12-17T00:23:08","slug":"post-14821","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=14821","title":{"rendered":"\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u3092\u9664\u53bb\u3057\u3066\u304f\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3082\u7cd6\u8cea\u904e\u5270\u3067\u6a5f\u80fd\u4e0d\u5168\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044"},"content":{"rendered":"<p>\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u306f\u9ad8\u8840\u7cd6\u306b\u306a\u308a\u3001\u305d\u308c\u306b\u3088\u308a\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u304c\u3067\u304d\u3066\u84c4\u7a4d\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3053\u306eAGEs\u304c\u69d8\u3005\u306a\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u3063\u305f\u308a\u3001\u8001\u5316\u3084\u7d44\u7e54\u306e\u6a5f\u80fd\u4e0d\u5168\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u7cd6\u5316\u3092\u85ac\u3067\u6291\u5236\u3059\u308b\u3053\u3068\u306f\u4eca\u306e\u3068\u3053\u308d\u3067\u304d\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u305d\u3046\u3059\u308b\u3068\u3053\u306eAGEs\u3092\u9664\u53bb\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u91cd\u8981\u3068\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u5341\u5206\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>AGEs\u306f\u3067\u304d\u3066\u3057\u307e\u3046\u3068\u306a\u304b\u306a\u304b\u9664\u53bb\u3067\u304d\u306a\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002AGEs\u304c\u5f62\u6210\u3055\u308c\u308b\u3068\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u7d50\u5408\u3055\u308c\u305f\u7cd6\u307e\u305f\u306f\u7cd6\u8a98\u5c0e\u4f53\u3092\u7279\u7570\u7684\u306b\u9664\u53bb\u3059\u308b\u7279\u5225\u306a\u9175\u7d20\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u4f53\u306e\u4e2d\u306b\u306f\u305d\u308c\u3092\u9664\u53bb\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001\u30e6\u30d3\u30ad\u30c1\u30f3-\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u30b7\u30b9\u30c6\u30e0\uff08UPS\uff09\u3068\u3044\u3046\u3082\u306e\u3068\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e2\u3064\u306e\u7d4c\u8def\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5206\u89e3\u7d4c\u8def\u306e\u6a5f\u80fd\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3046\u3088\u3046\u3067\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306f\u30cd\u30ba\u30df\u3055\u3093\u306e\u3082\u306e\u3067\u3059\u304c\u3001\u4eba\u9593\u306b\u3082\u5f53\u3066\u306f\u307e\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002p62\u3068\u547c\u3070\u308c\u308b\u30d1\u30c3\u30af\u30de\u30f3\uff08\u61d0\u304b\u3057\u3044\uff1f\uff09\u306e\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u901a\u3058\u3066\u3001\u7cd6\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u6709\u6bd2\u306a\u7d30\u80de\u8001\u5ec3\u7269\u306e\u9664\u53bb\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306ep62\u304c\u306a\u3044\u30de\u30a6\u30b9\u3067\u306f\u5927\u91cf\u306e\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3067\u306e\u751f\u5b58\u7387\u304c20\uff05\u3067\u3057\u305f\u304c\u3001p62\u306e\u3042\u308b\u30de\u30a6\u30b9\u3067\u306f\u751f\u5b58\u738750\uff05\u3067\u3057\u305f\u3002\u3064\u307e\u308ap62\u306f\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u7684\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u305d\u3057\u3066p62\u306e\u306a\u3044\u30de\u30a6\u30b9\u3067\u306f\u3088\u308aAGEs\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u3055\u3089\u306b\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u304b\u304b\u308b\u3068\u3001AGEs\u306e\u84c4\u7a4d\u306f\u3001p62\u304c\u3042\u3063\u3066\u3082\u306a\u304f\u3066\u3082\u3001\u7cd6\u5316\u7523\u7269\u306e\u6fc3\u5ea6\u3068\u6642\u9593\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7cd6\u5316\u304c\u95be\u5024\u306b\u9054\u3059\u308b\u3068\u3001AGEs\u306e\u5206\u89e3\u304c\u52b9\u7387\u7684\u3067\u306a\u304f\u3001\u4e0d\u6eb6\u5316\u307e\u305f\u306f\u51dd\u96c6\u304c\u8d77\u3053\u308a\u3001\u3053\u308c\u304c\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306e\u7d30\u80de\u6bd2\u6027\u306e\u52a0\u901f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3082\u3001\u7cd6\u5316\u306fAGEs\u3092\u9664\u53bb\u3059\u308bp62\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u6a5f\u80fd\u4e0d\u5168\u306b\u9665\u3089\u305b\u3066\u3044\u308b\u3088\u3046\u306a\u3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href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28507131\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p><span>p62\u3092\u6a5f\u80fd\u3055\u305b\u308b\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u30ec\u30d9\u30eb\u3067\u306f\u3001p62\u306fAGEs\u306e\u9664\u53bb\u306b\u5bfe\u3057\u3066\u4e3b\u8981\u306a\u5f79\u5272\u3092\u62c5\u3044\u307e\u3059\u3002<\/span><span>\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001p62\u306f\u6a5f\u80fd\u4e0d\u5168\u306b\u306a\u308a\u307e\u3059\u3002<\/span><span>\u3064\u307e\u308a\u3001\u6211\u3005\u4eba\u9593\u3067\u3082\u6bce\u65e5\u306e\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3088\u308b\u9ad8\u8840\u7cd6\u3068\u305d\u308c\u306b\u3088\u308b\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3067\u3001\u6a5f\u80fd\u4e0d\u5168\u306b\u9665\u3063\u305fp62\u4f9d\u5b58\u6027\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u3001\u52a0\u9f62\u306b\u4f34\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027\u306e\u55aa\u5931\u3001\u640d\u50b7\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u306e\u7d30\u80de\u6bd2\u6027\u306e\u84c4\u7a4d\u304a\u3088\u3073\u7d30\u80de\u6b7b\u3001\u8001\u5316\u306a\u3069\u306b\u5927\u304d\u304f\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p>\u6050\u3089\u304f\u9032\u5316\u306e\u4e2d\u3067\u3001\u73fe\u4ee3\u307b\u3069\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3059\u308b\u6642\u4ee3\u306f\u306a\u304f\u3001\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u80fd\u304c\u305d\u3053\u307e\u3067\u5099\u308f\u3063\u3066\u3044\u306a\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3053\u3053\u307e\u3067\u306e\u7cd6\u8cea\u904e\u5270\u306f\u60f3\u5b9a\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u3069\u308c\u3060\u3051\u8010\u3048\u3089\u308c\u308b\u304b\u306f\u3001\u305d\u306e\u7d44\u7e54\u3084\u7d30\u80de\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u7279\u306b\u8133\u306a\u3069\u306e\u795e\u7d4c\u306f\u8106\u5f31\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u3048\u308c\u3070\u3001\u307e\u3060\u9006\u8ee2\u3067\u304d\u308b\u7d44\u7e54\u3084\u7d30\u80de\u3082\u591a\u304f\u5b58\u5728\u3057\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>AGEs\u306f\u666e\u6bb5\u76ee\u306b\u898b\u3048\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3057\u3001\u84c4\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u4f55\u304b\u3067\u793a\u3055\u308c\u308b\u308f\u3051\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u3001\u4f55\u304b\u304c\u4e0d\u8abf\u306b\u306a\u3063\u3066\u3001\u4f55\u304b\u304c\u6a5f\u80fd\u4f4e\u4e0b\u3084\u6a5f\u80fd\u7570\u5e38\u3092\u8d77\u3053\u3057\u3066\u3001\u8001\u5316\u3084\u75c5\u6c17\u3068\u3044\u3046\u5f62\u3067\u8868\u308c\u3066\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u591a\u304f\u306f\u305d\u306e\u307e\u307e\u52a0\u9f62\u6027\u306e\u5909\u5316\u3067\u4ed5\u65b9\u304c\u306a\u3044\u3053\u3068\u3060\u3068\u53d7\u3051\u6d41\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u3084\u3081\u308b\u3053\u3068\u3067\u3001\u52a0\u9f62\u6027\u5909\u5316\u306f\u505c\u6b62\u306f\u3067\u304d\u306a\u304f\u3066\u3082\u3001\u3086\u3063\u304f\u308a\u3059\u308b\u3053\u3068\u306f\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<p>\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u5236\u3059\u308b\u306b\u306f\u3001\u7cd6\u8cea\u5236\u9650\u304c\u6700\u3082\u6709\u52b9\u306a\u624b\u6bb5\u3060\u3068\u8003\u3048\u307e\u3059\u3002\u6642\u9593\u306f\u304b\u304b\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u7cd6\u8cea\u5236\u9650\u3067\u9006\u8ee2\u3067\u304d\u308b\u75c7\u72b6\u3082\u591a\u304f\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u653e\u7f6e\u3057\u3066\u304a\u3044\u3066\u306f\u3001AGEs\u304c\u3069\u3093\u3069\u3093\u84c4\u7a4d\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u4eca\u304b\u3089\u3067\u3082\u7cd6\u8cea\u5236\u9650\u3092\u59cb\u3081\u307e\u3057\u3087\u3046\u3002<\/p>\n<p><span style=\"color: #ffffff;\">\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300cAutophagic receptor p62 protects against glycation\u2010derived toxicity and enhances viability\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u53d7\u5bb9\u4f53p62\u306f\u3001\u7cd6\u5316\u7531\u6765\u306e\u6bd2\u6027\u304b\u3089\u4fdd\u8b77\u3057\u3001\u751f\u5b58\u7387\u3092\u9ad8\u3081\u308b\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13257\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u306f\u9ad8\u8840\u7cd6\u306b\u306a\u308a\u3001\u305d\u308c\u306b\u3088\u308a\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u304c\u3067\u304d\u3066\u84c4\u7a4d\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3053\u306eAGEs\u304c\u69d8\u3005\u306a\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u3063\u305f\u308a\u3001\u8001\u5316\u3084\u7d44\u7e54\u306e\u6a5f\u80fd\u4e0d\u5168\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002 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