{"id":15878,"date":"2021-05-11T19:57:56","date_gmt":"2021-05-11T10:57:56","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=15878"},"modified":"2021-05-11T19:57:56","modified_gmt":"2021-05-11T10:57:56","slug":"post-15878","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=15878","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u96e3\u8074\u3092\u5897\u52a0\u3055\u305b\u308b"},"content":{"rendered":"
\n

PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u80c3\u9178\u3092\u5f37\u529b\u306b\u6291\u5236\u3057\u307e\u3059\u304c\u3001\u69d8\u3005\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u80c3\u9178\u3092\u6291\u3048\u308bH2\u30d6\u30ed\u30c3\u30ab\u30fc\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u96e3\u8074\u306f\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u3088\u3046\u3067\u3059\u3002\u30c7\u30fc\u30bf\u306fFDA\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n<\/header>\n

\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u526f\u4f5c\u7528<\/th>\nPPI<\/th>\nH2\u30d6\u30ed\u30c3\u30ab\u30fc<\/th>\n<\/tr>\n<\/thead>\n
\u96e3\u8074<\/td>\n134<\/td>\n2<\/td>\n<\/tr>\n
\u8074\u899a\u969c\u5bb3<\/td>\n127<\/td>\n0<\/td>\n<\/tr>\n
\u8074\u899a\u6d88\u5931<\/td>\n59<\/td>\n4<\/td>\n<\/tr>\n
\u7247\u5074\u96e3\u8074<\/td>\n20<\/td>\n0<\/td>\n<\/tr>\n
\u7a81\u767a\u6027\u96e3\u8074<\/td>\n12<\/td>\n0<\/td>\n<\/tr>\n
\u4e00\u6642\u7684\u96e3\u8074<\/td>\n1<\/td>\n0<\/td>\n<\/tr>\n
\u8074\u795e\u7d4c\u6027\u96e3\u8074<\/td>\n1<\/td>\n0<\/td>\n<\/tr>\n
\u4e21\u5074\u96e3\u8074<\/td>\n1<\/td>\n0<\/td>\n<\/tr>\n
\u7dcf\u8074\u899a\u969c\u5bb3<\/td>\n355\/42,537<\/td>\n6\/8,309<\/td>\n<\/tr>\n
\u30aa\u30c3\u30ba\u6bd4\uff0895\uff05CI\uff09[p\u5024]<\/td>\n11.64\uff085.20\u301c26.11\uff09[p <0.0001]<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n
\n

\u306a\u3093\u3068H2\u30d6\u30ed\u30c3\u30ab\u30fc\u3068\u6bd4\u8f03\u3059\u308b\u3068\u4f55\u3089\u304b\u306e\u8074\u899a\u969c\u5bb3\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u306f11.64\u500d\u3067\u3059\u3002<\/p>\n

\u306a\u305c\u305d\u306e\u3088\u3046\u306b\u306a\u308b\u306e\u304b\u306f\u306f\u3063\u304d\u308a\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u80c3\u9178\u306e\u9178\u6027\u5ea6\u306e\u4f4e\u4e0b\u306b\u3088\u308b\u611f\u67d3\u75c7\u3084\u708e\u75c7\u304c\u5897\u52a0\u3059\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u3001PPI\u306f\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\u3092\u793a\u3059\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u3067\u3001\u5185\u8033\u306e\u8840\u6d41\u6e1b\u5c11\u3084\u8840\u6813\u75c7\u3092\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u3082\u5897\u52a0\u3055\u305b\u308b\u3068\u3082\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u8074\u899a\u306b\u304b\u304b\u308f\u308b\u8133\u306e\u5909\u5316\u3082\u8d77\u304d\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\uff08\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306e\u6697\u9ed2\u9762\u3000\u305d\u306e2\u3000PPI\u306f\u591a\u304f\u306e\u75c5\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n

PPI\u3092\u51e6\u65b9\u3059\u308b\u5185\u79d1\u306e\u533b\u5e2b\u306f\u8033\u304c\u805e\u3053\u3048\u306a\u304f\u306a\u3063\u3066\u3082\u3001\u81ea\u5206\u306e\u51e6\u65b9\u3057\u305f\u85ac\u304c\u539f\u56e0\u3060\u3068\u306f\u601d\u308f\u306a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

PPI\u306f\u6f2b\u7136\u3068\u5185\u670d\u3059\u308b\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3067\u304d\u308b\u9650\u308a\u4e2d\u6b62\u3059\u308b\u3088\u3046\u306b\u52aa\u3081\u308b\u3079\u304d\u3067\u3059\u3002<\/p>\n

 <\/p>\n<\/div>\n

\u300cProton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory\u300d<\/span><\/p>\n

\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u306e\u4f7f\u7528\u306f\u3001\u8074\u899a\u3001\u8996\u899a\u3001\u8a18\u61b6\u306e\u969c\u5bb3\u3092\u542b\u3080\u5e83\u7bc4\u56f2\u306e\u795e\u7d4c\u5b66\u7684\u6709\u5bb3\u4e8b\u8c61\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u80c3\u9178\u3092\u5f37\u529b\u306b\u6291\u5236\u3057\u307e\u3059\u304c\u3001\u69d8\u3005\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u80c3\u9178\u3092\u6291\u3048\u308bH2\u30d6\u30ed\u30c3\u30ab\u30fc\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u96e3\u8074\u306f\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u3088\u3046\u3067\u3059\u3002\u30c7\u30fc\u30bf\u306fFDA\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539<\/p>\n","protected":false},"author":1,"featured_media":15879,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[156,15,5],"tags":[33,45],"class_list":["post-15878","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ppi","category-15","category-5","tag-ppi","tag-side","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/05\/202363_s.jpg?fit=640%2C427&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-486","jetpack-related-posts":[{"id":23485,"url":"https:\/\/promea2014.com\/blog\/?p=23485","url_meta":{"origin":15878,"position":0},"title":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u3081\u307e\u3044","author":"Dr.Shimizu","date":"2023\u5e748\u670817\u65e5","format":false,"excerpt":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u526f\u4f5c\u7528\u306e\u30aa\u30f3\u30d1\u30ec\u30fc\u30c9\u3067\u3059\u3002\uff08\u30aa\u30f3\u30d1\u30ec\u30fc\u30c9\u3068\u3044\u3046\u8868\u73fe\u304c\u53e4\u81ed\u3044\u304b\u306a\uff1f\uff09 \u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/08\/24872594_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/08\/24872594_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/08\/24872594_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":25692,"url":"https:\/\/promea2014.com\/blog\/?p=25692","url_meta":{"origin":15878,"position":1},"title":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u5c3f\u8def\u7d50\u77f3","author":"Dr.Shimizu","date":"2024\u5e745\u670815\u65e5","format":false,"excerpt":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u975e\u5e38\u306b\u591a\u304f\u306e\u526f\u4f5c\u7528\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5148\u65e5\u306e\u8a18\u4e8b\u300cPPI\uff08\u30d7\u30ed\u2026","rel":"","context":"PPI","block_context":{"text":"PPI","link":"https:\/\/promea2014.com\/blog\/?cat=156"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/03\/29683814_s.jpg?fit=640%2C480&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/03\/29683814_s.jpg?fit=640%2C480&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/03\/29683814_s.jpg?fit=640%2C480&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":7259,"url":"https:\/\/promea2014.com\/blog\/?p=7259","url_meta":{"origin":15878,"position":2},"title":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u814e\u81d3\u306b\u3082\u826f\u304f\u306a\u3044","author":"Dr.Shimizu","date":"2019\u5e743\u67085\u65e5","format":false,"excerpt":"\u4ee5\u524d\u306e\u8a18\u4e8b\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u98df\u9053\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u300d\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\u2026","rel":"","context":"\u75c5\u6c17","block_context":{"text":"\u75c5\u6c17","link":"https:\/\/promea2014.com\/blog\/?cat=15"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/02\/883428.jpg?fit=1200%2C724&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/02\/883428.jpg?fit=1200%2C724&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/02\/883428.jpg?fit=1200%2C724&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/02\/883428.jpg?fit=1200%2C724&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2019\/02\/883428.jpg?fit=1200%2C724&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":30038,"url":"https:\/\/promea2014.com\/blog\/?p=30038","url_meta":{"origin":15878,"position":3},"title":"\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u3068\u819d\u95a2\u7bc0\u7f6e\u63db\u8853\u306e\u30ea\u30b9\u30af","author":"Dr.Shimizu","date":"2025\u5e749\u670824\u65e5","format":false,"excerpt":"\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306f\u3001\u75db\u307f\u306e\u7de9\u548c\u306e\u305f\u3081\u306b\u93ae\u75db\u85ac\u306eNSAIDs\u3092\u98f2\u3093\u3067\u3044\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u306e\u526f\u4f5c\u7528\u4e88\u9632\u306e\u305f\u3081\u2026","rel":"","context":"\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4","block_context":{"text":"\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4","link":"https:\/\/promea2014.com\/blog\/?cat=111"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/31245102_s.jpg?fit=640%2C366&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/31245102_s.jpg?fit=640%2C366&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/31245102_s.jpg?fit=640%2C366&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":23936,"url":"https:\/\/promea2014.com\/blog\/?p=23936","url_meta":{"origin":15878,"position":4},"title":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u539f\u56e0\u5225\u6b7b\u4ea1\u30ea\u30b9\u30af","author":"Dr.Shimizu","date":"2024\u5e744\u670817\u65e5","format":false,"excerpt":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u30b9\u30bf\u30c1\u30f3\u306f\u30de\u30c3\u30c1\u30dd\u30f3\u30d7\u85ac\u306e\u4e8c\u5927\u5de8\u982d\u3067\u3059\u3002\u7279\u306bPPI\u306f\u69d8\u3005\u306a\u75be\u60a3\u30ea\u30b9\u30af\u2026","rel":"","context":"\u30b9\u30bf\u30c1\u30f3","block_context":{"text":"\u30b9\u30bf\u30c1\u30f3","link":"https:\/\/promea2014.com\/blog\/?cat=149"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/04\/433810_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/04\/433810_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/04\/433810_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":16719,"url":"https:\/\/promea2014.com\/blog\/?p=16719","url_meta":{"origin":15878,"position":5},"title":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u6162\u6027\u814e\u75be\u60a3\u3084\u672b\u671f\u814e\u4e0d\u5168\u3092\u5897\u52a0\u3055\u305b\u308b","author":"Dr.Shimizu","date":"2021\u5e748\u670827\u65e5","format":false,"excerpt":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u6c7a\u3057\u3066\u5b89\u5168\u306a\u85ac\u3067\u306f\u306a\u3044\u3053\u3068\u306f\u5468\u77e5\u306e\u4e8b\u5b9f\u3067\u3059\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3044\u307e\u3060\u2026","rel":"","context":"PPI","block_context":{"text":"PPI","link":"https:\/\/promea2014.com\/blog\/?cat=156"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/2440605.jpg?fit=1200%2C935&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/2440605.jpg?fit=1200%2C935&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/2440605.jpg?fit=1200%2C935&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/2440605.jpg?fit=1200%2C935&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/2440605.jpg?fit=1200%2C935&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15878"}],"version-history":[{"count":2,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15878\/revisions"}],"predecessor-version":[{"id":15919,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15878\/revisions\/15919"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/media\/15879"}],"wp:attachment":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}