{"id":16156,"date":"2021-06-21T08:56:46","date_gmt":"2021-06-20T23:56:46","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=16156"},"modified":"2021-06-21T08:56:46","modified_gmt":"2021-06-20T23:56:46","slug":"post-16156","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=16156","title":{"rendered":"\u4e73\u9178\u83cc\u3067\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\uff1f"},"content":{"rendered":"

\u5148\u65e5\u3053\u3093\u306a\u8a18\u4e8b\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002<\/p>\n

\u4e73\u9178\u83cc\u306b\u65b0\u305f\u306a\u53ef\u80fd\u6027 \u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b \u660e\u6cbb\u304c\u7814\u7a76\u6210\u679c<\/span><\/h2>\n

2021\u5e746\u670818\u65e5\u3000\u98df\u54c1\u65b0\u805e\uff08\u8a18\u4e8b\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u660e\u6cbb\u304c\u4fdd\u6709\u3059\u308b\u4e73\u9178\u83cc\u300cLactobacillus plantarum OLL2712\u300d\uff08\u4ee5\u4e0b\u3001MI-2\u4e73\u9178\u83cc\uff09\u306b\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002<\/span><\/p>\n

\u7cd6\u5c3f\u75c5\u306f\u3001\u8840\u6db2\u4e2d\u306e\u30d6\u30c9\u30a6\u7cd6\uff08\u8840\u7cd6\uff09\u304c\u5897\u3048\u7d9a\u3051\u308b\u75c5\u6c17\u3002\u8840\u7cd6\u5024\u304c\u9ad8\u3044\u3053\u3068\u3067\u8840\u7ba1\u3084\u8840\u6db2\u306e\u72b6\u614b\u304c\u60aa\u5316\u3001\u767a\u75c7\u3059\u308b\u75c5\u6c17\u3060\u304c\u3001\u660e\u6cbb\u3068\u6771\u4eac\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u306e\u7d50\u679c\u3001MI-2\u4e73\u9178\u83cc\u3092\u542b\u3080\u30e8\u30fc\u30b0\u30eb\u30c8\u3092\u7cd6\u5c3f\u75c5\u4e88\u5099\u7fa4\u306e\u6210\u4eba\u306b\u6bce\u65e51\u500b\uff08112\uff47\uff09\u300112\u9031\u9593\u6442\u53d6\u3057\u3066\u3082\u3089\u3063\u305f\u3068\u3053\u308d\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3001\u6709\u610f\u306bHbA1c\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u3002\u7814\u7a76\u6210\u679c\u306f\u300c\u7b2c25\u56de\u8178\u5185\u7d30\u83cc\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\u300d\uff086\u67081\uff5e2\u65e5\u958b\u50ac\uff09\u3067\u767a\u8868\u3055\u308c\u305f\u3002<\/span><\/p>\n

HbA1c\u306f\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3068\u8840\u6db2\u4e2d\u306e\u30d6\u30c9\u30a6\u7cd6\u304c\u7d50\u3073\u3064\u3044\u305f\u7cd6\u5316\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u304c\u3069\u306e\u7a0b\u5ea6\u306e\u5272\u5408\u3067\u5b58\u5728\u3057\u3066\u3044\u308b\u304b\u3092\u8868\u3059\u6570\u5024\u3002\u904e\u53bb1\uff5e2\u304b\u6708\u9593\u306e\u5e73\u5747\u7684\u306a\u8840\u7cd6\u5024\u3092\u53cd\u6620\u3059\u308b\u305f\u3081\u3001\u8840\u7cd6\u7ba1\u7406\u304c\u826f\u597d\u3067\u3042\u308b\u304b\u306e\u5224\u65ad\u304c\u53ef\u80fd\u3002<\/span><\/p>\n

MI-2\u4e73\u9178\u83cc\u304cHbA1c\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u3001\u300c\u8178\u7ba1\u514d\u75ab\u7cfb\u306eIL-10\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u5185\u81d3\u8102\u80aa\u7d44\u7e54\u306e\u6162\u6027\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4f5c\u7528\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u305f\u3081\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306f\u4e0d\u8db3\u3057\u3066\u3044\u306a\u3044\u3001\u3082\u3057\u304f\u306f\u5206\u6ccc\u904e\u5270\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u9ad8\u8840\u7cd6\u3068\u306a\u308b\u75c5\u614b\uff09\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u7cd6\u4ee3\u8b1d\u306e\u60aa\u5316\u3092\u9632\u304e\u3001\u65e5\u3005\u306e\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u826f\u597d\u306b\u3057\u305f\u7d50\u679c\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u78ba\u8a8d\u3055\u308c\u305f\u3053\u3068\u3092\u307e\u3068\u3081\u308b\u3068\u3001MI-2\u4e73\u9178\u83cc\u306e\u6442\u53d6\u306f\u3001HbA1c\u304c\u9ad8\u3081\u306e\u5065\u5e38\u6210\u4eba\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u3001HbA1c\u3092\u4e0b\u3052\u308b\u300d\u3068\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u304a\u30fc\u3002\u4e73\u9178\u83cc\u304cHbA1c\u3092\u3002\u306a\u308b\u307b\u3069\u3002\u3067\u3001\u660e\u6cbb\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3092\u306e\u305e\u3044\u3066\u307f\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u660e\u6cbb\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/a>\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u8a18\u4e8b\u306b\u3042\u308b\u4e73\u9178\u83cc\u3067\u306eHbA1c\u306e\u5909\u5316\u91cf\u306f\uff0d0.1\uff05\u7a0b\u5ea6\u3067\u3059\u3088\uff1fHOMA-IR\u3082\u5909\u5316\u3057\u3066\u3044\u306a\u3044\u3088\u3046\u3067\u3059\u304c\u2026\uff1f\u306a\u3093\u3068\u3082\u7d20\u6674\u3089\u3057\u3044\u7d50\u679c\u3067\u3059\u306d\uff1f<\/p>\n

\u3067\u306f\u3001\u5143\u306e\u8ad6\u6587\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u5bfe\u8c61\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c8\u3067\u306f\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u304c100\u301c125mg\/dL\u3067\u3001HbA1c\u306f5.6\u301c6.4\uff05\u306e20\u6b73\u304b\u308964\u6b73\u307e\u3067\u306e\u5065\u5eb7\u306a\u6210\u4eba\u3067\u3057\u305f\u3002OLL2712\u30e8\u30fc\u30b0\u30eb\u30c8\u306f\u3001\u5916\u89b3\u3068\u98a8\u5473\u306e\u70b9\u3067\u30d7\u30e9\u30bb\u30dc\u30e8\u30fc\u30b0\u30eb\u30c8\u3068\u540c\u4e00\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u3089\u306f\u4e21\u65b9\u3068\u308276kcal\u30014.5g\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30011.6g\u306e\u8102\u8cea\u300110.8g\u306e\u70ad\u6c34\u5316\u7269\uff08\u7cd6\u8cea\uff09\u30010.14g\u306e\u30ca\u30c8\u30ea\u30a6\u30e0\u3001\u304a\u3088\u30730.12g\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u542b\u3093\u3067\u3044\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u30d7\u30e9\u30bb\u30dc\u30e8\u30fc\u30b0\u30eb\u30c8\uff08n<\/span>\u00a0= 64\uff09<\/th>\nOLL2712\u30e8\u30fc\u30b0\u30eb\u30c8\uff08n<\/span>\u00a0= 62\uff09<\/th>\n<\/tr>\n
<\/th>\n0\u9031<\/th>\n12\u9031<\/th>\n0\u9031<\/th>\n12\u9031<\/th>\n<\/tr>\n<\/thead>\n
\u5e74\u9f62<\/td>\n51.2\u00b17.6<\/td>\nNA<\/td>\n50.6\u00b16.9<\/td>\nNA<\/td>\n<\/tr>\n
\u7537\u5973<\/td>\n44\/20<\/td>\nNA<\/td>\n42\/20<\/td>\nNA<\/td>\n<\/tr>\n
\u4f53\u91cd\uff08kg\uff09<\/td>\n69.4\u00b112.3<\/td>\n70.3\u00b112.5<\/span><\/td>\n69.1\u00b111.0<\/td>\n69.8\u00b110.8<\/span><\/td>\n<\/tr>\n
BMI<\/td>\n24.9\u00b13.2<\/td>\n25.2\u00b13.4<\/span><\/td>\n24.7\u00b13.3<\/td>\n25.0\u00b13.2<\/span><\/td>\n<\/tr>\n
\u53ce\u7e2e\u671f\u8840\u5727\uff08mmHg\uff09<\/td>\n123.3\u00b114.3<\/td>\n128.3\u00b114.2<\/span><\/td>\n126.6\u00b114.4<\/td>\n133.1\u00b113.2<\/span><\/td>\n<\/tr>\n
\u62e1\u5f35\u671f\u8840\u5727\uff08mmHg\uff09<\/td>\n74.4\u00b110.7<\/td>\n79.7\u00b19.7<\/span><\/td>\n77.4\u00b111.0<\/td>\n82.0\u00b111.2<\/span><\/td>\n<\/tr>\n
\u5fc3\u62cd\u6570\uff08\u62cd\/\u5206\uff09<\/td>\n76.4\u00b111.4<\/td>\n76.7\u00b112.1<\/td>\n76.7\u00b112.2<\/td>\n73.8\u00b112.2<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u30e8\u30fc\u30b0\u30eb\u30c8\u6442\u53d612\u9031\u306e\u69d8\u3005\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3067\u3059\u3002\u30d7\u30e9\u30bb\u30dc\u3082\u4f8b\u306e\u4e73\u9178\u83cc\u30e8\u30fc\u30b0\u30eb\u30c8\u308212\u9031\u9593\u3067\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3088\u308a\u3082\u4f53\u91cd\u3001BMI\u3001\u53ce\u7e2e\u671f\u8840\u5727\u3001\u62e1\u5f35\u671f\u8840\u5727\u306f\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u8a18\u4e8b\u3067\u306f\u7121\u8996\u3067\u3059\u306d\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u660e\u6cbb\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306e\u56f3\u3068\u540c\u3058\u3067\u3059\u3002\u3067\u3082\u3001\u7e26\u8ef8\u306e\u76ee\u76db\u308a\u306f\u975e\u5e38\u306b\u7d30\u304b\u304f\u30010.05\u523b\u307f\u3067\u3059\u306d\u3002\u5927\u3052\u3055\u306b\u5909\u5316\u304c\u8d77\u304d\u305f\u3088\u3046\u306b\u898b\u305b\u308b\u30c6\u30af\u30cb\u30c3\u30af\u3067\u3059\u306d\u3002\u901a\u5e38\u81e8\u5e8a\u7684\u306b\u5c0f\u6570\u70b9\u7b2c2\u4f4d\u306a\u3093\u3066\u8003\u3048\u307e\u305b\u3093\u3002\u305d\u3053\u307e\u3067\u92ed\u654f\u306a\u691c\u67fb\u3067\u306f\u306a\u3044\u304b\u3089\u3067\u3059\u3002\u75c5\u9662\u3067\u691c\u67fb\u3057\u3066\u3082\u901a\u5e38\u5c0f\u6570\u70b9\u7b2c1\u4f4d\u307e\u3067\u306e\u6570\u5024\u304c\u51fa\u308b\u3053\u3068\u306e\u65b9\u304c\u666e\u901a\u3067\u3057\u3087\u3046\u3002\u305d\u3053\u3067\u3001\u5b9f\u969b\u306e\u6e2c\u5b9a\u5024\u3067\u30b0\u30e9\u30d5\u3092\u4f5c\u308a\u76f4\u3057\u3066\u307f\u307e\u3057\u305f\u3002<\/div>\n
<\/div>\n
\"\"<\/a><\/div>\n
<\/div>\n
\u307b\u307c\u5909\u5316\u306a\u3057\u3067\u3059\u3002\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u5909\u5316\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002HbA1c\u306e0.1\u306e\u5909\u5316\u306f\u6050\u3089\u304f\u8aa4\u5dee\u7bc4\u56f2\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u3082\u3057\u304b\u3057\u305f\u3089\u7b2c8\u9031\u3067\u3069\u3061\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u3082HbA1c\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u672c\u4eba\u307e\u305f\u306f\u533b\u5e2b\u304c\u7126\u3063\u3066\u3001\u81ea\u5206\u3067\u98df\u4e8b\u306b\u6c17\u3092\u4ed8\u3051\u305f\u304b\u3001\u3061\u3087\u3063\u3068\u3057\u305f\u30a2\u30c9\u30d0\u30a4\u30b9\u304c\u52a0\u308f\u3063\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002\u6700\u521d\u306f8\u9031\u9593\u306e\u4e88\u5b9a\u304c\u7d50\u679c\u304c\u51fa\u306a\u3044\u306e\u306712\u9031\u9593\u307e\u3067\u3084\u3063\u305f\u3068\u304b\u3001\u3068\u3044\u3046\u306e\u3082\u3042\u308a\u3067\u3059\u304b\u306d\uff1f<\/div>\n
<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5909\u6570<\/th>\n\u30b0\u30eb\u30fc\u30d7<\/th>\n0\u9031<\/th>\n4\u9031<\/th>\n8\u9031<\/th>\n12\u9031<\/th>\n12\u9031\u9593\u306e\u5909\u5316<\/th>\n<\/tr>\n<\/thead>\n
\u7a7a\u8179\u6642\u8840\u7cd6\uff08mg \/ dL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n103.4\u00b17.9<\/td>\n101.0\u00b18.9<\/td>\n104.6\u00b19.6<\/td>\n101.4\u00b111.8<\/td>\n\u22122.0\u00b110.8<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n103.8\u00b17.8<\/td>\n102.3\u00b19.7<\/td>\n103.6\u00b110.3<\/td>\n102.1\u00b19.5<\/td>\n\u22121.7\u00b18.1<\/td>\n<\/tr>\n
HbA1c\uff08\uff05\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n5.85\u00b10.21<\/td>\n5.79\u00b10.22\u00a0**<\/sup><\/span><\/td>\n5.89\u00b10.22 **<\/span><\/td>\n5.78\u00b10.24 **<\/span><\/td>\n\u22120.07\u00b10.14<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n5.86\u00b10.22<\/td>\n5.82\u00b10.25\u00a0*<\/sup><\/span><\/td>\n5.89\u00b10.26<\/td>\n5.74\u00b10.26 **<\/span><\/td>\n\u22120.12\u00b10.14\u00a0\uff03<\/sup><\/span><\/td>\n<\/tr>\n
\u30b0\u30ea\u30b3\u30a2\u30eb\u30d6\u30df\u30f3\uff08\uff05\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n14.8\u00b11.2<\/td>\n14.7\u00b11.2<\/td>\n14.5\u00b11.2 **<\/span><\/td>\n14.5\u00b11.2 **<\/span><\/td>\n\u22120.2\u00b10.5<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n14.6\u00b11.1<\/td>\n14.5\u00b11.1<\/td>\n14.3\u00b11.2 **<\/span><\/td>\n14.2\u00b11.1 **<\/span><\/td>\n\u22120.3\u00b10.5<\/td>\n<\/tr>\n
\u30a4\u30f3\u30b9\u30ea\u30f3\uff08\u03bcU\/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n5.64\u00b12.87<\/td>\n6.40\u00b13.16 *<\/span><\/td>\n6.42\u00b13.28 **<\/span><\/td>\n7.31\u00b15.03 **<\/span><\/td>\n1.68\u00b14.03<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n5.88\u00b14.78<\/td>\n5.82\u00b12.88 *<\/span><\/td>\n6.16\u00b13.08 **<\/span><\/td>\n6.07\u00b13.24 *<\/span><\/td>\n0.24\u00b14.41<\/td>\n<\/tr>\n
HOMA-IR<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n1.45\u00b10.82<\/td>\n1.60\u00b10.82<\/td>\n1.68\u00b10.95 **<\/span><\/td>\n1.87\u00b11.38 *<\/span><\/td>\n0.42\u00b11.12<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n1.52\u00b11.32<\/td>\n1.48\u00b10.76<\/td>\n1.58\u00b10.79 *<\/span><\/td>\n1.53\u00b10.80<\/td>\n0.02\u00b11.25<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u56f3\u306f\u8840\u7cd6\u5024\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u306a\u3069\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002HbA1c\u306e\u4f4e\u4e0b\u306f12\u9031\u3067\u30fc0.12\u3067\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3001\u3057\u304b\u3082\u4e0a\u4e0b\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u30e8\u30fc\u30b0\u30eb\u30c8\u306e\u52b9\u679c\u306a\u306e\u304b\u7591\u554f\u3067\u3059\u306d\u3002\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u9055\u3044\u3082\u305f\u3063\u305f0.05\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306f\u3069\u3061\u3089\u306e\u7fa4\u3082\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3088\u308a\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u660e\u6cbb\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306b\u306f\u3001\u300cMI-2\u4e73\u9178\u83cc\u300d\u304cHbA1c\u3092\u4e0b\u3052\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u6b21\u306e\u3088\u3046\u306b\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002
\nMI-2\u4e73\u9178\u83cc\u304cHbA1c\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u8178\u7ba1\u514d\u75ab\u7cfb\u306eIL-10\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u5185\u81d3\u8102\u80aa\u7d44\u7e54\u306e\u6162\u6027\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4f5c\u7528\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u305f\u3081\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306f\u4e0d\u8db3\u3057\u3066\u3044\u306a\u3044\u3001\u3082\u3057\u304f\u306f\u5206\u6ccc\u904e\u5270\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9ad8\u8840\u7cd6\u3068\u306a\u308b\u75c5\u614b\uff09\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u7cd6\u4ee3\u8b1d\u306e\u60aa\u5316\u3092\u9632\u304e\u3001\u65e5\u3005\u306e\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u826f\u597d\u306b\u3057\u305f\u7d50\u679c\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u81e8\u5e8a\u8a66\u9a13\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u307e\u3068\u3081\u308c\u3070\u3001\u300cMI-2\u4e73\u9178\u83cc\u306e\u6442\u53d6\u306f\u3001HbA1c\u304c\u9ad8\u3081\u306e\u5065\u5e38\u6210\u4eba\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u3001HbA1c\u3092\u4e0b\u3052\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n

\u3067\u3082\u3001\u8ad6\u6587\u3092\u898b\u3066\u3082HOMA-IR\u306f\u7d50\u679c\u7684\u306b\u5909\u5316\u304c\u306a\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u305f\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002\u3057\u304b\u30828\u9031\u3067\u306f\u4e00\u6642\u7684\u306b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3088\u308a\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u4e0a\u6607\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5909\u6570<\/th>\n\u30b0\u30eb\u30fc\u30d7<\/th>\n0\u9031<\/th>\n4\u9031<\/th>\n8\u9031<\/th>\n12\u9031<\/th>\n12\u9031\u9593\u306e\u5909\u5316<\/th>\n<\/tr>\n<\/thead>\n
IL-6\uff08pg \/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n0.532\u00b10.268<\/td>\n0.496\u00b10.250<\/td>\n0.563\u00b10.310<\/td>\n0.601\u00b10.265 *<\/span><\/td>\n0.070\u00b10.236<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n0.801\u00b11.231<\/td>\n0.855\u00b11.456<\/td>\n0.779\u00b11.453<\/td>\n0.792\u00b11.296<\/td>\n\u22120.001\u00b10.507<\/td>\n<\/tr>\n
IL-8\uff08pg \/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n4.71\u00b12.52<\/td>\n2.65\u00b11.81 **<\/span><\/td>\n6.21\u00b15.80 *<\/span><\/td>\n5.72\u00b13.46 *<\/span><\/td>\n1.01\u00b13.12<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n5.24\u00b12.11<\/td>\n2.85\u00b11.76 **<\/span><\/td>\n5.41\u00b12.23<\/td>\n6.66\u00b18.41<\/td>\n1.38\u00b18.56<\/td>\n<\/tr>\n
MCP-1\uff08pg \/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n26.8\u00b121.7<\/td>\n16.6\u00b17.8 **<\/span><\/td>\n21.2\u00b111.1 **<\/span><\/td>\n24.9\u00b117.2<\/td>\n-1.95\u00b124.53<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n25.3\u00b111.9<\/td>\n16.6\u00b19.1 **<\/span><\/td>\n21.2\u00b110.8 **<\/span><\/td>\n23.5\u00b111.1 *<\/span><\/td>\n\u22122.10\u00b18.87<\/td>\n<\/tr>\n
TNF-\u03b1\uff08pg \/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n9.79\u00b15.22<\/td>\n6.79\u00b18.36<\/td>\n11.04\u00b15.41<\/td>\n10.09\u00b14.69<\/td>\n0.29\u00b13.64<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n9.93\u00b14.37<\/td>\n5.17\u00b13.34<\/td>\n10.99\u00b14.84<\/td>\n10.23\u00b15.41<\/td>\n0.20\u00b14.62<\/td>\n<\/tr>\n
hsCRP\uff08mg \/ dL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n0.058\u00b10.067<\/td>\nNA<\/td>\nNA<\/td>\n0.079\u00b10.098 **<\/span><\/td>\n0.030\u00b10.078<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n0.048\u00b10.049<\/td>\nNA<\/td>\nNA<\/td>\n0.054\u00b10.049<\/td>\n0.006\u00b10.031<\/td>\n<\/tr>\n
\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\uff08\u03bcg\/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n5038\u00b11924<\/td>\n5202\u00b12275<\/td>\n5233\u00b12090<\/td>\n5478\u00b12156 **<\/span><\/td>\n439\u00b1780<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n5472\u00b12002<\/td>\n5468\u00b12136<\/td>\n5559\u00b11975<\/td>\n6047\u00b12185 **<\/span><\/td>\n576\u00b11078<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u708e\u75c7\u3092\u793a\u3059\u30d1\u30e9\u30e1\u30fc\u30bf\u3082\u4e0a\u4e0b\u3057\u3066\u3044\u305f\u308a\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u8aa4\u5dee\u7bc4\u56f2\u307e\u305f\u306f\u81e8\u5e8a\u7684\u306b\u3042\u307e\u308a\u610f\u5473\u306e\u306a\u3044\u5909\u5316\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u6b63\u5e38\u7bc4\u56f2\u5185\u306e\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3067\u3042\u308b\u591a\u304f\u306e\u53c2\u52a0\u8005\u304c\u3044\u305f\u306e\u3067\u3001\u3053\u308c\u3089\u306e\u53c2\u52a0\u8005\u306e\u5f71\u97ff\u3092\u6392\u9664\u3059\u308b\u305f\u3081\u306b\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5206\u6790\u3092\u5b9f\u884c\u3057\u307e\u3057\u305f\u3002\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30680\u9031\u76ee\u306e\u30c6\u30b9\u30c8\u306e\u4e21\u65b9\u3067\u9078\u629e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\u53c2\u52a0\u8005\u306e\u30c7\u30fc\u30bf\u3067\u306e\u5206\u6790\u304c\u4e0b\u306e\u8868\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5909\u6570<\/th>\n\u30b0\u30eb\u30fc\u30d7<\/th>\n0\u9031<\/th>\n4\u9031<\/th>\n8\u9031<\/th>\n12\u9031<\/th>\n12\u9031\u9593\u306e\u5909\u5316<\/th>\n<\/tr>\n<\/thead>\n
\u7a7a\u8179\u6642\u8840\u7cd6\uff08mg\/dL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n107.0\u00b15.6<\/td>\n104.1\u00b18.2<\/td>\n108.1\u00b18.6<\/td>\n104.9\u00b110.4<\/td>\n\u22122.2\u00b110.4<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n107.6\u00b15.6<\/td>\n104.9\u00b19.4\u00a0*<\/sup><\/span><\/td>\n107.1\u00b19.4<\/td>\n104.8\u00b18.7 *<\/span><\/td>\n\u22122.8\u00b18.5<\/td>\n<\/tr>\n
HbA1c\uff08\uff05\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n5.92\u00b10.21<\/td>\n5.87\u00b10.21\u00a0**<\/sup><\/span><\/td>\n5.98\u00b10.21 **<\/span><\/td>\n5.85\u00b10.25 **<\/span><\/td>\n\u22120.07\u00b10.16<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n5.90\u00b10.22<\/td>\n5.87\u00b10.24<\/td>\n5.94\u00b10.24<\/td>\n5.77\u00b10.26 **<\/span><\/td>\n\u22120.12\u00b10.14<\/td>\n<\/tr>\n
GA\uff08\uff05\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n14.9\u00b11.2<\/td>\n14.9\u00b11.2<\/td>\n14.7\u00b11.1 *<\/span><\/td>\n14.7\u00b11.2 *<\/span><\/td>\n\u22120.2\u00b10.5<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n14.7\u00b11.2<\/td>\n14.7\u00b11.2<\/td>\n14.4\u00b11.2 **<\/span><\/td>\n14.3\u00b11.1 **<\/span><\/td>\n\u22120.3\u00b10.5<\/td>\n<\/tr>\n
\u30a4\u30f3\u30b9\u30ea\u30f3\uff08\u03bcU\/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n5.70\u00b12.47<\/td>\n6.43\u00b12.98 *<\/span><\/td>\n6.51\u00b13.65<\/span><\/td>\n7.34\u00b14.77 *<\/span><\/td>\n1.64\u00b13.90<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n6.24\u00b15.28<\/td>\n5.82\u00b12.92<\/td>\n6.19\u00b12.67<\/td>\n5.87\u00b12.67<\/td>\n\u22120.37\u00b14.89<\/td>\n<\/tr>\n
HOMA-IR<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n1.51\u00b10.66<\/td>\n1.66\u00b10.78<\/td>\n1.77\u00b11.09<\/td>\n1.95\u00b11.39<\/td>\n0.44\u00b11.13<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n1.67\u00b11.48<\/td>\n1.52\u00b10.80<\/td>\n1.65\u00b10.75<\/td>\n1.52\u00b10.72<\/td>\n\u22120.15\u00b11.41<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5148\u307b\u3069\u306e\u30c7\u30fc\u30bf\u3068\u5927\u304d\u304f\u306f\u9055\u3044\u304c\u3042\u308a\u307e\u305b\u3093\u3002HOMA-IR\u306f\u5909\u5316\u306a\u3057\u3067\u3059\u3002HbA1c\u3082\u30fc0.12\u3067\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5206\u6790\u3092\u5b9f\u884c\u3057\u3066\u3001OLL2712\u306e\u6442\u53d6\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u53c2\u52a0\u8005\u306b\u7279\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3057\u307e\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067HOMA-IR\u304c1.6\u3092\u8d85\u3048\u308b\u53c2\u52a0\u8005\u306e\u30c7\u30fc\u30bf\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5909\u6570<\/th>\n\u30b0\u30eb\u30fc\u30d7<\/th>\n0\u9031<\/th>\n4\u9031<\/th>\n8\u9031<\/th>\n12\u9031<\/th>\n12\u9031\u9593\u306e\u5909\u5316<\/th>\n<\/tr>\n<\/thead>\n
\u7a7a\u8179\u6642\u8840\u7cd6\uff08mg\/dL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n107.1\u00b18.2<\/td>\n103.9\u00b18.1<\/td>\n109.3\u00b110.9<\/td>\n105.5\u00b110.2<\/td>\n\u22121.6\u00b110.5<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n104.7\u00b18.7<\/td>\n102.6\u00b18.4<\/td>\n103.7\u00b111.7<\/td>\n100.0\u00b111.4<\/td>\n\u22124.7\u00b110.6<\/td>\n<\/tr>\n
HbA1c\uff08\uff05\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n5.94\u00b10.18<\/td>\n5.88\u00b10.20<\/td>\n6.01\u00b10.21<\/td>\n5.90\u00b10.26<\/td>\n\u22120.03\u00b10.17<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n5.94\u00b10.23<\/td>\n5.92\u00b10.23<\/td>\n5.99\u00b10.24<\/td>\n5.89\u00b10.29<\/td>\n\u22120.05\u00b10.17<\/td>\n<\/tr>\n
GA\uff08\uff05\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n14.6\u00b11.5<\/td>\n14.6\u00b11.5<\/td>\n14.5\u00b11.4<\/td>\n14.5\u00b11.5<\/td>\n\u22120.1\u00b10.5<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n14.4\u00b11.1<\/td>\n14.3\u00b11.0<\/td>\n14.1\u00b11.0 **<\/span><\/td>\n14.2\u00b11.1 *<\/span><\/td>\n\u22120.3\u00b10.5<\/td>\n<\/tr>\n
\u30a4\u30f3\u30b9\u30ea\u30f3\uff08\u03bcU\/ mL\uff09<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n8.61\u00b12.88<\/td>\n9.13\u00b12.66<\/td>\n9.38\u00b13.30<\/td>\n10.88\u00b15.03<\/td>\n2.27\u00b15.30<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n10.53\u00b16.93<\/td>\n8.40\u00b13.29<\/td>\n9.09\u00b13.15<\/td>\n8.68\u00b14.02<\/td>\n-1.85\u00b17.81<\/td>\n<\/tr>\n
HOMA-IR<\/td>\n\u30d7\u30e9\u30bb\u30dc<\/td>\n2.23\u00b10.89<\/td>\n2.34\u00b10.70<\/td>\n2.57\u00b11.05<\/td>\n2.89\u00b11.51<\/td>\n0.60\u00b11.55<\/td>\n<\/tr>\n
<\/td>\nOLL2712<\/td>\n2.74\u00b11.97<\/td>\n2.12\u00b10.84<\/td>\n2.32\u00b10.76<\/td>\n2.15\u00b10.97<\/td>\n\u22120.59\u00b12.22<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5148\u307b\u3069\u307e\u3067\u3088\u308a\u3082HbA1c\u306e\u5909\u5316\u91cf\u306f\u3055\u3089\u306b\u5c11\u306a\u304f\u306a\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u305f\u3060\u3001\u6709\u610f\u5dee\u306f\u7121\u304f\u3066\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u4f4e\u4e0b\u50be\u5411\u3001HOMA-IR\u3082\u4f4e\u4e0b\u50be\u5411\u306b\u306f\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u4e0d\u601d\u8b70\u306a\u3053\u3068\u306b4\u9031\u3067\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u8840\u7cd6\u5024\u306a\u3069\u304c\u6539\u5584\u50be\u5411\u306b\u306a\u308b\u306e\u306b\u30018\u9031\u3067\u306f\u307e\u305f\u60aa\u5316\u50be\u5411\u3001\u305d\u3057\u306612\u9031\u3067\u307e\u305f\u6539\u5584\u3068\u3044\u3046\u72b6\u6cc1\u3067\u3059\u3002\u3084\u306f\u308a8\u9031\u306e\u6570\u5024\u3092\u898b\u3066\u3001\u672c\u4eba\u304b\u533b\u5e2b\u304b\u660e\u6cbb\u3055\u3093\u304c\u614c\u3066\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u4f55\u3089\u304b\u306e\u3061\u3087\u3063\u3068\u3057\u305f\u4ecb\u5165\u304c\u3042\u3063\u305f\u306e\u304b\u3082\uff1f<\/p>\n

\u305d\u308c\u306b\u3057\u3066\u3082\u3001\u3053\u308c\u3089\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u306f\u30e8\u30fc\u30b0\u30eb\u30c8\u4ee5\u5916\u306e\u6bce\u65e5\u306e\u98df\u4e8b\u5185\u5bb9\u306b\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u4e2d\u8eab\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u3001\u672c\u5f53\u306b\u30e8\u30fc\u30b0\u30eb\u30c8\u306e\u52b9\u679c\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3082\u3088\u304f\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u306f\u305f\u3057\u3066\u3001\u3053\u308c\u3067\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u304b\uff1f\u3057\u304b\u3082\u4f53\u91cd\u3082\u8840\u5727\u3082\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304b\u3089\u3001\u5065\u5eb7\u306b\u826f\u3044\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u306d\u3002\u3053\u3093\u306a\u7d50\u679c\u3067\u3082\u30de\u30b9\u30b3\u30df\u3084CM\u3092\u901a\u3058\u3066\u3001\u300c\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u300d\u3068\u3044\u3046\u8a00\u8449\u3060\u3051\u304c\u72ec\u308a\u6b69\u304d\u3092\u59cb\u3081\u308b\u306e\u3067\u3057\u3087\u3046\u3002\u9a19\u3055\u308c\u306a\u3044\u3088\u3046\u306b\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4<\/span><\/p>\n

\u300cEffects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial\u300d<\/span><\/p>\n

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