{"id":16243,"date":"2021-06-30T13:51:04","date_gmt":"2021-06-30T04:51:04","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=16243"},"modified":"2021-06-30T13:51:37","modified_gmt":"2021-06-30T04:51:37","slug":"post-16243","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=16243","title":{"rendered":"\u65b0\u3057\u30442\u578b\u7cd6\u5c3f\u75c5\u306e\u85ac\u3000\u30c4\u30a4\u30df\u30fc\u30b0\u304c\u627f\u8a8d\u3055\u308c\u305f"},"content":{"rendered":"

\u65b0\u3057\u3044\u7cd6\u5c3f\u75c5\u85ac\u3067\u3042\u308b\u3001\u300c\u30c4\u30a4\u30df\u30fc\u30b0<\/a>\u300d\uff08\u4e00\u822c\u540d\u30a4\u30e1\u30b0\u30ea\u30df\u30f3\uff09\u304c\u539a\u52b4\u7701\u306b\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u88fd\u9020\u8ca9\u58f2\u5143\u306e\u5927\u65e5\u672c\u4f4f\u53cb\u88fd\u85ac\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/a>\u306b\u3088\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306b\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300c\u672c\u5264\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3078\u306e\u4f5c\u7528<\/span>\u3092\u4ecb\u3057\u3066\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u3059<\/span>\u81b5\u4f5c\u7528\u3068\u3001\u809d\u81d3\u30fb\u9aa8\u683c\u7b4b\u3067\u306e\u7cd6\u4ee3\u8b1d\u3092\u6539\u5584\u3059\u308b\u81b5\u5916\u4f5c\u7528(\u7cd6\u65b0\u751f\u6291\u5236\u30fb\u7cd6\u53d6\u8fbc\u307f\u80fd\u6539\u5584<\/span>)\u306b\u3088\u308a\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3092\u793a\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u7cd6\u5c3f\u75c5\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u7d30\u5c0f\u8840\u7ba1\u30fb\u5927\u8840\u7ba1\u969c\u5bb3\u306e\u4e88\u9632\u306b\u3064\u306a\u304c\u308b\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u304a\u3088\u3073\u62e1\u5f35\u6a5f\u80fd\u306e\u6539\u5584\u4f5c\u7528<\/span>\u3084\u3001\u81b5\u81d3\u03b2\u7d30\u80de\u306e\u4fdd\u8b77\u4f5c\u7528<\/span>\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7279\u5fb4\u7684\u306a\u4f5c\u7528\u6a5f\u5e8f\u306b\u3088\u308a\u3001\u672c\u5264\u306f\u30012 \u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u5358\u5264\u304a\u3088\u3073\u4f75\u7528\u306b\u3088\u308b\u8840\u7cd6\u964d\u4e0b\u7642\u6cd5\u306b\u304a\u3044\u3066\u3001\u5e45\u5e83\u304f\u4f7f\u7528\u3055\u308c\u308b\u6cbb\u7642\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span>\u300d<\/p>\n

\u3069\u3046\u3084\u3089\u4f5c\u7528\u6a5f\u5e8f\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3078\u306e\u4f5c\u7528\u3092\u4ecb\u3059\u308b\u3082\u306e\u3068\u60f3\u5b9a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u3069\u306e\u7a0b\u5ea6\u306e\u52b9\u679c\u3067\u3057\u3087\u3046\u304b\uff1f\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f24\u9031\u9593\uff086\u304b\u6708\uff09\u5f8c\u306e\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u6307\u6a19\u306fHbA1c\u3067\u3059\u3002\u30d7\u30e9\u30bb\u30dc\u3067\u306fHbA1c\u306f0.15\u4e0a\u6607\u3001\u30c4\u30a4\u30df\u30fc\u30b0\u3067\u306f0.72\u4f4e\u4e0b\u3067\u3057\u305f\u3002\u56f3\u306eB\u306f6\u304b\u6708\u306e\u63a8\u79fb\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3050\u3093\u3050\u3093\u4e0b\u304c\u3063\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u304c\u3001\u6240\u8a6e1\uff05\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u3088\u3046\u306a\u30b0\u30e9\u30d5\u306e\u30c8\u30ea\u30c3\u30af\u306f\u660e\u6cbb\u306e\u30e8\u30fc\u30b0\u30eb\u30c8\u306e\u4e73\u9178\u83cc\u306e\u30c7\u30fc\u30bf\u306e\u3068\u304d\u3068\u540c\u3058\u3067\u3059\u3002\u30e8\u30fc\u30b0\u30eb\u30c8\u3088\u308a\u306f\u304b\u306a\u308a\u30de\u30b7\u3067\u3059\u304c\u3002\uff08\u300c\u4e73\u9178\u83cc\u3067\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\uff1f<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u30c4\u30a4\u30df\u30fc\u30b0\uff08\u30a4\u30e1\u30b0\u30ea\u30df\u30f3\uff09<\/th>\n\u30d7\u30e9\u30bb\u30dc<\/th>\n<\/tr>\n<\/thead>\n
HbA1c\uff08\uff05\uff09<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n7.99\uff080.764\uff09<\/td>\n7.93\uff080.684\uff09<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316<\/td>\n\u22120.72\uff080.07\uff09<\/td>\n0.15\uff080.07\uff09<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n\u22120.87\uff08\u22121.041\u3001\u22120.691\uff09<\/td>\n<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u8840\u7cd6\uff08mg\/dL\uff09<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n163.6<\/td>\n159.3<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u5909\u5316<\/td>\n\u22125.6<\/td>\n12.8<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n\u221218.5<\/td>\n<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u306e\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\u5bfe\u30a4\u30f3\u30b9\u30ea\u30f3\u6bd4<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n0.1542\uff080.08168\uff09<\/td>\n0.1816\uff080.10990\uff09<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316<\/td>\n\u22120.0138\uff080.0088\uff09<\/td>\n0.0036\uff080.0092\uff09<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n\u22120.0173\uff08\u22120.03520\u30010.00059\uff09<\/td>\n<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u306e\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\u5bfeC-\u30da\u30d7\u30c1\u30c9\u6bd4<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n0.0031\uff080.00171\uff09<\/td>\n0.0034\uff080.00149\uff09<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316<\/td>\n\u22120.0003\uff080.0002\uff09<\/td>\n0.0002\uff080.0002\uff09<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n\u22120.0005\uff08\u22120.00083\u3001\u22120.00021\uff09<\/td>\n<\/td>\n<\/tr>\n
HOMA-IR<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n2.4700\uff081.85368\uff09<\/td>\n2.3298\uff081.67803\uff09<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316<\/td>\n0.1961\uff080.1775\uff09<\/td>\n0.1321\uff080.1835\uff09<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n0.0640\uff08\u22120.30471\u30010.43268\uff09<\/td>\n<\/td>\n<\/tr>\n
QUICKI<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n0.3504\uff080.03949\uff09<\/td>\n0.3546\uff080.04408\uff09<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316<\/td>\n0.0017\uff080.0033\uff09<\/td>\n\u22120.0076\uff080.0034\uff09<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n0.0093\uff080.00283\u30010.01569\uff09<\/td>\n<\/td>\n<\/tr>\n
HOMA-\u03b2<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/td>\n21.4532\uff0813.30453\uff09<\/td>\n22.4627\uff0815.89649\uff09<\/td>\n<\/tr>\n
\u2003\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316<\/td>\n3.5276\uff081.6059\uff09<\/td>\n\u22122.7121\uff081.6673\uff09<\/td>\n<\/tr>\n
\u2003\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u5dee<\/td>\n6.2397\uff082.96742\u30019.51196\uff09<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u306f\u69d8\u3005\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u5909\u5316\u3067\u3059\u3002HbA1c\u306f\u5148\u307b\u3069\u793a\u3057\u307e\u3057\u305f\u304c\u3001\u85ac\u306b\u3088\u308a\u7a7a\u8179\u6642\u8840\u7cd6\u306f\u22125.6\u306e\u4f4e\u4e0b\u3067\u3059\u3002\u7a7a\u8179\u6642\u8840\u7cd6\u306f150\u3092\u8d85\u3048\u3066\u3044\u308b\u72b6\u614b\u3067\u3059\u3002<\/p>\n

\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\/\u30a4\u30f3\u30b9\u30ea\u30f3\u6bd4\u306e\u57fa\u6e96\u5024\u306f\u306f\u3063\u304d\u308a\u3057\u307e\u305b\u3093\u304c\u30010.04\uff5e0.31\u7a0b\u5ea6\u3067\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u8010\u7cd6\u80fd\u7570\u5e38\u3067\u306f\u4e0a\u6607\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u85ac\u306b\u3088\u308b\u4f4e\u4e0b\u306f\u22120.0138\u3067\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u5b50\u306e\u4f4e\u4e0b\u304c\u3069\u3053\u307e\u3067\u306e\u610f\u5473\u304c\u3042\u308b\u304b\u306f\u4e0d\u660e\u3067\u3059\u3002<\/p>\n

\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\u5bfeC-\u30da\u30d7\u30c1\u30c9\u6bd4\u306e\u57fa\u6e96\u5024\u306f\u3088\u304f\u77e5\u308a\u307e\u305b\u3093\u3002<\/p>\n

HOMA-IR\u306f1.6\u4ee5\u4e0b\u306f\u6b63\u5e38\u30012.5\u4ee5\u4e0a\u306e\u5834\u5408\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u30c4\u30a4\u30df\u30fc\u30b0\u7fa4\u306e\u65b9\u304c2.5\u3092\u8d85\u3048\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

QUICKI\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u6307\u6570\uff09\u306e\u5065\u5e38\u4eba\u3067\u306e\u5024\u306f0.348\uff5e0.430\u7a0b\u5ea6\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u85ac\u306b\u3088\u308b\u5897\u52a0\u306f0.0017\u3067\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u3082\u3069\u3053\u307e\u3067\u610f\u5473\u304c\u3042\u308b\u6570\u5024\u306a\u306e\u3067\u3057\u3087\u3046\uff1f<\/p>\n

HOMA-\u03b2\u306f40\uff5e60\uff05\u304c\u6b63\u5e38\u3067\u300130\uff05\u4ee5\u4e0b\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u304c\u3042\u308b\u3068\u5224\u65ad\u3057\u307e\u3059\u3002\u30c4\u30a4\u30df\u30fc\u30b0\u7fa4\u306e\u65b9\u304c\u4e0a\u6607\u3057\u3066\u3044\u307e\u3059\u304c\u30013.5\u7a0b\u5ea6\u3067\u3059\u3002\u307e\u306030\uff05\u4ee5\u4e0b\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u85ac\u304c\u3046\u305f\u3046\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u3001\u7cd6\u65b0\u751f\u6291\u5236\u30fb\u7cd6\u53d6\u8fbc\u307f\u80fd\u6539\u5584\u3001\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u304a\u3088\u3073\u62e1\u5f35\u6a5f\u80fd\u306e\u6539\u5584\u4f5c\u7528\u3001\u03b2\u7d30\u80de\u306e\u4fdd\u8b77\u4f5c\u7528\u304c\u672c\u5f53\u306b\u3042\u308b\u3068\u8a00\u3048\u308b\u306e\u304b\u3069\u3046\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u03b2\u7d30\u80de\u306e\u4fdd\u8b77\u4f5c\u7528\u306b\u3088\u308a\u3001\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u6539\u5584\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u5897\u52a0\u3057\u305f\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u7121\u7406\u3084\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3055\u305b\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u307e\u3059\u307e\u3059\u03b2\u7d30\u80de\u306f\u75b2\u5f0a\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u3067\u98df\u5f8c\u9ad8\u8840\u7cd6\u306f\u3069\u3046\u306a\u306e\u304b\u3001\u5168\u304f\u89e6\u308c\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u6050\u3089\u304f\u601d\u308f\u3057\u304f\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u3002\u4f4e\u8840\u7cd6\u306f2.8\uff05\u306e\u767a\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u6b21\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\n\u2022 SU \u85ac\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089-0.56%
\n\u2022 GLP-1 \u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089-0.12%
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\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4<\/span><\/p>\n

\u300cEfficacy and Safety of Imeglimin Monotherapy Versus Placebo in Japanese Patients With Type 2 Diabetes (TIMES 1): A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 3 Trial\u300d<\/span><\/p>\n

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