{"id":17100,"date":"2021-10-21T08:24:07","date_gmt":"2021-10-20T23:24:07","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=17100"},"modified":"2021-10-21T08:24:07","modified_gmt":"2021-10-20T23:24:07","slug":"post-17100","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=17100","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u3052\u308b"},"content":{"rendered":"<p>PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u69d8\u3005\u306a\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u3053\u308c\u307e\u3067\u3044\u304f\u3064\u3082\u8a18\u4e8b\u306b\u3057\u307e\u3057\u305f\u3002\uff08\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=14264\" target=\"_blank\" rel=\"noopener\">PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u3059\u3044\u81d3\u304c\u3093<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=9585\" target=\"_blank\" rel=\"noopener\">PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306e\u9577\u671f\u4f7f\u7528\u3068\u80c3\u304c\u3093\u306e\u30ea\u30b9\u30af<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=6545\" target=\"_blank\" rel=\"noopener\">PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u304b\u3082\u3057\u308c\u306a\u3044<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306fPPI\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u306e\u95a2\u9023\u3067\u3059\u3002<\/p>\n<p>\u5bfe\u8c61\u306f2002\u5e74\u304b\u30892015\u5e74\u307e\u3067\u306e\u671f\u9593\u3067\u3001\u53f0\u6e7e\u306ePPI\u30b0\u30eb\u30fc\u30d7\u306e297,099\u4eba\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30b0\u30eb\u30fc\u30d7\u306e3,125,594\u4eba\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u767a\u75c7\u3057\u305f63.49\uff05\u306fPPI\u4f7f\u7528\u8005\u3067\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"17105\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=17105\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?fit=772%2C467&amp;ssl=1\" data-orig-size=\"772,467\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Sheng-Hong Lin&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;Background: Previous study revealed proton pump inhibitors (PPIs) have an effect on gut microbiota&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitors Increase the Risk of Autoimmune Diseases:&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Proton Pump Inhibitors Increase the Risk of Autoimmune Diseases:\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Background: Previous study revealed proton pump inhibitors (PPIs) have an effect on gut microbiota&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?fit=300%2C181&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?fit=640%2C387&amp;ssl=1\" class=\"size-full wp-image-17105\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?resize=640%2C387\" alt=\"\" width=\"640\" height=\"387\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?w=772&amp;ssl=1 772w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?resize=300%2C181&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?resize=768%2C465&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t002.jpg?resize=320%2C194&amp;ssl=1 320w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" 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href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"17104\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=17104\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?fit=798%2C1770&amp;ssl=1\" data-orig-size=\"798,1770\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"PPIfimmu-12-736036-g002\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?fit=135%2C300&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?fit=462%2C1024&amp;ssl=1\" class=\"alignnone size-full wp-image-17104\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?resize=640%2C1420\" alt=\"\" width=\"640\" height=\"1420\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?w=798&amp;ssl=1 798w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?resize=135%2C300&amp;ssl=1 135w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?resize=462%2C1024&amp;ssl=1 462w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?resize=768%2C1703&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?resize=693%2C1536&amp;ssl=1 693w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-g002.jpg?resize=320%2C710&amp;ssl=1 320w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306fPPI\u4f7f\u7528\u8005\u304a\u3088\u3073PPI\u975e\u4f7f\u7528\u8005\u306b\u304a\u3051\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3067\u3059\u3002A\u306f\u5168\u4f53\u7684\u306aAD\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3001B\u306f\u306e\u5168\u8eab\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001C\u306f\u81d3\u5668\u7279\u7570\u7684\u306a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u751f\u7387\u3067\u3059\u3002\u3069\u308c\u3082PPI\u4f7f\u7528\u8005\u306e\u65b9\u304c\u767a\u751f\u7387\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"17102\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=17102\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?fit=772%2C1490&amp;ssl=1\" data-orig-size=\"772,1490\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Sheng-Hong Lin&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;Background: Previous study revealed proton pump inhibitors (PPIs) have an effect on gut microbiota&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitors Increase the Risk of Autoimmune Diseases:&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Proton Pump Inhibitors Increase the Risk of Autoimmune Diseases:\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Background: Previous study revealed proton pump inhibitors (PPIs) have an effect on gut microbiota&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?fit=155%2C300&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?fit=531%2C1024&amp;ssl=1\" class=\"size-full wp-image-17102\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?resize=640%2C1235\" alt=\"\" width=\"640\" height=\"1235\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?w=772&amp;ssl=1 772w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?resize=155%2C300&amp;ssl=1 155w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?resize=531%2C1024&amp;ssl=1 531w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?resize=768%2C1482&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/10\/PPIfimmu-12-736036-t004.jpg?resize=320%2C618&amp;ssl=1 320w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u305d\u308c\u305e\u308c\u306e\u75be\u60a3\u3054\u3068\u306e\u30ea\u30b9\u30af\u3067\u3059\u3002PPI\u4f7f\u7528\u8005\u306f\u975e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001<\/p>\n<p>\u5f37\u76f4\u6027\u810a\u690e\u708e 3.67\u500d\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1 3.96\u500d\u3001\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c7\u5019\u7fa4 7.81\u500d\u3001SLE 7.03\u500d\u3001\u5168\u8eab\u6027\u8840\u7ba1\u708e 5.10\u500d\u3001\u4e7e\u766c 2.57\u500d\u3001\u5168\u8eab\u6027\u786c\u5316\u75c7\uff08\u5f37\u76ae\u75c7\uff09 15.85\u500d\u3001\u708e\u75c7\u6027\u7b4b\u75be\u60a3\uff08\u76ae\u819a\u7b4b\u708e\u304a\u3088\u3073\u591a\u767a\u6027\u7b4b\u708e\uff09 37.40\u500d\u3001\u30d0\u30bb\u30c9\u30a6\u75c5 3.28\u500d\u3001\u6a4b\u672c\u75c5 3.61\u500d\u3001\u81ea\u5df1\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8ca7\u8840 8.88\u500d\u3001\u7279\u767a\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u6027\u7d2b\u6591\u75c5 5.05\u500d\u3001\u30d8\u30ce\u30c3\u30db\u30fb\u30b7\u30a7\u30fc\u30f3\u30e9\u30a4\u30f3\u7d2b\u6591\u75c5 4.83\u500d\u3001\u91cd\u75c7\u7b4b\u7121\u529b\u75c7 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style=\"color: #3366ff;\">\u300cProton Pump Inhibitors Increase the Risk of Autoimmune Diseases: A Nationwide Cohort Study\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\uff1a\u5168\u56fd\u7684\u306a\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34659225\/\" target=\"_blank\" 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