{"id":17503,"date":"2021-12-06T08:35:46","date_gmt":"2021-12-05T23:35:46","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=17503"},"modified":"2021-12-06T08:35:46","modified_gmt":"2021-12-05T23:35:46","slug":"post-17503","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=17503","title":{"rendered":"\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u81ea\u5df1\u6297\u4f53"},"content":{"rendered":"

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\u62d9\u8457\u300c\u80a5\u6e80\u30fb\u7cd6\u5c3f\u75c5\u306e\u4eba\u306f\u306a\u305c\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u5f31\u3044\u306e\u304b \u300c\u7cd6\u8cea\u904e\u5270\u300d\u75c7\u5019\u7fa4II<\/a>\u300d\u3067\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u75be\u60a3\u306b\u81ea\u5df1\u514d\u75ab\u304c\u95a2\u308f\u3063\u3066\u304a\u308a\u3001\u9ad8\u8840\u5727\u3067\u3055\u3048\u81ea\u5df1\u6297\u4f53\u306f\u3001\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u306a\u3069\u306b\u5bfe\u3057\u3066\u6d3b\u6027\u5316\u4f5c\u7528\u3092\u53ca\u307c\u3057\u3001\u9ad8\u8840\u5727\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u81ea\u5df1\u6297\u4f53\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u4eba\u306b\u5b58\u5728\u3059\u308b\u304b\u3069\u3046\u304b\u3001\u5b58\u5728\u3059\u308b\u5834\u5408\u306f\u3001\u305d\u306e\u81ea\u5df1\u6297\u539f\u306f\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u306e\u304b\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08IR\uff0916\u4eba\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\uff08IS\uff0916\u4eba\u306e\u7537\u6027\u304c\u5bfe\u8c61\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u5224\u5b9a\u306fSSPG\u6cd5\uff08\u8a73\u7d30\u306f\u7701\u7565\uff09\u3068\u3044\u3046\u65b9\u6cd5\u3067\u884c\u3063\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08IR\uff09\u7fa4\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\uff08IS\uff09\u7fa4\u306e\u69d8\u3005\u306a\u6570\u5024\u3067\u3059\u3002\u5e74\u9f62\u3082BMI\u30822\u3064\u306e\u7fa4\u3067\u4e00\u81f4\u3055\u305b\u3066\u3044\u307e\u3059\u3002\u6709\u610f\u5dee\u304c\u3042\u308b\u306e\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3060\u3051\u3067\u3059\u3002<\/p>\n

2\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u8840\u6db2\u3092\u8abf\u3079\u308b\u3068\u9762\u767d\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3069\u3061\u3089\u3082\u81ea\u5df1\u6297\u4f53\u304c\u5b58\u5728\u3057\u3001\u3057\u304b\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u4eba\u3067\u306f\u660e\u3089\u304b\u306b\u305d\u306e\u81ea\u5df1\u6297\u4f53\u306b\u5bfe\u3059\u308b\u81ea\u5df1\u6297\u539f\u3092\u6301\u3063\u3066\u3044\u308b\u5272\u5408\u304c\u7570\u306a\u3063\u305f\u306e\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3067\u7279\u7570\u7684\u306b\u5206\u96e2\u3055\u308c\u305f122\u500b\u306e\u81ea\u5df1\u6297\u539f\u304c\u7279\u5b9a\u3055\u308c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3067\u306f114\u500b\u306e\u81ea\u5df1\u6297\u539f\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u4e0b\u306e\u8868\u306f\u305d\u306e\u3046\u3061\u306e\u4e0a\u4f4d10\u500b\u306e\u81ea\u5df1\u6297\u539f\u3092\u305d\u308c\u305e\u308c\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u6297\u539f<\/th>\n\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027<\/th>\n\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027<\/th>\n<\/tr>\n<\/thead>\n
GOSR1<\/td>\n72.22%<\/td>\n11.11%<\/td>\n<\/tr>\n
BTK<\/td>\n50%<\/td>\n5.56%<\/td>\n<\/tr>\n
GFAP<\/td>\n50%<\/td>\n5.56%<\/td>\n<\/tr>\n
ASPA<\/td>\n44.44%<\/td>\n5.56%<\/td>\n<\/tr>\n
NIF3L1<\/td>\n44.44%<\/td>\n5.56%<\/td>\n<\/tr>\n
PGD<\/td>\n44.44%<\/td>\n5.56%<\/td>\n<\/tr>\n
ALDH16A1<\/td>\n44.44%<\/td>\n5.56%<\/td>\n<\/tr>\n
KCNAB1<\/td>\n44.44%<\/td>\n5.56%<\/td>\n<\/tr>\n
RNA_POLYMERASE<\/td>\n61.11%<\/td>\n16.67%<\/td>\n<\/tr>\n
GSTA3<\/td>\n61.11%<\/td>\n16.67%<\/td>\n<\/tr>\n
\u6297\u539f<\/strong><\/td>\n\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027<\/strong><\/td>\n\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027<\/strong><\/td>\n<\/tr>\n
CTNNA1<\/td>\n11.11%<\/td>\n61.11%<\/td>\n<\/tr>\n
CDC37<\/td>\n5.56%<\/td>\n50%<\/td>\n<\/tr>\n
LGALS14<\/td>\n5.56%<\/td>\n50%<\/td>\n<\/tr>\n
BM88<\/td>\n11.11%<\/td>\n55.56%<\/td>\n<\/tr>\n
NCBP2<\/td>\n11.11%<\/td>\n55.56%<\/td>\n<\/tr>\n
PDDC1<\/td>\n5.56%<\/td>\n44.44%<\/td>\n<\/tr>\n
ALS2CR8<\/td>\n5.56%<\/td>\n44.44%<\/td>\n<\/tr>\n
PAFAH G SUBUNIT<\/td>\n16.67%<\/td>\n61.11%<\/td>\n<\/tr>\n
XRCC4<\/td>\n27.78%<\/td>\n72.22%<\/td>\n<\/tr>\n
Influenza A Antigen (H3N2)<\/td>\n44.44%<\/td>\n88.89%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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\u80a5\u6e80\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u7537\u6027\u306e70\uff05\u4ee5\u4e0a\u3067GOSR1\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u5c0f\u80de\u4f53\u3068\u30b4\u30eb\u30b8\u4f53\u306e\u9593\u3001\u304a\u3088\u3073\u30b4\u30eb\u30b8\u4f53\u306e\u9593\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8f38\u9001\u3059\u308b\u6a5f\u80fd\u304c\u3042\u308a\u3001\u30b4\u30eb\u30b8SNAP\u53d7\u5bb9\u4f53\uff08SNARE\uff09\u8907\u5408\u4f53\u3068\u3044\u3046\u3082\u306e\u306e\u5fc5\u9808\u6210\u5206\u3060\u305d\u3046\u3067\u3059\u3002\u3082\u3057\u304b\u3057\u305f\u3089\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u7b2c3\u4f4d\u306e\u81ea\u5df1\u6297\u539f\u306eGFAP\u306b\u5bfe\u3059\u308b\u81ea\u5df1\u6297\u4f53\u306f2\u578b\u7cd6\u5c3f\u75c5\u306e\u7d0420\uff05\u3067\u51fa\u73fe\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002GFAP\u306f\u30b0\u30ea\u30a2\u7dda\u7dad\u6027\u9178\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08glial fibrillary acidic protein\uff09\u3068\u3044\u3046\u3082\u306e\u3067\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u30b0\u30ea\u30a2\u7d30\u80de\u3067\u3042\u308b\u661f\u72b6\u81a0\u7d30\u80de\uff08\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\uff09\u306e\u7d30\u80de\u9aa8\u683c\u5185\u306b\u5b58\u5728\u3059\u308b\u4e2d\u9593\u5f84\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u305d\u3046\u3067\u3059\u3002\u4e2d\u67a2\u795e\u7d4c\u306e\u708e\u75c7\u306a\u3069\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u306d\u3002<\/p>\n

\u9032\u884c\u3057\u305f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u307b\u307c3\u5206\u306e1\u306f\u3001\u5185\u76ae\u7d30\u80de\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\u81ea\u5df1\u6297\u4f53\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n

\u9006\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3067\u975e\u5e38\u306b\u591a\u3044\u81ea\u5df1\u6297\u4f53\u3082\u3044\u304f\u3064\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u81ea\u5df1\u6297\u4f53\u306e\u4e00\u90e8\u306f\u75c5\u539f\u6027\u304c\u7121\u3044\u3060\u3051\u3067\u306a\u304f\u3001\u9632\u5fa1\u7684\u306a\u5f79\u5272\u3092\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u6211\u3005\u306e\u4f53\u306e\u4e2d\u3067\u3082\u3001\u69d8\u3005\u306a\u81ea\u5df1\u6297\u4f53\u304c\u5e38\u306b\u5faa\u74b0\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u3002\u305d\u308c\u304c\u826f\u3044\u3082\u306e\u306a\u306e\u304b\u60aa\u3044\u3082\u306e\u306a\u306e\u304b\u306f\u6050\u3089\u304f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306b\u3088\u3063\u3066\u5909\u5316\u3059\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3088\u308a\u75c5\u539f\u6027\u306e\u3042\u308b\u81ea\u5df1\u6297\u4f53\u304c\u51fa\u73fe\u3057\u3001\u69d8\u3005\u306a\u75be\u60a3\u306e\u539f\u56e0\u3084\u4fc3\u9032\u8981\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u307e\u305f\u3001\u81ea\u5df1\u6297\u4f53\u3067\u3055\u3089\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u81ea\u5df1\u6297\u4f53\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3060\u3051\u306e\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

 <\/p>\n

\u300cB Lymphocytes Promote Insulin Resistance through Modulation of T Lymphocytes and Production of Pathogenic IgG Antibody\u300d<\/span><\/p>\n

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