{"id":17619,"date":"2022-01-20T08:09:05","date_gmt":"2022-01-19T23:09:05","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=17619"},"modified":"2022-01-20T08:09:05","modified_gmt":"2022-01-19T23:09:05","slug":"post-17619","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=17619","title":{"rendered":"\u4e73\u304c\u3093\u3068\u8102\u8cea\u5408\u6210\u7cfb\u306e\u5897\u52a0"},"content":{"rendered":"

\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306a\u3069\u3067\u306f\u3001\u7cd6\u8cea\u304b\u3089\u8102\u8cea\u3078\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6d41\u308c\u304c\u4ea2\u9032\u3057\u3001\u30d5\u30ec\u30a4\u30eb\u306a\u3069\u4f4e\u6804\u990a\u75c5\u614b\u3067\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u7cd6\u8cea\u3078\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6d41\u308c\u304c\u5897\u52a0\u3057\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6d41\u308c\u306f\u9006\u6d41\u3059\u308b\u3053\u3068\u306f\u306a\u304f\u3001\u3044\u308f\u3086\u308b\uff13\u5927\u6804\u990a\u7d20\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6d41\u308c\u306f\u4e00\u65b9\u5411\u6027\u3067\u3042\u308a\u3001\u305d\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u672c\u6765\u3001\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u305d\u306e\u5236\u5fa1\u306b\u6700\u3082\u91cd\u8981\u306a\u3082\u306e\u306e\u4e00\u3064\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u3067\u3059\u3002<\/p>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u3092\u6291\u5236\u3057\u3001\u8102\u8cea\u5408\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u7b51\u6ce2\u5927\u5b66\u304c\u89e3\u660e\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b3\u5927\u6804\u990a\u7d20\u9593\u306e\u30d0\u30e9\u30f3\u30b9\u7dad\u6301\u6a5f\u69cb\u306f\u4e0b\u306e\u56f3\u306e\u3088\u3046\u3067\u3059\u3002\uff08\u56f3\u306f\u3053\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308a\u30b9\u30a4\u30c3\u30c1\u304c\u30aa\u30f3\u3001\u30aa\u30d5\u306b\u306a\u308b\u3088\u3046\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u5897\u52a0\u3059\u308b\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u7cfb\u304c\u30aa\u30d5\u306b\u306a\u308a\u3001\u8102\u8cea\u5408\u6210\u7cfb\u304c\u30aa\u30f3\u306b\u306a\u308a\u307e\u3059\u3002\u9006\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u6b20\u4e4f\u6642\u3001\u3064\u307e\u308a\u98e2\u9913\u3001\u7d76\u98df\u306a\u3069\u306e\u5834\u5408\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u7cfb\u304c\u30aa\u30f3\u306b\u306a\u308a\u3001\u8102\u8cea\u5408\u6210\u7cfb\u304c\u30aa\u30d5\u306b\u306a\u308a\u307e\u3059\u3002\u8102\u8cea\u5408\u6210\u7cfb\u306fSREBP-1\uff08\u30b9\u30c6\u30ed\u30fc\u30eb\u8abf\u7bc0\u914d\u5217\u7d50\u5408\u30bf\u30f3\u30d1\u30af-1\uff09\u3092\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u305f\u3060\u3001\u7cd6\u8cea\u5236\u9650\u306f\u98e2\u9913\u72b6\u614b\u3067\u306f\u306a\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u5c11\u306a\u3044\u3051\u308c\u3069\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u306f\u8c4a\u5bcc\u306a\u72b6\u614b\u306a\u306e\u3067\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306a\u5358\u7d14\u306a\u3082\u306e\u3067\u306f\u7121\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u4eca\u56de\u8a00\u3044\u305f\u3044\u306e\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5897\u52a0\u3059\u308b\u3068SREBP-1\u304c\u5897\u52a0\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002SREBP-1\u306f\u8102\u80aa\u9178\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0\u3001\u3064\u307e\u308a\u4e2d\u6027\u8102\u80aa\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u305d\u306eSREBP-1\u3068\u4e73\u304c\u3093\u3068\u306e\u95a2\u9023\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u4e73\u304c\u3093\u60a3\u800582\u4eba\u306e\u7d44\u7e54\u30b5\u30f3\u30d7\u30eb\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u305d\u3046\u3059\u308b\u3068SREBP-1\u306f\u3001\u304c\u3093\u306e\u5468\u308a\u306e\u7d44\u7e54\u3068\u6bd4\u8f03\u3057\u3066\u3001\u304c\u3093\u306e\u7d44\u7e54\u306e\u5927\u90e8\u5206\u3067\u78ba\u5b9f\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u3001SREBP-1\u306e\u767a\u73fe\u306e\u5897\u52a0\u3068\u81e8\u5e8a\u75c5\u7406\u5b66\u7684\u7279\u5fb4\u3068\u306e\u95a2\u9023\u3092\u5206\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u9ad8\u3044SREBP-1\u767a\u73fe\u304c\u816b\u760d\u5206\u5316\u3001\u816b\u760d\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\uff08TNM\uff09\u75c5\u671f\u3001\u304a\u3088\u3073\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u3068\u5f37\u304f\u76f8\u95a2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f5\u5e74\u751f\u5b58\u7387\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002A\u306f\u5168\u4f53\u3001B\u306f\u4e73\u304c\u3093\u306b\u3088\u3063\u3066\u6b7b\u4ea1\u3057\u305f\u304b\u3069\u3046\u304b\u306e\u751f\u5b58\u7387\u3067\u3059\u3002\u5b9f\u7dda\u304cSREBP-1\u304c\u4f4e\u3044\u5834\u5408\u3001\u70b9\u7dda\u304cSREBP-1\u304c\u9ad8\u3044\u5834\u5408\u3067\u3059\u3002\u3069\u3061\u3089\u306e\u56f3\u3082SREBP-1\u306e\u9ad8\u767a\u73fe\u306f\u3001\u4e73\u304c\u3093\u60a3\u8005\u306e5\u5e74\u751f\u5b58\u7387\u306e\u4f4e\u4e0b\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u5168\u751f\u5b58<\/th>\n\u75be\u60a3\u7279\u7570\u7684\u751f\u5b58<\/th>\n<\/tr>\n
\u5909\u6570<\/th>\nHR<\/th>\n95\uff05CI<\/th>\nP\u5024<\/th>\nHR<\/th>\n95\uff05CI<\/th>\nP\u5024<\/th>\n<\/tr>\n<\/thead>\n
SREBP-1<\/td>\n2.976<\/span><\/td>\n1.109\u301c7.987<\/td>\n0.030<\/td>\n2.327<\/span><\/td>\n1.093\u301c4.955<\/td>\n0.029<\/td>\n<\/tr>\n
\u5e74\u9f62<\/td>\n0.993<\/td>\n0.741\u301c1.352<\/td>\n0.836<\/td>\n0.854<\/td>\n0.651\u301c1.223<\/td>\n0.885<\/td>\n<\/tr>\n
\u816b\u760d\u30b5\u30a4\u30ba<\/td>\n2.731<\/span><\/td>\n1.945\u301c3.786<\/td>\n0.003<\/td>\n2.912<\/span><\/td>\n1.883\u301c4.147<\/td>\n0.001<\/td>\n<\/tr>\n
\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb<\/td>\n3.183<\/span><\/td>\n1.991\u301c4.505<\/td>\n0.001<\/td>\n3.962<\/span><\/td>\n2.975\u301c4.756<\/td>\n<0.001<\/td>\n<\/tr>\n
\u7d44\u7e54\u5b66\u30b0\u30ec\u30fc\u30c9<\/td>\n1.842<\/span><\/td>\n1.185\u301c2.846<\/td>\n0.023<\/td>\n1.954<\/span><\/td>\n1.512\u301c2.513<\/td>\n0.032<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n
\n

\u4e0a\u306e\u8868\u306f\u69d8\u3005\u306a\u5909\u6570\u304c5\u5e74\u751f\u5b58\u7387\u306b\u3069\u308c\u307b\u3069\u95a2\u9023\u3057\u3066\u3044\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002SREBP-1\u306f\u30015\u5e74\u751f\u5b58\u7387\u306e\u72ec\u7acb\u3057\u305f\u4e88\u5f8c\u30de\u30fc\u30ab\u30fc\u3067\u3057\u305f\u3002SREBP-1\u304c\u9ad8\u3044\u3068\u7d043\u500d\u3082\u751f\u5b58\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3057\u3001\u4e73\u304c\u3093\u3067\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3082\u4e0a\u304c\u308a\u307e\u3059\u3002<\/p>\n

SREBP-1\u304c\u4e73\u304c\u3093\u7d30\u80de\u306e\u904a\u8d70\u3068\u6d78\u6f64\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u305d\u306e\u5143\u3092\u8003\u3048\u308c\u3070\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5897\u52a0\u304cSREBP-1\u5897\u52a0\u3092\u3082\u305f\u3089\u3057\u3001\u305d\u3057\u3066\u4e73\u304c\u3093\u7d30\u80de\u306e\u6d78\u6f64\u3084\u8ee2\u79fb\u3092\u3082\u305f\u3089\u3057\u3001\u6b7b\u4ea1\u7387\u5897\u52a0\u3092\u3082\u305f\u3089\u3059\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u4e73\u304c\u3093\u306b\u306a\u3063\u3066\u3082\u597d\u304d\u306a\u3082\u306e\u3092\u98df\u3079\u3066\u3044\u3066\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u5897\u52a0\u3057\u3001\u8102\u8cea\u5408\u6210\u7cfb\u304c\u6d3b\u6027\u5316\u3057\u3001\u4e88\u5f8c\u4e0d\u826f\u306b\u306a\u308b\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308b\u3067\u3057\u3087\u3046\u3002\u304c\u3093\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u3002\u7cd6\u8cea\u5236\u9650\u304c\u57fa\u672c\u3067\u3057\u3087\u3046\u3002<\/p>\n<\/div>\n<\/div>\n

 <\/p>\n

\u300cSREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancer\u300d<\/span><\/p>\n

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