{"id":18103,"date":"2022-03-01T20:24:14","date_gmt":"2022-03-01T11:24:14","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=18103"},"modified":"2022-03-01T20:24:14","modified_gmt":"2022-03-01T11:24:14","slug":"post-18103","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=18103","title":{"rendered":"\u89e3\u71b1\u5264\u304c\u5f53\u305f\u308a\u524d\u306e\u3088\u3046\u306b\u4f7f\u308f\u308c\u904e\u304e\u3066\u3044\u308b"},"content":{"rendered":"<p>\u73fe\u5728\u306e\u533b\u7642\u3067\u306f\u3001\u60a3\u8005\u306e\u82e6\u75db\u3092\u3067\u304d\u308b\u9650\u308a\u6392\u9664\u3001\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u539f\u5247\u306f\u9593\u9055\u3063\u3066\u306f\u3044\u307e\u305b\u3093\u304c\u3001\u305d\u308c\u306b\u3088\u308a\u75be\u60a3\u304c\u9577\u5f15\u3044\u305f\u308a\u3001\u60aa\u5316\u3057\u305f\u308a\u3001\u6b7b\u4ea1\u3057\u305f\u308a\u3057\u3066\u3057\u307e\u3063\u3066\u306f\u672c\u672b\u8ee2\u5012\u3067\u3042\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u5916\u6765\u3001\u5165\u9662\u3092\u542b\u3081\u3066\u3001\u73fe\u5728\u89e3\u71b1\u5264\u304c\u5f53\u305f\u308a\u524d\u306e\u3088\u3046\u306b\u4f7f\u308f\u308c\u904e\u304e\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u3061\u3087\u3063\u3068\u3067\u3082\u767a\u71b1\u3059\u308b\u3068\u3001\u770b\u8b77\u5e2b\u306f\u533b\u5e2b\u306b\u5831\u544a\u3057\u3001\u533b\u5e2b\u306f\u89e3\u71b1\u5264\u3092\u51e6\u65b9\u3057\u307e\u3059\u3002\u98a8\u90aa\uff08\u3082\u3061\u308d\u3093\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3092\u542b\u307f\u307e\u3059\uff09\u3001\u6700\u8fd1\u306f\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3067\u3082\u6050\u3089\u304f\u591a\u304f\u306e\u533b\u5e2b\u306f\u89e3\u71b1\u5264\u3092\u51e6\u65b9\u3057\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u611f\u67d3\u306b\u304a\u3051\u308b\u6025\u6027\u671f\u306e\u767a\u71b1\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u3084\u514d\u75ab\u53cd\u5fdc\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3053\u3068\u3067\u3042\u308a\u3001\u4eba\u4f53\u306b\u5099\u308f\u3063\u305f\u975e\u5e38\u306b\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3067\u3059\u3002\u767a\u71b1\u306b\u306f\u6b21\u306e\u3088\u3046\u306a\u5229\u70b9\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30fb\u597d\u4e2d\u7403\u304a\u3088\u3073\u5358\u7403\u306e\u904b\u52d5\u6027\u3068\u904a\u8d70\u98f2\u4f5c\u7528<\/p>\n<p>\u30fb\u98df\u4f5c\u7528\u304a\u3088\u3073\u98f2\u4f5c\u7528\u306e\u5897\u5f37<\/p>\n<p>\u30fb\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09\u7523\u751f\u306e\u5897\u52a0<\/p>\n<p>\u30fb\u6297\u30a6\u30a4\u30eb\u30b9\u3001\u6297\u816b\u760d\u3001\u6297\u5897\u6b96\u3001\u304a\u3088\u3073IFN\u306e\u6d3b\u6027\u3092\u523a\u6fc0\u3059\u308bNK\u7d30\u80de\u306e\u5897\u52a0<\/p>\n<p>\u30fbIFN\u306b\u3088\u308b\u6297\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\uff08\u30a2\u30ec\u30eb\u30ae\u30fc\uff09\u4f5c\u7528\u306e\u5897\u5f37<\/p>\n<p>\u30fb\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3001\u767a\u73fe\u3001\u52d5\u54e1\u3001\u304a\u3088\u3073\u7d30\u80de\u6bd2\u6027\u6d3b\u6027\u306e\u5897\u52a0<\/p>\n<p>\u30fb\u6297\u4f53\u7523\u751f\u306e\u5897\u52a0<\/p>\n<p>\u30fb\u7d30\u80de\u5185\u7d30\u83cc\u306e\u6bba\u50b7\u529b\u306e\u5897\u52a0<\/p>\n<p>\u30fb\u6297\u83cc\u5264\u306e\u6bba\u83cc\u52b9\u679c\u306e\u5897\u52a0<\/p>\n<p>\u30fb\u5bbf\u4e3b\u7d30\u80de\u306b\u304a\u3051\u308b\u7d30\u80de\u4fdd\u8b77\u6027\u306e\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08HSP\uff09\u306e\u8a98\u5c0e<\/p>\n<p>\u30fb\u5bbf\u4e3b\u306e\u9632\u5fa1\u6a5f\u80fd\u3092\u6d3b\u6027\u5316\u3059\u308b\u75c5\u539f\u4f53HSP\u306e\u8a98\u5c0e<\/p>\n<p>\u306a\u3069\u306a\u3069\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u767a\u71b1\u306f\u69d8\u3005\u306a\u514d\u75ab\u53cd\u5fdc\u306e\u6709\u76ca\u306a\u52b9\u679c\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u9006\u306b\u8a00\u3048\u3070\u3001\u305d\u306e\u3088\u3046\u306a\u6709\u76ca\u306a\u52b9\u679c\u3092\u89e3\u71b1\u5264\u306f\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6162\u6027\u306e\u708e\u75c7\u3001\u514d\u75ab\u53cd\u5fdc\u306f\u6709\u5bb3\u3068\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u6025\u6027\u671f\u306e\u708e\u75c7\u3001\u514d\u75ab\u53cd\u5fdc\u306f\u81ea\u5206\u3092\u5b88\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002<\/p>\n<p>Janeway&#8217;s Immunobiology\u3068\u3044\u3046\u514d\u75ab\u306e\u6559\u79d1\u66f8\u306b\u306f\u3001\u300c\u9ad8\u71b1\u3067\u306f\u3001\u7d30\u83cc\u3068\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u306e\u52b9\u7387\u304c\u60aa\u304f\u306a\u308a\u307e\u3059\u304c\u3001\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u306f\u3088\u308a\u52b9\u7387\u7684\u306b\u6a5f\u80fd\u3057\u307e\u3059\u300d\u3068\u66f8\u304b\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n<p>\u30cf\u30ea\u30bd\u30f3\u5185\u79d1\u5b66\u3068\u3044\u3046\u6559\u79d1\u66f8\u306b\u306f\u300c\u767a\u71b1\u3068\u305d\u306e\u6cbb\u7642\u306f\u5bb3\u3092\u53ca\u307c\u3055\u305a\u3001\u4e00\u822c\u7684\u306a\u30a6\u30a4\u30eb\u30b9\u304a\u3088\u3073\u7d30\u83cc\u611f\u67d3\u306e\u89e3\u6c7a\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u300d\u3068\u66f8\u304b\u308c\u3066\u304a\u308a\u3001\u610f\u898b\u304c\u5206\u304b\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5b9f\u969b\u306b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u611f\u67d3\u306b\u3088\u308b\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u3001\u89e3\u71b1\u5264\uff08\u30a2\u30b9\u30d4\u30ea\u30f3\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3001\u30b8\u30af\u30ed\u30d5\u30a7\u30ca\u30af\uff09\u306e\u4f7f\u7528\u306f\u6b7b\u4ea1\u3059\u308b\u53ef\u80fd\u6027\u309234\uff05\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20929891\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u96c6\u4e2d\u6cbb\u7642\u5ba4\u306b\u304a\u3044\u3066\u3001\u7a4d\u6975\u7684\u306b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u4f7f\u7528\u3057\u3066\u89e3\u71b1\u3092\u306f\u304b\u3063\u305f\u4eba\u306e\u65b9\u304c\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3001\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16433601\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>A\u578b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u308f\u3056\u3068\u611f\u67d3\u3055\u305b\u305f\u5b9f\u9a13\u3067\u306f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u307e\u305f\u306f\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u6295\u4e0e\u3055\u308c\u305f\u4eba\u306e\u65b9\u304c\u3001\u89e3\u71b1\u5264\u3092\u4f7f\u7528\u3057\u306a\u3044\u4eba\u3088\u308a\u30823\u65e5\u4ee5\u4e0a\u75c7\u72b6\u306e\u3042\u308b\u671f\u9593\u304c\u5ef6\u9577\u3057\u307e\u3057\u305f\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11130213\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u304c\u6c34\u75d8\uff08\u6c34\u307c\u3046\u305d\u3046\uff09\u306e\u5b50\u4f9b\u305f\u3061\u306e\u75c7\u72b6\u3092\u7de9\u548c\u305b\u305a\u3001\u75c5\u6c17\u306e\u671f\u9593\u3092\u9577\u5f15\u304b\u305b\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2656959\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u89e3\u71b1\u5264\u306e\u4f7f\u7528\u3067\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u6b7b\u4ea1\u304c5\uff05\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8a08\u7b97\u3057\u3066\u3044\u308b\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24452021\/\" target=\"_blank\" 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style=\"color: #3366ff;\">\u300cPopulation-level effects of suppressing fever\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u767a\u71b1\u6291\u5236\u306e\u4eba\u53e3\u30ec\u30d9\u30eb\u306e\u52b9\u679c\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24452021\/\" target=\"_blank\" 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