{"id":19633,"date":"2022-08-02T20:37:43","date_gmt":"2022-08-02T11:37:43","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=19633"},"modified":"2022-08-02T20:37:43","modified_gmt":"2022-08-02T11:37:43","slug":"ldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%e3%81%8c%e9%9d%9e%e5%b8%b8%e3%81%ab%e4%bd%8e%e3%81%84%e3%81%a8%e6%ad%bb%e4%ba%a1%e7%8e%87%e3%81%8c%e4%b8%8a%e3%81%8c","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=19633","title":{"rendered":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u975e\u5e38\u306b\u4f4e\u3044\u3068\u6b7b\u4ea1\u7387\u304c\u4e0a\u304c\u308a\u3001\u8133\u5352\u4e2d\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f4\u500d\u306b\u306a\u308b"},"content":{"rendered":"

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u3068\u3001\u533b\u5e2b\u306b\u300c\u6b7b\u306c\u3088\u300d\u3068\u8105\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u3092\u98f2\u3080\u3088\u3046\u306b\u5f37\u304f\u52e7\u3081\u3089\u308c\u307e\u3059\u3002\u3067\u3082\u672c\u5f53\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u3068\u5371\u967a\u306a\u3093\u3067\u3057\u3087\u3046\u304b\uff1f\u9006\u306b\u975e\u5e38\u306b\u4f4e\u3044LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3069\u3046\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f18 \u6b73\u4ee5\u4e0a\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u5e73\u5747\u5e74\u9f6241.5 \u6b73\u3001\u5973\u602751.9%\uff09\u306e\u6210\u4eba 14,035 \u4eba\u3092\u5bfe\u8c61\u306b\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u5fdc\u3058\u3066 6 \u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u3089\u308c\u307e\u3057\u305f\u300270mg\/dL\u672a\u6e80\u300170-99.9\u3001100-129.9\u3001130-159.9\u3001160-189.9\u3001190mg\/dL\u4ee5\u4e0a\u3067\u3059\u3002\u5e73\u5747\u306723.2\u5e74\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002\uff08\u8868\u304c\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Characteristics<\/th>\nLDL\u2010C levels<\/span><\/th>\nP<\/i>\u00a0value<\/th>\n<\/tr>\n
<70\u00a0mg\/dL<\/th>\n70\u201399.9\u00a0mg\/dL<\/th>\n100\u2013129.9\u00a0mg\/dL<\/th>\n130\u2013159.9\u00a0mg\/dL<\/th>\n160\u2013189.9\u00a0mg\/dL<\/th>\n\u2265190\u00a0mg\/dL<\/th>\n<\/tr>\n<\/thead>\n
No. of participants<\/td>\n790<\/td>\n3071<\/td>\n4481<\/td>\n3326<\/td>\n1585<\/td>\n782<\/td>\n\u2026<\/td>\n<\/tr>\n
Age, y<\/td>\n33.00 (0.61)<\/td>\n35.24 (0.43)<\/td>\n40.16 (0.50)<\/td>\n45.00 (0.54)<\/td>\n49.25 (0.69)<\/td>\n52.42 (0.85)<\/td>\n<\u20090.001<\/td>\n<\/tr>\n
Sex, %<\/td>\n<\/td>\n<\/td>\n0.002<\/td>\n<\/tr>\n
Male<\/td>\n46.47 (2.75)<\/td>\n45.67 (1.16)<\/td>\n45.80 (1.28)<\/td>\n51.69 (1.25)<\/td>\n52.23 (1.70)<\/td>\n48.11 (2.63)<\/td>\n<\/td>\n<\/tr>\n
Female<\/td>\n53.53 (2.75)<\/td>\n54.33 (1.16)<\/td>\n54.20 (1.28)<\/td>\n48.31 (1.25)<\/td>\n47.77 (1.70)<\/td>\n51.89 (2.63)<\/td>\n<\/td>\n<\/tr>\n
Race and ethnicity, %<\/td>\n<\/td>\n<\/td>\n0.002<\/td>\n<\/tr>\n
Non\u2010Hispanic White<\/td>\n72.07 (2.46)<\/td>\n71.84 (2.03)<\/td>\n74.52 (1.68)<\/td>\n77.63 (1.28)<\/td>\n78.49 (2.14)<\/td>\n76.00 (2.38)<\/td>\n<\/td>\n<\/tr>\n
Non\u2010Hispanic Black<\/td>\n14.69 (1.31)<\/td>\n12.42 (0.95)<\/td>\n11.21 (0.74)<\/td>\n9.95 (0.73)<\/td>\n9.63 (0.93)<\/td>\n12.11 (1.32)<\/td>\n<\/td>\n<\/tr>\n
Mexican\u2010American<\/td>\n6.55 (0.86)<\/td>\n6.38 (0.73)<\/td>\n6.04 (0.54)<\/td>\n4.88 (0.38)<\/td>\n3.72 (0.40)<\/td>\n3.94 (0.71)<\/td>\n<\/td>\n<\/tr>\n
Other<\/td>\n6.69 (1.88)<\/td>\n9.36 (1.49)<\/td>\n8.23 (1.17)<\/td>\n7.54 (0.86)<\/td>\n8.16 (1.82)<\/td>\n7.95 (1.66)<\/td>\n<\/td>\n<\/tr>\n
Education, %<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n0.003<\/td>\n<\/tr>\n
Less than high school<\/td>\n3.50 (0.85)<\/td>\n4.26 (0.48)<\/td>\n4.46 (0.46)<\/td>\n4.92 (0.47)<\/td>\n4.79 (0.72)<\/td>\n7.74 (1.22)<\/td>\n<\/td>\n<\/tr>\n
High school<\/td>\n55.74 (2.09)<\/td>\n50.89 (2.14)<\/td>\n52.06 (1.39)<\/td>\n53.51 (1.50)<\/td>\n58.86 (1.70)<\/td>\n55.15 (3.13)<\/td>\n<\/td>\n<\/tr>\n
College or above<\/td>\n40.44 (2.24)<\/td>\n44.37 (2.24)<\/td>\n43.08 (1.45)<\/td>\n41.13 (1.61)<\/td>\n36.05 (1.82)<\/td>\n36.82 (3.18)<\/td>\n<\/td>\n<\/tr>\n
Marital status, %<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<0.001<\/td>\n<\/tr>\n
Married<\/td>\n48.34 (3.57)<\/td>\n54.49 (1.15)<\/td>\n64.10 (1.10)<\/td>\n69.83 (1.10)<\/td>\n70.96 (1.54)<\/td>\n68.60 (2.75)<\/td>\n<\/td>\n<\/tr>\n
Widowed<\/td>\n1.82 (0.45)<\/td>\n3.57 (0.45)<\/td>\n4.57 (0.33)<\/td>\n6.66 (0.52)<\/td>\n7.91 (0.84)<\/td>\n12.43 (1.84)<\/td>\n<\/td>\n<\/tr>\n
Divorced<\/td>\n9.70 (1.74)<\/td>\n8.15 (1.01)<\/td>\n7.12 (0.57)<\/td>\n8.36 (0.70)<\/td>\n8.32 (1.10)<\/td>\n7.78 (1.61)<\/td>\n<\/td>\n<\/tr>\n
Single<\/td>\n40.14 (3.38)<\/td>\n33.67 (1.41)<\/td>\n24.15 (0.93)<\/td>\n15.07 (0.91)<\/td>\n12.64 (1.25)<\/td>\n10.95 (1.76)<\/td>\n<\/td>\n<\/tr>\n
Ratio of family income to poverty, %<\/td>\n<\/td>\n<\/td>\n<\u20090.001<\/td>\n<\/tr>\n
\u22641.30<\/td>\n23.95 (2.79)<\/td>\n19.53 (1.35)<\/td>\n17.34 (0.96)<\/td>\n13.6 (1.01)<\/td>\n16.75 (1.68)<\/td>\n16.73 (1.85)<\/td>\n<\/td>\n<\/tr>\n
1.31\u20133.50<\/td>\n41.87 (2.82)<\/td>\n42.13 (1.71)<\/td>\n42.26 (1.42)<\/td>\n43.56 (1.85)<\/td>\n40.92 (2.15)<\/td>\n46.01 (2.46)<\/td>\n<\/td>\n<\/tr>\n
>3.50<\/td>\n28.96 (3.25)<\/td>\n32.08 (1.74)<\/td>\n34.33 (1.65)<\/td>\n36.52 (2.18)<\/td>\n33.75 (1.87)<\/td>\n30.63 (2.12)<\/td>\n<\/td>\n<\/tr>\n
Missing<\/td>\n5.23 (0.97)<\/td>\n6.27 (0.77)<\/td>\n6.07 (0.49)<\/td>\n6.32 (0.75)<\/td>\n8.58 (1.13)<\/td>\n6.62 (1.08)<\/td>\n<\/td>\n<\/tr>\n
Smoking status, %<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<0.001<\/td>\n<\/tr>\n
Non\u2010smoker<\/td>\n51.96 (2.70)<\/td>\n50.47 (1.46)<\/td>\n48.57 (1.10)<\/td>\n45.40 (1.52)<\/td>\n44.53 (2.33)<\/td>\n43.52 (2.13)<\/td>\n<\/td>\n<\/tr>\n
Past smoker<\/td>\n15.45 (1.90)<\/td>\n17.63 (0.99)<\/td>\n22.70 (0.96)<\/td>\n27.39 (1.19)<\/td>\n27.07 (1.74)<\/td>\n28.33 (1.77)<\/td>\n<\/td>\n<\/tr>\n
Current smoker<\/td>\n32.59 (2.04)<\/td>\n31.89 (1.50)<\/td>\n28.73 (1.20)<\/td>\n27.20 (1.50)<\/td>\n28.39 (1.97)<\/td>\n28.15 (2.52)<\/td>\n<\/td>\n<\/tr>\n
Alcohol intake, g\/day<\/td>\n15.77 (1.93)<\/td>\n14.99 (1.32)<\/td>\n12.16 (0.88)<\/td>\n9.93 (1.04)<\/td>\n8.33 (1.03)<\/td>\n6.83 (1.09)<\/td>\n0.007<\/td>\n<\/tr>\n
Physical activity, %<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n0.001<\/td>\n<\/tr>\n
Inactive<\/td>\n15.44 (2.29)<\/td>\n12.69 (1.22)<\/td>\n12.59 (0.85)<\/td>\n13.26 (0.85)<\/td>\n18.92 (1.76)<\/td>\n14.28 (1.69)<\/td>\n<\/td>\n<\/tr>\n
Insufficient<\/td>\n41.09 (3.07)<\/td>\n44.23 (1.43)<\/td>\n45.26 (1.30)<\/td>\n47.78 (1.36)<\/td>\n44.80 (1.71)<\/td>\n45.47 (2.53)<\/td>\n<\/td>\n<\/tr>\n
Recommended level<\/td>\n43.47 (2.66)<\/td>\n43.08 (1.63)<\/td>\n42.15 (1.52)<\/td>\n38.96 (1.55)<\/td>\n36.28 (2.08)<\/td>\n40.25 (2.49)<\/td>\n<\/td>\n<\/tr>\n
Lipids<\/td>\n<\/tr>\n
TC, mg\/dL<\/td>\n137.89 (1.66)<\/td>\n162.08 (0.58)<\/td>\n190.16 (0.50)<\/td>\n220.04 (0.46)<\/td>\n249.79 (0.67)<\/td>\n292.33 (1.58)<\/td>\n<0.001<\/td>\n<\/tr>\n
LDL\u2010C, mg\/dL<\/td>\n57.97 (0.69)<\/td>\n87.17 (0.22)<\/td>\n114.89 (0.19)<\/td>\n143.69 (0.25)<\/td>\n172.15 (0.32)<\/td>\n212.07 (0.98)<\/td>\n<0.001<\/td>\n<\/tr>\n
HDL\u2010C, mg\/dL<\/td>\n57.15 (0.98)<\/td>\n54.10 (0.52)<\/td>\n51.52 (0.44)<\/td>\n48.53 (0.36)<\/td>\n48.24 (0.48)<\/td>\n47.90 (1.35)<\/td>\n<0.001<\/td>\n<\/tr>\n
Triglyceride, mg\/dL<\/td>\n113.82 (5.88)<\/td>\n104.04 (2.20)<\/td>\n118.76 (2.13)<\/td>\n139.10 (1.97)<\/td>\n147.01 (2.16)<\/td>\n161.83 (4.22)<\/td>\n<0.001<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Risk factors<\/th>\nLDL\u2010C levels<\/span><\/th>\nP<\/i>\u00a0value<\/th>\n<\/tr>\n
<70\u00a0mg\/dL<\/th>\n70\u201399.9\u00a0mg\/dL<\/th>\n100\u2013129.9\u00a0mg\/dL<\/th>\n130\u2013159.9\u00a0mg\/dL<\/th>\n160\u2013189.9\u00a0mg\/dL<\/th>\n\u2265190\u00a0mg\/dL<\/th>\n<\/tr>\n<\/thead>\n
CRP, %<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<0.001<\/td>\n<\/tr>\n
0.00\u20132.99\u00a0mg\/L<\/td>\n78.85 (2.52)<\/td>\n79.63 (1.31)<\/td>\n73.81 (1.41)<\/td>\n69.88 (1.62)<\/td>\n68.04 (2.28)<\/td>\n67.38 (3.05)<\/td>\n<\/td>\n<\/tr>\n
\u22653.00\u00a0mg\/L<\/td>\n19.75 (2.51)<\/td>\n19.37 (1.31)<\/td>\n25.36 (1.47)<\/td>\n29.09 (1.72)<\/td>\n31.28 (2.26)<\/td>\n31.50 (3.08)<\/td>\n<\/td>\n<\/tr>\n
BMI categories, %<\/td>\n<0.001<\/td>\n<\/tr>\n
<25.0<\/td>\n62.57 (3.01)<\/td>\n64.30 (1.37)<\/td>\n50.13 (1.35)<\/td>\n35.92 (1.60)<\/td>\n28.86 (1.92)<\/td>\n33.17 (2.60)<\/td>\n<\/td>\n<\/tr>\n
25.0\u201329.9<\/td>\n26.16 (2.86)<\/td>\n22.60 (1.33)<\/td>\n28.33 (1.19)<\/td>\n37.55 (1.26)<\/td>\n46.08 (1.98)<\/td>\n39.78 (1.95)<\/td>\n<\/td>\n<\/tr>\n
\u226530.0<\/td>\n11.25 (1.52)<\/td>\n13.05 (0.93)<\/td>\n21.49 (1.35)<\/td>\n26.42 (1.26)<\/td>\n24.91 (1.44)<\/td>\n27.00 (2.70)<\/td>\n<\/td>\n<\/tr>\n
Hypertension, %<\/td>\n20.34 (2.51)<\/td>\n23.34 (1.15)<\/td>\n32.85 (1.30)<\/td>\n46.40 (1.36)<\/td>\n54.48 (2.14)<\/td>\n53.81 (3.17)<\/td>\n<0.001<\/td>\n<\/tr>\n
SBP, mm\u00a0Hg<\/td>\n115.21 (0.68)<\/td>\n115.36 (0.38)<\/td>\n119.09 (0.57)<\/td>\n123.41 (0.41)<\/td>\n126.44 (0.65)<\/td>\n129.70 (0.92)<\/td>\n<0.001<\/td>\n<\/tr>\n
DBP, mm\u00a0Hg<\/td>\n69.27 (0.58)<\/td>\n71.02 (0.30)<\/td>\n73.12 (0.28)<\/td>\n75.49 (0.28)<\/td>\n76.74 (0.35)<\/td>\n77.14 (0.56)<\/td>\n<0.001<\/td>\n<\/tr>\n
Pulse pressure, mm\u00a0Hg<\/td>\n45.95 (0.68)<\/td>\n44.33 (0.43)<\/td>\n45.96 (0.48)<\/td>\n47.92 (0.37)<\/td>\n49.70 (0.55)<\/td>\n52.55 (0.78)<\/td>\n0.003<\/td>\n<\/tr>\n
Diabetes, %<\/td>\n7.12 (1.99)<\/td>\n4.43 (0.54)<\/td>\n6.66 (0.47)<\/td>\n8.24 (0.69)<\/td>\n8.15 (0.75)<\/td>\n8.39 (1.53)<\/td>\n0.001<\/td>\n<\/tr>\n
Fasting glucose, mg\/dL<\/td>\n97.59 (3.78)<\/td>\n93.07 (0.66)<\/td>\n95.88 (0.61)<\/td>\n98.87 (0.64)<\/td>\n98.92 (0.72)<\/td>\n101.65 (1.38)<\/td>\n0.575<\/td>\n<\/tr>\n
Respiratory diseases, %<\/td>\n0.887<\/td>\n<\/tr>\n
Yes<\/td>\n13.72 (2.41)<\/td>\n11.00 (0.81)<\/td>\n11.83 (0.70)<\/td>\n12.09 (0.92)<\/td>\n11.85 (1.33)<\/td>\n11.54 (2.13)<\/td>\n<\/td>\n<\/tr>\n
No<\/td>\n86.28 (2.41)<\/td>\n89.00 (0.81)<\/td>\n88.17 (0.70)<\/td>\n87.91 (0.92)<\/td>\n88.15 (1.33)<\/td>\n88.46 (2.13)<\/td>\n<\/td>\n<\/tr>\n
Liver diseases, %<\/td>\n0.013<\/td>\n<\/tr>\n
Yes<\/td>\n35.49 (4.57)<\/td>\n27.73 (1.54)<\/td>\n30.76 (1.67)<\/td>\n34.80 (1.80)<\/td>\n35.80 (2.40)<\/td>\n33.50 (4.00)<\/td>\n<\/td>\n<\/tr>\n
No<\/td>\n64.51 (4.57)<\/td>\n72.27 (1.54)<\/td>\n69.24 (1.67)<\/td>\n65.20 (1.80)<\/td>\n64.20 (2.40)<\/td>\n66.50 (4.00)<\/td>\n<\/td>\n<\/tr>\n
Chronic kidney disease, %<\/td>\n5.95 (0.99)<\/td>\n7.95 (0.72)<\/td>\n10.52 (0.74)<\/td>\n16.19 (0.99)<\/td>\n22.33 (1.43)<\/td>\n27.12 (2.37)<\/td>\n<0.001<\/td>\n<\/tr>\n
eGFR, mL\/min per 1.73\u00a0m2<\/sup><\/td>\n85.73 (1.08)<\/td>\n82.74 (0.58)<\/td>\n79.14 (0.54)<\/td>\n75.58 (0.54)<\/td>\n72 (0.64)<\/td>\n69.9 (0.91)<\/td>\n<0.001<\/td>\n<\/tr>\n
Cholesterol\u2010lowering drugs, %<\/td>\n<0.001<\/td>\n<\/tr>\n
Yes<\/td>\n0.17 (0.14)<\/td>\n0.53 (0.22)<\/td>\n1.37 (0.30)<\/td>\n3.08 (0.42)<\/td>\n4.80 (0.63)<\/td>\n4.05 (0.93)<\/td>\n<\/td>\n<\/tr>\n
No<\/td>\n99.83 (0.14)<\/td>\n99.47 (0.22)<\/td>\n98.63 (0.30)<\/td>\n96.92 (0.42)<\/td>\n95.20 (0.63)<\/td>\n95.95 (0.93)<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7279\u5fb4\u3067\u3059\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c100-129.9 mg\/dL\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u300170 mg\/dL\u672a\u6e80\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u82e5\u304f (\u5e73\u5747\u5e74\u9f62 33.0 \u6b73)\u3001\u6559\u80b2\u30ec\u30d9\u30eb\u3068\u53ce\u5165\u304c\u4f4e\u304f\u3001\u672a\u5a5a\u3001\u8eab\u4f53\u6d3b\u52d5\u7684\u3001\u4e2d\u7a0b\u5ea6\u307e\u305f\u306f\u91cd\u5ea6\u306e\u98f2\u9152\u8005\u3001\u73fe\u5728\u306e\u55ab\u7159\u307e\u305f\u306f\u975e\u55ab\u7159\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u904e\u53bb\u306e\u55ab\u7159\u8005\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9ad8\u304f\u3001CRP\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u304f\u3001\u80a5\u6e80\u304c\u5c11\u306a\u304f\u3001\u9ad8\u8840\u5727\u306f\u5c11\u306a\u304f\u3001\u814e\u75be\u60a3\u304c\u5c11\u306a\u304f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c100-129.9 mg\/dL\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u3001190mg\/dL\u4ee5\u4e0a\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u5e74\u3092\u3068\u3063\u3066\u3044\u3066 (\u5e73\u5747\u5e74\u9f62 52.4 \u6b73) \u3001\u6559\u80b2\u6c34\u6e96\u3068\u53ce\u5165\u304c\u4f4e\u304f\u3001\u7d50\u5a5a\u3057\u3066\u304a\u308a\u3001\u904e\u53bb\u306e\u55ab\u7159\u304a\u3088\u3073\u8eab\u4f53\u7684\u306b\u4e0d\u6d3b\u767a\u3001\u9ad8\u8840\u5727\u3067\u3042\u308a\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u80a5\u6e80\u3001\u814e\u75be\u60a3\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u304a\u3088\u3073 \u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u91cf\u304c\u5c11\u306a\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u6bd4\u8f03\u3059\u308b\u30b0\u30eb\u30fc\u30d7\u306e\u80cc\u666f\u304c\u9055\u3044\u904e\u304e\u308b\u6c17\u304c\u3057\u307e\u3059\u3002\u307e\u3042\u6c17\u306b\u305b\u305a\u898b\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/span><\/th>\n<\/tr>\n
<70\u00a0mg\/dL<\/th>\n70\u201399.9\u00a0mg\/dL<\/th>\n100\u2013129.9\u00a0mg\/dL<\/th>\n130\u2013159.9\u00a0mg\/dL<\/th>\n160\u2013189.9\u00a0mg\/dL<\/th>\n\u2265190\u00a0mg\/dL<\/th>\n<\/tr>\n<\/thead>\n
\u5168\u539f\u56e0\u6b7b\u4ea1<\/td>\n<\/tr>\n
Model 4<\/td>\n1.45 (1.10\u20131.93)<\/span><\/td>\n1.03 (0.86\u20131.22)<\/td>\n1 (ref)<\/td>\n0.92 (0.83\u20131.02)<\/td>\n0.88 (0.76\u20131.01)<\/td>\n1.08 (0.88\u20131.32)<\/td>\n<\/tr>\n
\u5fc3\u8840\u7ba1\u6b7b\u4ea1<\/td>\n<\/tr>\n
Model 4<\/td>\n1.60 (1.01\u20132.54)<\/span><\/td>\n1.28 (0.86\u20131.90)<\/td>\n1 (ref)<\/td>\n1.19 (0.87\u20131.62)<\/td>\n1.30 (0.98\u20131.72)<\/td>\n1.49 (1.09\u20132.02)<\/span><\/td>\n<\/tr>\n
\u304c\u3093\u6b7b\u4ea1<\/td>\n<\/tr>\n
Model 4<\/td>\n1.02 (0.58\u20131.79)<\/td>\n0.76 (0.52\u20131.09)<\/td>\n1 (ref)<\/td>\n0.88 (0.64\u20131.20)<\/td>\n0.71 (0.46\u20131.08)<\/td>\n0.90 (0.59\u20131.36)<\/td>\n<\/tr>\n
\u975e\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\u975e\u304c\u3093\u6b7b\u4ea1<\/td>\n<\/tr>\n
Model 4<\/td>\n1.63 (1.08\u20132.46)<\/span><\/td>\n1.08 (0.89\u20131.32)<\/td>\n1 (ref)<\/td>\n0.85 (0.72\u20130.99)<\/span><\/td>\n0.80 (0.67\u20130.95)<\/span><\/td>\n1.01 (0.81\u20131.27)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u8868\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5168\u539f\u56e0\u6b7b\u4ea1\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c70\u672a\u6e80\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u307f\u30ea\u30b9\u30af\u304c1.45\u500d\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c190\u4ee5\u4e0a\u3067\u3082\u30ea\u30b9\u30af\u5897\u52a0\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305f\u3060\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u306f190\u4ee5\u4e0a\u3060\u30681.49\u500d\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u8208\u5473\u6df1\u3044\u3053\u3068\u306b70\u672a\u6e80\u306e\u65b9\u304c1.6\u500d\u3068\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u304c\u3093\u306e\u6b7b\u4ea1\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u306f\u95a2\u4fc2\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\u3067\u3082\u306a\u304f\u3001\u304c\u3093\u3067\u3082\u306a\u3044\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb70\u672a\u6e80\u30671.63\u500d\u3067\u3057\u305f\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n
<\/td>\nLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/span><\/th>\n<\/tr>\n
<70\u00a0mg\/dL<\/th>\n70\u201399.9\u00a0mg\/dL<\/th>\n100\u2013129.9\u00a0mg\/dL<\/th>\n130\u2013159.9\u00a0mg\/dL<\/th>\n160\u2013189.9\u00a0mg\/dL<\/th>\n\u2265190\u00a0mg\/dL<\/th>\n<\/tr>\n<\/thead>\n
\u51a0\u52d5\u8108\u75be\u60a3\u6b7b\u4ea1<\/td>\n<\/tr>\n
Model 4<\/td>\n1.08 (0.58\u20132.02)<\/td>\n1.32 (0.86\u20132.00)<\/td>\n1 (ref)<\/td>\n1.22 (0.87\u20131.72)<\/td>\n1.32 (0.95\u20131.82)<\/td>\n1.63 (1.12\u20132.39)<\/span><\/td>\n<\/tr>\n
\u8133\u5352\u4e2d\u6b7b\u4ea1<\/td>\n<\/tr>\n
Model 4<\/td>\n4.04 (1.83\u20138.89)<\/span><\/td>\n1.16 (0.54\u20132.49)<\/td>\n1 (ref)<\/td>\n1.07 (0.63\u20131.82)<\/td>\n1.22 (0.76\u20131.94)<\/td>\n1.01 (0.54\u20131.89)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u8868\u306f\u51a0\u52d5\u8108\u75be\u60a3\u3068\u8133\u5352\u4e2d\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3067\u3059\u3002\u51a0\u52d5\u8108\u75be\u60a3\u3060\u3051\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb190\u4ee5\u4e0a\u30671.63\u500d\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u6050\u308d\u3057\u3044\u3053\u3068\u306b\u8133\u5352\u4e2d\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb70\u672a\u6e80\u306e\u5834\u5408\u30014\u500d\u306b\u3082\u306a\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002<\/p>\n

\u7cd6\u8cea\u5236\u9650\u3092\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3053\u306e\u3088\u3046\u306a\u7d50\u679c\u304c\u3042\u307e\u308a\u53c2\u8003\u306b\u306a\u3089\u306a\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u5236\u9650\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u304c\u307f\u3089\u308c\u308b\u5834\u5408\u3001\u540c\u6642\u306bHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u3001\u4e2d\u6027\u8102\u80aa\u4f4e\u4e0b\u304c\u901a\u5e38\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u4eca\u56de\u306e\u7814\u7a76\u306e\u3088\u3046\u306b\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u3001\u4e2d\u6027\u8102\u80aa\u4e0a\u6607\u3001\u3064\u307e\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u8a8d\u3081\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u4e00\u822c\u306e\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u3057\u3066\u3044\u308b\u4eba\u3067\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u3068\u300c\u6b7b\u306c\u3088\u300d\u3068\u8105\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u3088\u3046\u306a\u533b\u5e2b\u306fLDL\u304c70\u672a\u6e80\u306b\u306a\u3063\u3066\u3044\u3066\u3082\u4f55\u3082\u8a00\u308f\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u6050\u6016\u3084\u4e0d\u5b89\u306f\u4eba\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u306e\u306b\u6700\u3082\u826f\u3044\u65b9\u6cd5\u306a\u3093\u3067\u3057\u3087\u3046\u3002\u30ab\u3007\u30c8\u6559\u3007\u3082\u65b0\u578b\u30b3\u30ed\u30ca\u30d3\u30b8\u30cd\u30b9\u3082\u540c\u69d8\u3067\u3059\u3002<\/p>\n

\u79c1\u306fLDL\u304c\u975e\u5e38\u306b\u4f4e\u3044\u5834\u5408\u3001\u4f4e\u3059\u304e\u308b\u306e\u306f\u5371\u967a\u3067\u3059\u3088\u3001\u3068\u6307\u6458\u3057\u307e\u3059\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3053\u306e\u7814\u7a76\u4ee5\u5916\u306b\u3082\u3042\u308a\u307e\u3059\u3002\uff08\u300c\u4f4eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3059\u3079\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u3092\u5897\u52a0\u3055\u305b\u308b<\/a>\u300d\u300cLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u975e\u5e38\u306b\u4f4e\u3044\u3068\u5168\u539f\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/a>\u300d\u53c2\u7167\uff09\u305d\u3057\u3066\u3082\u3063\u3068LDL\u306f\u9ad8\u3044\u65b9\u304c\u826f\u3044\u3067\u3059\u3088\u3001\u3068\u30a2\u30c9\u30d0\u30a4\u30b9\u3057\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u7cd6\u8cea\u5236\u9650\u3068\u30bb\u30c3\u30c8\u3067\u3002<\/p>\n

 <\/p>\n

\u300cAssociation of Low-Density Lipoprotein Cholesterol Levels with More than 20-Year Risk of Cardiovascular and All-Cause Mortality in the General Population\u300d<\/span><\/p>\n

\u300cLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30ec\u30d9\u30eb\u3068\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u5168\u6b7b\u56e0\u6b7b\u4ea1\u306e20\u5e74\u4ee5\u4e0a\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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