{"id":19658,"date":"2022-08-05T12:25:15","date_gmt":"2022-08-05T03:25:15","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=19658"},"modified":"2022-08-05T12:25:15","modified_gmt":"2022-08-05T03:25:15","slug":"%e9%a2%a8%e9%82%aa%e3%81%ae%e9%a3%9f%e6%ac%b2%e4%b8%8d%e6%8c%af%e3%81%a7%e3%81%af%e7%84%a1%e7%90%86%e3%81%ab%e9%a3%9f%e3%81%b9%e3%82%8c%e3%82%8b%e3%82%82%e3%81%ae%e3%82%92%e9%a3%9f%e3%81%b9%e3%81%aa","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=19658","title":{"rendered":"\u98a8\u90aa\u306e\u98df\u6b32\u4e0d\u632f\u3067\u306f\u7121\u7406\u306b\u98df\u3079\u308c\u308b\u3082\u306e\u3092\u98df\u3079\u306a\u3044\u65b9\u304c\u826f\u3044\u304b\u3082\u3057\u308c\u306a\u3044"},"content":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30aa\u30df\u30af\u30ed\u30f3\u682a\u306eBA5\u3082\u30de\u30b9\u30b3\u30df\u304c\u5927\u9a12\u304e\u3057\u3066\u3044\u308b\u5272\u306b\u3001\u305d\u308d\u305d\u308d\u30d4\u30fc\u30af\u3067\u3057\u3087\u3046\u3002\u611f\u67d3\u75c7\u306e\u5b66\u4f1a\u304c\u300c\u666e\u901a\u306e\u98a8\u90aa\u300d\u3068\u306f\u3063\u304d\u308a\u8a00\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u65e5\u672c\u3082\u304b\u306a\u308a\u4e16\u754c\u304b\u3089\u9045\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u300c\u65b0\u578b\u300d\u3092\u5916\u3057\u3066\u3001\u666e\u901a\u306e\u98a8\u90aa\u306e\u300c\u30b3\u30ed\u30ca\u300d\u306b\u3059\u3079\u304d\u3067\u3059\u3002\u666e\u901a\u306e\u98a8\u90aa\u3001\u305f\u3060\u306e\u98a8\u90aa\u3068\u3044\u3046\u3053\u3068\u306f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u672a\u6e80\u3067\u3059\u306e\u3067\u30015\u985e\u306e\u5206\u985e\u3055\u3048\u901a\u308a\u8d8a\u3057\u3066\u5206\u985e\u306a\u3057\u306b\u3059\u3079\u304d\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u767a\u71b1\u5916\u6765\u3082\u3001\u4f01\u696d\u3084\u5b66\u6821\u306a\u3069\u304c\u967d\u6027\u8a3c\u660e\u3001\u9670\u6027\u8a3c\u660e\u3092\u6c42\u3081\u308b\u306e\u304c\u60aa\u3044\u306e\u3067\u3059\u3002\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3067\u3082\u540c\u69d8\u306a\u3053\u3068\u304c\u8d77\u304d\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u9670\u6027\u304b\u967d\u6027\u306e\u8a3c\u660e\u306f\u5fc5\u8981\u306a\u3044\u3057\u3001\u610f\u5473\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u56fd\u304c\u3061\u3083\u3093\u3068\u8a3c\u660e\u3092\u51fa\u3055\u305b\u306a\u3044\u3088\u3046\u306b\u65b9\u5411\u4ed8\u3051\u3092\u3059\u3079\u304d\u3067\u3059\u3002\u98a8\u90aa\u3092\u3072\u3044\u305f\u3089\u4f53\u8abf\u304c\u623b\u308b\u307e\u3067\u4f11\u3080\u3002\u305f\u3060\u3053\u308c\u3060\u3051\u3067\u826f\u3044\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u98a8\u90aa\u306b\u52b9\u304f\u85ac\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u89e3\u71b1\u85ac\u306e1\u3064\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306e\u54c1\u8584\u304c\u5831\u9053\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u71b1\u3092\u4e0b\u3052\u308b\u3053\u3068\u305d\u3093\u306a\u306b\u91cd\u8981\u3067\u3057\u3087\u3046\u304b\uff1f\u9006\u306b\u71b1\u304c\u4e0b\u304c\u308c\u3070\u514d\u75ab\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u6cbb\u308a\u304c\u60aa\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3067\u3082\u30bf\u30df\u30d5\u30eb\u7b49\u306e\u85ac\u3092\u3082\u3089\u304a\u3046\u3068\u75c5\u9662\u3092\u53d7\u8a3a\u3059\u308b\u65e5\u672c\u4eba\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u4e16\u754c\u4e2d\u3067\u30bf\u30df\u30d5\u30eb\u306e\u4f7f\u7528\u306f\u65e5\u672c\u304c\u307b\u3068\u3093\u3069\u3067\u3059\u3002\u4e16\u754c\u306e\u4e2d\u3067\u898b\u308c\u3070\u3001\u305f\u304b\u304c\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3084\u98a8\u90aa\u3067\u5927\u9a12\u304e\u3059\u308b\u306e\u306f\u65e5\u672c\u4eba\u304f\u3089\u3044\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u3055\u3066\u3001\u98a8\u90aa\u3092\u3072\u3044\u305f\u3068\u304d\u306b\u98df\u6b32\u4e0d\u632f\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u306eBA5\u3067\u8a00\u3048\u3070\u5589\u304c\u975e\u5e38\u306b\u75db\u304f\u306a\u308a\u3001\u98df\u3079\u7269\u304c\u5589\u3092\u901a\u3089\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u306e\u3088\u3046\u306a\u3068\u304d\u306b\u300c\u4f55\u3067\u3082\u3044\u3044\u304b\u3089\u98df\u3079\u3089\u308c\u308b\u3082\u306e\u3092\u98df\u3079\u3066\u300d\u300c\u306e\u3069\u3054\u3057\u306e\u826f\u3044\u3082\u306e\u98df\u3079\u3066\u300d\u3068\u3044\u3046\u7121\u8cac\u4efb\u306a\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u3059\u308b\u533b\u7642\u5f93\u4e8b\u8005\u3082\u3044\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u5589\u306e\u75db\u307f\u306f\u5225\u3068\u3057\u3066\u3082\u3001\u98df\u6b32\u4e0d\u632f\u306f\u3064\u308f\u308a\u3068\u540c\u69d8\u306b\u3001\u4f53\u304c\u305d\u308c\u3092\u6c42\u3081\u3066\u3044\u308b\u3068\u601d\u3063\u30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CD4+ T \u7d30\u80de\uff08\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff09\u306e\u6a5f\u80fd\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30b1\u30c8\u30f3\u4f53\u306f CD4+ T \u7d30\u80de\u304b\u3089\u306e\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3 \u306e\u751f\u5b58\u3068\u7523\u751f\u306e\u4e21\u65b9\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002CD8+T\u7d30\u80de\uff08\u30ad\u30e9\u30fcT\u7d30\u80de\uff09\u3082\u540c\u69d8\u3067\u3001\u5341\u5206\u306a\u30b1\u30c8\u30f3\u4f53\u306e\u4f9b\u7d66\u304c\u5fc5\u8981\u306a\u3088\u3046\u3067\u3059\u3002\u30b1\u30c8\u30f3\u4f53\u304c\u5341\u5206\u306b\u4f9b\u7d66\u3055\u308c\u306a\u3044\u5834\u5408\u3001\u30ad\u30e9\u30fc T \u7d30\u80de\u3068\u30d8\u30eb\u30d1\u30fc T 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style=\"color: #3366ff;\">\u300cImpaired ketogenesis ties metabolism to T cell dysfunction in COVID-19\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u30b1\u30c8\u30b8\u30a7\u30cd\u30b7\u30b9\u306e\u969c\u5bb3\u306f\u3001COVID-19 \u306b\u304a\u3051\u308b\u4ee3\u8b1d\u3068 T \u7d30\u80de\u306e\u6a5f\u80fd\u4e0d\u5168\u3092\u7d50\u3073\u3064\u3051\u308b\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/www.nature.com\/articles\/s41586-022-05128-8\" target=\"_blank\" 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