{"id":20044,"date":"2022-09-20T19:09:47","date_gmt":"2022-09-20T10:09:47","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=20044"},"modified":"2022-09-20T19:09:47","modified_gmt":"2022-09-20T10:09:47","slug":"%e6%9c%80%e8%bf%91ldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%8b%e3%82%89lpa%e3%81%8a%e3%82%88%e3%81%b3apob%e3%81%ab%e3%82%b7%e3%83%95%e3%83%88%e3%81%97%e3%81%a6-2","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=20044","title":{"rendered":"\u6700\u8fd1LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089Lp(a)\u304a\u3088\u3073ApoB\u306b\u30b7\u30d5\u30c8\u3057\u3066\u304d\u3066\u3044\u308b\u3000\u305d\u306e2"},"content":{"rendered":"<p>\u5faa\u74b0\u5668\u9818\u57df\u306e\u5c02\u9580\u5bb6\u306f\u307e\u3059\u307e\u3059\u904e\u6fc0\u306b\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u306b\u3082\u898b\u3048\u307e\u3059\u3002LDL\u3001\u305d\u306e\u3082\u306e\u3092\u6bd2\u7269\u6271\u3044\u3092\u3059\u308b\u4eba\u307e\u3067\u73fe\u308c\u307e\u3057\u305f\u3002<\/p>\n<blockquote class=\"twitter-tweet\">\n<p dir=\"ltr\" lang=\"en\">\u201cIt\u2019s not really about statins any more, it\u2019s about LDL being a toxin.\u201d\u00a0<a href=\"https:\/\/twitter.com\/MarcBonaca?ref_src=twsrc%5Etfw\">@MarcBonaca<\/a>\u00a0<a href=\"https:\/\/twitter.com\/hashtag\/TCT2022?src=hash&amp;ref_src=twsrc%5Etfw\">#TCT2022<\/a>\u00a0<a href=\"https:\/\/t.co\/TxtN6WruTv\">pic.twitter.com\/TxtN6WruTv<\/a><\/p>\n<p>\u2014 David Homan, MD (@heartdoc45)\u00a0<a href=\"https:\/\/twitter.com\/heartdoc45\/status\/1571109671137857539?ref_src=twsrc%5Etfw\">September 17, 2022<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p>LDL\u306f\u4eba\u9593\u306b\u3068\u3063\u3066\u306a\u304f\u3066\u306f\u306a\u3089\u306a\u3044\u91cd\u8981\u306a\u3082\u306e\u3067\u3059\u3002\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u30ef\u30af\u30c1\u30f3\u3068\u540c\u69d8\u306b\u4f01\u696d\u306e\u5f8c\u308d\u76fe\u304c\u3042\u308b\u3068\u3001\u4f55\u3092\u8a00\u3063\u3066\u3082\u5e73\u6c17\u306b\u306a\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u5148\u65e5\u306e\u8a18\u4e8b\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=19932\" target=\"_blank\" rel=\"noopener\">\u6700\u8fd1LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089Lp(a)\u304a\u3088\u3073ApoB\u306b\u30b7\u30d5\u30c8\u3057\u3066\u304d\u3066\u3044\u308b\u3000\u305d\u306e1<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u5faa\u74b0\u5668\u7cfb\u306e\u9818\u57df\u306e\u52d5\u304d\u3092\u898b\u3066\u3044\u308b\u3068\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089Lp(a)\u3084ApoB\u306b\u6ce8\u76ee\u304c\u30b7\u30d5\u30c8\u3057\u3066\u304d\u3066\u3044\u308b\u3088\u3046\u306b\u611f\u3058\u307e\u3059\u3002<\/p>\n<p>\u3053\u306eLp(a)\u3001\u5b9f\u306f\u98df\u4e8b\u306b\u3088\u308a\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n<p>\u4f8b\u3048\u3070\u3001\u8102\u8cea\u304a\u3088\u3073\u98fd\u548c\u8102\u80aa\u9178\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u5143\u51f6\u3068\u3082\u601d\u3044\u3053\u307e\u308c\u3066\u3044\u308b\u3001\u3053\u306e\u8102\u8cea\u3084\u98fd\u548c\u8102\u80aa\u9178\u3092\u6e1b\u3089\u3059\u3068\u3001Lp(a)\u306f\u3069\u3046\u306a\u308b\u3067\u3057\u3087\u3046\u304b\uff1f\u3042\u308b\u7814\u7a76\u3067\u30018\u9031\u9593\u305a\u3064\u7dcf\u8102\u8cea\u304a\u3088\u3073\u98fd\u548c\u8102\u80aa\u9178\u306e\u6442\u53d6\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u98df\u4e8b\u3092\u6442\u53d6\u3059\u308b\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u4e0b\u306e\u8868\u306e\u3088\u3046\u306b\u6700\u521d\u306f\u7dcf\u8102\u8cea34\uff05\u3067\u6700\u7d42\u7684\u306b\u306f25\uff05\u307e\u3067\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u98fd\u548c\u8102\u80aa\u9178\u306f\u6700\u521d15\uff05\u3067\u3001\u6700\u7d42\u304c6.1\uff05\u3067\u3059\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6442\u53d6\u91cf\u306f\u5909\u5316\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u5f53\u7136\u3001\u8102\u8cea\u3092\u6e1b\u3089\u3057\u305f\u5206\u70ad\u6c34\u5316\u7269\u6442\u53d6\u91cf\u304c\u5897\u52a0\u3057\u3001\u7dcf\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u306e48%\u219255%\u219259%\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\uff08\u8868\u306f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9514413\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u3088\u308a\u6539\u5909\uff09<\/p>\n<div id=\"T2\" class=\"article-table-content\">\n<table class=\"table article-section__table\">\n<caption>\u00a0<\/caption>\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">AAD Assay<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Step 1 Assay<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Low-Sat Assay<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7dcf\u8102\u8cea % kcal<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">34.3\u00b10.5<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">28.6\u00b10.2<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">25.3\u00b10.5<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u98fd\u548c\u8102\u80aa\u9178% kcal<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">15.0\u00b10.4<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">9.0\u00b10.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">6.1\u00b10.5<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178 % kcal<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">12.8 \u00b10.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">12.9\u00b10.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">12.4\u00b10.1<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178% kcal<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">6.5\u00b10.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">6.7 \u00b10.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">6.7\u00b10.1<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb mg\/d<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">285 \u00b13.9<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">267\u00b17.6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">275\u00b14.0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"tableFooter\">\n<div class=\"footnote\">\n<p>\u305d\u306e\u7d50\u679c\u306f\u6b21\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"T3\" class=\"article-table-content\">\n<table class=\"table article-section__table\" style=\"width: 48.9902%; height: 311px;\">\n<caption>\u00a0<\/caption>\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">AAD<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Step 1<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Low-Sat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">202.1\u00b12.8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">191.0\u00b12.7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">183.4\u00b12.7<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">131.4\u00b12.7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">122.2\u00b12.6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">116.9\u00b12.6<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">52.2\u00b11.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">48.5\u00b11.1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">46.2\u00b11.0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4e2d\u6027\u8102\u80aa<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">85.1 \u00b13.4<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">92.4\u00b13.7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">93.0\u00b13.7<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Apo B<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">116.8\u00b12.4<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">113.6 \u00b12.6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">111.6\u00b12.6<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Apo A-I<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">142.2\u00b12.0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">135.4 \u00b12.0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">130.4\u00b11.9<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Lp(a)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">15.5\u00b11.8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">17.0 \u00b11.8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">18.2\u00b11.9<\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TC\/HDL<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">4.07\u00b10.10<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">4.16\u00b10.11<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">4.21 \u00b10.11<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4f4e\u4e0b\u3057\u3001HDL\u3082\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u4e2d\u6027\u8102\u80aa\u306f\u5897\u52a0\u3067\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066Lp(a)\u306f\u6700\u592715%\u5897\u52a0\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u8102\u8cea\u3001\u98fd\u548c\u8102\u80aa\u9178\u3092\u6e1b\u3089\u3059\u3068\u3001\u6709\u5bb3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308bLp(a)\u306f\u5897\u52a0\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n<p>\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u8102\u8cea\u304b\u3089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc36%\u306e\u4e2d\u306e\u98fd\u548c\u8102\u80aa\u9178\u304b\u3089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e7%\u3092\u70ad\u6c34\u5316\u7269\u307e\u305f\u306f\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u306b\u7f6e\u304d\u63db\u3048\u305f\u98df\u4e8b\u30927\u9031\u9593\u305a\u3064\u6442\u53d6\u3057\u307e\u3057\u305f\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18065577\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09\u7d50\u679c\u306f\u540c\u69d8\u3067\u3001\u70ad\u6c34\u5316\u7269\u307e\u305f\u306f\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u306b\u7f6e\u304d\u63db\u3048\u305f\u5834\u5408\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068LDL\u3001\u305d\u3057\u3066HDL\u307e\u3067\u3082\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u4e2d\u6027\u8102\u80aa\u306f\u70ad\u6c34\u5316\u7269\u306b\u7f6e\u304d\u63db\u3048\u305f\u98df\u4e8b\u3067\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066Lp(a)\u306f\u3001\u70ad\u6c34\u5316\u7269\u7f6e\u304d\u63db\u3048\u306720%\u3001\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u7f6e\u304d\u63db\u3048\u3067 11%\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u305d\u3046\u3059\u308b\u3068\u3001Lp(a)\u3082\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u4e0a\u304c\u3063\u3066\u3044\u308b\u3060\u3051\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u7cd6\u8cea\u5236\u9650\u3067\u306f\u6050\u3089\u304f\u4f4e\u4e0b\u3059\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3067\u7cd6\u8cea\u5236\u9650\u3092\u3055\u308c\u3066\u3044\u308b\u65b9\u306e\u30c7\u30fc\u30bf\u3067\u306f\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f529\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f427\u3067\u3059\u304c\u3001Lp(a)\u306f12.8\u3067\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30ab\u30eb\u30cb\u30c1\u30f3\u3067\u3082Lp(a)\u306f\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u30ab\u30eb\u30cb\u30c1\u30f3\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3001\u8102\u8cea\u4ee3\u8b1d\u306b\u91cd\u8981\u3067\u3001\u8102\u80aa\u9178\u3092\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u306b\u904b\u642c\u3057\u305f\u308a\u3001\u751f\u6210\u3055\u308c\u305f\u6709\u6bd2\u306a\u7269\u8cea\u3092\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5916\u306b\u904b\u3073\u3060\u3057\u305f\u308a\u3057\u3066\u3044\u307e\u3059\u3002\u69d8\u3005\u306a\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u30ab\u30eb\u30cb\u30c1\u30f3\u306e\u7d4c\u53e3\u6295\u4e0e\u3067Lp(a) \u306e\u6709\u610f\u306a\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26754058\/\" target=\"_blank\" 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\u201cIt\u2019s not really about statins any more, it\u2019s about 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