{"id":20586,"date":"2022-11-10T09:00:44","date_gmt":"2022-11-10T00:00:44","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=20586"},"modified":"2022-11-10T09:00:44","modified_gmt":"2022-11-10T00:00:44","slug":"%e5%a4%9a%e7%99%ba%e6%80%a7%e5%9a%a2%e8%83%9e%e8%85%8e%e3%81%ab%e3%81%af%e7%b3%96%e8%b3%aa%e5%88%b6%e9%99%90%e3%82%92%e3%80%80%e3%81%9d%e3%81%ae2","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=20586","title":{"rendered":"\u591a\u767a\u6027\u56a2\u80de\u814e\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3092\u3000\u305d\u306e2"},"content":{"rendered":"

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u591a\u767a\u6027\u56a2\u80de\u814e\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3092\u3000\u305d\u306e1<\/a>\u300d\u3067\u591a\u767a\u6027\u56a2\u80de\u814e\u306b\u5bfe\u3059\u308b\u30b1\u30c8\u30f3\u98df\u306e\u52b9\u679c\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u66f8\u304d\u307e\u3059\u3002\u4eca\u56de\u3082\u540c\u69d8\u3067\u3059\u304c\u3001\u4eca\u56de\u306f\u5b66\u4f1a\u767a\u8868\u30ec\u30d9\u30eb\u3067\u3059\u300211\u67086\u65e5\u307e\u3067\u30a2\u30e1\u30ea\u30ab\u30aa\u30fc\u30e9\u30f3\u30c9\u3067\u884c\u308f\u308c\u3066\u3044\u305f\u3001\u30a2\u30e1\u30ea\u30ab\u814e\u81d3\u5b66\u4f1a\u306ethe Kidney Week<\/a>\u3067\u767a\u8868\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n

\u30b1\u30eb\u30f3\u5927\u5b66\u306e\u7814\u7a76\u3067\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n

\u30b1\u30eb\u30f3\u3067\u5b9f\u65bd\u3055\u308c\u305fKeto-ADPKD \u7814\u7a76\u306b\u306f\u300163 \u4eba\u306e \u5e38\u67d3\u8272\u4f53\u512a\u6027\u591a\u767a\u6027\u56a2\u80de\u814e (ADPKD) \u60a3\u8005\u304c\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u76ee\u7684\u306f\u3001ADPKD\u60a3\u8005\u306e\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u306e\u30b1\u30c8\u30f3\u98df\u306e\u5b9f\u73fe\u53ef\u80fd\u6027\u3001\u6709\u52b9\u6027\u3001\u304a\u3088\u3073\u5b89\u5168\u6027\u3092\u5b9f\u8a3c\u3059\u308b\u3053\u3068\u3067\u3057\u305f\u3002\u60a3\u8005\u306f3\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u3089\u308c\u30011\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u70ad\u6c34\u5316\u7269\u3068\u7802\u7cd6\u304c\u5c11\u306a\u304f\u3001\u8102\u8cea\u304c\u591a\u3044\u30b1\u30c8\u30f3\u98df\u30923\u304b\u6708\u7d9a\u3051\u307e\u3057\u305f\u30022\u756a\u76ee\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7814\u7a76\u671f\u9593\u4e2d\u3001\u6bce\u67083\u65e5\u9593\u306e\u6c34\u65ad\u98df\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3082\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u4ee3\u8b1d\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u30023\u756a\u76ee\u306e\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u533b\u5e2b\u304c\u901a\u5e38 ADPKD \u306b\u5bfe\u3057\u3066\u4e0e\u3048\u308b\u4e00\u822c\u7684\u306a\u98df\u4e8b\u306e\u63a8\u5968\u4e8b\u9805\u306b\u5f93\u3044\u307e\u3057\u305f\u3002\u5869\u5206\u6442\u53d6\u91cf\u3092\u6e1b\u3089\u3057\u30011\u65e5\u3042\u305f\u308a2\uff5e3\u30ea\u30c3\u30c8\u30eb\u4ee5\u4e0a\u98f2\u3080\u3053\u3068\u3067\u3059\u3002\u30b1\u30c8\u30fc\u30b7\u30b9\u306f\u8840\u4e2d\u306e\u03b2-\u30d2\u30c9\u30ed\u30ad\u30b7\u916a\u9178\u3001\u547c\u6c17\u4e2d\u306e\u30a2\u30bb\u30c8\u30f3\u3067\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30b1\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u6c34\u65ad\u98df\u306e3\u3064\u306e\u30d5\u30a7\u30fc\u30ba\u3059\u3079\u3066\u3067\u3001\u53c2\u52a0\u8005\u306e85%\u3067\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u30b1\u30c8\u30f3\u98df\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u30b1\u30c8\u30f3\u4f53\u306e3\u3064\u306e\u6642\u70b9\u306e\u5024\u306778\uff05\u304c\u958b\u59cb\u524d\u3088\u308a\u3082\u9ad8\u3044\u5024\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4e3b\u8981\u306a\u5b9f\u73fe\u53ef\u80fd\u6027\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff08\u8a73\u7d30\u306f\u308f\u304b\u308a\u307e\u305b\u3093\uff09\u306e\u9054\u6210\u306f\u6c34\u65ad\u98df\u30b0\u30eb\u30fc\u30d7\u306e80%\u3067\u9054\u6210\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u30b1\u30c8\u30f3\u98df\u30b0\u30eb\u30fc\u30d7\u3067\u306f43%\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u6050\u3089\u304f\u4e8b\u524d\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u03b2\u30d2\u30c9\u30ed\u30ad\u30b7\u916a\u9178\u306e\u95be\u5024 (\u3059\u3079\u3066\u306e\u691c\u67fb\u3067 0.8 mmol\/l \u4ee5\u4e0a) \u306b\u3088\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u7dcf\u814e\u81d3\u5bb9\u7a4d (TKV)\u3068\u7dcf\u809d\u81d3\u5bb9\u7a4d (TLV) \u3082\u6e2c\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002\u8eab\u9577\u3067\u88dc\u6b63\u3057\u305f\u7dcf\u814e\u81d3\u5bb9\u7a4d (htTKV) \u306f\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3059\u30023\u304b\u6708\u5f8c\u3001\u814e\u81d3\u306e\u5927\u304d\u3055\u3084\u814e\u6a5f\u80fd\u306a\u3069\u306e\u91cd\u8981\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306b\u95a2\u3057\u3066\u6709\u76ca\u306a\u30c7\u30fc\u30bf\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u814e\u81d3\u306f\u30b1\u30c8\u30f3\u98df\u3067\u5c0f\u3055\u304f\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u5bfe\u7167\u7fa4\u3067\u306f\u30b5\u30a4\u30ba\u304c\u5927\u304d\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u5e73\u5747htTKV\u5909\u5316\u91cf\u306f\u3001\u5bfe\u7167\u7fa4\u3067+13.9ml\/m\u3001\u6c34\u65ad\u98df\u7fa4\u3067+7.1\u3001\u30b1\u30c8\u30f3\u98df\u3067\u306f-12.8\u3067\u3057\u305f\u3002<\/p>\n

\u809d\u81d3\u306e\u5bb9\u7a4d\u3082\u5e73\u5747htTLV\u306e\u5909\u5316\u91cf\u306f\u3001\u5bfe\u7167\u7fa4+42.2ml\/m\u3001\u6c34\u65ad\u98df -10.0\u00b198.2\u3001\u30b1\u30c8\u30f3\u98df\u7fa4-55.1\u00b172.5\u3067\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u305f\u3063\u305f3\u30f6\u6708\u3067\u814e\u6a5f\u80fd\u306eeGFR\u306f\u30b1\u30c8\u30f3\u98df\u304a\u3088\u3073\u6c34\u65ad\u98df\u3067\u5897\u52a0\u3057\u3001\u30b1\u30c8\u30f3\u98df\u3067\u306f5.04ml\/min\u3001\u6c34\u65ad\u98df\u3067\u306f 0.21\u306e\u5897\u52a0\u3067\u3057\u305f\u304c\u3001\u5bfe\u7167\u3067\u306f-1.26\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u6c34\u65ad\u98df\u30ec\u30d9\u30eb\u3067\u306f\u3084\u306f\u308a\u52b9\u679c\u306f\u5c11\u306a\u3044\u3067\u3059\u306d\u3002<\/p>\n

\u305f\u3060\u3057\u30012\u4eba\u306f\u30b1\u30c8\u30f3\u98df\u4e2d\u306b\u814e\u7d50\u77f3\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u591a\u767a\u6027\u56a2\u80de\u814e\u306b\u30b1\u30c8\u30f3\u98df\u304c\u6709\u52b9\u306a\u306e\u306f\u9593\u9055\u3044\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u6050\u3089\u304f\u7cd6\u8cea\u5236\u9650\u3067\u3082\u5341\u5206\u3060\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u30c7\u30fc\u30bf\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u540c\u3058\u5b66\u4f1a\u3067\u5185\u81d3\u8102\u80aa\u3068\u591a\u767a\u6027\u56a2\u80de\u814e\u306e\u814e\u81d3\u306e\u5927\u304d\u3055\u306e\u6210\u9577\u3068\u306e\u95a2\u9023\u306e\u7814\u7a76\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8eab\u9577\u88dc\u6b63\u7dcf\u814e\u81d3\u5bb9\u7a4d (htTKV)\u3068\u306e\u95a2\u9023\u3092\u5206\u6790\u3059\u308b\u3068\u3001\u8179\u90e8\u76ae\u4e0b\u8102\u80aa\u3001 \u5185\u81d3\u8102\u80aa\u3001\u7dcf\u8179\u90e8\u8102\u80aa\u7d44\u7e54\u306f\u3001htTKV\u306e\u3088\u308a\u5927\u304d\u306a\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u8179\u90e8\u8102\u80aa\u3001\u7279\u306b\u5185\u81d3\u8102\u80aa\u306f\u3001\u521d\u671f\u6bb5\u968e\u306e\u591a\u767a\u6027\u56a2\u80de\u814e\u60a3\u8005\u306e htTKV \u306e\u5897\u52a0\u3068\u5f37\u304f\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u306b\u3064\u3044\u3066\u3001\u8102\u80aa\u7d44\u7e54\u306f\u6d3b\u767a\u306a\u5185\u5206\u6ccc\u5668\u5b98\u306a\u306e\u3067\u3001\u5185\u81d3\u8102\u80aa\u7d44\u7e54\u3067\u306f\u3001\u708e\u75c7\u8a98\u767a\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306e\u653e\u51fa\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u8102\u80aa\u7d30\u80de\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u308b\u591a\u6570\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3082\u3001\u6f5c\u5728\u7684\u306b\u524d\u56a2\u80de\u5f62\u6210\u74b0\u5883\u3092\u4fc3\u9032\u3059\u308b\u304b\u3089\u3060\u3068\u3001\u3053\u306e\u7814\u7a76\u8005\u306f\u8003\u3048\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u305d\u3046\u3044\u3046\u3053\u3068\u3082\u91cd\u8981\u306a\u3053\u3068\u3060\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u79c1\u306f\u8102\u80aa\u7d44\u7e54\u3001\u5185\u81d3\u8102\u80aa\u304c\u5897\u52a0\u3059\u308b\u98df\u4e8b\u3053\u305d\u304c\u6700\u5927\u306e\u4fc3\u9032\u56e0\u5b50\u3001\u5371\u967a\u56e0\u5b50\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067mTOR\u3084IGF-1\u304c\u5f37\u304f\u6d3b\u6027\u5316\u3055\u308c\u3066\u3001\u56a2\u80de\u6570\u3068\u56a2\u80de\u30b5\u30a4\u30ba\u304c\u5897\u52a0\u3059\u308b\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305a\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3059\u306d\u3002<\/p>\n

 <\/p>\n

\u300cKETO-ADPKD: A Randomized, Controlled Trial on Ketogenic Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease\u300d<\/span><\/p>\n

\u300cKETO-ADPKD: \u5e38\u67d3\u8272\u4f53\u512a\u6027\u591a\u767a\u6027\u56a2\u80de\u814e\u306b\u304a\u3051\u308b\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u98df\u4e8b\u4ecb\u5165\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u5bfe\u7167\u8a66\u9a13\u300d\uff08\u6284\u9332\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u300cVisceral Adiposity Is Strongly Associated With Kidney Growth in Early-Stage Autosomal Dominant Polycystic Kidney Disease (ADPKD)\u300d<\/span><\/p>\n

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