{"id":20602,"date":"2022-11-16T08:33:43","date_gmt":"2022-11-15T23:33:43","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=20602"},"modified":"2022-11-16T08:33:43","modified_gmt":"2022-11-15T23:33:43","slug":"%e9%a3%9f%e4%ba%8b%e3%81%af%e9%a3%9f%e5%be%8c%e3%81%ae%e4%b8%ad%e6%80%a7%e8%84%82%e8%82%aa%e3%82%84%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%e3%81%ab%e3%81%a9%e3%81%ae","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=20602","title":{"rendered":"\u98df\u4e8b\u306f\u98df\u5f8c\u306e\u4e2d\u6027\u8102\u80aa\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\uff1f"},"content":{"rendered":"

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<\/p>\n

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\u4ee3\u8b1d\u304c\u4e0a\u624b\u304f\u6a5f\u80fd\u3057\u3066\u3044\u306a\u3044\u3068\u300112\u6642\u9593\u306e\u7d76\u98df\u3067\u3082\u30ec\u30e0\u30ca\u30f3\u30c8\u304c\u5927\u91cf\u306b\u6b8b\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u98df\u5f8c12\u6642\u9593\u7d4c\u3063\u3066\u3082\u5927\u91cf\u306b\u6b8b\u3063\u3066\u3044\u308b<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5834\u5408\u3067\u306f\u3001\u6b63\u5e38\u3068\u6bd4\u3079\u3066\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d0411\u500d\u3001VLDL\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d049\u500d\u3001\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u4e2d\u6027\u8102\u80aa\u306f\u7d046\u500d\u3001VLDL\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u4e2d\u6027\u8102\u80aa\u306f\u7d0413\u500d\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u9ad8\u4e2d\u6027\u8102\u80aa\u3001\u4f4eHDL\u3068\u8a00\u3048\u3070\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3067\u3059\u306d\u3002\u307e\u305f\u3001\u901a\u5e38\u306e\u98df\u4e8b\u3068\u6bd4\u8f03\u3057\u3066\u4f4e\u8102\u80aa\u9ad8\u7cd6\u8cea\u306e\u98df\u4e8b\u306b\u3059\u308b\u3068\u305d\u308c\u3060\u3051\u3067\u3082\u7a7a\u8179\u6642\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u5897\u52a0\u3057\u307e\u3059\u3002\uff08\u300c\u4f4e\u8102\u8cea\u9ad8\u7cd6\u8cea\u306e\u98df\u4e8b\u306f\u7a7a\u8179\u6642\u3067\u3082\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6fc0\u5897\u3055\u305b\u308b<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

\u3067\u306f\u3001\u9ad8\u8840\u7cd6\u306f\u9ad8\u4e2d\u6027\u8102\u80aa\u3092\u62db\u304f\u306e\u304b\uff1f\u3053\u308c\u306f\u3061\u3087\u3063\u3068\u96e3\u3057\u3044\u3067\u3059\u306d\u3002\u9ad8\u8840\u7cd6\u3092\u8d77\u3053\u3059\u30c6\u30b9\u30c8\u3068\u8a00\u3048\u3070\u3001\u7d4c\u53e3\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u8a66\u9a13\uff08OGTT\uff09\u3067\u3059\u306d\u3002OGTT\u306e\u3068\u304d\u306b\u4e2d\u6027\u8102\u80aa\u5024\u304c\u5909\u5316\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u898b\u305f\u7814\u7a76\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u307e\u305a\u306f\u5b66\u4f1a\u767a\u8868\u304b\u3089\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n

\u3053\u306e\u7814\u7a76\u306f\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u306e\u8a3a\u65ad\u3067\u3001OGTT\u306b\u304a\u3051\u308b\u4e2d\u6027\u8102\u80aa\u5024\uff08TG\uff09\u304cNAFLD\u306e\u4e88\u6e2c\u306b\u6709\u52b9\u304b\u3092\u8abf\u3079\u305f\u3082\u306e\u3067\u3059\u3002\u305d\u3046\u3057\u305f\u3068\u3053\u308dTG\u5909\u5316\u91cf\uff08\u8ca0\u8377\u5f8c2\u6642\u9593\u5024\uff0d\u7a7a\u8179\u6642\u5024\u3001\u22bfTGOGTT\uff09\u306f\u3001NAFLD\u306e\u72ec\u7acb\u3057\u305f\u5f37\u529b\u306a\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u3068\u8a00\u3048\u3070\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3001\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u306e\u4ee3\u8868\u7684\u306a\u75be\u60a3\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u306f\u8ad6\u6587\u5316\u3055\u308c\u3001TG\u5909\u5316\u91cf\u3067\u306f\u306a\u304f\u3001\u8ca0\u8377\u5f8c2\u6642\u9593\u3068\u7a7a\u8179\u6642\u306e\u4e2d\u6027\u8102\u80aa\u5024\u306e\u6bd4\u7387\u3092\u898b\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\u4e0a\u306e\u56f3\u306e\u53f3\u5074\u304c\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u306e\u3042\u308b\u30b0\u30eb\u30fc\u30d7\u3001\u771f\u3093\u4e2d\u304cNAFLD\u306e\u7121\u3044\u30b0\u30eb\u30fc\u30d7\u3067\u3059\u3002NAFLD\u306a\u3057\u30b0\u30eb\u30fc\u30d7\u306f\u7a7a\u8179\u6642\u8840\u7cd6\u304c5.18\uff08\u65e5\u672c\u306e\u5358\u4f4d\u3067\u7d0493mg\/dL\uff09\u3001OGTT\u306e2\u6642\u9593\u5024\u306f\u7d04120mg\/dL\u3067\u3059\u3002\u4e00\u65b9NAFLD\u3042\u308a\u30b0\u30eb\u30fc\u30d7\u306f\u7a7a\u8179\u6642\u8840\u7cd6\u304c5.45\uff08\u65e5\u672c\u306e\u5358\u4f4d\u3067\u7d0498mg\/dL\uff09\u3001OGTT\u306e2\u6642\u9593\u5024\u306f\u7d04138mg\/dL\u3067\u3059\u3002<\/p>\n

\u4e2d\u6027\u8102\u80aa\uff08TG\uff09\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002NAFLD\u306a\u3057\u30b0\u30eb\u30fc\u30d7\u306f\u7a7a\u8179\u6642TG\u304c104.8mg\/dL\u3001OGTT\u306e2\u6642\u9593TG\u306f92.1\u3067\u3059\u3002\u305d\u306e\u6bd4\uff08Fold-change TGOGTT\uff09\u306f0.86\u3067\u3059\u3002\u3064\u307e\u308a\u8840\u7cd6\u5024\u304c\u4e0a\u304c\u3063\u3066\u3044\u308b\u306e\u306bTG\u306f\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9NAFLD\u3042\u308a\u30b0\u30eb\u30fc\u30d7\u306f\u7a7a\u8179\u6642TG\u304c132.9mg\/dL\u3001OGTT\u306e2\u6642\u9593TG\u306f132.4\u3067\u3059\u3002\u305d\u306e\u6bd4\uff08Fold-change TGOGTT\uff09\u306f1.00\u3067\u3059\u3002\u3064\u307e\u308a\u5909\u5316\u304c\u307b\u3068\u3093\u3069\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u306e2\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u5927\u304d\u306a\u9055\u3044\u306fNAFLD\u3042\u308a\u30b0\u30eb\u30fc\u30d7\u306f\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u3067\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027HOMA-IR\u30822.6\u3067\u3059\u3002<\/p>\n

\u901a\u5e38\u3001\u4ee3\u8b1d\u304c\u554f\u984c\u306a\u3051\u308c\u3070\u30a4\u30f3\u30b9\u30ea\u30f3\u306fLPL\u6d3b\u6027\u3092\u4fc3\u9032\u3059\u308b\u306e\u3067\u4e2d\u6027\u8102\u80aa\u5024\u306f\u6e1b\u5c11\u3059\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u3044\u3068LPL\u6d3b\u6027\u306f\u6d3b\u6027\u5316\u3057\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u3067\u3001OGTT\u4e2d\u306bTG\u304c\u5897\u52a0\u3057\u305f\u4eba\u306f\u3001TG\u304c\u6e1b\u5c11\u3057\u305f\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u306e\u53ef\u80fd\u6027\u306f3.5\u500d\u3067\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u7d50\u8ad6\u3092\u8a00\u3048\u3070\u5358\u7d14\u306b\u7cd6\u8cea\uff08\u30d6\u30c9\u30a6\u7cd6\uff09\u306e\u307f\u306e\u8ca0\u8377\u3067\u8840\u7cd6\u5024\u304c\u4e0a\u6607\u3057\u3066\u3082\u4e2d\u6027\u8102\u80aa\u5024\u306f\u30b9\u30d1\u30a4\u30af\u3092\u8d77\u3053\u3055\u305a\u3001\u4ee3\u8b1d\u304c\u554f\u984c\u306a\u3051\u308c\u3070\u9006\u306b\u6e1b\u5c11\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305f\u3060\u30572\u6642\u9593\u5024\u306a\u306e\u3067\u3001\u305d\u306e\u5f8c\u306e\u3053\u3068\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u305f\u3060\u901a\u5e38\u3067\u306f\u7cd6\u8cea\u3060\u3051\u6442\u308b\u98df\u4e8b\u306f\u307e\u305a\u3057\u307e\u305b\u3093\u3002\u3067\u306f\u3001\u901a\u5e38\u306b\u8fd1\u3044\u98df\u4e8b\u3067\u8840\u7cd6\u5024\u3068\u4e2d\u6027\u8102\u80aa\u5024\u306f\u3069\u3046\u306a\u3093\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u6442\u53d6\u30a8\u30cd\u30eb\u30ae\u30fc\u306e25\uff05\u306e\u679c\u7cd6\u306f\u4e2d\u6027\u8102\u80aa\u3092\u5897\u52a0\u3055\u305b\u308b<\/a>\u300d\u3067\u53d6\u308a\u4e0a\u3052\u305f\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u300220\u4ee3\u5f8c\u534a\u306eBMI\u304c25\u524d\u5f8c\u306e\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u30011\u65e5\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u91cf\u306e\u70ad\u6c34\u5316\u7269\u306e\u5272\u540855\uff05\u306e\u3046\u3061\u300125\uff05\u3092\u30d6\u30c9\u30a6\u7cd6\u3001\u679c\u7cd6\u3001\u9ad8\u679c\u7cd6\u30b3\u30fc\u30f3\u30b7\u30ed\u30c3\u30d7 (HFCS)\u306b\u7f6e\u304d\u63db\u3048\u305f\u5834\u5408\u3092\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u3053\u3053<\/a>\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

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\"\u5199\u771f\u3084\u30a4\u30e9\u30b9\u30c8\u306a\u3069\u3092\u4fdd\u6301\u3059\u308b\u5916\u90e8\u30d5\u30a1\u30a4\u30eb\u3002\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u540d\u306fzeg0101183860001.jpg\"<\/p>\n

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 <\/p>\n

\u300cAn extended fatty liver index to predict non-alcoholic fatty liver disease\u300d<\/span><\/p>\n

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