{"id":21187,"date":"2023-01-05T07:58:19","date_gmt":"2023-01-04T22:58:19","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=21187"},"modified":"2023-01-05T07:58:19","modified_gmt":"2023-01-04T22:58:19","slug":"%e6%9e%9c%e7%b3%96%e3%81%af%e3%83%96%e3%83%89%e3%82%a6%e7%b3%96%e3%82%88%e3%82%8a%e3%82%82apociii%e3%82%92%e5%a4%a7%e5%b9%85%e3%81%ab%e5%a2%97%e5%8a%a0%e3%81%95%e3%81%9b%e3%82%8b","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=21187","title":{"rendered":"\u679c\u7cd6\u306f\u30d6\u30c9\u30a6\u7cd6\u3088\u308a\u3082ApoCIII\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u308b"},"content":{"rendered":"

\u731b\u6bd2\u300c\u679c\u7cd6\u300d\u306f\u7cd6\u8cea\u306e\u4e2d\u3067\u6700\u3082\u6709\u5bb3\u3067\u3057\u3087\u3046\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u9ad8HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5065\u5eb7\u7684\u306a\u306e\u304b\uff1f\u3000\u305d\u306e2<\/a>\u300d\u300c\u98df\u4e8b\u3092\u5909\u3048\u308b\u3053\u3068\u304c\u4e00\u756a\u306e\u6cbb\u7642<\/a>\u300d\u306a\u3069\u3067\u66f8\u3044\u305fApoCIII\u3092\u5897\u52a0\u3055\u305b\u308b\u4f5c\u7528\u306f\u30d6\u30c9\u30a6\u7cd6\u3088\u308a\u3082\u5927\u304d\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u6442\u53d6\u30a8\u30cd\u30eb\u30ae\u30fc\u306e25\uff05\u3092\u30d6\u30c9\u30a6\u7cd6\u307e\u305f\u306f\u679c\u7cd6\u306e\u98f2\u6599\u306710\u9031\u9593\u6442\u53d6\u3057\u305f\u5834\u5408\u306e\u5909\u5316\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3059\u3079\u3066\u306e\u53c2\u52a0\u8005\uff0831\u4eba\uff09\u306e\u5e73\u5747\u5e74\u9f6253.7 \u6b73\u3001BMI30.8\u3001\u304a\u3088\u3073\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7a7a\u8179\u6642\u4e2d\u6027\u8102\u80aa\u5024\u306f145.2mg\/dL\u3067\u3057\u305f\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u98df\u4e8b\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u306e55%\u304c\u4e3b\u306b\u8907\u5408\u70ad\u6c34\u5316\u7269\u300130%\u304c\u8102\u8cea\u300115%\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u4ecb\u5165\u98df\u306f\u300130%\u306e\u8907\u5408\u70ad\u6c34\u5316\u7269\u306825%\u306e\u30d6\u30c9\u30a6\u7cd6\u307e\u305f\u306f\u679c\u7cd6\u3067\u7518\u5473\u3092\u4ed8\u3051\u305f\u98f2\u6599\u4ee5\u5916\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u98df\u4e8b\u3092\u6a21\u5023\u3057\u307e\u3057\u305f\u3002\u30d6\u30c9\u30a6\u7cd6\u307e\u305f\u306f\u679c\u7cd6\u3067\u7518\u5473\u3092\u4ed8\u3051\u305f\u98f2\u6599\u309210\u9031\u9593\u6442\u53d6\u3059\u308b\u524d\u5f8c\u3067\u3069\u3046\u306a\u3063\u305f\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u4e0b\u306e\u8868\u306f\u4e2d\u6027\u8102\u80aa\u304c\u8c4a\u5bcc\u306a\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea (TRL) \u304a\u3088\u3073LDL\u306e\u5206\u753b\u306b\u304a\u3051\u308b\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u4e2d\u6027\u8102\u80aa\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u3067\u3059\u3002\u5206\u753b\u306f\u305d\u308c\u305e\u308c\u6570\u5b57\u304c\u5927\u304d\u3044\u307b\u3069\u5c0f\u3055\u306a\u7c92\u5b50\u306b\u306a\u308a\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/div>\n
<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u76f4\u5f84<\/th>\n\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb (mg\/dL)<\/th>\n\u4e2d\u6027\u8102\u80aa (mg\/dL)<\/th>\n<\/tr>\n
\u7a7a\u8179\u6642<\/th>\n\u98df\u5f8c<\/th>\n\u7a7a\u8179\u6642<\/th>\n\u98df\u5f8c<\/th>\n<\/tr>\n
(nm)<\/th>\n\u30d6\u30c9\u30a6\u7cd6<\/th>\n\u679c\u7cd6<\/th>\n\u30d6\u30c9\u30a6\u7cd6<\/th>\n\u679c\u7cd6<\/th>\n\u30d6\u30c9\u30a6\u7cd6<\/th>\n\u679c\u7cd6<\/th>\n\u30d6\u30c9\u30a6\u7cd6<\/th>\n\u679c\u7cd6<\/th>\n<\/tr>\n<\/thead>\n
TRLp1<\/td>\n>90<\/td>\n2.7\u00b10.6<\/td>\n3.2\u00b10.8<\/td>\n3.4\u00b10.7<\/td>\n3.6\u00b10.9<\/td>\n10.0\u00b12.6<\/td>\n14.1\u00b13.4<\/td>\n19.0\u00b14.1<\/td>\n22.1\u00b15.0<\/td>\n<\/tr>\n
TRLp2<\/td>\n75<\/td>\n1.4\u00b10.2<\/td>\n1.5\u00b10.3<\/td>\n1.6\u00b10.2<\/td>\n1.6\u00b10.3<\/td>\n6.6\u00b11.3<\/td>\n6.9\u00b11.3<\/td>\n10.1\u00b11.7<\/td>\n10.3\u00b12.1<\/td>\n<\/tr>\n
TRLp3<\/td>\n64<\/td>\n3.8\u00b10.5<\/td>\n3.7\u00b10.5<\/td>\n4.1\u00b10.5<\/td>\n3.7\u00b10.6<\/td>\n14.9\u00b12.6<\/td>\n14.1\u00b12.3<\/td>\n18.4\u00b12.7<\/td>\n17.9\u00b12.9<\/td>\n<\/tr>\n
TRLp4<\/td>\n53.6<\/td>\n7.4\u00b10.7<\/td>\n6.8\u00b10.7<\/td>\n7.1\u00b10.7<\/td>\n6.4\u00b10.8<\/td>\n27.1\u00b14.0<\/td>\n23.9\u00b13.4<\/td>\n29.7\u00b14.0<\/td>\n28.0\u00b14.0<\/td>\n<\/tr>\n
TRLp5<\/td>\n44.5<\/td>\n16.5\u00b11.0<\/td>\n14.6\u00b11.0<\/td>\n14.4\u00b11.2<\/td>\n12.6\u00b11.1<\/td>\n33.9\u00b14.4<\/td>\n28.9\u00b13.5<\/td>\n35.0\u00b14.3<\/td>\n32.7\u00b13.9<\/td>\n<\/tr>\n
TRLp6<\/td>\n36.8<\/td>\n12.9\u00b11.1<\/td>\n11.5\u00b11.2<\/td>\n10.6\u00b11.4<\/td>\n9.5\u00b11.3<\/td>\n17.7\u00b12.0<\/td>\n15.1\u00b11.7<\/td>\n18.5\u00b12.0<\/td>\n17.6\u00b11.9<\/td>\n<\/tr>\n
TRLp7<\/td>\n31.3<\/td>\n6.0\u00b10.4<\/td>\n5.5\u00b10.6<\/td>\n6.4\u00b10.5<\/td>\n6.0\u00b10.5<\/td>\n5.0\u00b10.5<\/td>\n4.3\u00b10.5<\/td>\n5.6\u00b10.5<\/td>\n5.5\u00b10.5<\/td>\n<\/tr>\n
LDLp1<\/td>\n28.6<\/td>\n19.4\u00b11.1<\/td>\n18.2\u00b11.2<\/td>\n20.7\u00b11.6<\/td>\n19.1\u00b11.2<\/td>\n7.6\u00b10.6<\/td>\n6.9\u00b10.7<\/td>\n8.7\u00b10.7<\/td>\n8.5\u00b10.7<\/td>\n<\/tr>\n
LDLp2<\/td>\n25.5<\/td>\n39.0\u00b11.3<\/td>\n36.3\u00b12.1<\/td>\n36.6\u00b11.6<\/td>\n35.7\u00b12.1<\/td>\n8.4\u00b10.6<\/td>\n8.0\u00b10.8<\/td>\n9.4\u00b10.7<\/td>\n9.6\u00b11.0<\/td>\n<\/tr>\n
LDLp3<\/td>\n23.0<\/td>\n21.7\u00b11.3<\/td>\n20.2\u00b11.9<\/td>\n19.0\u00b11.6<\/td>\n18.6\u00b11.7<\/td>\n5.5\u00b10.5<\/td>\n5.1\u00b10.6<\/td>\n5.9\u00b10.6<\/td>\n6.0\u00b10.8<\/td>\n<\/tr>\n
LDLp4<\/td>\n20.7<\/td>\n6.3\u00b10.5<\/td>\n5.8\u00b10.6<\/td>\n5.6\u00b10.7<\/td>\n5.2\u00b10.5<\/td>\n2.1\u00b10.2<\/td>\n1.9\u00b10.2<\/td>\n2.2\u00b10.3<\/td>\n2.2\u00b10.3<\/td>\n<\/tr>\n
LDLp5<\/td>\n18.6<\/td>\n2.5\u00b10.2<\/td>\n2.4\u00b10.2<\/td>\n2.3\u00b10.2<\/td>\n2.2\u00b10.2<\/td>\n1.1\u00b10.1<\/td>\n1.1\u00b10.1<\/td>\n1.4\u00b10.2<\/td>\n1.3\u00b10.2<\/td>\n<\/tr>\n
LDLp6<\/td>\n16.7<\/td>\n1.4\u00b10.1<\/td>\n1.3\u00b10.1<\/td>\n1.3\u00b10.1<\/td>\n1.2\u00b10.1<\/td>\n0.7\u00b10.1<\/td>\n0.7\u00b10.1<\/td>\n1.0\u00b10.1<\/td>\n0.9\u00b10.1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n
<\/div>\n<\/div>\n

\u4e0b\u306e\u56f3\u306f10\u9031\u9593\u5f8c\u306eApoCIII\u306e\u5909\u5316\u7387\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u5de6\u304c\u7a7a\u8179\u6642\u3001\u53f3\u304c\u98df\u5f8c\u3001\u9ed2\u3044\u30d0\u30fc\u304c\u30d6\u30c9\u30a6\u7cd6\u3001\u30b0\u30ec\u30fc\u304c\u679c\u7cd6\u3067\u3059\u3002\u660e\u3089\u304b\u306b\u679c\u7cd6\u306e\u65b9\u304cApoCIII\u306e\u5897\u52a0\u7387\u304c\u5927\u304d\u304f\u3001\u98df\u5f8c\u3067\u306f10\uff05\u3092\u8d85\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u3001TRL\u306e\u4e2d\u6027\u8102\u80aa\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u5316\u7387\u3067\u3059\u3002TRL1\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3067\u3059\u30022\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3068VLDL\u3067\u3057\u3087\u3046\u3002\u4e2d\u6027\u8102\u80aa\u306b\u5bcc\u3080\u3068\u5927\u304d\u3044VLDL\u304c\u5206\u6ccc\u3055\u308c\u3001\u305d\u3046\u3067\u306a\u3051\u308c\u3070\u5c0f\u578b\u306eVLDL\u304c\u5206\u6ccc\u3055\u308c\u307e\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3067\u306f\u5927\u304d\u3044VLDL\u304c\u5897\u52a0\u3057\u307e\u3059\u3002<\/p>\n

A\u306f\u7a7a\u8179\u6642\u306e\u4e2d\u6027\u8102\u80aa\u3001B\u306f\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u3067\u3001C\u306f\u7a7a\u8179\u6642\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001D\u306f\u98df\u5f8c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3059\u3002\u9762\u767d\u3044\u3053\u3068\u306b\u3001\u7a7a\u8179\u6642\u4e2d\u6027\u8102\u80aa\u306f\u3001\u30d6\u30c9\u30a6\u7cd6\u3068\u679c\u7cd6\u3067\u306f\u5168\u304f\u9006\u306e\u5909\u5316\u3067\u3057\u305f\u3002\u30d6\u30c9\u30a6\u7cd6\u306fTRL\u306e\u7c92\u5b50\u304c\u5927\u304d\u3044\u307b\u3069\u4e2d\u6027\u8102\u80aa\u304c\u5897\u52a0\u3057\u3001\u679c\u7cd6\u3067\u306f\u7c92\u5b50\u304c\u5c0f\u3055\u3044\u307b\u3069\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\uff08\u7a7a\u8179\u6642\u306b\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\uff08TRL1\uff09\u304c\u3042\u308b\u3053\u3068\u3082\u4e0d\u601d\u8b70\u3067\u3059\u304c\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u306a\u3093\u3067\u3057\u3087\u3046\u306d\u3002\uff09<\/p>\n

\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u306f\u3069\u3061\u3089\u3082\u3088\u308a\u5927\u304d\u306a\u7c92\u5b50\u3067\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u9055\u3044\u306f\u5927\u304d\u304f\u3001\u679c\u7cd6\u3067\u306f\u5927\u5e45\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u679c\u7cd6\u3067\u306f100\uff05\u4ee5\u4e0a\u5897\u52a0\u3057\u3066\u3044\u308b\u5206\u753b\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

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\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306fLDL\u306e\u5909\u5316\u7387\u3067\u3059\u30026\u3064\u306eLDL\u5206\u753b\u306b\u304a\u3044\u3066\u3001\u3069\u308c\u3082\u7a7a\u8179\u6642\u306e\u4e2d\u6027\u8102\u80aa\u306f\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u98df\u5f8c\u306e\u4e2d\u6027\u8102\u80aa\u306e\u5897\u52a0\u306f\u3001\u30d6\u30c9\u30a6\u7cd6\u3088\u308a\u3082\u679c\u7cd6\u306e\u65b9\u304c\u5897\u52a0\u304c\u5927\u304d\u304f\u3001\u7c92\u5b50\u304c\u5c0f\u3055\u3044\u307b\u3069\u5897\u52a0\u304c\u5927\u304d\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u7a7a\u8179\u6642\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30d6\u30c9\u30a6\u7cd6\u3068\u6bd4\u8f03\u3057\u3066\u3001\u679c\u7cd6\u3067\u5927\u5e45\u306b\u5897\u52a0\u3057\u3001\u5c0f\u3055\u3044sdLDL\u3067\u7279\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u98df\u5f8c\u3067\u306f\u3069\u3061\u3089\u3082\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u679c\u7cd6\u306e\u65b9\u304c\u3088\u308a\u5927\u304d\u306a\u5897\u52a0\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30d6\u30c9\u30a6\u7cd6\u3068\u6bd4\u8f03\u3057\u3066\u3001\u679c\u7cd6\u6442\u53d6\u306e\u98df\u5f8c\u3067\u306f\u3001\u3059\u3079\u3066\u306eLDL\u5206\u753b\u306e\u4e2d\u6027\u8102\u80aa\u542b\u6709\u91cf\u306e\u5897\u52a0\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4e2d\u6027\u8102\u80aa\u304c\u8c4a\u5bcc\u306aLDL\u306f\u3001LDL \u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u89aa\u548c\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u4e2d\u306e\u6ede\u7559\u6642\u9593\u304c\u9577\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u5c0f\u3055\u3044sdLDL\u7c92\u5b50 (LDLp3-6) \u306f\u9178\u5316\u3084\u7cd6\u5316\u3092\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u30d6\u30c9\u30a6\u7cd6<\/th>\n\u679c\u7cd6<\/th>\n<\/tr>\n
0\u9031\u9593<\/th>\n10\u9031\u9593<\/th>\n\uff05 \u5909\u5316<\/th>\n0\u9031\u9593<\/th>\n10\u9031\u9593<\/th>\n\uff05 \u5909\u5316<\/th>\n<\/tr>\n<\/thead>\n
\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u6027\u8102\u80aa (mg\/dL)<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
TRL\u4e2d\u6027\u8102\u80aa\u2013\u7a7a\u8179\u6642<\/td>\n116.4\u00b117.3<\/td>\n122.8\u00b116.6<\/td>\n14.3\u00b16.0<\/span><\/td>\n107.3\u00b114.5<\/td>\n111.9\u00b115.4<\/td>\n7.2\u00b16.8<\/td>\n<\/tr>\n
TRL\u4e2d\u6027\u8102\u80aa\u2013\u98df\u5f8c<\/td>\n138.3\u00b119.4<\/td>\n149.8\u00b118.9<\/td>\n11.4\u00b16.1<\/td>\n134.2\u00b118.8<\/td>\n180.9\u00b122.4<\/td>\n42.9 \u00b1 8.3<\/span><\/td>\n<\/tr>\n
LDL\u4e2d\u6027\u8102\u80aa\u2013\u7a7a\u8179\u6642<\/td>\n24.7\u00b12.3<\/td>\n26.1\u00b12.2<\/td>\n6.3\u00b16.3<\/td>\n23.7\u00b12.5<\/td>\n26.8\u00b12.9<\/td>\n13.9 \u00b1 5.3<\/span><\/td>\n<\/tr>\n
LDL\u4e2d\u6027\u8102\u80aa\u2013\u98df\u5f8c<\/td>\n27.3\u00b12.7<\/td>\n30.6\u00b12.2<\/td>\n8.8\u00b14.4<\/span><\/td>\n28.5\u00b12.9<\/td>\n33.2\u00b13.1<\/td>\n18.6 \u00b1 3.1<\/span><\/td>\n<\/tr>\n
\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb (mg\/dL)<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
TRL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u2013\u7a7a\u8179\u6642<\/td>\n51.3\u00b143.7<\/td>\n46.3\u00b15.3<\/td>\n\u22124.1\u00b13.0<\/td>\n46.7\u00b14.0<\/td>\n47.9\u00b14.7<\/td>\n2.6\u00b13.8<\/td>\n<\/tr>\n
TRL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u2013\u98df\u5f8c<\/td>\n48.1\u00b14.3<\/td>\n46.4\u00b16.1<\/td>\n\u22122.7\u00b13.6<\/td>\n43.4\u00b14.5<\/td>\n49.8\u00b14.7<\/td>\n16.3 \u00b1 5.1<\/span><\/td>\n<\/tr>\n
LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb-\u7a7a\u8179\u6642<\/td>\n90.4\u00b13.3<\/td>\n96.1\u00b13.9<\/td>\n7.0\u00b13.7<\/td>\n84.3.0\u00b15.3<\/td>\n101\u00b17<\/td>\n19.3 \u00b1 2.9<\/span><\/td>\n<\/tr>\n
LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u2013\u98df\u5f8c<\/td>\n86.0\u00b13.9<\/td>\n90.3\u00b13.4<\/td>\n7.1\u00b12.6<\/span><\/td>\n82.1\u00b15.0<\/td>\n94.3\u00b16.1<\/td>\n14.7 \u00b1 1.9<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n
\u4e0a\u306e\u8868\u306f\u5168\u4f53\u306e\u5909\u5316\u7387\u3067\u3059\u3002\u30d6\u30c9\u30a6\u7cd6\u306fTRL\u306e\u7a7a\u8179\u6642\u306e\u4e2d\u6027\u8102\u80aa\u3068LDL\u306e\u98df\u5f8c\u306e\u4e2d\u6027\u8102\u80aa\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5897\u52a0\u3055\u305b\u3001\u679c\u7cd6\u306fTRL\u306e\u98df\u5f8c\u306e\u4e2d\u6027\u8102\u80aa\u3092\u5927\u304d\u304f\u5897\u52a0\u3055\u305b\u3001TRL\u306e\u98df\u5f8c\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u5897\u52a0\u3055\u305b\u3001LDL\u306f\u7a7a\u8179\u3082\u98df\u5f8c\u3082\u4e21\u65b9\u3067\u4e2d\u6027\u8102\u80aa\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002<\/div>\n
\u3055\u3089\u306b\u3001\u7a7a\u8179\u3068\u98df\u5f8c\u306eApoCIII\u306e\u5909\u5316\u3068\u306e\u95a2\u9023\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u679c\u7cd6\u3067\u306f\u98df\u5f8c\u306eApoCIII\u3068\u7a7a\u8179\u6642\u7dcfLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u679c\u7cd6\u6442\u53d6\u7fa4\u3067\u3001\u7a7a\u8179\u6642sdLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5897\u52a0\u3068\u98df\u5f8cApoCIII\u304a\u3088\u3073TRLp2\u3068TRLp3\u306b\u304a\u3051\u308b\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u5897\u52a0\u304c\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5927\u304d\u306aTRL\u306e\u5897\u52a0\u306fsdLDL\u306e\u5897\u52a0\u3092\u62db\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u308c\u306b\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002<\/div>\n
<\/div>\n
\u679c\u7cd6\u306e10\u9031\u9593\u6442\u53d6\u5f8c\u306b\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u306eApoCIII\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u305f\u306e\u306f\u3001ApoCIII\u767a\u73fe\u306e\u8ca0\u306e\u8ee2\u5199\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002ApoCIII\u306e\u767a\u73fe\u306f\u30d6\u30c9\u30a6\u7cd6\u306b\u3088\u3063\u3066ChREBP-1\u304a\u3088\u3073SREBP-1\u3092\u6d3b\u6027\u5316\u3057\u3066\u5897\u52a0\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u3063\u3066\u6e1b\u5c11\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u6e1b\u5c11\u307e\u305f\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u5897\u52a0\u306b\u3088\u308a\u8ca0\u306e\u8abf\u6574\u304c\u50cd\u304b\u306a\u304f\u306a\u308a\u3001ApoCIII\u306f\u5897\u52a0\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u6050\u3089\u304f\u30d6\u30c9\u30a6\u7cd6\u306b\u3088\u308bApoCIII\u306e\u767a\u73fe\u5897\u52a0\u306f\u4e00\u6642\u7684\u3067\u3042\u308a\u3001\u8840\u7cd6\u5024\u30b9\u30d1\u30a4\u30af\u306b\u7d9a\u304f\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5897\u52a0\u306b\u3088\u3063\u3066\u6025\u901f\u306b\u9006\u8ee2\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3067\u306f\u3001\u9ad8\u30ec\u30d9\u30eb\u306eApoCIII\u3092\u793a\u3057\u307e\u3059\u3002<\/div>\n
\u4e00\u65b9\u3001\u679c\u7cd6\u306e\u6442\u53d6\u306f\u3001\u30d6\u30c9\u30a6\u7cd6\u306e\u6442\u53d6\u3068\u540c\u69d8\u306bChREBP-1\u304a\u3088\u3073SREBP-1\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u304c\u3001\u30d6\u30c9\u30a6\u7cd6\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u523a\u6fc0\u3057\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u679c\u7cd6\u6442\u53d6\u5f8c\u306eApoCIII\u767a\u73fe\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8ca0\u306e\u8abf\u6574\u304c\u50cd\u304b\u306a\u304f\u306a\u308a\u3001ApoCIII\u304c\u5927\u304d\u304f\u5897\u52a0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/div>\n

\u73fe\u5728\u306e\u69d8\u3005\u306a\u98f2\u98df\u7269\u306e\u5546\u54c1\u306b\u306f\u7570\u6027\u5316\u7cd6\uff08\u679c\u7cd6\u30d6\u30c9\u30a6\u7cd6\u6db2\u7cd6\uff09\u304c\u3044\u3063\u3071\u3044\u5165\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3089\u3092\u6bce\u65e5\u306e\u3088\u3046\u306b\u6442\u3063\u3066\u5065\u5eb7\u306b\u306a\u308c\u308b\u306f\u305a\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u30ea\u30f3\u30b4\u306e\u7f8e\u5473\u3057\u3044\u5b63\u7bc0\u3067\u3059\u304c\u3001\u30ea\u30f3\u30b41\u500b\u306b\u306f\u304a\u3088\u305d33g\u306e\u7cd6\u8cea\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u3046\u3061\u304a\u3088\u305d3\u5206\u306e2\u306f\u679c\u7cd6\u3067\u3059\u3002\u98df\u3079\u305f\u3068\u3057\u3066\u30824\u5206\u306e1\u7a0b\u5ea6\u3067\u3059\u306d\u3002\u30ea\u30f3\u30b4\u30b8\u30e5\u30fc\u30b9\u306a\u3093\u3066\u6700\u60aa\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u7cd6\u8cea\u3001\u7279\u306b\u679c\u7cd6\u306fApoCIII\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u305d\u308c\u306f\u69d8\u3005\u306a\u6709\u5bb3\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\u300cEffects of Fructose or Glucose on Circulating ApoCIII and Triglyceride and Cholesterol Content of Lipoprotein Subfractions in Humans\u300d<\/span><\/p>\n

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