{"id":21966,"date":"2023-02-27T22:37:53","date_gmt":"2023-02-27T13:37:53","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=21966"},"modified":"2023-02-27T22:37:53","modified_gmt":"2023-02-27T13:37:53","slug":"sglt2%e9%98%bb%e5%ae%b3%e5%89%a4%e5%af%be%e7%b3%96%e8%b3%aa%e5%88%b6%e9%99%90%ef%bc%9f%e3%82%bf%e3%82%a4%e3%83%88%e3%83%ab%e3%81%ab%e9%a8%99%e3%81%95%e3%82%8c%e3%82%8b%e3%81%aa","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=21966","title":{"rendered":"SGLT2\u963b\u5bb3\u5264\u5bfe\u7cd6\u8cea\u5236\u9650\uff1f\u30bf\u30a4\u30c8\u30eb\u306b\u9a19\u3055\u308c\u308b\u306a"},"content":{"rendered":"

\u4eca\u56de\u306f\u307e\u305a\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u3068\u7d50\u679c\u3092\u5148\u306b\u898b\u3066\u3082\u3089\u3044\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u300cSGLT2 inhibitor versus carbohydrate-restricted isocaloric diet: reprogramming substrate oxidation in type 2 diabetes\u300d<\/span><\/p>\n

\u300cSGLT2\u963b\u5bb3\u5264\u5bfe\u70ad\u6c34\u5316\u7269\u5236\u9650\u7b49\u30ab\u30ed\u30ea\u30fc\u98df\uff1a2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u57fa\u8cea\u9178\u5316\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u70ad\u6c34\u5316\u7269\u5236\u9650\u3092\u7cd6\u8cea\u5236\u9650\u3068\u8aad\u307f\u66ff\u3048\u308b\u3068\u3001SGLT2\u963b\u5bb3\u5264\u5bfe\u7cd6\u8cea\u5236\u9650\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u7814\u7a76\u306f\u307e\u3060\u672a\u6cbb\u7642\u306eHbA1c10\u4ee5\u4e0a\u30671 \u65e5\u5e73\u5747\u98df\u524d\u8840\u7cd6\u5024\u304c200\u4ee5\u4e0a\u306e23\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\uff0b\u666e\u901a\u306e\u98df\u4e8b\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u91cf\u306f28kcal\/kg\u306a\u306e\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u5236\u9650\u98df\u304b\u306a\uff09\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\uff0b\u666e\u901a\u98df\uff0bSGLT2\u963b\u5bb3\u5264\u306e\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\uff0b\u70ad\u6c34\u5316\u7269\u5236\u9650\u98df\u7fa4\u3067\u3059\u300212\u9031\u9593\u3067\u3069\u3046\u306a\u3063\u305f\u304b\uff1f<\/p>\n

\u3067\u306f\u7d50\u679c\u3067\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f0\u9031\u30011\u9031\u300112\u9031\u306e\u7dcf\u30a4\u30f3\u30b9\u30ea\u30f3\u6295\u4e0e\u91cf\u3067\u3059\u3002\u306a\u305c0\u9031\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u3042\u308b\u306e\u304b\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u30011\u9031\u306812\u9031\u3067\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u3068\u70ad\u6c34\u5316\u7269\u5236\u9650\u98df\u7fa4\u3067\u6709\u610f\u5dee\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u70ad\u6c34\u5316\u7269\u5236\u9650\u98df\u306e\u65b9\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u6295\u4e0e\u91cf\u304c\u591a\u304b\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306812\u9031\u3067\u306e\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u63a8\u79fb\u3067\u3059\u3002\u3069\u306e\u7fa4\u3082\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306f\u9055\u3044\u306f\u3042\u308a\u307e\u305b\u3093\u300212\u9031\u3067\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u304c\u5c11\u3057\u9ad8\u3081\u306b\u63a8\u79fb\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002<\/p>\n

\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u524d (0w)<\/th>\n\u5f8c (12w)<\/th>\n<\/tr>\n
\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/th>\nSGLT2<\/th>\n\u70ad\u6c34\u5316\u7269\u5236\u9650<\/th>\n\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/th>\n%\u00a0\u25b3<\/span>\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/th>\nSGLT2<\/th>\n%\u00a0\u25b3<\/span> SGLT2<\/th>\n\u70ad\u6c34\u5316\u7269\u5236\u9650<\/th>\n%\u00a0\u25b3<\/span> \u70ad\u6c34\u5316\u7269\u5236\u9650<\/th>\n<\/tr>\n<\/thead>\n
HbA1c (%)<\/td>\n12.9\u00b11.8<\/td>\n11.8\u00b11.3<\/td>\n12.8\u00b11.8<\/td>\n5.6\u00b10.6<\/td>\n\u2212 55.5 \u00b1 8.7<\/td>\n6.1\u00b10.6<\/td>\n\u2212 48.4 \u00b1 7.7<\/td>\n6.1\u00b10.7<\/td>\n\u2212 51.9 \u00b1 7.0<\/td>\n<\/tr>\n
T-CHO (mg\/dl)<\/td>\n196.4\u00b136.2<\/td>\n192.1\u00b143.7<\/td>\n239.9 \u00b1 29.8**\u00a0\u3001<\/sup>\u00a0***<\/td>\n164.5\u00b132.8<\/td>\n\u2212 15.5\u00b113.7<\/td>\n199.9\u00b160.5<\/td>\n\u2212 2.0 \u00b1 14.0*<\/td>\n205.0 \u00b1 28.9**<\/td>\n\u2212 14.1 \u00b1 10.8<\/td>\n<\/tr>\n
HDL-C (mg\/dl)<\/td>\n44.6\u00b19.1<\/td>\n49.9\u00b113.0<\/td>\n50.9\u00b110.8<\/td>\n47.5\u00b18.1<\/td>\n7.5\u00b110.7<\/td>\n59.4\u00b117.2<\/td>\n18.1\u00b112.7<\/td>\n59.6 \u00b1 10.1**<\/td>\n18.5\u00b115.9<\/td>\n<\/tr>\n
LDL-C (mg\/dl)<\/td>\n119.4\u00b128.6<\/td>\n119.3\u00b138.3<\/td>\n163.6 \u00b1 29.2**\u00a0\u3001<\/sup>\u00a0***<\/td>\n102.4\u00b130.9<\/td>\n\u2212 14.9 \u00b1 19.2<\/td>\n125.4\u00b152.2<\/td>\n\u2212 3.1\u00b114.6<\/td>\n132.7 \u00b1 32.6**<\/td>\n\u2212 18.9 \u00b1 13.8***<\/td>\n<\/tr>\n
\u4e2d\u6027\u8102\u80aa (mg\/dl)<\/td>\n146.3\u00b156.3<\/td>\n166.9\u00b194.8<\/td>\n170.9\u00b1119.7<\/td>\n92.4\u00b144.4<\/td>\n\u2212 35.5 \u00b1 25.0<\/td>\n107.0\u00b144.6<\/td>\n\u2212 25.0 \u00b1 25.2<\/td>\n85.6\u00b117.4<\/td>\n\u2212 37.8 \u00b1 22.4<\/td>\n<\/tr>\n
\u30ec\u30d7\u30c1\u30f3 (ng\/ml)<\/td>\n19.4\u00b111.7<\/td>\n12.3\u00b16.7<\/td>\n13.3\u00b16.4<\/td>\n21.3\u00b119.5<\/td>\n11.9\u00b157.0<\/td>\n13.5\u00b18.1<\/td>\n17.6\u00b136.9<\/td>\n22.1\u00b119.0<\/td>\n55.2\u00b187.7<\/td>\n<\/tr>\n
\u9ad8\u5206\u5b50\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3 (\u03bcg\/ml)<\/td>\n1.76\u00b10.80<\/td>\n1.81\u00b11.55<\/td>\n1.86\u00b10.66<\/td>\n2.47\u00b11.04<\/td>\n53.7\u00b162.5<\/td>\n3.18\u00b12.34<\/td>\n71.5\u00b144.4<\/td>\n2.85\u00b11.66<\/td>\n50.8\u00b159.3<\/td>\n<\/tr>\n
\u7dcf\u30b1\u30c8\u30f3 (\u00b5mol\/l)<\/td>\n557.6\u00b1753.1<\/td>\n329.2\u00b1314.4<\/td>\n751.7\u00b11172.0<\/td>\n256.8\u00b1245.4<\/td>\n\u2212 5.7 \u00b1 87.3<\/td>\n349.0\u00b1496.4<\/td>\n\u2212 25.8 \u00b1 71.3<\/td>\n173.0\u00b1121.5<\/td>\n\u2212 24.8 \u00b1 91.7<\/td>\n<\/tr>\n
\u30a2\u30bb\u30c8\u9162\u9178 (\u03bcmol\/l)<\/td>\n124.1\u00b1116.4<\/td>\n96.8\u00b176.8<\/td>\n205.1\u00b1298.7<\/td>\n77.8\u00b166.8<\/td>\n4.1\u00b1100.6<\/td>\n75.4\u00b176.4<\/td>\n\u2212 28.0 \u00b1 58.5<\/td>\n52.1\u00b140.6<\/td>\n\u2212 29.8 \u00b1 89.3<\/td>\n<\/tr>\n
\u03b2\u30d2\u30c9\u30ed\u30ad\u30b7\u916a\u9178 (\u03bcmol\/l)<\/td>\n433.4\u00b1638.4<\/td>\n232.3\u00b1238.5<\/td>\n546.6\u00b1873.5<\/td>\n179.0\u00b1179.6<\/td>\n\u2212 8.3 \u00b1 84.1<\/td>\n273.6\u00b1425.7<\/td>\n\u2212 24.6 \u00b1 78.0<\/td>\n120.9\u00b182.6<\/td>\n\u2212 22.2 \u00b1 93.2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*p < 0.05%\u25b3Control vs %\u25b3SGLT2\u3000\u3000**p < 0.05\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb vs \u70ad\u6c34\u5316\u7269\u5236\u9650\u3000***p < 0.05 SGLT2i\u5bfe\u70ad\u6c34\u5316\u7269\u5236\u9650<\/p>\n<\/div>\n<\/div>\n

\n

\u4e0a\u306e\u8868\u306f\u69d8\u3005\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u5909\u5316\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u6295\u4e0e\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u5f53\u7136HbA1c\u306f\u3059\u3079\u3066\u306e\u7fa4\u3067\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u306f\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u304c\u5c11\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u3059\u3079\u3066\u306e\u7fa4\u3067\u975e\u5e38\u306b\u9ad8\u3044\u30b1\u30c8\u30f3\u4f53\u5024\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u3082\u4f4e\u3044\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u3067\u3082330\u304f\u3089\u3044\u3001\u70ad\u6c34\u5316\u7269\u5236\u9650\u7fa4\u3067\u306f750\u304f\u3089\u3044\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4f5c\u7528\u304c\u304b\u306a\u308a\u4e0d\u8db3\u3057\u3066\u3044\u308b\u72b6\u614b\u306a\u306e\u3067\u3057\u3087\u3046\u3002\u305d\u3057\u306612\u9031\u5f8c\u306b\u306f\u3069\u306e\u7fa4\u3082\u30b1\u30c8\u30f3\u4f53\u5024\u304c\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n

\"\"<\/a><\/p>\n

\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u91cf (EE)\u3067\u3059\u3002\u7a7a\u8179\u6642\u306f\u540c\u3058\u3067\u3059\u304c\u3001\u98df\u5f8c30\u5206\u3068150\u5206\u3067\u3001\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u3068\u70ad\u6c34\u5316\u7269\u5236\u9650\u7fa4\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u91cf\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3088\u308a\u3082\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u547c\u5438\u5546\uff08RQ\uff09\u3067\u3059\u3002\u4f4e\u3044\u65b9\u304c\u8102\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u306b\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u7a7a\u8179\u6642RQ\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u3067\u308f\u305a\u304b\u306b\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002RQ\u306e\u5909\u5316\uff08\u98df\u5f8cRQ\/\u7a7a\u8179\u6642RQ\uff09\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ab\u30ca\u30b0\u30eb100mg\u6295\u4e0e\u7fa4\u306e\u0394RQ90\uff08RQ0\u5206\u3068RQ90\u5206\u306e\u5dee\uff09\u3067\u306e\u70ad\u6c34\u5316\u7269\u57fa\u8cea\u5229\u7528\u306e\u5897\u52a0\u306b\u3088\u308a\u4e0a\u6607\u3057\u307e\u3057\u305f\u3002\u70ad\u6c34\u5316\u7269\u5236\u9650\u3067\u306f\u0394RQ30 \uff08RQ0\u5206\u3068RQ30\u5206\u306e\u5dee\uff09\u3068\u0394RQ90 \u304c \u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u306e\u7d50\u8ad6\u3067\u306f\u3001\u70ad\u6c34\u5316\u7269\u5236\u9650\u98df\u306f\u3001SGLT2\u963b\u5bb3\u5264\u3068\u6bd4\u8f03\u3057\u3066\u540c\u69d8\u306e\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u91cf\u304a\u3088\u3073\u57fa\u8cea\u9178\u5316\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u304c\u3001\u70ad\u6c34\u5316\u7269\u5236\u9650\u98df\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5fc5\u8981\u91cf\u306e\u5897\u52a0\u306f\u3001SGLT2\u963b\u5bb3\u5264\u304a\u3088\u3073\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u8102\u8cea\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d88\u8cbb\u91cf\u304c\u6bd4\u8f03\u7684\u591a\u3044\u3053\u3068\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u5fc5\u8981\u91cf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3001\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u306f\u65e5\u672c\u306e\u6771\u90a6\u5927\u5b66\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u306e\u7d50\u679c\u304c\u72ec\u308a\u6b69\u304d\u3092\u3059\u308b\u3068\u3057\u305f\u3089\u3001\u70ad\u6c34\u5316\u7269\u3092\u5236\u9650\u3059\u308b\u3068\u3001\u3064\u307e\u308a\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068\u3001SGLT2\u963b\u5bb3\u5264\u3092\u5185\u670d\u3059\u308b\u3088\u308a\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5fc5\u8981\u91cf\u304c\u591a\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3001\u3068\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n

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