{"id":22061,"date":"2023-03-07T19:35:03","date_gmt":"2023-03-07T10:35:03","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=22061"},"modified":"2023-03-07T19:35:03","modified_gmt":"2023-03-07T10:35:03","slug":"%e5%8a%b9%e6%9e%9c%e3%82%92%e7%b6%ad%e6%8c%81%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e3%81%af%e3%82%84%e3%82%81%e3%82%8b%e3%81%93%e3%81%a8%e3%81%8c%e3%81%a7%e3%81%8d%e3%81%aa%e3%81%84glp-1","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=22061","title":{"rendered":"\u52b9\u679c\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3084\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac"},"content":{"rendered":"

\u73fe\u5728\u306e\u6cbb\u7642\u85ac\u306e\u307b\u3068\u3093\u3069\u306f\u5bfe\u75c7\u7642\u6cd5\u3067\u3042\u308a\u3001\u6839\u672c\u7684\u306b\u6cbb\u3057\u3066\u3044\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u6162\u6027\u75be\u60a3\u306e\u5834\u5408\u3001\u305d\u306e\u85ac\u3092\u3084\u3081\u308c\u3070\u3082\u3068\u306b\u623b\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u7cd6\u5c3f\u75c5\u306e\u85ac\u3082\u305d\u306e\u4e2d\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u3067\u3059\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u5b50\u4f9b\u306e\u80a5\u6e80\u306b\u3082\u85ac\u3068\u624b\u8853\u3092\u63a8\u5968\u3059\u308b\u7570\u5e38\u306a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/a>\u300d\u3067\u3082\u53d6\u308a\u4e0a\u3052\u305f\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3068\u3044\u3046GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u65e5\u672c\u3067\u306f\u9069\u5fdc\u5916\u3067\u3059\u304c\u3001\u4f53\u91cd\u6e1b\u5c11\u306e\u305f\u3081\u306b\u3082\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u305d\u306e\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff09\u3092BMI30\u4ee5\u4e0a\u307e\u305f\u306f27\u4ee5\u4e0a\u3067\u4f53\u91cd\u95a2\u9023\u306e\u4f75\u5b58\u75c7\u304c 1 \u3064\u4ee5\u4e0a\u3042\u308b\u3001\u7cd6\u5c3f\u75c5\u306e\u306a\u30441961\u4eba\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c92.4mg \u90311\u56de\u76ae\u4e0b\u6295\u4e0e\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u309268\u9031\u9593\u884c\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u540c\u6642\u306b\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3078\u306e\u4ecb\u5165\u304c\u884c\u308f\u308c\u3001\u5185\u5bb9\u306f\u98df\u4e8b\u306b\u95a2\u3059\u308b4\u9031\u9593\u3054\u3068\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\uff081\u65e5\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u3092500kcal\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\uff09\u3068\u8eab\u4f53\u6d3b\u52d5 \uff08\u9031150\u5206\uff09\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u6cbb\u7642\u306f\u4e2d\u6b62\u3055\u308c\u3001\u305d\u306e\u5f8c\u3092\u8ffd\u3044\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u4f53\u91cd\u5909\u5316\u3067\u3059\u3002A\u306b\u793a\u3059\u3088\u3046\u306b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u7fa4\u3067\u306f\u5927\u304d\u304f\u4f53\u91cd\u6e1b\u5c11\u3057\u300168\u9031\u306718\u338f\u306e\u6e1b\u91cf\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u30d7\u30e9\u30bb\u30dc\u306f2\u338f\u7a0b\u5ea6\u306e\u6e1b\u91cf\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3092\u6b62\u3081\u305f\u9014\u7aef\u306b\u3069\u3093\u3069\u3093\u4f53\u91cd\u304c\u623b\u308a\u30011\u5e74\u5f8c\u306b\u306f\u5143\u306e\u4f53\u91cd\u3088\u308a\u30826.6\u338f\u5c11\u306a\u3044\u3068\u3053\u308d\u307e\u3067\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u307e\u3057\u305f\u3002B\u306b\u793a\u3059\u3088\u3046\u306b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067\u4f53\u91cd\u6e1b\u5c11\u304c\u5927\u304d\u304b\u3063\u305f\u65b9\u304c\u30011\u5e74\u5f8c\u306b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u4f53\u91cd\u4f4e\u4e0b\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u4ecb\u5165\u306e\u52b9\u679c\u304c\u7d50\u679c\u306b\u5927\u304d\u306a\u5f71\u97ff\u304c\u3042\u308b\u3088\u3046\u306b\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n

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<\/th>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3 (\u9031 0)<\/th>\n68\u9031\u76ee<\/th>\n120\u9031\u76ee<\/th>\n<\/tr>\n
\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/th>\n\u30d7\u30e9\u30bb\u30dc\u7fa4<\/th>\n\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/th>\n\u30d7\u30e9\u30bb\u30dc\u7fa4<\/th>\n\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/th>\n\u30d7\u30e9\u30bb\u30dc\u7fa4<\/th>\n<\/tr>\n
\u5e73\u5747<\/th>\n\u5e73\u5747<\/th>\n\u5e73\u5747<\/th>\n\u5e73\u5747<\/th>\n\u5e73\u5747<\/th>\n\u5e73\u5747<\/th>\n<\/tr>\n<\/thead>\n
\u4f53\u91cd (kg)\u3001\u5e73\u5747 \u00b1 SD<\/td>\n105.6\u00b121.8<\/td>\n105.4\u00b125.6<\/td>\n87.5\u00b121.4<\/td>\n103.2\u00b125.6<\/td>\n99.0\u00b122.5<\/td>\n105.5\u00b126.2<\/td>\n<\/tr>\n
BMI\u3001\u5e73\u5747\u5024 \u00b1 SD<\/td>\n37.6\u00b17.0<\/td>\n37.7\u00b18.0<\/td>\n31.2\u00b17.2<\/td>\n36.9\u00b18.0<\/td>\n35.0\u00b17.1<\/td>\n37.6\u00b18.2<\/td>\n<\/tr>\n
\u53ce\u7e2e\u671f\u8840\u5727 (mmHg)\u3001\u5e73\u5747 \u00b1 SD<\/td>\n129\u00b114<\/td>\n130\u00b115<\/td>\n121\u00b114<\/td>\n128\u00b113<\/td>\n131\u00b115<\/td>\n132\u00b115<\/td>\n<\/tr>\n
\u62e1\u5f35\u671f\u8840\u5727 (mmHg)\u3001\u5e73\u5747 \u00b1 SD<\/td>\n81\u00b110<\/td>\n80\u00b110<\/td>\n78\u00b111<\/td>\n79\u00b19<\/td>\n82\u00b110<\/td>\n81\u00b111<\/td>\n<\/tr>\n
HbA1c (%)\u3001\u5e73\u5747 \u00b1 SD<\/td>\n5.7\u00b10.3<\/td>\n5.7\u00b10.3<\/td>\n5.2\u00b10.3<\/td>\n5.5\u00b10.4<\/td>\n5.6\u00b10.3<\/td>\n5.7\u00b10.5<\/td>\n<\/tr>\n
\u8102\u8cea\u30ec\u30d9\u30eb (mg\/dl)<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n193.4 (18.4)<\/td>\n194.8 (19.4)<\/td>\n184.6 (20.9)<\/td>\n194.9 (19.7)<\/td>\n191.4 (19.7)<\/td>\n193.4 (20.2)<\/td>\n<\/tr>\n
HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n49.3 (23.9)<\/td>\n48.9 (26.8)<\/td>\n52.8 (23.8)<\/td>\n50.1 (26.2)<\/td>\n53.1 (26.2)<\/td>\n49.4 (25.2)<\/td>\n<\/tr>\n
LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n113.4 (29.4)<\/td>\n113.7 (27.2)<\/td>\n108.2 (32.0)<\/td>\n115.0 (32.8)<\/td>\n108.5 (30.4)<\/td>\n108.8 (33.4)<\/td>\n<\/tr>\n
VLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/td>\n25.5 (44.7)<\/td>\n25.9 (54.1)<\/td>\n18.6 (49.1)<\/td>\n23.4 (52.4)<\/td>\n23.5 (52.7)<\/td>\n27.4 (56.4)<\/td>\n<\/tr>\n
\u4e2d\u6027\u8102\u80aa<\/td>\n131.1 (46.5)<\/td>\n132.7 (53.7)<\/td>\n95.7 (50.1)<\/td>\n119.4 (51.9)<\/td>\n122.4 (57.3)<\/td>\n140.8 (57.7)<\/td>\n<\/tr>\n
CRP (mg\/L)<\/td>\n2.95 (170.1)<\/td>\n3.08 (112.8)<\/td>\n1.28 (211.6)<\/td>\n2.69 (142.9)<\/td>\n1.83 (183.9)<\/td>\n2.65 (152.2)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/section>\n<\/article>\n<\/div>\n<\/div>\n
\u4e0a\u306e\u8868\u306f\u69d8\u3005\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u5909\u5316\u3067\u3059\u3002\u4e0b\u306e\u56f3\u3082\u3042\u308b\u306e\u3067\u3001\u56f3\u306b\u306a\u3044\u9805\u76ee\u306b\u3064\u3044\u3066\u3001\u4e2d\u6027\u8102\u80aa\u306f\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u4f7f\u7528\u4e2d\u306b\u306f\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u304c\u3001\u3084\u306f\u308a\u85ac\u4e2d\u6b62\u5f8c\u306b\u306f\u623b\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002<\/div>\n
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\u4e0a\u306e\u56f3\u306f\u8840\u5727\u3068CRP\u3068HbA1c\u3067\u3059\u3002\u4f8b\u3048\u3070HbA1c\u306f5.7\u304c5.2\u307e\u3067\u4e0b\u304c\u3063\u305f\u306e\u306b\u3001\u85ac\u3092\u6b62\u3081\u308b\u30685.6\u307e\u3067\u623b\u3063\u3066\u3044\u307e\u3059\u3002\u8840\u5727\u3082\u540c\u69d8\u3067\u3059\u3002<\/div>\n
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\u672c\u6765\u6cbb\u7642\u306f\u75c5\u6c17\u3084\u75c5\u614b\u3092\u6539\u5584\u3055\u305b\u3066\u3001\u85ac\u3092\u6b62\u3081\u3089\u308c\u308b\u3088\u3046\u306b\u3059\u3079\u304d\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/div>\n
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\u300cWeight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension\u300d<\/span><\/div>\n
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