{"id":22083,"date":"2023-03-22T08:53:57","date_gmt":"2023-03-21T23:53:57","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=22083"},"modified":"2023-03-22T08:53:57","modified_gmt":"2023-03-21T23:53:57","slug":"%e8%84%b3%e9%9c%87%e7%9b%aa%e3%82%92%e8%b5%b7%e3%81%93%e3%81%99%e3%82%b3%e3%83%b3%e3%82%bf%e3%82%af%e3%83%88%e3%82%b9%e3%83%9d%e3%83%bc%e3%83%84%e3%81%b8%e3%81%ae%e5%ad%90%e4%be%9b%e3%81%ae%e5%8f%82","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=22083","title":{"rendered":"\u8133\u9707\u76ea\u3092\u8d77\u3053\u3059\u30b3\u30f3\u30bf\u30af\u30c8\u30b9\u30dd\u30fc\u30c4\u3078\u306e\u5b50\u4f9b\u306e\u53c2\u52a0\u306f\u5236\u9650\u3059\u3079\u304d\u304b\u3082\u3057\u308c\u306a\u3044"},"content":{"rendered":"<p>\u3044\u304f\u3064\u3082\u306e\u7814\u7a76\u3067\u3001\u8133\u9707\u76ea\u3092\u8d77\u3053\u3059\u3088\u3046\u306a\u30b9\u30dd\u30fc\u30c4\u3092\u3084\u3063\u3066\u3044\u305f\u4eba\u306e\u8a8d\u77e5\u75c7\u3092\u306f\u3058\u3081\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=10447\" target=\"_blank\" rel=\"noopener\">\u30a2\u30b9\u30ea\u30fc\u30c8\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3000\u305d\u306e1<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=10488\" target=\"_blank\" rel=\"noopener\">\u305d\u306e2<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=11623\" target=\"_blank\" rel=\"noopener\">\u30b5\u30c3\u30ab\u30fc\u306e\u30d8\u30c7\u30a3\u30f3\u30b0\u7981\u6b62<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=20254\" target=\"_blank\" rel=\"noopener\">\u5143\u30a8\u30ea\u30fc\u30c8\u30e9\u30b0\u30d3\u30fc\u9078\u624b\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u30ea\u30b9\u30af<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u795e\u7d4c\u5b66\u7684\u640d\u50b7\u3068\u5916\u50b7\u6027\u8133\u75c7\u306e\u7814\u7a76\u306e\u305f\u3081\u306b\u3001\u8133\u30d0\u30f3\u30af\u306b\u8133\u3092\u5bc4\u4ed8\u3057\u305f\u7537\u6027\u306e\u5143\u30a2\u30e1\u30ea\u30ab\u30f3 \u30d5\u30c3\u30c8\u30dc\u30fc\u30eb\u9078\u624b205 \u4eba\u3092\u5bfe\u8c61\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u5256\u691c\u6642\u306e\u5e73\u5747\u5e74\u9f62\u306f67.17\u6b73 \u3067\u3059\u3002<\/p>\n<p>\u6162\u6027\u5916\u50b7\u6027\u8133\u75c7 (CTE)\u304c73.7%\u306b\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u30df\u30a8\u30ea\u30f3\u95a2\u9023\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea (MAG) \u3084\u30d7\u30ed\u30c6\u30aa\u30ea\u30d4\u30c9\u30bf\u30f3\u30d1\u30af\u8cea 1 (PLP) \u306a\u3069\u3001\u8133\u640d\u50b7\u5f8c\u306e\u767d\u8cea\u306e\u5b8c\u5168\u6027\u306b\u5bfe\u3059\u308b\u6700\u3082\u521d\u671f\u306e\u5909\u5316\u3092\u8868\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u3088\u308a\u65b0\u3057\u3044\u6307\u6a19\u3089\u3057\u3044\u3067\u3059\u3002\uff08\u8a73\u3057\u304f\u306f\u308f\u304b\u308a\u307e\u305b\u3093\uff09<\/p>\n<p>\u30d7\u30ec\u30fc\u5e74\u6570\u304c\u9577\u3044\u307b\u3069 PLP \u6fc3\u5ea6\u304c\u4f4e\u3044\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\uff08\u304b\u306a\u308a\u306e\u30d0\u30e9\u30c4\u30ad\u3067\u3059\u304c\uff09\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"22190\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=22190\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg?fit=520%2C265&amp;ssl=1\" data-orig-size=\"520,265\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u8133\u30a2\u30e1\u30d5\u30c8m_fcad019f1\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg?fit=300%2C153&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg?fit=520%2C265&amp;ssl=1\" class=\"alignnone size-full wp-image-22190\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg?resize=520%2C265\" alt=\"\" width=\"520\" height=\"265\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg?w=520&amp;ssl=1 520w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/9602a9b6d4567f85ca019f5819ecbaa3.jpeg?resize=300%2C153&amp;ssl=1 300w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/a><\/p>\n<p>\u307e\u305f\u3001\u30a2\u30e1\u30d5\u30c8\u306b\u521d\u3081\u3066\u89e6\u308c\u305f\u5e74\u9f62\u304c\u82e5\u3044\u307b\u3069\u3001PLP \u6fc3\u5ea6\u304c\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u53cd\u5fa9\u7684\u306a\u982d\u90e8\u885d\u6483 (RHI)\u306f\u3001\u8133\u306e\u767d\u8cea\u640d\u50b7\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u81e8\u5e8a\u7684\u306b\u8a3a\u65ad\u3055\u308c\u305f\u8133\u9707\u76ea\u304c\u306a\u3044\u5834\u5408\u3067\u3082\u3001\u30e6\u30fc\u30b9\u306e\u3088\u3046\u306a\u82e5\u3044\u4e16\u4ee3\u3067\u3082\u30b3\u30f3\u30bf\u30af\u30c8\u30b9\u30dd\u30fc\u30c4\u30921\u30b7\u30fc\u30ba\u30f3\u30d7\u30ec\u30fc\u3057\u305f\u3060\u3051\u3067\u767d\u8cea\u306e\u5909\u5316\u304c\u898b\u3089\u308c\u307e\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27775478\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<div class=\"inline-table__head\">\u6700\u8fd1\u306e\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u7814\u7a76\u3067\u3001\u30b5\u30c3\u30ab\u30fc\u3092\u3057\u3066\u3044\u305f\u30a8\u30ea\u30fc\u30c8\u9078\u624b\u306e\u30ea\u30b9\u30af\u3092\u5206\u6790\u3057\u305f\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\uff08<a href=\"https:\/\/www.thelancet.com\/journals\/lanpub\/article\/PIIS2468-2667(23)00027-0\/fulltext\" target=\"_blank\" rel=\"noopener\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09<\/div>\n<div class=\"table-with-References\">\n<table class=\"scrollable bordered\" style=\"width: 100%;\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\">\n<thead>\n<tr>\n<th class=\"rowsep\" style=\"width: 0.253485%;\"><\/th>\n<th class=\"rowsep\" style=\"width: 36.6286%;\"><\/th>\n<th class=\"rowsep\" style=\"width: 20.9125%;\"><strong>\u30b5\u30c3\u30ab\u30fc\u9078\u624b\u00a0<\/strong><\/th>\n<th class=\"rowsep\" style=\"width: 21.5463%;\"><strong>\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/strong><\/th>\n<th class=\"rowsep\" style=\"width: 20.4056%;\"><strong>\u30cf\u30b6\u30fc\u30c9\u6bd4 (95% CI)<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 36.8821%;\" colspan=\"2\">\u795e\u7d4c\u5909\u6027\u75be\u60a3<\/p>\n<div class=\"dropBlock reference-citations\"><\/div>\n<\/td>\n<td style=\"width: 20.9125%;\">537 (8\u30fb9%)<\/td>\n<td style=\"width: 21.5463%;\">3485 (6\u30fb2%)<\/td>\n<td style=\"width: 20.4056%;\"><span style=\"color: #ff0000;\">1\u30fb46\uff081\u30fb33\uff5e1\u30fb60\uff09<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 0.253485%;\"><\/td>\n<td style=\"width: 36.6286%;\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u8a8d\u77e5\u75c7<\/td>\n<td style=\"width: 20.9125%;\">491 (8\u30fb2%)<\/td>\n<td style=\"width: 21.5463%;\">2889 (5\u30fb1%)<\/td>\n<td style=\"width: 20.4056%;\"><span style=\"color: #ff0000;\">1\u30fb62 (1\u30fb47\u20131\u30fb78)<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 0.253485%;\"><\/td>\n<td style=\"width: 36.6286%;\">\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u75be\u60a3<\/td>\n<td style=\"width: 20.9125%;\">14 (0\u30fb2%)<\/td>\n<td style=\"width: 21.5463%;\">100 (0\u30fb2%)<\/td>\n<td style=\"width: 20.4056%;\">1\u30fb27\uff080\u30fb73\uff5e2\u30fb22\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 0.253485%;\"><\/td>\n<td style=\"width: 36.6286%;\">\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5<\/td>\n<td style=\"width: 20.9125%;\">57 (0\u30fb9%)<\/td>\n<td style=\"width: 21.5463%;\">737 (1\u30fb3%)<\/td>\n<td style=\"width: 20.4056%;\">0\u30fb68\uff080\u30fb52\uff5e0\u30fb89\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 36.8821%;\" colspan=\"2\">\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1<\/td>\n<td style=\"width: 20.9125%;\">323 (5\u30fb4%)<\/td>\n<td style=\"width: 21.5463%;\">1979 (3\u30fb5%)<\/td>\n<td style=\"width: 20.4056%;\"><span style=\"color: #ff0000;\">1\u30fb54\uff081\u30fb37\uff5e1\u30fb73\uff09<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 0.253485%;\"><\/td>\n<td style=\"width: 36.6286%;\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u305d\u306e\u4ed6\u306e\u8a8d\u77e5\u75c7\u306b\u3088\u308b\u6b7b\u4ea1<\/td>\n<td style=\"width: 20.9125%;\">290 (4\u30fb8%)<\/td>\n<td style=\"width: 21.5463%;\">1616 (2\u30fb9%)<\/td>\n<td style=\"width: 20.4056%;\"><span style=\"color: #ff0000;\">1\u30fb69\uff081\u30fb50\uff5e1\u30fb92\uff09<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 0.253485%;\"><\/td>\n<td style=\"width: 36.6286%;\">\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1<\/td>\n<td style=\"width: 20.9125%;\">13 (0\u30fb2%)<\/td>\n<td style=\"width: 21.5463%;\">84 (0\u30fb1%)<\/td>\n<td style=\"width: 20.4056%;\">1\u30fb41\uff080\u30fb79\uff5e2\u30fb53\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 0.253485%;\"><\/td>\n<td style=\"width: 36.6286%;\">\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u3088\u308b\u6b7b\u4ea1<\/td>\n<td style=\"width: 20.9125%;\">28 (0\u30fb5%)<\/td>\n<td style=\"width: 21.5463%;\">365 (0\u30fb6%)<\/td>\n<td style=\"width: 20.4056%;\">0\u30fb70\uff080\u30fb48\uff5e1\u30fb03\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u30b5\u30c3\u30ab\u30fc\u9078\u624b\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3001\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u304c\u3084\u306f\u308a\u9ad8\u3044\u3088\u3046\u3067\u3059\u3002\u30dd\u30b8\u30b7\u30e7\u30f3\u5225\u3067\u5206\u6790\u3059\u308b\u3068\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30b4\u30fc\u30eb\u30ad\u30fc\u30d1\u3067\u306f\u306a\u304f\u30d5\u30a3\u30fc\u30eb\u30c9\u30d7\u30ec\u30fc\u30e4\u30fc\u3067\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u306e\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u30b4\u30fc\u30eb\u30ad\u30fc\u30d1\u306f\u30ea\u30b9\u30af\u5897\u52a0\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u30d8\u30c7\u30a3\u30f3\u30b0\u3092\u3059\u308b\u3053\u3068\u304c\u5c11\u306a\u3044\u304b\u3089\u3067\u3057\u3087\u3046\u3002\u3082\u3057\u3001\u30b5\u30c3\u30ab\u30fc\u3092\u3084\u308b\u306a\u3089\u30b4\u30fc\u30eb\u30ad\u30fc\u30d1\u304c\u5b89\u5168\uff1f<\/p>\n<p>\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u30a2\u30b9\u30ea\u30fc\u30c8\u3001\u7279\u306b\u5b50\u4f9b\u305f\u3061\u306e\u8133\u3078\u306e\u7e70\u308a\u8fd4\u3057\u306e\u885d\u6483\u304b\u3089\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u3001\u3055\u3089\u306b\u591a\u304f\u5bfe\u7b56\u3001\u5236\u9650\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u5927\u5b66\u751f\u306b\u306a\u308b\u307e\u3067\u306f\u3001\u30a2\u30e1\u30d5\u30c8\u3084\u30e9\u30b0\u30d3\u30fc\u306e\u30bf\u30c3\u30af\u30eb\u7981\u6b62\u3001\u30b5\u30c3\u30ab\u30fc\u306e\u30d8\u30c7\u30a3\u30f3\u30b0\u7981\u6b62\u3001\u67d4\u9053\u306e\u6295\u3052\u6280\u7981\u6b62\u306a\u3069\u304c\u5fc5\u8981\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u5b50\u4f9b\u306e\u9803\u306f\u30b3\u30f3\u30bf\u30af\u30c8\u3057\u306a\u3044\u500b\u4eba\u30b9\u30dd\u30fc\u30c4\u4e2d\u5fc3\u306e\u65b9\u304c\u826f\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002<\/p>\n<p><span style=\"color: #3366ff;\">\u300cDecreased myelin proteins in brain donors exposed to football-related repetitive head impacts\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u30d5\u30c3\u30c8\u30dc\u30fc\u30eb\u95a2\u9023\u306e\u53cd\u5fa9\u7684\u306a\u982d\u90e8\u885d\u6483\u306b\u3055\u3089\u3055\u308c\u305f\u8133\u30c9\u30ca\u30fc\u306e\u30df\u30a8\u30ea\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6e1b\u5c11 \u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/academic.oup.com\/braincomms\/article\/5\/2\/fcad019\/7067353\" target=\"_blank\" 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