{"id":22236,"date":"2023-03-29T12:33:17","date_gmt":"2023-03-29T03:33:17","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=22236"},"modified":"2023-03-29T12:33:17","modified_gmt":"2023-03-29T03:33:17","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ab%e3%82%88%e3%82%8bigg4%e5%a2%97%e5%8a%a0%e3%81%ae%e5%bd%b1%e9%9f%bf","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=22236","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308bIgG4\u5897\u52a0\u306e\u5f71\u97ff"},"content":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3067\u69d8\u3005\u306a\u5f8c\u907a\u75c7\u3001\u526f\u4f5c\u7528\u304c\u8d77\u304d\u3066\u3044\u307e\u3059\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=21247\" target=\"_blank\" rel=\"noopener\">\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u3092\u4f55\u5ea6\u3082\u63a5\u7a2e\u3059\u308b\u3068\u611f\u67d3\u3057\u3084\u3059\u304f\u306a\u308b\u7406\u7531<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30ef\u30af\u30c1\u30f3\u306e\u8907\u6570\u56de\u63a5\u7a2e\u306fIgG4\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002<\/p>\n<p>IgG4\u3068\u8a00\u3048\u3070\u3001IgG4\u95a2\u9023\u75be\u60a3\u3092\u8003\u3048\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u5c11\u306a\u304f\u3068\u308213\u306e\u2f83\u2f30\u514d\u75ab\u75be\u60a3\u306e\u75c5\u56e0\u306e\u91cd\u8981\u306a\u90e8\u5206\u3082IgG4\u304c\u62c5\u3063\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002\u307e\u305f\u3001\u52d5\u8108\u5468\u56f2\u708e\u3082\u8d77\u3053\u3059\u306e\u3067\u3001\u30ef\u30af\u30c1\u30f3\u5f8c\u306b\u5927\u52d5\u8108\u89e3\u96e2\u306a\u3069\u304c\u5897\u52a0\u3059\u308b\u306e\u3082IgG4\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u305d\u3057\u3066\u304c\u3093\u7d30\u80de\u306fIgG4\u306b\u3088\u308a\u514d\u75ab\u3092\u56de\u907f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8ad6\u6587\u306f\u30d7\u30ec\u30d7\u30ea\u30f3\u30c8\u306a\u306e\u3067\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\uff09<\/p>\n<p><a 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data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/4a700ec11ca923f8d24b49716056f524.png?fit=300%2C199&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/4a700ec11ca923f8d24b49716056f524.png?fit=611%2C406&amp;ssl=1\" class=\"alignnone size-full wp-image-22238\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/4a700ec11ca923f8d24b49716056f524.png?resize=611%2C406\" alt=\"\" width=\"611\" height=\"406\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/4a700ec11ca923f8d24b49716056f524.png?w=611&amp;ssl=1 611w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/4a700ec11ca923f8d24b49716056f524.png?resize=300%2C199&amp;ssl=1 300w\" sizes=\"auto, (max-width: 611px) 100vw, 611px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u3001\u304c\u3093\u6297\u539f\u306b\u2ed1\u6642\u9593\u3055\u3089\u3055\u308c\u308b\u3068\u3001B\u7d30\u80de\u306e\u30af\u30e9\u30b9\u304c\u5909\u5316\u3057\u3001IgG4\u304c\u2f63\u6210\u3055\u308c\u307e\u3059\u3002\u304c\u3093\u7279\u7570\u7684IgG1\u6297\u4f53\u3068IgG4\u306fFc \u53d7\u5bb9\u4f53\u3078\u306e\u7d50\u5408\u306b\u304a\u3044\u3066\u7af6\u5408\u3059\u308b\u3088\u3046\u3067\u3059\u3002in vivo\u306e\u7814\u7a76\u3067IgG1\u6297\u4f53\u306f\u304c\u3093\u306e\u9032\u2f8f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u304c\u3001IgG4\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002IgG4\u6297\u4f53\u306f\u3001\u816b\u760d\u7d30\u80de\u3092\u76f4\u63a5\u653b\u6483\u3059\u308b\u80fd\u2f12\u3092\u2f4b\u3044\u3066\u304a\u308a\u3001IgG1 \u6297\u4f53\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u816b\u760d\u7d30\u80de\u6b7b\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u59a8\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u816b\u760d\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308bIgG4\u5408\u6210\u306f\u3001\u816b\u760d\u306b\u5bfe\u3059\u308b\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u6027\u3092\u5236\u9650\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001IgG4\u6297\u4f53\u306f\u3001\u304c\u3093\u306e\u514d\u75ab\u56de\u907f\u306b\u91cd\u8981\u304b\u3064\u5fc5\u8981\u3067\u3059\u3002\u2fb7\u9053\u304c\u3093\u60a3\u8005\u306e\u7814\u7a76\u3067\u306f\u3001\u2fbc\u6fc3\u5ea6\u306eIgG4\u3092\u7523\u2f63\u3059\u308bB\u7d30\u80de\u304c\u60aa\u6027\u7d30\u80de\u3067\u8457\u3057\u304f\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3088\u308a\u591a\u304f\u306eIgG4\u306f\u3001\u3088\u308a\u653b\u6483\u7684\u306a\u304c\u3093\u306e\u6210\u2ed1\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u308a\u3001\u3088\u308a\u2fbc\u3044\u304c\u3093\u306e\u60aa\u6027\u5ea6\u304a\u3088\u3073\u4e88\u5f8c\u4e0d\u826f\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u30de\u30a6\u30b9\u306e\u5b9f\u9a13\u3067\u306f\u3001IgG4\u306e\u5c40\u6240\u6295\u4e0e\u306f\u3001\u79fb\u690d\u3055\u308c\u305f\u7d50\u8178\u76f4\u8178\u816b\u760d\u3068\u4e73\u623f\u816b\u760d\u306a\u3069\u306e\u6210\u2ed1\u3092\u5287\u7684\u306b\u901f\u3081\u308b\u3053\u3068\u304c\u767a\u2f92\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30de\u30a6\u30b9\u3067\u2fae\u304c\u3093\u7279\u7570\u7684IgG4\u3092\u4e73\u304c\u3093\u7d30\u80de\u306e\u2f6a\u4e0b\u63a5\u7a2e\u90e8\u4f4d\u306b\u6ce8\u2f0a\u3057\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u306f\u5287\u7684\u306b\u52a0\u901f\u3055\u308c\u300121\u2f47\u307e\u3067\u306b\u6709\u610f\u306b\u2f24\u304d\u306a\u304c\u3093\u306e\u584a\u304c\u2f63\u6210\u3055\u308c\u307e\u3057\u305f\u3002IgG4\u306f\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u306b\u76f4\u63a5\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u305f\u3081\u3001\u304c\u3093\u7d30\u80de\u304c IgG4\u6297\u4f53\u3092\u5229\u2f64\u3057\u3066\u5c40\u6240\u7684\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u906e\u65ad\u3057\u3001\u304c\u3093\u306e\u5897\u6b96\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u2f70\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u304c\u30bf\u30fc\u30dc\u304c\u3093\u306e\u4e00\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=21247\" target=\"_blank\" rel=\"noopener\">\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u3092\u4f55\u5ea6\u3082\u63a5\u7a2e\u3059\u308b\u3068\u611f\u67d3\u3057\u3084\u3059\u304f\u306a\u308b\u7406\u7531<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30ef\u30af\u30c1\u30f3\u306fIgG4\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\uff08<a href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/sciimmunol.ade2798\" target=\"_blank\" rel=\"noopener\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u524d\u306b\u611f\u67d3\u3057\u305f\u4eba\u3067\u306f\uff4dRNA\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3067IgG4\u304c\u4e0a\u6607\u3057\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u307e\u305f\u30d5\u30a1\u30a4\u30b6\u30fc\u30ef\u30af\u30c1\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30e2\u30c7\u30eb\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306f\u3001\u9577\u671f\u9593\u306eIgG4\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u80fd\u529b\u304c\u9ad8\u3044\u3088\u3046\u3067\u3059\u3002\u3053\u308c\u306f\u751f\u6210\u3055\u308c\u308b\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u3068\u6301\u7d9a\u6642\u9593\u304cmRNA \u6fc3\u5ea6\u304c\u9ad8\u3044\u3053\u3068\uff08\u30d5\u30a1\u30a4\u30b6\u30fc\u30ef\u30af\u30c1\u30f3\uff0830\u03bcg\uff09\u3001\u30e2\u30c7\u30eb\u30ca\u30ef\u30af\u30c1\u30f3\uff08100\u03bcg\uff09\uff09\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"22239\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=22239\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png?fit=589%2C375&amp;ssl=1\" data-orig-size=\"589,375\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"IgG4\u611f\u67d3\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png?fit=300%2C191&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png?fit=589%2C375&amp;ssl=1\" class=\"alignnone size-full wp-image-22239\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png?resize=589%2C375\" alt=\"\" width=\"589\" height=\"375\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png?w=589&amp;ssl=1 589w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/03\/89e2bc6c5477ff1a00180ab15ce54793.png?resize=300%2C191&amp;ssl=1 300w\" sizes=\"auto, (max-width: 589px) 100vw, 589px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306bIgG3\u6297\u4f53\u306f\u3001\u611f\u67d3\u3057\u305f\u7d30\u80de\u306e\u819c\u306b\u9732\u51fa\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306b\u304f\u3063\u4ed8\u304d\u307e\u3059\u3002\u7d30\u80de\u50b7\u5bb3\u6027 T 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style=\"color: #3366ff;\">\u300cIgG4 Antibodies Induced by mRNA Vaccines Generate Immune Tolerance to SARS-CoV-2\u2019spike Protein by Suppressing the Immune System\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300cmRNA\u30ef\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u305fIgG4\u6297\u4f53\u306f\u3001\u514d\u75ab\u7cfb\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066SARS-CoV-2\u306e\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5bdb\u5bb9\u3092\u751f\u307f\u51fa\u3059\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/www.preprints.org\/manuscript\/202303.0441\/v1\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3067\u69d8\u3005\u306a\u5f8c\u907a\u75c7\u3001\u526f\u4f5c\u7528\u304c\u8d77\u304d\u3066\u3044\u307e\u3059\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u3092\u4f55\u5ea6\u3082\u63a5\u7a2e\u3059\u308b\u3068\u611f\u67d3\u3057\u3084\u3059\u304f\u306a\u308b\u7406\u7531\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30ef\u30af\u30c1\u30f3\u306e\u8907\u6570\u56de\u63a5\u7a2e\u306fIgG4\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002 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