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\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001FDA\u306e\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308b\u30d5\u30a1\u30fc\u30de\u30b3\u30d3\u30b8\u30e9\u30f3\u30b9\u306e\u7814\u7a76\u3067\u3059\u3002<\/p>\n

2013\u5e74\u306e\u7b2c1\u56db\u534a\u671f\u304b\u30892021\u5e74\u306e\u7b2c4\u56db\u534a\u671f\u307e\u3067\u306b\u5408\u8a0876,872\u4ef6\u306e\u6025\u6027\u81b5\u708e\u95a2\u9023\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u8a18\u9332\u3055\u308c\u3001\u305d\u306e\u3046\u3061757\u4ef6\u304cSGLT-2\u963b\u5bb3\u85ac\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u5185\u8a33\u306f\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067317\u4ef6\u3001\u30c0\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067150\u4ef6\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067287\u4ef6\u3001\u30a8\u30eb\u30c4\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08\u65e5\u672c\u672a\u767a\u58f2\uff09\u3067 3 \u4ef6\u3067\u3057\u305f\u3002 70.0%\u304c\u5165\u9662\u6cbb\u7642\u307e\u305f\u306f\u9577\u671f\u5165\u9662\u30014.2%\u306e\u60a3\u8005\u304c\u6b7b\u4ea1\u3057\u307e\u3057\u305f\u3002\u5831\u544a\u30aa\u30c3\u30ba\u6bd4\uff08ROR\uff09\u306f\u304a\u3088\u305d5\u3067\u3057\u305f\u3002<\/p>\n

SGLT-2\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6025\u6027\u81b5\u708e\u306e\u767a\u75c7\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f54\u65e5\u3067\u3001\u5831\u544a\u3055\u308c\u305f\u75c7\u4f8b\u306e\u7d0483%\u306f\u85ac\u5264\u6295\u4e0e\u958b\u59cb\u5f8c\u6700\u521d\u306e6\u304b\u6708\u4ee5\u5185\u306b\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u4f75\u7528\u85ac\u5264\u306e\u5f71\u97ff\u306e\u89e3\u6790\u3067\u306f\u3001DPP-4\u963b\u5bb3\u85ac\u3001GLP-1\u85ac\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3001ACE\u963b\u5bb3\u85ac\u3001PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306a\u3069\u306f\u3001SGLT-2\u963b\u5bb3\u85ac\u5358\u72ec\u7642\u6cd5\u3088\u308a\u3082\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u591a\u5909\u91cf\u89e3\u6790\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u3068\u69d8\u3005\u306aSGLT-2\u963b\u5bb3\u85ac\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u6025\u6027\u81b5\u708e\u6b7b\u4ea1\u306e\u53ef\u80fd\u6027\u304c3.81\u500d\u9ad8\u304f\u306a\u308a\u3001\u72ec\u7acb\u3057\u305f\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

SGLT-2\u963b\u5bb3\u85ac\u304c\u6025\u6027\u81b5\u708e\u306e\u767a\u751f\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305b\u3063\u304b\u304f\uff08\uff1f\uff09\u7d4c\u53e3\u6442\u53d6\u3057\u305f\u7cd6\u3092\u304a\u3057\u3063\u3053\u3068\u3057\u3066\u3059\u3050\u306b\u6368\u3066\u3066\u3057\u307e\u3046\u85ac\u3067\u3059\u3002\u305d\u308c\u306a\u306e\u306b\u3001\u6025\u6027\u81b5\u708e\u3068\u3082\u95a2\u4fc2\u304c\u3042\u308a\u305d\u3046\u3067\u3059\u3002SGLT-2\u963b\u5bb3\u85ac\u30928\u9031\u9593\u3001\u524d\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u6295\u4e0e\u3057\u3066\u3082\u3001\u3059\u3044\u81d3\u8102\u80aa\u542b\u91cf\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u5bfe\u3057\u3066\u5f71\u97ff\u304c\u306a\u3044\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u7cd6\u5c3f\u75c5\u85ac\uff1f\u3084\u305b\u85ac\uff1fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u526f\u4f5c\u7528\u3000\u305d\u306e3 \u6025\u6027\u81b5\u708e<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3082\u591a\u304f\u306e\u75c7\u4f8b\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

SGLT-2\u963b\u5bb3\u85ac\u306f\u6c7a\u3057\u3066\u5922\u306e\u3088\u3046\u306a\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u65e5\u672c\u672a\u627f\u8a8d\u306e\u30a8\u30eb\u30c4\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\u30a2\u30e1\u30ea\u30ab\u3067\u7b2c4\u306eSGLT-2\u963b\u5bb3\u85ac\u3067\u3059\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u3092\u6291\u5236\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\uff08\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u4e0b\u80a2\u306e\u5207\u65ad\u624b\u8853\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u3092\u53d7\u3051\u305f\u60a3\u800545\u4eba\uff081.6\uff05\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30a8\u30eb\u30c4\u30b0\u30ea\u30d5\u30ed\u30b8\u30f35mg\u6295\u4e0e\u3092\u53d7\u3051\u305f\u60a3\u800554\u4eba\uff082.0\uff05\uff09\u306815mg\u6295\u4e0e\u3092\u53d7\u3051\u305f\u60a3\u8005 57 \u4eba\uff082.1\uff05\uff09\u3067\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u4f55\u3068\u306a\u304f\u30b9\u30bf\u30c1\u30f3\u3068\u540c\u3058\u5302\u3044\u304c\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7cd6\u8cea\u306f\u4f53\u306b\u4e00\u65e6\u5165\u308c\u3066\u3001\u6368\u3066\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6700\u521d\u304b\u3089\u6442\u3089\u306a\u3044\u306e\u304c\u4e00\u756a\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u300cAnalysis of acute pancreatitis associated with SGLT-2 inhibitors and predictive factors of the death risk: Based on food and drug administration adverse event report system database\u300d<\/span><\/p>\n

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