{"id":23476,"date":"2023-08-22T20:40:22","date_gmt":"2023-08-22T11:40:22","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=23476"},"modified":"2023-08-22T20:40:22","modified_gmt":"2023-08-22T11:40:22","slug":"glp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%81%absglt2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%82%92%e5%8a%a0%e3%81%88%e3%81%9f%e3%82%891%e5%b9%b4%e5%be%8c%e3%81%a9%e3%81%86%e3%81%aa%e3%82%8b","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=23476","title":{"rendered":"GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306bSGLT2\u963b\u5bb3\u85ac\u3092\u52a0\u3048\u305f\u30891\u5e74\u5f8c\u3069\u3046\u306a\u308b\uff1f"},"content":{"rendered":"

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u306bSGLT2\u963b\u5bb3\u85ac\u306e\u30eb\u30bb\u30aa\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3092\u52a0\u3048\u305f\u3089\u3001\u3069\u308c\u307b\u3069\u306e\u52b9\u679c\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u305d\u3093\u306a\u3053\u3068\u3092\u65e5\u672c\u4eba\u306e2\u578b\u7cd6\u5c3f\u75c5\u306e\u4eba\u306b52\u9031\u9593\u884c\u3044\u307e\u3057\u305f\u3002\u5bfe\u8c61\u306f\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u5358\u5264\u7642\u6cd5\u309212\u9031\u9593\u4ee5\u4e0a\u51e6\u65b9\u3057\u3066\u3044\u308b62\u4eba\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u306e\u5e73\u5747\u5e74\u9f6258.4\u6b73\u3001\u5e73\u5747HbA1c8.52\u3001\u5e73\u5747\u4f53\u91cd70.93kg\u3001\u5e73\u5747BMI26.53\u3067\u3057\u305f\u3002\u4ed6\u306e\u7cd6\u5c3f\u75c5\u85ac\u306f\u7814\u7a76\u7d42\u4e86\u307e\u3067\u7981\u6b62\u3055\u308c\u307e\u3057\u305f\u3002\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u3092\u6e2c\u5b9a\u3059\u308b\u3068\u304d\u306e\u98df\u4e8b\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u91cf516 kcal \uff08\u30bf\u30f3\u30d1\u30af\u8cea19.2%\u3001\u8102\u8cea19.7%\u3001\u70ad\u6c34\u5316\u726958.4%)\u3067\u3057\u305f\u3002\u70ad\u6c34\u5316\u7269\u304c\u304a\u3088\u305d75g\u3067\u3059\u306d\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/th>\n12\u9031\u76ee<\/th>\n24\u9031\u76ee<\/th>\n36\u9031\u76ee<\/th>\n52\u9031\u76ee<\/th>\n<\/tr>\n<\/thead>\n
HbA1c (%)<\/td>\n8.52\u00b11.08<\/td>\n7.94\u00b10.95<\/td>\n7.88\u00b10.93<\/td>\n7.83\u00b10.98<\/td>\n7.74\u00b10.91<\/td>\n<\/tr>\n
\u22120.54<\/td>\n\u22120.58<\/td>\n\u22120.68<\/td>\n\u22120.68<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u8840\u7cd6\u5024 (mg\/dL)<\/td>\n183.7\u00b135.9<\/td>\n159.7\u00b128.2<\/td>\n154.8\u00b129.5<\/td>\n149.2\u00b125.0<\/td>\n150.1\u00b125.8<\/td>\n<\/tr>\n
\u221223.8<\/td>\n\u221228.8<\/td>\n\u221235.0<\/td>\n\u221232.1<\/td>\n<\/tr>\n
\u98df\u5f8c2\u6642\u9593\u8840\u7cd6\u5024 (mg\/dL)<\/td>\n292.9\u00b168.1<\/td>\n236.0\u00b157.4<\/td>\n\u2013<\/td>\n\u2013<\/td>\n229.3\u00b153.8<\/td>\n<\/tr>\n
\u221256.7<\/td>\n\u221256.5<\/td>\n<\/tr>\n
\u98df\u5f8c2\u6642\u9593\u8840\u7cd6\u5024\u66f2\u7dda\u4e0b\u9762\u7a4d0 \uff5e 2 \u6642\u9593(mg\u00b7h\/dL)<\/td>\n558\u00b197.2<\/td>\n481\u00b178.4<\/td>\n\u2013<\/td>\n\u2013<\/td>\n470\u00b174.4<\/td>\n<\/tr>\n
\u221277.0<\/td>\n\u221280.5<\/td>\n<\/tr>\n
\u7cd6\u5316\u30a2\u30eb\u30d6\u30df\u30f3 (%)<\/td>\n23.47\u00b14.39<\/td>\n20.37\u00b13.58<\/td>\n20.41\u00b13.72<\/td>\n20.44\u00b14.09<\/td>\n20.31\u00b13.90<\/td>\n<\/tr>\n
\u22123.06<\/td>\n\u22122.83<\/td>\n\u22122.85<\/td>\n\u22122.57<\/td>\n<\/tr>\n
\u4f53\u91cd(kg)<\/td>\n70.93\u00b116.40<\/td>\n69.47\u00b116.46<\/td>\n68.91\u00b116.79<\/td>\n68.49\u00b116.76<\/td>\n68.64\u00b117.01<\/td>\n<\/tr>\n
\u22121.65<\/td>\n\u22122.52<\/td>\n\u22122.86<\/td>\n\u22122.71<\/td>\n<\/tr>\n
\u4f53\u91cd\u306e\u5909\u5316 (%)<\/td>\n0.00\u00b10.00<\/td>\n\u22122.45\u00b11.92<\/td>\n\u22123.65\u00b12.42<\/td>\n\u22124.20\u00b12.84<\/td>\n\u22123.95\u00b12.63<\/td>\n<\/tr>\n
\u22122.45<\/td>\n\u22123.65<\/td>\n\u22124.20<\/td>\n\u22123.95<\/td>\n<\/tr>\n
\u8179\u56f2(cm)<\/td>\n92.88\u00b112.11<\/td>\n91.45\u00b112.42<\/td>\n90.20\u00b112.62<\/td>\n89.85\u00b112.57<\/td>\n90.15\u00b112.84<\/td>\n<\/tr>\n
\u22121.39<\/td>\n\u22122.63<\/td>\n\u22123.09<\/td>\n\u22122.86<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3 (\u03bcU\/mL)<\/td>\n12.237 \u00b1 9.031<\/td>\n10.287 \u00b1 7.733<\/td>\n10.003\u00b17.727<\/td>\n10.368 \u00b1 8.346<\/td>\n9.251\u00b17.735<\/td>\n<\/tr>\n
\u22121.926<\/td>\n\u22122.469<\/td>\n\u22122.161<\/td>\n\u22123.490<\/td>\n<\/tr>\n
2\u6642\u9593\u30a4\u30f3\u30b9\u30ea\u30f3 (\u03bcU\/mL)<\/td>\n50.065\u00b147.390<\/td>\n42.358\u00b135.112<\/td>\n\u2013<\/td>\n\u2013<\/td>\n44.051\u00b138.282<\/td>\n<\/tr>\n
\u22128.407<\/td>\n\u22129.020<\/td>\n<\/tr>\n
\u30a4\u30f3\u30b9\u30ea\u30f3\u66f2\u7dda\u4e0b\u9762\u7a4d0 \uff5e 2 \u6642\u9593(\u03bcU h\/mL)<\/td>\n68.5\u00b158.4<\/td>\n63.5\u00b149.2<\/td>\n\u2013<\/td>\n\u2013<\/td>\n67.5\u00b161.0<\/td>\n<\/tr>\n
\u22125.81<\/td>\n\u22124.59<\/td>\n<\/tr>\n
CPR\uff08C-\u30da\u30d7\u30c1\u30c9\uff09 (ng\/mL)<\/td>\n1.92\u00b10.94<\/td>\n1.81\u00b10.91<\/td>\n1.81\u00b10.94<\/td>\n1.73\u00b10.86<\/td>\n1.70\u00b10.88<\/td>\n<\/tr>\n
\u22120.09<\/td>\n\u22120.08<\/td>\n\u22120.17<\/td>\n\u22120.19<\/td>\n<\/tr>\n
\u98df\u5f8c2\u6642\u9593CPR (ng\/mL)<\/td>\n5.04\u00b12.34<\/td>\n5.27\u00b12.56<\/td>\n\u2013<\/td>\n\u2013<\/td>\n5.20\u00b12.45<\/td>\n<\/tr>\n
<\/td>\n0.23<\/td>\n0.15<\/td>\n<\/tr>\n
\u98df\u5f8cCPR\u66f2\u7dda\u4e0b\u9762\u7a4d0 \uff5e 2 \u6642\u9593(ng h\/mL)<\/td>\n6.87\u00b13.17<\/td>\n7.27\u00b13.39<\/td>\n\u2013<\/td>\n\u2013<\/td>\n7.09\u00b13.51<\/td>\n<\/tr>\n
0.384<\/td>\n0.202<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u30b0\u30eb\u30ab\u30b4\u30f3 (pg\/dL)<\/td>\n94.0\u00b126.3<\/td>\n98.5\u00b126.1<\/td>\n99.2\u00b123.6<\/td>\n98.3\u00b122.0<\/td>\n104.5\u00b132.4<\/td>\n<\/tr>\n
4.8<\/td>\n5.7<\/td>\n4.4<\/td>\n11.1<\/td>\n<\/tr>\n
\u98df\u5f8c2\u6642\u9593\u30b0\u30eb\u30ab\u30b4\u30f3 (pg\/mL)<\/td>\n92.4\u00b123.4<\/td>\n93.9\u00b121.4<\/td>\n\u2013<\/td>\n\u2013<\/td>\n98.5\u00b122.8<\/td>\n<\/tr>\n
1.7<\/td>\n7.4<\/td>\n<\/tr>\n
\u98df\u5f8c\u30b0\u30eb\u30ab\u30b4\u30f3\u66f2\u7dda\u4e0b\u9762\u7a4d0 \uff5e 2 \u6642\u9593(pg h\/mL)<\/td>\n203\u00b151.3<\/td>\n207\u00b150.9<\/td>\n\u2013<\/td>\n\u2013<\/td>\n224\u00b157.3<\/td>\n<\/tr>\n
4.52<\/td>\n23.3<\/td>\n<\/tr>\n
\u677e\u7530\u30a4\u30f3\u30c7\u30c3\u30af\u30b9<\/td>\n3.41\u00b12.33<\/td>\n4.61\u00b13.55<\/td>\n\u2013<\/td>\n\u2013<\/td>\n5.32\u00b14.44<\/td>\n<\/tr>\n
1.26<\/td>\n1.94<\/td>\n<\/tr>\n
HOMA-R<\/td>\n5.46\u00b13.89<\/td>\n4.10\u00b13.28<\/td>\n3.79\u00b12.92<\/td>\n3.79\u00b13.05<\/td>\n3.41\u00b12.88<\/td>\n<\/tr>\n
\u22121.34<\/td>\n\u22121.76<\/td>\n\u22121.80<\/td>\n\u22122.19<\/td>\n<\/tr>\n
HOMA-\u03b2 (%)<\/td>\n40.8\u00b136.6<\/td>\n40.9\u00b133.1<\/td>\n43.7\u00b137.3<\/td>\n47.5\u00b142.9<\/td>\n42.2\u00b140.0<\/td>\n<\/tr>\n
0.1<\/td>\n1.8<\/td>\n5.5<\/td>\n\u22121.4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u8868\u306f\u69d8\u3005\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u63a8\u79fb\u3068\u5909\u5316\u91cf\u3067\u3059\u3002<\/p>\n

HbA1c\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30892\u9031\u76ee\u307e\u3067\u306b\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u3001\u3053\u306e\u6e1b\u5c11\u306f 52 \u9031\u76ee\u307e\u3067\u7dad\u6301\u3055\u308c\u307e\u3057\u305f\u3002\u5927\u5e45\u3068\u8a00\u3063\u3066\u3082\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089 52 \u9031\u76ee\u307e\u3067\u306eHbA1c\u306e\u5e73\u5747\u5909\u5316\u306f\u3001\u305f\u3063\u305f-0.68%\u3067\u3059\u30028.52\u304c7.74\u306b\u306a\u3063\u305f\u306b\u3059\u304e\u307e\u305b\u3093\u3002\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3068\u4f53\u91cd\u30822\u9031\u76ee\u4ee5\u964d\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u3001\u3053\u308c\u3089\u306e\u6e1b\u5c11\u306f52\u9031\u76ee\u307e\u3067\u7dad\u6301\u3055\u308c\u307e\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089 52 \u9031\u76ee\u307e\u3067\u306b\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u306f-32.1mg\/dL\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u306e\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u304c180\u3092\u8d85\u3048\u3066\u3044\u305f\u306e\u3067\u300152\u9031\u9593\u5f8c\u3067\u3082\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u306f\u307e\u3060150\u3067\u3059\u3002\u98df\u5f8c2\u6642\u9593\u8840\u7cd6\u5024\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067292.9mg\/dL\u3060\u3063\u305f\u306e\u304c229.3\u3067\u3059\u3002\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3082\u98df\u5f8c\u8840\u7cd6\u5024\u30b9\u30d1\u30a4\u30af\u3082\u3053\u3093\u306a\u30ec\u30d9\u30eb\u30671\u5e74\u3082\u7814\u7a76\u306b\u53c2\u52a0\u3055\u305b\u3089\u308c\u3066\u975e\u5e38\u306b\u304b\u308f\u3044\u305d\u3046\u3067\u3059\u3002<\/p>\n

\u4f53\u91cd\u6e1b\u5c11\u3082\u5927\u5e45\u3068\u8a00\u3063\u3066\u3082-2.71kg \u3067\u3057\u305f\u3002<\/p>\n

\u3069\u306e\u5024\u3082\u6539\u5584\u306f\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u975e\u5e38\u306b\u30b7\u30e7\u30dc\u3044\u30ec\u30d9\u30eb\u3067\u3001\u5065\u5eb7\u306b\u306f\u7a0b\u9060\u3044\u3082\u306e\u3067\u3059\u30021\u5e74\u9593\u3067\u3082\u3053\u306e\u7a0b\u5ea6\u306a\u306e\u3067\u3059\u3002\u3053\u308c\u3063\u3066\u6cbb\u7642\u3068\u547c\u3079\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u4f53\u91cd\u6e1b\u5c11\u304c\u8102\u80aa\uff08\u767d\uff09\u3068\u9664\u8102\u80aa\uff08\u3064\u307e\u308a\u7b4b\u8089\uff1a\u9ed2\uff09\u306e\u3069\u3061\u3089\u304c\u6e1b\u5c11\u3057\u305f\u306e\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u307b\u3068\u3093\u3069\u304c\u8102\u80aa\u306e\u6e1b\u5c11\u3067\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3001C\u30da\u30d7\u30c1\u30c9\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u306e\u63a8\u79fb\u3067\u3059\u300252\u9031\u3067\u6709\u610f\u5dee\u304c\u3042\u308b\u3068\u8a00\u3063\u3066\u3082\u3001\u81e8\u5e8a\u7684\u306b\u306f\u307b\u3068\u3093\u3069\u610f\u5473\u306e\u306a\u3044\u30ec\u30d9\u30eb\u3067\u3057\u3087\u3046\u3002\u305d\u3082\u305d\u3082\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u30b9\u30d1\u30a4\u30af\u304c200\u3092\u8d85\u3048\u308b\u3088\u3046\u306a\u98df\u4e8b\u3092\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u9593\u9055\u3044\u3067\u3059\u3002<\/p>\n

\u91cd\u5927\u306a\u6709\u5bb3\u4e8b\u8c61\u306f4\u4ef6\u3067\u3001\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u3068\u8133\u5e79\u6897\u585e\u3082\u8d77\u3053\u3063\u3066\u3044\u307e\u3059\u3002\u4f4e\u8840\u7cd6\u75c7\u306f5\u4eba\uff086.6%\uff09\u306b\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n

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 <\/p>\n

\u300cSodium-glucose cotransporter-2 inhibitor luseogliflozin added to glucagon-like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: A 52-week, open-label, single-arm study\u300d<\/span><\/p>\n

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