{"id":23936,"date":"2024-04-17T08:47:16","date_gmt":"2024-04-16T23:47:16","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=23936"},"modified":"2024-04-17T08:47:16","modified_gmt":"2024-04-16T23:47:16","slug":"ppi%ef%bc%88%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3%e3%83%9d%e3%83%b3%e3%83%97%e9%98%bb%e5%ae%b3%e8%96%ac%ef%bc%89%e3%81%a8%e5%8e%9f%e5%9b%a0%e5%88%a5%e6%ad%bb%e4%ba%a1%e3%83%aa%e3%82%b9%e3%82%af","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=23936","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u539f\u56e0\u5225\u6b7b\u4ea1\u30ea\u30b9\u30af"},"content":{"rendered":"

PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3068\u30b9\u30bf\u30c1\u30f3\u306f\u30de\u30c3\u30c1\u30dd\u30f3\u30d7\u85ac\u306e\u4e8c\u5927\u5de8\u982d\u3067\u3059\u3002\u7279\u306bPPI\u306f\u69d8\u3005\u306a\u75be\u60a3\u30ea\u30b9\u30af\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\uff08\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u6b7b\u4ea1\u7387\u3092\u5897\u52a0\u3055\u305b\u308b<\/a>\u300d\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u69d8\u3005\u306a\u6b7b\u4ea1\u7387\u3092\u4e0a\u6607\u3055\u305b\u308b\u304b\u3082\u3057\u308c\u306a\u3044<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306fPPI\u3068\u5168\u539f\u56e0\u6b7b\u4ea1\u304a\u3088\u3073\u539f\u56e0\u5225\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

PPI\u306e\u65b0\u898f\u306e\u4f7f\u7528\u8005733,885\u4eba\u3068H2\u30d6\u30ed\u30c3\u30ab\u30fc\u306e\u65b0\u898f\u4f7f\u7528\u8005124,410\u4eba\u3068\u6bd4\u8f03\u3057\u305f\u306e\u3068\u3001PPI\u306e\u65b0\u898f\u4f7f\u7528\u8005689,60\u4eba\u3068\u80c3\u9178\u6291\u5236\u6cbb\u7642\u3092\u884c\u3063\u3066\u3044\u306a\u30441,361,245\u4eba\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u4e0b\u306e2\u3064\u306e\u56f3\u306f\u69d8\u3005\u306a\u539f\u56e0\u3067\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u7dd1\u304cH2\u30d6\u30ed\u30c3\u30ab\u30fc\u4f7f\u7528\u8005\u3001\u30aa\u30ec\u30f3\u30b8\u304cPPI\u4f7f\u7528\u8005\u3067\u3001\u7d2f\u7a4d\u306e\u5168\u539f\u56e0\u6b7b\u4ea1\u7387\u3067\u3059\u3002PPI\u4f7f\u7528\u8005\u306e\u65b9\u304c\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u4e0b\u306e\u8868\u306fH2\u30d6\u30ed\u30c3\u30ab\u30fc\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u305fPPI\u4f7f\u7528\u8005\u306e\u3001\u500b\u3005\u306e\u539f\u56e0\u5225\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/strong><\/td>\nPPI \u4f7f\u7528\u8005\/H2\u30d6\u30ed\u30c3\u30ab\u30fc\u4f7f\u7528\u8005<\/strong><\/td>\n<\/tr>\n
\u6b7b\u56e0<\/strong><\/td>\nHR<\/td>\n95%\u4fe1\u983c\u533a\u9593<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u3059\u3079\u3066\u306e\u539f\u56e0<\/td>\n1.31<\/span><\/td>\n1.26-1.37<\/span><\/td>\n<\/tr>\n
\u611f\u67d3\u6027\u75be\u60a3<\/td>\n1.39<\/span><\/td>\n1.20-1.60<\/span><\/td>\n<\/tr>\n
\u975e\u611f\u67d3\u6027\u75be\u60a3<\/td>\n1.32<\/span><\/td>\n1.27-1.38<\/span><\/td>\n<\/tr>\n
\u30b1\u30ac\/\u5916\u50b7<\/td>\n0.94<\/span><\/td>\n0.74-1.20<\/span><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u816b\u760d<\/td>\n1.62<\/span><\/td>\n1.50-1.74<\/span><\/td>\n<\/tr>\n
\u5fc3\u81d3\u8840\u7ba1\/\u5faa\u74b0\u5668\u7cfb<\/td>\n1.14<\/span><\/td>\n1.07-1.22<\/span><\/td>\n<\/tr>\n
\u6162\u6027\u547c\u5438\u5668\u75be\u60a3<\/td>\n1.33<\/span><\/td>\n1.14-1.55<\/span><\/td>\n<\/tr>\n
\u809d\u786c\u5909<\/td>\n1.90<\/span><\/td>\n1.01-3.56<\/span><\/td>\n<\/tr>\n
\u809d\u786c\u5909\u4ee5\u5916\u306e\u6d88\u5316\u5668\u7cfb<\/td>\n1.39<\/span><\/td>\n1.12-1.74<\/span><\/td>\n<\/tr>\n
\u795e\u7d4c<\/td>\n0.78<\/td>\n0.53-1.15<\/td>\n<\/tr>\n
\u7cbe\u795e\u7684\u304a\u3088\u3073\u884c\u52d5<\/td>\n0.87<\/td>\n0.67-1.13<\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5\u3001\u6ccc\u5c3f\u751f\u6b96\u5668\u3001\u8840\u6db2\u3001\u5185\u5206\u6ccc<\/td>\n1.23<\/span><\/td>\n1.01-1.48<\/span><\/td>\n<\/tr>\n
\u7b4b\u9aa8\u683c\u7cfb<\/td>\n1.03<\/td>\n0.67-1.57<\/td>\n<\/tr>\n
PPI\u306b\u95a2\u9023\u3059\u308b\u500b\u3005\u306e\u539f\u56e0<\/strong><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u80ba\u708e<\/td>\n1.31<\/span><\/td>\n1.11-1.54<\/td>\n<\/tr>\n
\u6025\u6027\u814e\u969c\u5bb3<\/td>\n2.61<\/td>\n0.95-7.17<\/td>\n<\/tr>\n
C.\u30c7\u30a3\u30d5\u30a3\u30b7\u30eb \u8178\u708e<\/td>\n1.57<\/td>\n0.73-3.35<\/td>\n<\/tr>\n
\u5fc3\u623f\u7d30\u52d5\/\u7c97\u52d5<\/td>\n1.04<\/td>\n0.68-1.57<\/td>\n<\/tr>\n
\u5fc3\u4e0d\u5168<\/td>\n1.25<\/td>\n0.94-1.67<\/td>\n<\/tr>\n
\u5927\u52d5\u8108\u7624<\/td>\n1.03<\/td>\n0.67-1.59<\/td>\n<\/tr>\n
\u8a8d\u77e5\u75c7\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5<\/td>\n0.85<\/td>\n0.68-1.08<\/td>\n<\/tr>\n
\u6162\u6027\u814e\u81d3\u75c5<\/td>\n1.63<\/td>\n0.93-2.84<\/td>\n<\/tr>\n
\u9ad8\u8840\u5727\u6027\u5fc3\u75be\u60a3<\/td>\n0.58<\/td>\n0.34-1.00<\/td>\n<\/tr>\n
\u865a\u8840\u6027\u5fc3\u75be\u60a3<\/td>\n1.21<\/span><\/td>\n1.10-1.33<\/span><\/td>\n<\/tr>\n
\u80ba\u304c\u3093<\/td>\n1.89<\/span><\/td>\n1.63-2.20<\/span><\/td>\n<\/tr>\n
\u4e2d\u76ae\u816b<\/td>\n1.60<\/span><\/td>\n1.00-2.57<\/span><\/td>\n<\/tr>\n
\u4e73\u304c\u3093<\/td>\n1.83<\/span><\/td>\n1.45-2.31<\/span><\/td>\n<\/tr>\n
\u809d\u304c\u3093<\/td>\n1.98<\/span><\/td>\n1.23-3.19<\/span><\/td>\n<\/tr>\n
\u524d\u7acb\u817a\u304c\u3093<\/td>\n1.42<\/span><\/td>\n1.03-1.96<\/span><\/td>\n<\/tr>\n
\u80c3\u304c\u3093<\/td>\n2.71<\/span><\/td>\n1.73-4.23<\/span><\/td>\n<\/tr>\n
\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3<\/td>\n2.93<\/span><\/td>\n1.59-5.39<\/span><\/td>\n<\/tr>\n
\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3<\/td>\n1.34<\/span><\/td>\n1.11-1.61<\/span><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u8ee2\u5012\u3092\u9664\u304f\u5076\u767a\u7684\u306a\u5916\u50b7<\/td>\n1.07<\/td>\n0.72-1.59<\/td>\n<\/tr>\n
\u80ba\u585e\u6813\u75c7<\/td>\n1.50<\/td>\n0.98-2.31<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5168\u539f\u56e0\u6b7b\u4ea1\u30671.31\u500d\u3001\u611f\u67d3\u6027\u75be\u60a3\u3067\u30821.39\u500d\u3067\u3059\u3002\u305d\u3057\u3066\u672c\u5f53\u306b\u69d8\u3005\u306a\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u7279\u306b\u304c\u3093\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f\u9ad8\u304f\u3001\u80c3\u304c\u3093\u306f2.71\u500d\u3067\u3059\u3002<\/p>\n

\u4e0b\u306e\u8868\u306fPPI\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u4eba\u3068\u6bd4\u8f03\u3057\u305fPPI\u4f7f\u7528\u8005\u306e\u69d8\u3005\u306a\u6b7b\u4ea1\u30ea\u30b9\u30af\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u6b7b\u56e0<\/strong><\/td>\nHR<\/td>\n95%\u4fe1\u983c\u533a\u9593<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u3059\u3079\u3066\u306e\u539f\u56e0<\/td>\n1.96<\/span><\/td>\n1.94-1.99<\/span><\/td>\n<\/tr>\n
\u611f\u67d3\u6027\u75be\u60a3<\/td>\n1.49<\/span><\/td>\n1.42-1.56<\/span><\/td>\n<\/tr>\n
\u975e\u611f\u67d3\u6027\u75be\u60a3<\/td>\n1.99<\/span><\/td>\n1.96-2.02<\/span><\/td>\n<\/tr>\n
\u30b1\u30ac\/\u5916\u50b7<\/td>\n1.26<\/span><\/td>\n1.17-1.35<\/span><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u816b\u760d<\/td>\n3.74<\/span><\/td>\n3.64-3.84<\/span><\/td>\n<\/tr>\n
\u5fc3\u81d3\u8840\u7ba1\/\u5faa\u74b0\u5668\u7cfb<\/td>\n1.36<\/span><\/td>\n1.33-1.39<\/span><\/td>\n<\/tr>\n
\u6162\u6027\u547c\u5438\u5668\u75be\u60a3<\/td>\n1.46<\/span><\/td>\n1.40-1.53<\/span><\/td>\n<\/tr>\n
\u809d\u786c\u5909<\/td>\n4.10<\/span><\/td>\n3.36-5.01<\/span><\/td>\n<\/tr>\n
\u809d\u786c\u5909\u4ee5\u5916\u306e\u6d88\u5316\u5668\u7cfb<\/td>\n1.88<\/span><\/td>\n1.78-2.00<\/span><\/td>\n<\/tr>\n
\u795e\u7d4c<\/td>\n1.16<\/span><\/td>\n1.08-1.24<\/span><\/td>\n<\/tr>\n
\u7cbe\u795e\u7684\u304a\u3088\u3073\u884c\u52d5<\/td>\n1.07<\/span><\/td>\n1.00-1.15<\/span><\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5\u3001\u6ccc\u5c3f\u751f\u6b96\u5668\u3001\u8840\u6db2\u3001\u5185\u5206\u6ccc<\/td>\n1.60<\/span><\/td>\n1.50-1.71<\/span><\/td>\n<\/tr>\n
\u7b4b\u9aa8\u683c\u7cfb<\/td>\n1.56<\/span><\/td>\n1.35-1.80<\/span><\/td>\n<\/tr>\n
PPI\u306b\u95a2\u9023\u3059\u308b\u500b\u3005\u306e\u539f\u56e0<\/strong><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u80ba\u708e<\/td>\n1.44<\/span><\/td>\n1.37-1.53<\/span><\/td>\n<\/tr>\n
\u6025\u6027\u814e\u969c\u5bb3<\/td>\n1.56<\/span><\/td>\n1.10-2.21<\/span><\/td>\n<\/tr>\n
C.\u30c7\u30a3\u30d5\u30a3\u30b7\u30eb \u8178\u708e<\/td>\n2.16<\/span><\/td>\n1.71-2.74<\/span><\/td>\n<\/tr>\n
\u5fc3\u623f\u7d30\u52d5\/\u7c97\u52d5<\/td>\n1.54<\/span><\/td>\n1.32-1.79<\/span><\/td>\n<\/tr>\n
\u5fc3\u4e0d\u5168<\/td>\n1.87<\/span><\/td>\n1.67-2.10<\/span><\/td>\n<\/tr>\n
\u5927\u52d5\u8108\u7624<\/td>\n1.06<\/td>\n0.97-1.16<\/td>\n<\/tr>\n
\u8a8d\u77e5\u75c7\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5<\/td>\n1.03<\/td>\n0.96-1.09<\/td>\n<\/tr>\n
\u6162\u6027\u814e\u81d3\u75c5<\/td>\n2.11<\/span><\/td>\n1.64-2.71<\/span><\/td>\n<\/tr>\n
\u9ad8\u8840\u5727\u6027\u5fc3\u75be\u60a3<\/td>\n1.02<\/td>\n0.87-1.19<\/td>\n<\/tr>\n
\u865a\u8840\u6027\u5fc3\u75be\u60a3<\/td>\n1.35<\/span><\/td>\n1.31-1.39<\/span><\/td>\n<\/tr>\n
\u80ba\u304c\u3093<\/td>\n3.16<\/span><\/td>\n2.98-3.34<\/span><\/td>\n<\/tr>\n
\u4e2d\u76ae\u816b<\/td>\n3.62<\/span><\/td>\n2.91-4.50<\/span><\/td>\n<\/tr>\n
\u4e73\u304c\u3093<\/td>\n2.80<\/span><\/td>\n2.57-3.04<\/span><\/td>\n<\/tr>\n
\u809d\u304c\u3093<\/td>\n4.72<\/span><\/td>\n3.83-5.82<\/span><\/td>\n<\/tr>\n
\u524d\u7acb\u817a\u304c\u3093<\/td>\n3.14<\/span><\/td>\n2.84-3.48<\/span><\/td>\n<\/tr>\n
\u80c3\u304c\u3093<\/td>\n14.59<\/span><\/td>\n11.16-19.08<\/span><\/td>\n<\/tr>\n
\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3<\/td>\n3.24<\/span><\/td>\n2.80-3.75<\/span><\/td>\n<\/tr>\n
\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3<\/td>\n1.29<\/span><\/td>\n1.22-1.35<\/span><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u8ee2\u5012\u3092\u9664\u304f\u5076\u767a\u7684\u306a\u5916\u50b7<\/td>\n1.28<\/span><\/td>\n1.15-1.43<\/span><\/td>\n<\/tr>\n
\u80ba\u585e\u6813\u75c7<\/td>\n1.43<\/span><\/td>\n1.23-1.67<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u307b\u307c\u3059\u3079\u3066\u306e\u539f\u56e0\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002H2\u30d6\u30ed\u30c3\u30ab\u30fc\u4f7f\u7528\u8005\u3068\u306e\u6bd4\u8f03\u3088\u308a\u3082\u3055\u3089\u306b\u30ea\u30b9\u30af\u5897\u52a0\u304c\u3042\u308a\u307e\u3059\u3002\u5168\u539f\u56e0\u6b7b\u4ea1\u306f1.96\u500d\u3001\u816b\u760d\u5168\u4f53\u30673.74\u500d\u3001\u80ba\u304c\u30933.16\u500d\u3001\u4e73\u304c\u30932.8\u500d\u3001\u809d\u304c\u30934.72\u500d\u3001\u524d\u7acb\u817a\u304c\u30933.14\u500d\u3001\u80c3\u304c\u3093\u306f\u4f55\u306814.59\u500d\u3067\u3059\u3002\u80ba\u585e\u6813\u75c7\u3067\u30821.43\u500d\u3067\u3059\u3002<\/p>\n

\u3042\u306a\u305f\u306f\u305d\u308c\u3067\u3082PPI\u3092\u98f2\u307f\u307e\u3059\u304b\uff1fPPI\u306e\u5371\u967a\u6027\u3092\u5168\u304f\u8aac\u660e\u305b\u305a\u306b\u305a\u3063\u3068\u51e6\u65b9\u3057\u7d9a\u3051\u308b\u533b\u5e2b\u3092\u4fe1\u7528\u3067\u304d\u307e\u3059\u304b\uff1f<\/p>\n

 <\/p>\n

\u300cProton pump inhibitors and risk of all-cause and cause-specific mortality: A cohort study\u300d<\/span><\/p>\n

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