{"id":23955,"date":"2023-10-04T12:06:08","date_gmt":"2023-10-04T03:06:08","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=23955"},"modified":"2023-10-04T12:06:42","modified_gmt":"2023-10-04T03:06:42","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6glp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%82%84sglt-2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%a7%e8%b5%b7%e3%81%93%e3%82%8b","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=23955","title":{"rendered":"\u7cd6\u5c3f\u75c5\u306b\u304a\u3044\u3066GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3084SGLT-2\u963b\u5bb3\u85ac\u3067\u8d77\u3053\u308b\u7b4b\u8089\u91cf\u306e\u6e1b\u5c11"},"content":{"rendered":"

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3084SGLT-2\u963b\u5bb3\u85ac\u306a\u3069\u304c\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u3001\u80a5\u6e80\u306e\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001SUSTAIN 8\u3068\u3044\u3046\u5b89\u5b9a\u3057\u305f\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b2\u578b\u7cd6\u5c3f\u75c5788\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u90311\u56de\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff091.0mg\u30681\u65e51\u56de\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08SGLT-2\u963b\u5bb3\u85ac\uff09300mg\u3092\u6bd4\u8f03\u3059\u308b52\u9031\u9593\u306e\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u306e\u30b5\u30d6\u7814\u7a76\u3067\u3059\u3002178 \u4eba\u306e\u53c2\u52a0\u8005\u306f\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff0888\u4eba\uff09\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f390\u4eba\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308952\u9031\u76ee\u307e\u3067\u306e\u4f53\u91cd\u5909\u5316\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u306f\u5168\u4f53\u306e\u5e73\u5747HbA1c\u306f8.4\u3067\u3001\u4f53\u91cd\u306f88.3kg\u3067\u3057\u305f\u3002\u307e\u305f\u4f53\u7d44\u6210\u306f\u7dcf\u8102\u80aa\u91cf33.2kg\uff0837.6%\uff09\u3001\u7dcf\u9664\u8102\u80aa\u91cf\u304c51.3k\uff0859.4%\uff09\u3001\u304a\u3088\u3073 1.5 kg (0.8) \u3067\u3057\u305f\u3002\u8179\u90e8\u8102\u80aa\u306e 43.9% [15.7]\uff09\u3001\u5185\u81d3\u8102\u80aa\u91cf\u306b\u3064\u3044\u3066\u306f\u3002\u5168\u4f53\u306e\u5e73\u5747 (SD) \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7dcf\u8102\u80aa\u91cf\u3068\u7dcf\u9664\u8102\u80aa\u91cf\u306e\u6bd4\u306f 0.7 (0.2) \u3067\u3057\u305f\u3002<\/p>\n

\u52a0\u8005\u306f\u3001\u5168\u4f53\u306e\u5e73\u5747 (SD) \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3 HbA 1c\u5024\u304c 68.0 mmol\/mol (11.5) [8.4% (1.0)]\u3001\u4f53\u91cd\u304c 88.3 kg (18.2) \u3067\u3057\u305f\u3002\u5168\u4f53\u306e\u5e73\u5747 (SD) \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u4f53\u7d44\u6210\u5024\u306f\u3001\u7dcf\u8102\u80aa\u91cf\u304c 33.2 kg (11.0) \u3068 37.6% (7.8)\u3001\u7dcf\u9664\u8102\u80aa\u91cf\u304c 51.3 kg (10.4) \u3068 59.4% (7.5)\u3001\u5185\u81d3\u8102\u80aa\u91cf\u306f1.5 kg\uff08\u8179\u90e8\u8102\u80aa\u306e43.9%\uff09\u3067\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u30bb\u30de\u30b0\u30eb\u30c1\u30c9( a<\/strong> ) \u304a\u3088\u3073\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3 (\u00a0b<\/strong>\u00a0)\u306b\u3088\u308b 52 \u9031\u9593\u306e\u4f53\u91cd\u6e1b\u5c11\u7387\u3067\u3059\u30021\u5e74\u9593\u3067\u3082\u4f53\u91cd\u304c10\uff05\u4ee5\u4e0a\u6e1b\u5c11\u3057\u305f\u306e\u306fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306720\uff05\u7a0b\u5ea6\u3001SGLT-2\u963b\u5bb3\u85ac\u3067\u306f10\uff05\u7a0b\u5ea6\u3067\u3059\u3002\u307e\u3042\u3001\u75e9\u305b\u306a\u3044\u3088\u308a\u306f\u826f\u3044\u3067\u3059\u304c\u30011\u5e74\u9593\u306e\u7d50\u679c\u3068\u3057\u3066\u306f\u304b\u306a\u308a\u30b7\u30e7\u30dc\u3044\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u30bb\u30de\u30b0\u30eb\u30c1\u30c9 1.0 mg<\/th>\n\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3 300 mg<\/th>\n<\/tr>\n<\/thead>\n
\u7dcf\u8102\u80aa\u91cf<\/td>\n<\/tr>\n
\u2003\u200352\u9031\u76ee\u306e\u5909\u5316\u3001kg<\/td>\n\u22123.41 (0.51)<\/td>\n\u22122.62(0.45)<\/td>\n<\/tr>\n
\u7dcf\u9664\u8102\u80aa\u91cf<\/td>\n<\/tr>\n
\u2003\u200352\u9031\u76ee\u306e\u5909\u5316\u3001kg<\/td>\n\u22122.26\uff080.30\uff09<\/td>\n\u22121.48\uff080.28\uff09<\/td>\n<\/tr>\n
\u7dcf\u8102\u80aa\u3068\u9664\u8102\u80aa\u91cf<\/td>\n<\/tr>\n
\u2003\u200352\u9031\u76ee\u306e\u5909\u5316\u3001kg<\/td>\n\u22125.7<\/td>\n\u22124.1<\/td>\n<\/tr>\n
\u5185\u81d3\u8102\u80aa\u91cf<\/td>\n<\/tr>\n
\u2003\u200352\u9031\u76ee\u306e\u5909\u5316\u3001kg<\/td>\n\u22120.18\uff080.05\uff09<\/td>\n\u22120.11\uff080.04\uff09<\/td>\n<\/tr>\n
\u8179\u56f2\u3001cm<\/td>\n<\/tr>\n
\u3000\u3000<\/sup>52\u9031\u76ee\u306e\u5909\u5316<\/td>\n\u22123.9\uff085.6\uff09<\/td>\n\u22122.5\uff085.5\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u56f3\u3068\u8868\u306f\u4f53\u91cd\u5909\u5316\u304c\u4f53\u7d44\u6210\u306e\u4f55\u304c\u5909\u5316\u3057\u305f\u306e\u304b\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u5168\u4f53\u306e1\u5e74\u9593\u3067\u306e\u4f53\u91cd\u5909\u5316\uff08\u7dcf\u8102\u80aa\u91cf\u3068\u7dcf\u9664\u8102\u80aa\u91cf\u306e\u6e1b\u5c11\u306e\u5408\u8a08\uff09\u306f\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067-5.7kg\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067-4.1kg\u3067\u3057\u305f\u3002<\/p>\n

\u5185\u81d3\u8102\u80aa\u91cf\u306f\u307b\u3068\u3093\u3069\u6e1b\u5c11\u3057\u3066\u3044\u307e\u305b\u3093\u306d\u3002\u6ce8\u76ee\u3059\u3079\u304d\u306f\u9664\u8102\u80aa\u91cf\u306e\u6e1b\u5c11\u3067\u3059\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067-2.26kg\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067-1.48kg\u3067\u3057\u305f\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067\u306f\u4f53\u91cd\u6e1b\u5c11\u306e\u7d0440\uff05\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067\u306f\u7d0436\uff05\u304c\u9664\u8102\u80aa\u3001\u3064\u307e\u308a\u7b4b\u8089\u306e\u6e1b\u5c11\u3067\u8d77\u304d\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u305d\u3057\u3066\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u52b9\u679c\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3084\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001GLP-1\u85ac\u306f\u6b62\u3081\u308c\u3070\u4f53\u91cd\u3082\u691c\u67fb\u30c7\u30fc\u30bf\u3082\u3082\u3068\u306b\u623b\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u60a3\u8005\u3092\u60a3\u8005\u306e\u307e\u307e\u3067\u3044\u3055\u305b\u308b\u85ac\u3067\u3059\u3002\u3082\u3061\u308d\u3093SFLT-2\u85ac\u3082\u540c\u69d8\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u85ac\u3092\u3084\u3081\u3066\u4f53\u91cd\u304c\u623b\u3063\u3066\u3082\u3001\u7b4b\u8089\u306f\u623b\u3089\u306a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u901a\u5e38\u7cd6\u8cea\u5236\u9650\u3067\u306f\u7b4b\u8089\u306f\u6e1b\u5c11\u3057\u307e\u305b\u3093\u3002\u4f53\u91cd\u6e1b\u5c11\u306e\u52b9\u679c\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u4eba\u9593\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u91cd\u8981\u306a\u7b4b\u8089\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u3089\u306e\u85ac\u3067\u4f53\u91cd\u6e1b\u5c11\u304c\u3042\u308b\u304b\u3089\u51e6\u65b9\u3057\u3066\u3044\u308b\u533b\u5e2b\u306e\u3069\u308c\u307b\u3069\u304c\u3001\u7b4b\u8089\u91cf\u6e1b\u5c11\u306e\u5371\u967a\u6027\u3092\u8aac\u660e\u3057\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u7cd6\u5c3f\u75c5\u3092\u6539\u5584\u3001\u75e9\u305b\u308b\u305f\u3081\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002<\/p>\n

\u300cEffects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial\u300d<\/span><\/p>\n

\u300c2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u4f53\u7d44\u6210\u306b\u5bfe\u3059\u308b\u90311\u56de\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u30681\u65e51\u56de\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u52b9\u679c\uff1aSUSTAIN 8\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u81e8\u5e8a\u8a66\u9a13\u306e\u30b5\u30d6\u7814\u7a76\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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8\u3068\u3044\u3046\u5b89\u5b9a\u3057\u305f\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b2\u578b\u7cd6\u5c3f\u75c5788\u4eba\u3092\u5bfe\u8c61\u3068<\/p>\n","protected":false},"author":1,"featured_media":24009,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8,150],"tags":[19,32,60,98],"class_list":["post-23955","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-8","category-diabetes","tag-toushitsuseigen","tag-diabetes","tag-obesity","tag-98","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/10\/27559600_s.jpg?fit=640%2C359&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-6en","jetpack-related-posts":[{"id":29482,"url":"https:\/\/promea2014.com\/blog\/?p=29482","url_meta":{"origin":23955,"position":0},"title":"GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3088\u308b\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u3068\u9aa8\u7c97\u9b06\u75c7","author":"Dr.Shimizu","date":"2025\u5e745\u67081\u65e5","format":false,"excerpt":"GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u4f7f\u7528\u3059\u308b\u3068\u78ba\u304b\u306b\u4f53\u91cd\u306f\u6e1b\u308b\u3067\u3057\u3087\u3046\u3002\u3082\u3061\u308d\u3093\u4f7f\u3063\u3066\u3044\u308b\u9593\u3060\u3051\u3067\u3001\u6b62\u3081\u308c\u3070\u307e\u305f\u2026","rel":"","context":"\u7cd6\u5c3f\u75c5","block_context":{"text":"\u7cd6\u5c3f\u75c5","link":"https:\/\/promea2014.com\/blog\/?cat=150"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/04\/31737382_s.jpg?fit=640%2C479&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/04\/31737382_s.jpg?fit=640%2C479&ssl=1&resize=350%2C200 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