{"id":24045,"date":"2023-11-27T08:45:58","date_gmt":"2023-11-26T23:45:58","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=24045"},"modified":"2023-11-27T08:45:58","modified_gmt":"2023-11-26T23:45:58","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e8%96%ac%ef%bc%9f%e3%82%84%e3%81%9b%e8%96%ac%ef%bc%9fglp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%81%ae%e5%89%af%e4%bd%9c%e7%94%a8%e3%80%80%e3%81%9d-7","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=24045","title":{"rendered":"\u7cd6\u5c3f\u75c5\u85ac\uff1f\u3084\u305b\u85ac\uff1fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u526f\u4f5c\u7528\u3000\u305d\u306e7\u3000\u7532\u72b6\u817a\u304c\u3093"},"content":{"rendered":"

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u69d8\u3005\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\uff08\u300c\u305d\u306e1<\/a>\u300d\u300c\u305d\u306e2<\/a>\u300d\u300c\u305d\u306e3<\/a>\u300d\u300c\u305d\u306e4<\/a>\u300d\u300c\u305d\u306e5<\/a>\u300d\u300c\u305d\u306e6<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

\u3067\u3082\u3053\u306e\u85ac\u306e\u9700\u8981\u306f\u975e\u5e38\u306b\u5927\u304d\u304f\u3001\u88fd\u85ac\u4f1a\u793e\u3082\u533b\u7642\u5074\u3082\u5132\u304b\u308b\u306e\u3067\u3001\u3042\u307e\u308a\u526f\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u8aac\u660e\u3055\u308c\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002<\/p>\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u7532\u72b6\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u80053,746,672\u4eba\u304c\u53c2\u52a0\u3057\u3001\u305d\u306e\u3046\u30614,466\u4eba\u304c\u7532\u72b6\u817a\u304c\u3093\u3092\u767a\u75c7\u3057\u307e\u3057\u305f\u3002\u304c\u3093\u306e\u65e2\u5f80\u6b74\u306e\u3042\u308b\u4eba\u3092\u9664\u5916\u3057\u305f\u5f8c\u3001\u7532\u72b6\u817a\u304c\u3093\u306e\u6210\u4eba2,562\u4eba\u3068\u7532\u72b6\u817a\u304c\u3093\u306e\u306a\u3044\u5bfe\u716745,184\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\"<\/p>\n

\u305d\u306e\u7d50\u679c\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u73fe\u5728\u305d\u306e\u85ac\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u4eba\u306b\u6bd4\u3079\u3066\u3059\u3079\u3066\u306e\u7532\u72b6\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c1.46\u500d\u9ad8\u304f\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u30921\uff5e3\u5e74\u9593\u4f7f\u7528\u3057\u305f\u4eba\u3067\u306f1.58\u500d\u30013\u5e74\u4ee5\u4e0a\u4f7f\u7528\u3057\u305f\u4eba\u3067\u306f1.36\u500d\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u7532\u72b6\u817a\u9ac4\u69d8\u304c\u3093\u306f1.78\u500d\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3067\u3057\u305f\u3002<\/p>\n

DPP-4\u963b\u5bb3\u85ac\u30923\u5e74\u4ee5\u4e0a\u4f7f\u7528\u3057\u305f\u4eba\u306f\u3001\u975e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u7532\u72b6\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u5897\u52a0\u304c1.19\u500d\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u6700\u8fd1\u51fa\u3055\u308c\u305fFDA\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u306b\u304a\u3051\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u7532\u72b6\u817a\u304c\u3093\u3068\u306e\u95a2\u9023\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\u3002\u30d7\u30ec\u30d7\u30ea\u30f3\u30c8\u306a\u306e\u3067\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\uff09<\/p>\n

17,653\u4ef6\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u30b0\u30eb\u30fc\u30d7\u306814,102\u4ef6\u306eSGLT-2\u963b\u5bb3\u85ac\u306e\u5831\u544a\u3092\u542b\u3080\u5408\u8a0831,755\u4ef6\u306e\u5358\u72ec\u7642\u6cd5\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\u3002
\n\u4e0b\u306e\u56f3\u306e\u3088\u3046\u306b\u3001GLP-1\u85ac\u306e\u5358\u72ec\u7642\u6cd5\u306e\u5831\u544a\u3067\u306f\u3001\u7532\u72b6\u817a\u904e\u5f62\u6210\/\u816b\u760d\u306fSGLT-2 \u963b\u5bb3\u5264\u3068\u6bd4\u8f03\u3057\u305f\u5834\u5408\u306e\u5831\u544a\u30aa\u30c3\u30ba\u6bd4 \uff08ROR\uff09 \u306f 21.80\u3067\u3057\u305f\u3002GLP-1\u85ac\u3092\u500b\u5225\u306b\u5206\u6790\u3057\u305f\u5834\u5408\u3001\u3059\u3079\u3066\u306e GLP-1\u85ac\u306f\u3001SGLT-2 \u963b\u5bb3\u85ac\u3068\u6bd4\u8f03\u3057\u3066\u3001ROR\u306f\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\u306a\u3069\uff0920.58\u500d\u3001\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\uff08\u30c8\u30eb\u30ea\u30b7\u30c6\u30a3\uff0917.6\u500d\u3001\u30a8\u30af\u30bb\u30ca\u30c1\u30c9\uff08\u30d0\u30a4\u30a8\u30c3\u30bf\uff097.62\u500d\u3001\u304a\u3088\u3073\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\uff08\u30d3\u30af\u30c8\u30fc\u30b6\uff0935.31\u500d\u3067\u3057\u305f\u3002\uff08\u56f3\u306f\u3053\u306e\u8ad6\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4f8b\u3048\u3070\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\u306e\u6dfb\u4ed8\u6587\u66f8\u306b\u306f\u7532\u72b6\u817a\u306b\u95a2\u3057\u3066\u306f\u6b21\u306e\u3088\u3046\u306a\u3053\u3068\u3057\u304b\u66f8\u304b\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

8.8\uff0e \u672c\u5264\u6295\u4e0e\u4e2d\u306f\u3001\u7532\u72b6\u817a\u95a2\u9023\u306e\u75c7\u5019\u306e\u6709\u7121\u3092\u78ba\u8a8d\u3057\u3001\u7532\u72b6\u817a\u95a2\u9023\u306e\u7570\u5e38\u304c\u8a8d\u3081\u3089\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u5c02\u9580\u533b\u3092\u53d7\u8a3a\u3059\u308b\u3088\u3046\u6307\u5c0e\u3059\u308b\u3053\u3068<\/span><\/p>\n

5.2\uff0e \u975e\u81e8\u5e8a\u8a66\u9a13\u306b\u57fa\u3065\u304f\u60c5\u5831<\/span>
\n\u30e9\u30c3\u30c8\u53ca\u3073\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b2\u5e74\u9593\u304c\u3093\u539f\u6027\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u81e8\u5e8a\u7528\u91cf\u306b\u76f8\u5f53\u3059\u308b\u53c8\u306f\u4e0b\u56de\u308b\u7528\u91cf\uff08\u6700\u5927\u81e8\u5e8a\u7528\u91cf\u3067\u306eAUC\u6bd4\u8f03\u306b\u304a\u3044\u3066\u30e9\u30c3\u30c8\u3067\u306f\u5b9a\u91cf\u4e0b\u9650\u672a\u6e80\u306e\u305f\u3081\u7b97\u51fa\u3067\u304d\u305a\u3001\u30de\u30a6\u30b9\u3067\u7d041.3\u500d\uff09\u3067\u3001\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u306e\u767a\u751f\u983b\u5ea6\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u3002<\/span>
\n\u7532\u72b6\u817a\u9ac4\u69d8\u764c\u306e\u65e2\u5f80\u306e\u3042\u308b\u60a3\u8005\u53ca\u3073\u7532\u72b6\u817a\u9ac4\u69d8\u764c\u53c8\u306f\u591a\u767a\u6027\u5185\u5206\u6ccc\u816b\u760d\u75c72\u578b\u306e\u5bb6\u65cf\u6b74\u306e\u3042\u308b\u60a3\u8005\u306b\u5bfe\u3059\u308b\u3001\u672c\u5264\u306e\u5b89\u5168\u6027\u306f\u78ba\u7acb\u3057\u3066\u3044\u306a\u3044<\/span><\/p>\n

\u3064\u307e\u308a\u3001\u51e6\u65b9\u3055\u308c\u308b\u60a3\u8005\u3055\u3093\u306b\u306f\u6050\u3089\u304f\u7532\u72b6\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u306f\u5168\u304f\u77e5\u3089\u3055\u308c\u3066\u3044\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u7cd6\u5c3f\u75c5\u306e\u5834\u5408\u3001\u7cd6\u8cea\u5236\u9650\u3068\u6bd4\u8f03\u3059\u308b\u306e\u3067\u3042\u308c\u3070\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u5f97\u3089\u308c\u308b\u5229\u76ca\u306f\u9ad8\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u4ed6\u306e\u7cd6\u5c3f\u75c5\u85ac\u3068\u6bd4\u8f03\u3059\u308b\u3068\u5229\u76ca\u306f\u3042\u308b\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u3002\u69d8\u3005\u306a\u30ea\u30b9\u30af\u3092\u8003\u3048\u308c\u3070\u3001\u3053\u306e\u85ac\u3092\u4f7f\u7528\u3059\u308b\u610f\u7fa9\u306f\u5fae\u5999\u3067\u3059\u3002\u533b\u7642\u5074\u306f\u305d\u308c\u306a\u308a\u306b\u9ad8\u3044\u85ac\u306a\u306e\u3067\u4f7f\u3044\u305f\u304c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u3057\u304b\u3057\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u5358\u306b\u7f8e\u5bb9\u3001\u6e1b\u91cf\u76ee\u7684\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u3061\u3083\u3093\u3068\u7406\u89e3\u3057\u3066\u3044\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u75e9\u305b\u305f\u3044\u3068\u601d\u3063\u3066\u4f7f\u3063\u305f\u3089\u7532\u72b6\u817a\u304c\u3093\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u306e\u3067\u306f\u5927\u5909\u3067\u3059\u3002<\/p>\n

\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u526f\u4f5c\u7528\u306e\u306a\u3044\u85ac\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7cd6\u5c3f\u75c5\u3001\u6e1b\u91cf\u306e\u305f\u3081\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u300cGLP-1 Receptor Agonists and the Risk of Thyroid Cancer\u300d<\/span><\/p>\n

\u300cGLP-1 \u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u7532\u72b6\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u69d8\u3005\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\uff08\u300c\u305d\u306e1\u300d\u300c\u305d\u306e2\u300d\u300c\u305d\u306e3\u300d\u300c\u305d\u306e4\u300d\u300c\u305d\u306e5\u300d\u300c\u305d\u306e6\u300d\u53c2\u7167\uff09 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