{"id":24266,"date":"2023-11-28T18:53:56","date_gmt":"2023-11-28T09:53:56","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=24266"},"modified":"2023-11-28T18:53:56","modified_gmt":"2023-11-28T09:53:56","slug":"%e9%81%8e%e4%bd%93%e9%87%8d%e3%81%8a%e3%82%88%e3%81%b3%e8%82%a5%e6%ba%80%e3%81%ae%e4%bb%a3%e8%ac%9d%e6%a9%9f%e8%83%bd%e4%b8%8d%e5%85%a8%e9%96%a2%e9%80%a3%e8%84%82%e8%82%aa%e6%80%a7%e8%82%9d%e7%96%be","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=24266","title":{"rendered":"\u904e\u4f53\u91cd\u304a\u3088\u3073\u80a5\u6e80\u306e\u4ee3\u8b1d\u6a5f\u80fd\u4e0d\u5168\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09\u306b\u5bfe\u3059\u308b\u7cd6\u8cea\u5236\u9650\u306e\u5f71\u97ff"},"content":{"rendered":"

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u306e\u75c5\u540d\u304c\u5909\u308f\u308b\u3051\u3069\u2026<\/a>\u300d\u3067\u3001\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u75be\u60a3\u306e\u75c5\u540d\u304c\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09\u306b\u5909\u308f\u308b\u3053\u3068\u3092\u66f8\u304d\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u5f53\u7136\u539f\u56e0\u306f\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306a\u306e\u3067\u3001\u7cd6\u8cea\u5236\u9650\u304c\u6cbb\u7642\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u8d85\u4f4e\u30ab\u30ed\u30ea\u30fc\u30b1\u30c8\u30f3\u98df \uff08VLCKD\uff09\u306b\u3088\u308b\u6539\u5584\u52b9\u679c\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u8d85\u4f4e\u30ab\u30ed\u30ea\u30fc\u3068\u3044\u3046\u306e\u304c\u5f15\u3063\u639b\u304b\u308a\u307e\u3059\u304c\u3002<\/p>\n

\u5bfe\u8c61\u306f\u300118\uff5e64\u6b73\uff08\u5e73\u5747\u5e74\u9f62\u306f42.14\u6b73\uff09\u3067\u3001BMI25\u4ee5\u4e0a\uff08\u5e73\u574735.59\uff09\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u91cf\u304c\u591a\u304f\u306a\u3044\u4eba87\u4eba\u3067\u3059\u3002<\/p>\n

\u98df\u4e8b\u306f1\u65e5\u306e\u70ad\u6c34\u5316\u7269\u6442\u53d6\u91cf\u304c20\uff5e50g\u306b\u8a2d\u5b9a\u3055\u308c\u30011\u65e5\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\u91cf\u306f1\uff5e1.4g\/kg\u7406\u60f3\u4f53\u91cd\u306b\u56fa\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u63a8\u5968\u3055\u308c\u308b1\u65e5\u306e\u8102\u8cea\u6442\u53d6\u91cf\u306f15\u301c30g\u3067\u3057\u305f\u3002\u307e\u305f\u30011\u65e5\u3042\u305f\u308a\u6700\u4f4e2\u30ea\u30c3\u30c8\u30eb\u306e\u6c34\u304c\u63a8\u5968\u3055\u308c\u3001\u6bce\u65e5800\u30ad\u30ed\u30ab\u30ed\u30ea\u30fc\u672a\u6e80\u306e\u30ab\u30ed\u30ea\u30fc\u3092\u6442\u53d6\u3059\u308b\u3088\u3046\u6307\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u30b1\u30c8\u30f3\u98df\u306e\u671f\u9593\u306f8\u9031\u9593\u3067\u3059\u3002<\/p>\n

\u809d\u8102\u80aa\u306e\u91cf\u306f\u30d5\u30a3\u30d6\u30ed\u30b9\u30ad\u30e3\u30f3\u3068\u3044\u3046\u3082\u306e\u3092\u4f7f\u3044\u3001Controlled Attenuation Parameter\uff08CAP\uff09\u3068\u3044\u3046\u3082\u306e\u3092\u6e2c\u5b9a\u3057\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002CAP\u304c215\uff5e250dB\/m\u306e\u5834\u5408\u306b\u306f\u8efd\u5ea6\u306eMASLD\u304c\u5b58\u5728\u3057\u3001CAP\u304c302dB\/m\u3088\u308a\u9ad8\u3044\u5834\u5408\u306b\u306f\u91cd\u5ea6\u306e\u8102\u80aa\u5909\u6027\u304c\u5b58\u5728\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/div>\n
\u3053\u306e\u7814\u7a76\u306e\u4e3b\u306a\u76ee\u7684\u306f\u809d\u81d3\u306e\u8102\u80aa\u3060\u3051\u3067\u306a\u304f\u3001\u708e\u75c7\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3068\u3057\u3066\u306e\u767d\u8840\u7403\u6570\u304a\u3088\u3073\u8840\u5c0f\u677f\u6570\u3001 hs-PCR\u30ec\u30d9\u30eb\u306e\u5909\u5316\u306b\u5bfe\u3059\u308b 8 \u9031\u9593\u306eVLCKD\u306e\u52b9\u679c\u3092\u898b\u308b\u3053\u3068\u3067\u3059\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/div>\n
<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\nVLCKD\u4ee5\u524d<\/th>\nVLCKD\u5f8c<\/th>\n<\/tr>\n<\/thead>\n
BMI (kg\/m\u00a02<\/sup>\u00a0)<\/td>\n35.59 (6.31)<\/td>\n32.59 (6.06)<\/td>\n<\/tr>\n
\u8179\u56f2(cm)<\/td>\n112.15 (16.17)<\/td>\n103.98 (15.71)<\/td>\n<\/tr>\n
\u53ce\u7e2e\u671f\u8840\u5727 (mmHg)<\/td>\n131.63 (12.42)<\/td>\n123.48 (9.00)<\/td>\n<\/tr>\n
\u62e1\u5f35\u671f\u8840\u5727 (mmHg)<\/td>\n83.62 (9.16)<\/td>\n76.89 (7.22)<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u8840\u7cd6(mg\/dL)<\/td>\n96.10 (13.12)<\/td>\n88.78 (10.05)<\/td>\n<\/tr>\n
\u30a4\u30f3\u30b9\u30ea\u30f3 (\u03bcU\/mL)<\/td>\n16.94 (10.78)<\/td>\n10.25 (6.12)<\/td>\n<\/tr>\n
HOMA \u30a4\u30f3\u30c7\u30c3\u30af\u30b9<\/td>\n4.10 (3.04)<\/td>\n2.28 (1.47)<\/td>\n<\/tr>\n
HbA1c (%)<\/td>\n5.49 (0.52)<\/td>\n5.27 (0.44)<\/td>\n<\/tr>\n
\u4e2d\u6027\u8102\u80aa (mg\/dL)<\/td>\n112.10 (54.79)<\/td>\n89.34 (37.54)<\/td>\n<\/tr>\n
\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb (mg\/dL)<\/td>\n196.34 (49.57)<\/td>\n168.80 (40.40)<\/td>\n<\/tr>\n
HDL \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb (mg\/dL)<\/td>\n52.49 (13.82)<\/td>\n46.77 (11.94)<\/td>\n<\/tr>\n
LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb(mg\/dL)<\/td>\n134.24 (35.51)<\/td>\n113.73 (28.47)<\/td>\n<\/tr>\n
25-OH-\u30d3\u30bf\u30df\u30f3D (ng\/mL)<\/td>\n19.78 (6.05)<\/td>\n25.02 (7.11)<\/td>\n<\/tr>\n
AST (U\/L)<\/td>\n22.33 (10.63)<\/td>\n20.43 (8.71)<\/td>\n<\/tr>\n
ALT(U\/L)<\/td>\n31.07 (23.71)<\/td>\n25.80 (21.07)<\/td>\n<\/tr>\n
\u03b3-GT(U\/L)<\/td>\n25.31 (16.16)<\/td>\n16.84 (8.69)<\/td>\n<\/tr>\n
CAP (db\/m)<\/td>\n287 (255; 325)<\/td>\n230 (188; 278)<\/td>\n<\/tr>\n
CAP \u30ab\u30c6\u30b4\u30ea<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<215db\/m<\/td>\n10 (11%)<\/td>\n33 (38%)<\/td>\n<\/tr>\n
\u2265215db\/m<\/td>\n77 (89%)<\/td>\n54 (62%)<\/td>\n<\/tr>\n
\u4f53\u8102\u80aa\u91cf(kg)<\/td>\n40.17 (13.14)<\/td>\n33.41 (11.91)<\/td>\n<\/tr>\n
\u9664\u8102\u80aa\u4f53\u91cd (kg)<\/td>\n58.80 (13.27)<\/td>\n56.76 (13.08)<\/td>\n<\/tr>\n
hs-CRP<\/td>\n0.42 (0.36)<\/td>\n0.40 (0.34)<\/td>\n<\/tr>\n
\u767d\u8840\u7403\u6570\uff0810\u00a03<\/sup>\u00a0\/\u03bcL\uff09<\/td>\n6.72 (1.37)<\/td>\n5.98 (1.36)<\/td>\n<\/tr>\n
\u8840\u5c0f\u677f (10\u00a03<\/sup>\u00a0\/\u03bcL)<\/td>\n269.72 (54.25)<\/td>\n244.91 (58.32)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u306f8\u9031\u9593\u306eVLCKD\u524d\u5f8c\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u5909\u5316\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u809d\u81d3\u306eCAP\u306f\u3001VLCKD\u5f8c\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002\u8102\u80aa\u75c7\uff08CAP > 215 db\/m\uff09\u3092\u6709\u3059\u308b\u5272\u5408\u306f\u3001VLCKD\u524d\u3067\u306f89%\u3067\u3057\u305f\u304c\u3001VLCKD\u5f8c\u3067\u306f62%\u3068\u306a\u308a\u3001\u7dda\u7dad\u75c7\uff08\u809d\u786c\u3055> 8.2kPA\uff09\u3092\u6709\u3059\u308b\u5272\u5408\u306f68.75 %\u3044\u305f\u306e\u304c\u3001VLCKD\u5f8c\u3067\u306f31.25%\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001ALT\u3068\u03b3GT\u306f\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n

BMI\u3001\u8179\u56f2\u3001\u8102\u80aa\u91cf\u3001\u9664\u8102\u80aa\u91cf\u3001\u53ce\u7e2e\u671f\u8840\u5727\u304a\u3088\u3073\u62e1\u5f35\u671f\u8840\u5727\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3001HbA1c\u3001\u4e2d\u6027\u8102\u80aa\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001HDL \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3059\u3079\u3066\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3093\uff1fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u6e1b\u5c11\uff1f\u3053\u308c\u306f\u8d85\u4f4e\u30ab\u30ed\u30ea\u30fc\u306e\u5f0a\u5bb3\u3067\u3059\u306d\u3002\u8102\u8cea\u6442\u53d6\u91cf\u304c\u5927\u304d\u304f\u6e1b\u5c11\u3057\u305f\u304b\u3089\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

VLCKD\u5f8c\u3001\u767d\u8840\u7403\u6570\u3068\u8840\u5c0f\u677f\u6570\u306f\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001hs-CRP\u306f\u5927\u304d\u306a\u5909\u5316\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u306a\u305c\u304b\u306f\u3088\u304f\u308f\u304b\u308a\u307e\u305b\u3093\u30028\u9031\u9593\u306eVLCKD\u5f8c\u306e\u8840\u5c0f\u677f\u6570\u3068\u767d\u8840\u7403\u6570\u306e\u6e1b\u5c11\u306f\u3001CAP>215dB\/m\u306e\u4eba\u3067\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3057\u305f\u304c\u3001\u809d\u81d3\u306e\u8102\u80aa\u5909\u6027\u306e\u306a\u3044\u4eba\uff08CAP<215dB\/m\uff09\u3067\u306f\u3001\u767d\u8840\u7403\u6570\u304a\u3088\u3073\u8840\u5c0f\u677f\u6570\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3092\u793a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001VLCKD\u5f8c\u306e\u767d\u8840\u7403\u6570\u3068\u8840\u5c0f\u677f\u6570\u306e\u6e1b\u5c11\u306f\u3001\u9ad8\u9f62\u306e\u4eba\u306e\u65b9\u304c\u4f4e\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3082\u306a\u3093\u3067\u3067\u3057\u3087\u3046\uff1f\u3084\u306f\u308a\u9ad8\u9f62\u306b\u306a\u308b\u3068\u6539\u5584\u3059\u308b\u306e\u306b\u3082\u6642\u9593\u304c\u304b\u304b\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u3055\u3089\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001VLCKD\u5f8c\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u3068\u3044\u3046\u3053\u3068\u306f\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u304c\u4f4e\u3044\u3053\u3068\u306f\u6442\u53d6\u4e0d\u8db3\u3068\u3044\u3046\u3088\u308a\u306f\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306e\u5f71\u97ff\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3053\u308c\u306b\u3064\u3044\u3066\u306f\u6b21\u56de\u4ee5\u964d\u3067\u3002<\/p>\n

\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u8102\u80aa\u809d\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u300cEffects of an Eight Week Very Low-Calorie Ketogenic Diet (VLCKD) on White Blood Cell and Platelet Counts in Relation to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Subjects with Overweight and Obesity\u300d<\/span><\/p>\n

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