{"id":24366,"date":"2023-11-13T08:43:10","date_gmt":"2023-11-12T23:43:10","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=24366"},"modified":"2023-11-13T08:43:10","modified_gmt":"2023-11-12T23:43:10","slug":"%e9%99%a4%e8%84%82%e8%82%aa%e9%87%8f%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%83%ac%e3%82%b9%e3%83%9d%e3%83%b3%e3%83%80%e3%83%bc%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%b9%e3%82%bf%e3%83%81%e3%83%b3","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=24366","title":{"rendered":"\u9664\u8102\u80aa\u91cf\u30cf\u30a4\u30d1\u30fc\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u306b\u304a\u3051\u308b\u30b9\u30bf\u30c1\u30f3\u4e2d\u6b62\u3068\u7cd6\u8cea\u5236\u9650\u958b\u59cb\u5f8c\u306e\u51a0\u52d5\u8108\u75be\u60a3\u306e\u6025\u901f\u306a\u9032\u884c\uff1f"},"content":{"rendered":"<p>\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u6284\u9332\u306fAHA Scientific Sessions 2023\u3068\u3044\u3046\u5b66\u4f1a\u306e\u767a\u8868\u3060\u3068\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u975e\u5e38\u306b\u60aa\u610f\u304c\u611f\u3058\u3089\u308c\u307e\u3059\u3002\u9664\u8102\u80aa\u91cf\u30cf\u30a4\u30d1\u30fc\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\uff08lean mass hyper-responders\uff1aLMHR\uff09\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u8868\u73fe\u578b\u306e\u4eba\u306f\u3001\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5927\u304d\u304f\u5897\u52a0\u3057\u307e\u3059\u3002\u79c1\u3082\u305d\u306e\u4e00\u4eba\u3067\u3059\u3002\u4e00\u5fdc\u3053\u306e\u3053\u3068\u3092\u7814\u7a76\u3057\u3066\u3044\u308b\u30b0\u30eb\u30fc\u30d7\u306e\u5b9a\u7fa9\u306f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb200mg\/dL\u4ee5\u4e0a\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb80mg\/dL\u4ee5\u4e0a\u3001\u4e2d\u6027\u8102\u80aa70mg\/dl\u4ee5\u4e0b\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u75c7\u4f8b\u5831\u544a\u3067\u306fLMHR\u306e\u4eba\u304c\u30b9\u30bf\u30c1\u30f3\u3092\u4e2d\u6b62\u3057\u3066\u30b1\u30c8\u30f3\u98df\u3092\u59cb\u3081\u305f\u3089\u6025\u901f\u306b\u51a0\u52d5\u8108\u75be\u60a3\u304c\u9032\u884c\u3057\u305f\u3068\u3044\u3046\u306e\u3067\u3059\u3002\u6284\u9332\u306a\u306e\u3067\u8a73\u7d30\u306a\u4e2d\u8eab\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u306a\u305c\u3053\u308c\u304c\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u3001\u767a\u8868\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u304b\u7406\u89e3\u3067\u304d\u307e\u305b\u3093\u3002\u307e\u3042\u3001\u5b66\u4f1a\u767a\u8868\u30ec\u30d9\u30eb\u306a\u306e\u3067\u3001\u67fb\u8aad\u3068\u3044\u3046\u307b\u3069\u306e\u3082\u306e\u306f\u306a\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u767a\u8868\u306e\u984c\u540d\u306f<span style=\"color: #3366ff;\">\u300cRapid Progression of CAD After Stopping Statin and Starting a Ketogenic Diet in a Phenotypic Lean Mass Hyper-Responder\u300d<\/span><span style=\"color: #3366ff;\">\u300c\u8868\u73fe\u578b\u306e\u9664\u8102\u80aa\u91cf\u30cf\u30a4\u30d1\u30fc\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u306b\u304a\u3044\u3066\u30b9\u30bf\u30c1\u30f3\u3092\u4e2d\u6b62\u3057\u30b1\u30c8\u30f3\u98df\u3092\u958b\u59cb\u3057\u305f\u5f8c\u306eCAD\u306e\u6025\u901f\u306a\u9032\u884c\u300d<\/span>\u3067\u3059\u3002<\/p>\n<p>\u75c7\u4f8b\u306f\u5fc3\u81d3\u306e\u4e0b\u58c1\u306eST\u4e0a\u6607\u578b\u5fc3\u7b4b\u6897\u585e\uff08STEMI\uff09\u3092\u5448\u3059\u308b51\u6b73\u306e\u7537\u6027\u3002BMI\u306f23\u3002\u4ee5\u524d\u306b\u51a0\u52d5\u8108\u306e\u5de6\u524d\u4e0b\u884c\u679d\u8fd1\u4f4d\u90e8\u306bPCI\uff08\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff1a\u30ab\u30c6\u30fc\u30c6\u30eb\u3067\u72ed\u304f\u306a\u3063\u305f\u51a0\u52d5\u8108\u3092\u5e83\u3052\u308b\u6cbb\u7642\uff09\u3092\u53d7\u3051\u3066\u3044\u3066\u3001\u9ad8\u8840\u5727\u3068\u8102\u8cea\u7570\u5e38\u75c7\u3082\u65e2\u5f80\u3068\u65e9\u671f\u306e\u51a0\u52d5\u8108\u75be\u60a3\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u4ee5\u524d\u306e\u30ab\u30c6\u30fc\u30c6\u30eb\u691c\u67fb\u3067\u53f3\u51a0\u52d5\u8108\u306e\u9060\u4f4d\u90e8\u306b\u4e2d\u7b49\u5ea6\u306e\u72ed\u7a84\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u6700\u521d\u306e\u51a0\u52d5\u8108\u306ePCI\u5f8c\u304b\u3089\u30b9\u30bf\u30c1\u30f3\u306e\u4e00\u3064\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\u304c\u51e6\u65b9\u3055\u308c\u3066\u3044\u3066\u3001\u305d\u306e2\u5e74\u534a\u5f8c\u306b\u7b4b\u8089\u75db\u306e\u305f\u3081\u30b9\u30bf\u30c1\u30f3\u3092\u4e2d\u6b62\u3057\u307e\u3057\u305f\u3002\u5f7c\u306f\u30b9\u30bf\u30c1\u30f3\u30922\u5e74\u534a\u306e\u9593\u670d\u7528\u3057\u7d9a\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u671f\u9593\u306f\u30d7\u30e9\u30fc\u30af\u9032\u884c\u306e\u3055\u3089\u306a\u308b\u6e2c\u5b9a\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u30b9\u30bf\u30c1\u30f3\u958b\u59cb\u524d\u306e\u30c7\u30fc\u30bf\u3067\u3001\u300c<span style=\"color: #3366ff;\">\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb207\u3001LDL131\u3001HDL43\u3001\u4e2d\u6027\u8102\u80aa67\u3067\u3001BMI\u306f\u6b63\u5e38\u3067\u3001LMHR\u8868\u73fe\u578b\u3068\u540c\u69d8\u306e\u7279\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/span>\u300d\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u304c\u3001LMHR\u306e\u5b9a\u7fa9\u306b\u5408\u3063\u3066\u3044\u308b\u306e\u306f\u4e2d\u6027\u8102\u80aa\u3060\u3051\u3067\u3059\u3002<\/p>\n<p>\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f380mg\u306e\u6295\u4e0e\u304c\u958b\u59cb\u3055\u308c\u3001LDL\u306f44\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u3092\u4e2d\u6b62\u3057\u305f\u5f8c\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u51a0\u52d5\u8108\u75be\u60a3\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306b\u30b1\u30c8\u30f3\u98df\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001\u30b1\u30c8\u30f3\u98df\u958b\u59cb\u304b\u3089\u3069\u308c\u307b\u3069\u306e\u6642\u9593\u3001\u671f\u9593\u304c\u7d4c\u3063\u305f\u306e\u304b\u5168\u304f\u66f8\u304b\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u5168\u304f\u4e0d\u660e\u306e\u6642\u9593\u306e\u7d4c\u904e\u5f8c\u3001\u4e0b\u58c1\u306eST\u4e0a\u6607\u578b\u5fc3\u7b4b\u6897\u585e\uff08STEMI\uff09\u3092\u8d77\u3053\u3057\u307e\u3057\u305f\u3002\u53f3\u51a0\u52d5\u8108\u4e2d\u9593\u90e8\u306e95\uff05\u306e\u72ed\u7a84\u3068\u53f3\u51a0\u52d5\u8108\u306e\u9060\u4f4d\u90e8\u306e99\uff05\u306e\u9589\u585e\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u30012\u672c\u306e\u85ac\u5264\u6eb6\u51fa\u30b9\u30c6\u30f3\u30c8\u3067\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u53f3\u51a0\u52d5\u8108\u306f\u4ee5\u524d\u306e\u30ab\u30c6\u30fc\u30c6\u30eb\u3067\u3059\u3067\u306b\u4e2d\u7b49\u5ea6\u306e\u72ed\u7a84\u3092\u8a8d\u3081\u3066\u3044\u308b\u51a0\u52d5\u8108\u3067\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306e2\u5e74\u534a\u306e\u9593\u306b\u9032\u884c\u3057\u3066\u3044\u3066\u3082\u4f55\u3089\u4e0d\u601d\u8b70\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002STEMI\u3092\u8d77\u3053\u3057\u305f\u6642\u306e\u30c7\u30fc\u30bf\u3067\u306f\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f388\u3001LDL301\u3001HDL73\u3001TG71\u3001Lp(a) 155nmol\/L\u3067\u3057\u305f\u3002\u3053\u306e\u6642\u70b9\u3067\u3082\u53b3\u5bc6\u306b\u3044\u3048\u3070LMHR\u306e\u5b9a\u7fa9\u306b\u5408\u81f4\u3057\u3066\u304a\u3089\u305a\u3001\u5408\u81f4\u3057\u3066\u3044\u308b\u306e\u306fLDL\u3060\u3051\u3067\u3059\u3002<\/p>\n<p>\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f380mg\u306e\u518d\u958b\u3068PCSK9\u963b\u5bb3\u85ac\u306e\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u307e\u3067\u6295\u4e0e\u3055\u308c\u3066\u3001\u5f7c\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f14\u307e\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002\u6050\u308d\u3057\u3044\u3002<\/p>\n<p>\u5b9a\u7fa9\u7684\u306b\u3082LMHR\u306b\u5f53\u3066\u306f\u307e\u3089\u305a\u3001\u3057\u304b\u3082\u3059\u3067\u306b\u6cbb\u7642\u304c\u5fc5\u8981\u3060\u3063\u305f\u91cd\u7be4\u306a\u51a0\u52d5\u8108\u75be\u60a3\u304c\u3042\u3063\u305f\u3053\u3068\u3084\u5bb6\u65cf\u6b74\u3092\u542b\u3081\u3066\u3001\u30b1\u30c8\u30f3\u98df\u3092\u59cb\u3081\u308b\u307e\u3067\u306e\u72b6\u614b\u304c\u304b\u306a\u308a\u60aa\u3044\u4eba\u3092\u5bfe\u8c61\u306b\u3057\u3066\u3001\u7121\u7406\u3084\u308a\u30b1\u30c8\u30f3\u98df\u306e\u5371\u967a\u6027\u3092\u767a\u8868\u3059\u308b\u3068\u3044\u3046\u306e\u304c\u3001\u60aa\u610f\u3057\u304b\u611f\u3058\u307e\u305b\u3093\u3002\u30b1\u30c8\u30f3\u98df\u3067\u300c\u6025\u901f\u306b\u300d\u9032\u884c\u3057\u305f\u306e\u304b\u3069\u3046\u304b\u3082\u5168\u304f\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u30b9\u30bf\u30c1\u30f3\u306f\u51a0\u52d5\u8108\u306e\u77f3\u7070\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f380mg\u3067\u7dda\u7dad\u30a2\u30c6\u30ed\u30fc\u30e0\u304c10\uff05\u5897\u52a0\u3059\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\uff08<a href=\"https:\/\/www.hmpgloballearningnetwork.com\/site\/jic\/articles\/effect-intensive-atorvastatin-therapy-coronary-atherosclerosis-progression-composition-arte\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u3053\u306e\u75c7\u4f8b\u306e\u51a0\u52d5\u8108\u75be\u60a3\u306e\u9032\u884c\u304c\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4e2d\u6b62\u3068\u30b1\u30c8\u30f3\u98df\u306e\u958b\u59cb\u306b\u3088\u3063\u3066\u8d77\u304d\u305f\u3068\u3044\u3046\u8a3c\u62e0\u306f\u3042\u308a\u307e\u305b\u3093\u3002Lp(a)\u306e\u5897\u52a0\u3092\u6301\u3061\u51fa\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u7cd6\u8cea\u5236\u9650\u3067\u672c\u5f53\u306bLp(a)\u306f\u5897\u52a0\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u3042\u3001\u4e00\u822c\u7684\u306b\u306f\u5fc3\u8840\u7ba1\u7cfb\u306e\u5c02\u9580\u5bb6\u306e\u9593\u3067\u306fLp(a)\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u6050\u3089\u304f\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u540c\u69d8\u306b\u672c\u5f53\u306f\u5927\u3057\u3066\u95a2\u4fc2\u306a\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3057\u304b\u3082\u3001\u8102\u8cea\u3001\u98fd\u548c\u8102\u80aa\u9178\u3092\u6e1b\u3089\u3059\u3068\u3001\u6709\u5bb3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308bLp(a)\u306f\u5897\u52a0\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002\uff08\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=20044\" target=\"_blank\" rel=\"noopener\">\u6700\u8fd1LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089Lp(a)\u304a\u3088\u3073ApoB\u306b\u30b7\u30d5\u30c8\u3057\u3066\u304d\u3066\u3044\u308b\u3000\u305d\u306e2<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=22391\" target=\"_blank\" rel=\"noopener\">\u9838\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u306b\u95a2\u4fc2\u3059\u308b\u306e\u306fLp(a)\u3088\u308a\u3082\u8840\u7cd6\u5024<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n<p>\u662f\u975e\u3001\u3053\u306e\u75c7\u4f8b\u5831\u544a\u306e\u767a\u8868\u5f8c\u3001\u8ad6\u6587\u5316\u3057\u3066\u307b\u3057\u3044\u3082\u306e\u3067\u3059\u3002\u30a6\u30bd\u304c\u3070\u308c\u308b\u306e\u3067\u8ad6\u6587\u5316\u306f\u3067\u304d\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3002\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u300cRapid Progression of CAD After Stopping Statin and Starting a Ketogenic Diet in a 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