{"id":24430,"date":"2023-11-24T08:58:48","date_gmt":"2023-11-23T23:58:48","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=24430"},"modified":"2023-11-24T08:58:48","modified_gmt":"2023-11-23T23:58:48","slug":"ldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e4%bd%8e%e4%b8%8b%e7%99%82%e6%b3%95%e3%82%92%e3%82%82%e3%81%86%e4%b8%80%e5%ba%a6%e8%a6%8b%e7%9b%b4%e3%81%99","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=24430","title":{"rendered":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u7642\u6cd5\u3092\u3082\u3046\u4e00\u5ea6\u898b\u76f4\u3059"},"content":{"rendered":"

\u73fe\u5728\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u4fe1\u7528\u3067\u304d\u307e\u305b\u3093\u304c\u30012004\u5e74\u4ee5\u524d\u306e\u4e00\u90e8\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\u69d8\u3005\u306a\u554f\u984c\u304c\u3042\u308a\u30012005\u5e74\u4ee5\u964d\u81e8\u5e8a\u8a66\u9a13\u306e\u65b0\u3057\u3044\u898f\u5236\u898f\u5247\u304c\u9069\u5fdc\u3055\u308c\u307e\u3057\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u3082\u521d\u671f\u306e\u3053\u308d\u306e\u7814\u7a76\u3067\u306f\u5927\u304d\u306a\u6b7b\u4ea1\u7387\u306e\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u30012005\u5e74\u4ee5\u964d\u306e\u7814\u7a76\u3067\u306f\u4e00\u8cab\u3057\u305f\u6b7b\u4ea1\u7387\u306e\u6539\u5584\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u3082\u3061\u308d\u3093\u3001\u307b\u3068\u3093\u3069\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\u88fd\u85ac\u4f1a\u793e\u304c\u30b9\u30dd\u30f3\u30b5\u30fc\u306a\u306e\u3067\u3001\u88fd\u85ac\u4f1a\u793e\u306b\u3068\u3063\u3066\u90fd\u5408\u306e\u826f\u3044\u7d50\u679c\u304c\u51fa\u3066\u3082\u304a\u304b\u3057\u304f\u306a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u5b9f\u969b\u306e2005\u5e74\u4ee5\u964d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u3001\u7279\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u7642\u6cd5\u3067\u6b7b\u4ea1\u7387\u306b\u5bfe\u3059\u308b\u5229\u76ca\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u3078\u306e\u5229\u76ca\u304c\u3069\u3093\u306a\u3082\u306e\u304b\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u7814\u7a76<\/th>\n\u5e74<\/th>\n\u4ecb\u5165<\/th>\n\u7814\u7a76\u671f\u9593<\/th>\n\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b<\/th>\n\u6b7b\u4ea1\u306b\u5bfe\u3059\u308b\u5229\u76ca<\/th>\n\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u5bfe\u3059\u308b\u5229\u76ca<\/th>\n<\/tr>\n<\/thead>\n
St. Francis<\/td>\n2005<\/td>\nAtorvastatin 20 mg\/d<\/td>\n4.3 y<\/td>\n39%-43% LDL<\/td>\nNR<\/td>\nNo (P<\/em>\u202f=\u202f.08)<\/td>\n<\/tr>\n
TNT<\/td>\n2005<\/td>\nAtorvastatin 10 mg\/d or 80 mg\/d<\/td>\n4.9 y<\/td>\n24% LDL<\/td>\nNo (HR 1.01; 95% CI, 0.85-1.19)<\/td>\nYes (HR 0.78; 95% CI, 0.69-0.89)<\/span><\/td>\n<\/tr>\n
IDEAL<\/td>\n2005<\/td>\nAtorvastatin 80 mg\/d or simvastatin 20 mg\/d<\/td>\n4.8 y<\/td>\n20% LDL<\/td>\nNo (HR 0.98; 95% CI, 0.85-1.13)<\/td>\nNo (HR 0.89; 95% CI, 0.78-1.01)<\/td>\n<\/tr>\n
FIELD<\/td>\n2005<\/td>\nFenofibrate 200 mg\/d<\/td>\n6 y<\/td>\n12% LDL<\/td>\nNo (HR 1.11; 95% CI, 0.95-1.29)<\/td>\nNo (HR 0.89; 95% CI, 0.75-1.05)<\/td>\n<\/tr>\n
4D<\/td>\n2005<\/td>\nAtorvastatin 20 mg\/d<\/td>\n4 y<\/td>\n42% LDL<\/td>\nNo (RR 0.93; 95% CI, 0.79-1.08)<\/td>\nNo (RR 0.92; 95% CI, 0.77-1.10)<\/td>\n<\/tr>\n
ASPEN<\/td>\n2006<\/td>\nAtorvastatin 10 mg\/d<\/td>\n4 y<\/td>\n29% LDL<\/td>\nNo<\/td>\nNo (HR 0.9; 95% CI, 0.73-1.12)<\/td>\n<\/tr>\n
SPARCL<\/td>\n2006<\/td>\nAtorvastatin 80 mg\/d<\/td>\n4.9 y<\/td>\n43% LDL<\/td>\nNo (HR 1.0; 95% CI, 0.82-1.21)<\/td>\nYes (HR 0.84; 95% CI, 0.71-0.99)<\/span><\/td>\n<\/tr>\n
WHI<\/td>\n2006<\/td>\nLow-fat diet<\/td>\n8.1 y<\/td>\n7% LDL<\/td>\nNo (HR 1.01, 95% CI, 0.81-1.27)<\/td>\nNo (HR 0.97; 95% CI, 0.9-1.06)<\/td>\n<\/tr>\n
MEGA<\/td>\n2006<\/td>\nPravastatin 10-20 mg\/d<\/td>\n5.3 y<\/td>\n15% LDL<\/td>\nNo (HR 0.72; 95% CI, 0.51-1.01)<\/td>\nYes (HR 0.67; 95% CI, 0.49-0.91)<\/span><\/td>\n<\/tr>\n
ILLUMINATE<\/td>\n2007<\/td>\nTorcetrapib<\/td>\n2.2 y<\/td>\n25% LDL<\/td>\nNo (HR 1.58; 95% CI, 1.14-2.19)<\/span><\/td>\nNo (HR 1.25; 95% CI, 1.09-1.44)<\/span><\/td>\n<\/tr>\n
CORONA<\/td>\n2007<\/td>\nRosuvastatin 10 mg\/d<\/td>\n33 mo<\/td>\n45% LDL<\/td>\nNo (HR 0.95; 95% CI, 0.86-1.05)<\/td>\nNo (HR 0.92; 95% CI, 0.83-1.02)<\/td>\n<\/tr>\n
SEAS<\/td>\n2008<\/td>\nSimvastatin 40 mg\u202f+\u202fezetimibe 10 mg\/d<\/td>\n4.4 y<\/td>\n50% LDL<\/td>\nNo (HR 1.04; 95% CI, 0.79-1.36)<\/td>\nNo (HR 0.96; 95% CI, 0.83-1.12)<\/td>\n<\/tr>\n
GISSI-HF<\/td>\n2008<\/td>\nRosuvastatin 10 mg\/d<\/td>\n3.9 y<\/td>\n27%-32% LDL<\/td>\nNo (RR 1.00; 95% CI, 0.90-1.22)<\/td>\nNo (HR 1.01; 95% CI, 0.91-1.11)<\/td>\n<\/tr>\n
JUPITER<\/td>\n2008<\/td>\nRosuvastatin 20 mg\/d<\/td>\n1.9 y<\/td>\n49% LDL<\/td>\nYes (HR 0.80; 95% CI, 0.67-0.97)<\/span><\/td>\nYes (HR 0.56; 95% CI, 0.46-0.69)<\/span><\/td>\n<\/tr>\n
AURORA<\/td>\n2009<\/td>\nRosuvastatin 10 mg\/d<\/td>\n3.8 y<\/td>\n43% LDL<\/td>\nNo (HR 0.96; 95% CI, 0.86-1.07)<\/td>\nNo (HR 0.96; 95% CI, 0.84-1.11)<\/td>\n<\/tr>\n
SEARCH<\/td>\n2010<\/td>\nSimvastatin 80 or 20 mg\/d<\/td>\n6.7 y<\/td>\n0.35 mmol\/L LDL<\/td>\nNo (RR 0.99; 95% CI, 0.91-1.09)<\/td>\nNo (RR 0.94; 95% CI, 0.88-1.01)<\/td>\n<\/tr>\n
AIM-HIGH<\/td>\n2011<\/td>\nNiacin ER 1.5-2.0 g\/d<\/td>\n3 y<\/td>\n16% LDL<\/td>\nNo (HR 1.16; 95% CI, 0.87-1.56)<\/td>\nNo (HR 1.02; 95% CI, 0.87-1.21)<\/td>\n<\/tr>\n
SHARP<\/td>\n2011<\/td>\nSimvastatin 20 mg\/d\u202f+\u202fezetimibe 10 mg\/d<\/td>\n4.9 y<\/td>\n31% LDL<\/td>\nNo (RR 1.01; 95% CI, 0.75-1.35) CHD death<\/td>\nYes (RR 0.83; 95% CI, 0.74-0.94)<\/span><\/td>\n<\/tr>\n
SDHS<\/td>\n2013<\/td>\nPUFA or SFA diet<\/td>\n39 mo<\/td>\n7.8% TC<\/td>\nNo (HR 1.62; 95% CI, 1.00-2.64)<\/span><\/td>\nNo (HR 1.70; 95% CI, 1.03-2.80)<\/span><\/td>\n<\/tr>\n
HPS2-THRIVE<\/td>\n2014<\/td>\nNiacin ER 2 g\/d\u202f+\u202flaropiprant 40 mg\/d<\/td>\n3.9 y<\/td>\n16% LDL<\/td>\nNo (RtR 1.09; 95% CI, 0.99-1.21)<\/td>\nNo (RtR 0.96; 95% CI, 0.90-1.03)<\/td>\n<\/tr>\n
IMPROVE-IT<\/td>\n2015<\/td>\nEzetimibe 10 mg\/d<\/td>\n7 y<\/td>\n24% LDL<\/td>\nNo (HR 0.99; 95% CI, 0.91-1.07)<\/td>\nYes (HR 0.94; 95% CI, 0.89-0.99)<\/span><\/td>\n<\/tr>\n
MCE<\/td>\n2016<\/td>\nPUFA or SFA diet<\/td>\n41-56 mo<\/td>\n13% TC<\/td>\nNo (HR 1.22; 95% CI, 1.14-1.32)<\/span><\/td>\nNR<\/td>\n<\/tr>\n
HOPE-3<\/td>\n2016<\/td>\nRosuvastatin 10 mg\/d<\/td>\n5.6 y<\/td>\n26% LDL<\/td>\nNo (HR 0.93; 95% CI, 0.80-1.08)<\/td>\nYes (HR 0.76; 95% CI, 0.64-0.91)<\/span><\/td>\n<\/tr>\n
ACCELERATE<\/td>\n2017<\/td>\nEvacetrapib 130 mg\/d<\/td>\n26 mo<\/td>\n37% LDL<\/td>\nYes (HR 0.84;95% CI, 0.70-1.00)<\/span><\/td>\nNo (HR 1.01; 95% CI, 0.91-1.11)<\/td>\n<\/tr>\n
HIJ-PROPER<\/td>\n2017<\/td>\nEzetimibe 10 mg\/d<\/td>\n3.9 y<\/td>\n15% LDL<\/td>\nNo (HR 0.70; 95% CI, 0.47-1.04)<\/td>\nNo (HR 0.89; 95% CI, 0.76-1.04)<\/td>\n<\/tr>\n
FOURIER<\/td>\n2017<\/td>\nEvolocumab 140 mg q 2 wk or 420 mg\/mo<\/td>\n2.2 y<\/td>\n59% LDL<\/td>\nNo (HR 1.04; 95% CI, 0.91-1.19)<\/td>\nYes (HR 0.85; 95% CI, 0.79-0.92)<\/span><\/td>\n<\/tr>\n
REVEAL<\/td>\n2017<\/td>\nAnacetrapib 100 mg\/d<\/td>\n4.1 y<\/td>\n41% LDL<\/td>\nNo (P<\/em>\u202f=\u202f.46)<\/td>\nYes (RR 0.91; 95% CI, 0.85-0.97)<\/span><\/td>\n<\/tr>\n
EMPATHY<\/td>\n2018<\/td>\nIntensive vs standard dose statin<\/td>\n60 mo<\/td>\n26% LDL<\/td>\nNo (HR 1.21; 95% CI, 0.77-1.91)<\/td>\nNo (HR 0.84; 95% CI, 0.67-1.07)<\/td>\n<\/tr>\n
ODYSSEY<\/td>\n2018<\/td>\nAlirocumab 75-150 mg q 2 wk<\/td>\n2.8 y<\/td>\n55% LDL<\/td>\nYes (HR 0.85, 95% CI, 0.73-0.98)<\/span><\/td>\nYes (HR 0.85; 95% CI, 0.78-0.93)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u306e\u8d64\u3044\u3068\u3053\u308d\u304c\u4ecb\u5165\u3057\u3066\u6b7b\u4ea1\u7387\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3067\u304d\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u9752\u3044\u306e\u306f\u9006\u306b\u6b7b\u4ea1\u3084\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u305f\u3082\u306e\u3067\u3059\u3002\u9752\u3044\u30ea\u30b9\u30af\u5897\u52a0\u306f\u98df\u4e8b\u7642\u6cd5\u307e\u305f\u306fTorcetrapib\u3068\u3044\u3046HDL\u3092\u5897\u52a0\u3055\u305b\u308b\u85ac\u306e\u3082\u306e\u3067\u3059\u3002<\/p>\n

\u85ac\u7269\u7642\u6cd5\u3067\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u306e\u306f\u3001\u305f\u3063\u305f3\u3064\u306e\u7814\u7a76\u3060\u3051\u3067\u3059\u3002CETP\u963b\u5bb3\u5264\u306eEvacetrapib\u3068\u3044\u3046\u85ac\u3092\u4f7f\u3063\u305fACCELERATE\u3068\u3044\u3046\u7814\u7a76\u3067\u306f\u4f55\u3068\u304b\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f\u6e1b\u5c11\u3057\u307e\u3057\u305f\u304c\u3001\u809d\u5fc3\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306f\u5168\u304f\u6e1b\u3089\u305b\u3066\u3044\u307e\u305b\u3093\u3002\uff08\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09<\/p>\n

\u3082\u3046\u4e00\u3064\u306eODYSSEY\u3068\u3044\u3046\u7814\u7a76\u306fPCSK9\u963b\u5bb3\u5264\u306eAlirocumab\u4f7f\u3063\u305f\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3082\u6e1b\u5c11\u3055\u305b\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306e\u4e0a\u5074\u304c\u3059\u3079\u3066\u306e\u6b7b\u4ea1\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3067\u3001\u4e0b\u5074\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u3067\u3059\u3002\u7279\u306b\u6b7b\u4ea1\u306e\u767a\u751f\u7387\u306f\u866b\u773c\u93e1\u3067\u62e1\u5927\u3057\u306a\u3044\u3068\u308f\u304b\u3089\u306a\u3044\u3088\u3046\u306a\u30ec\u30d9\u30eb\u306e\u9055\u3044\u3067\u3059\u3002\u5229\u76ca\u76f8\u53cd\u30d0\u30ea\u30d0\u30ea\u306e\u7814\u7a76\u3067\u3055\u3048\u3001\u3053\u306e\u30ec\u30d9\u30eb\u306e\u9055\u3044\u3057\u304b\u51fa\u307e\u305b\u3093\u3002<\/p>\n

\u5225\u306ePCSK9\u963b\u5bb3\u5264\u306eEvolocumab\u3092FOURIER\u8a66\u9a13\u306f\u6050\u3089\u304f\u4e0d\u6b63\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300cLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4f4e\u3044\u307b\u3069\u826f\u3044\uff1f<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u5fc3\u81d3\u6b7b\u3068\u8840\u7ba1\u6b7b\u3092\u5225\u3005\u306b\u30ab\u30a6\u30f3\u30c8\u3059\u308b\u3068\u3001\u518d\u5224\u5b9a\u5f8c\u306e\u5fc3\u81d3\u6b7b\u306f\u30d7\u30e9\u30bb\u30dc\u7fa488\u4eba\u3088\u308a\u3082\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306e\u65b9\u304c113\u4eba\u3068\u591a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u5927\u306a\u308a\u5c0f\u306a\u308a\u3053\u306e\u3088\u3046\u306a\u30c7\u30fc\u30bf\u306e\u64cd\u4f5c\u306f\u65e5\u5e38\u8336\u98ef\u4e8b\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3092\u6700\u3082\u4f4e\u4e0b\u3055\u305b\u305fJUPITER\u8a66\u9a13\u3067\u306f\u3001\u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3\u3068\u3044\u3046\u30b9\u30bf\u30c1\u30f3\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u3053\u306e\u6b7b\u4ea1\u306e\u7d2f\u7a4d\u767a\u751f\u7387\uff08\u56f3\u306eD\uff09\u3082\u540c\u69d8\u306b\u866b\u773c\u93e1\u3067\u898b\u306a\u3044\u3068\u9055\u3044\u304c\u308f\u304b\u3089\u306a\u3044\u30ec\u30d9\u30eb\u3067\u3059\u306d\u3002\u3053\u308c\u304c\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u3063\u3066\u552f\u4e00\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u305b\u305f\u7814\u7a76\u3067\u3059\u3002<\/p>\n

\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u3063\u305f15\u306e\u7814\u7a76\u306e\u3046\u30616\u3064\u3057\u304b\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u6e1b\u3089\u3059\u3053\u3068\u306f\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u4f55\u5ea6\u3082\u8a00\u3044\u307e\u3059\u304c\u3001\u5229\u76ca\u76f8\u53cd\u30d0\u30ea\u30d0\u30ea\u306a\u306e\u306b\u3001\u3053\u306e\u72b6\u6cc1\u3067\u3059\u3002<\/p>\n

SEAS\u8a66\u9a13\u3067\u306f\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3092\u3069\u3061\u3089\u3082\u6e1b\u3089\u305b\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u304c\u3093\u306e\u767a\u75c7\u3092\u5897\u52a0\u3055\u305b\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\uff08\u4e0b\u306e\u56f3\u306f\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3 – \u30a8\u30bc\u30c1\u30df\u30d6\u7fa4\u3067\u306f\u3001\u304c\u3093\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u306f105\u4eba\uff0811.1%\uff09\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f70\u4eba\uff087.5%\uff09\u3067\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u304c\u3093\u95a2\u9023\u6b7b\u4ea1\u7387\u306f1.67\u500d\u306b\u3082\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u30b9\u30bf\u30c1\u30f3\u304c\u672c\u5f53\u306b\u5fc5\u8981\u306a\u306e\u304b\uff1fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4f4e\u4e0b\u3055\u305b\u308b\u3079\u304d\u306a\u306e\u304b\uff1f\u591a\u304f\u306e\u3053\u308c\u307e\u3067\u306e\u5229\u76ca\u76f8\u53cd\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u308b\u7814\u7a76\u3067\u3055\u3048\u3001\u6b7b\u4ea1\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u307e\u305a\u8003\u3048\u3089\u308c\u307e\u305b\u3093\u3057\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u5bfe\u3059\u308b\u5229\u76ca\u3082\u3054\u304f\u308f\u305a\u304b\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u4ee3\u308f\u308a\u3001\u7cd6\u5c3f\u75c5\u3084\u7b4b\u8089\u306e\u969c\u5bb3\u3001\u304c\u3093\u306a\u3069\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3042\u3068\u306f\u3054\u81ea\u8eab\u3067\u5224\u65ad\u3092\u3002<\/p>\n

\u300cA Reappraisal of the Lipid Hypothesis\u300d<\/span><\/p>\n

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