{"id":24494,"date":"2023-12-05T18:24:54","date_gmt":"2023-12-05T09:24:54","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=24494"},"modified":"2023-12-05T18:24:54","modified_gmt":"2023-12-05T09:24:54","slug":"%e7%b3%96%e8%b3%aa%e5%88%b6%e9%99%90%e3%81%a8sglt2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%80%80%e3%81%a9%e3%81%a3%e3%81%a1%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=24494","title":{"rendered":"\u7cd6\u8cea\u5236\u9650\u3068SGLT2\u963b\u5bb3\u85ac\u3000\u3069\u3063\u3061\uff1f"},"content":{"rendered":"

\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u4e16\u754c\u3067\u306fSGLT2\u963b\u5bb3\u85ac\u304c\u73fe\u5728\u4e00\u62bc\u3057\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u85ac\u306e\u52b9\u679c\u3092\u8a8d\u3081\u308c\u3070\u8a8d\u3081\u308b\u307b\u3069\u3001\u7cd6\u8cea\u5236\u9650\u306e\u7d20\u6674\u3089\u3057\u3055\u3092\u8a8d\u3081\u3056\u308b\u3092\u5f97\u306a\u304f\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u3042\u308c\u3060\u3051\u30b1\u30c8\u30f3\u4f53\u3092\u60aa\u8005\u6271\u3044\u3057\u3066\u3044\u305f\u306e\u306b\u3001SGLT2\u85ac\u306e\u52b9\u679c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u304c\u30b1\u30c8\u30f3\u4f53\u5897\u52a0\u306b\u3042\u308b\u3068\u308f\u304b\u308b\u3068\u3001\u30b1\u30c8\u30f3\u4f53\u306f\u6709\u76ca\u306a\u3082\u306e\u306b\u5909\u308f\u308a\u307e\u3057\u305f\u3002\u624b\u306e\u5e73\u306f\u3059\u3050\u306b\u304b\u3048\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u305d\u308c\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u306f\u7cd6\u8cea\u5236\u9650\u3092\u63a8\u5968\u3057\u307e\u305b\u3093\u3002\u3042\u304f\u307e\u3067\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3055\u305b\u3066\u3001\u85ac\u3067\u6cbb\u7642\u306a\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u814e\u81d3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001\u69d8\u3005\u306a\u7269\u8cea\u3092\u308d\u904e\u3057\u305f\u308a\u3001\u6392\u6cc4\u3057\u305f\u308a\u3001\u518d\u5438\u53ce\u3057\u305f\u308a\u3057\u307e\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u306f\u9ad8\u8840\u7cd6\u3068\u306a\u308a\u307e\u3059\u304c\u3001\u814e\u81d3\u306e\u7cf8\u7403\u4f53\u3067\u308d\u904e\u3055\u308c\u305f\u30d6\u30c9\u30a6\u7cd6\u306f\u3001\u304a\u3088\u305d180 mg\/dL\u306e\u9650\u754c\u307e\u3067\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3067\u518d\u5438\u53ce\u3055\u308c\u307e\u3059\u3002\u305d\u308c\u3092\u8d85\u3048\u308b\u8840\u7cd6\u5024\u3060\u3068\u3001\u5c3f\u306b\u30d6\u30c9\u30a6\u7cd6\u304c\u6392\u6cc4\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u518d\u5438\u53ce\u306e\u4e3b\u5f79\u306fSGLT2\u3067\u3001\u518d\u5438\u53ce\u306e80\uff5e90%\u3092\u62c5\u3044\u3001\u6b8b\u308a\u306e10\uff5e20%\u3092SGLT1\u304c\u62c5\u3044\u307e\u3059\u3002<\/p>\n

\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3068\u306a\u308b\u3068\u3001\u7528\u91cf\u4f9d\u5b58\u7684\u306bSGLT2\u306e\u767a\u73fe\u3092\u5897\u5927\u3055\u305b\u3001\u3053\u306e\u518d\u5438\u53ce\u30b7\u30b9\u30c6\u30e0\u306e\u80fd\u529b\u3092\u5897\u5927\u3055\u305b\u3001\u30d6\u30c9\u30a6\u7cd6\u3060\u3051\u3067\u306a\u304f\u30ca\u30c8\u30ea\u30a6\u30e0\u3082\u518d\u5438\u53ce\u3059\u308b\u80fd\u529b\u304c\u5897\u5927\u3059\u308b\u3068\u3044\u3046\u60aa\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u9ad8\u8840\u7cd6\u3068\u30ca\u30c8\u30ea\u30a6\u30e0\u304a\u3088\u3073\u4f53\u6db2\u8caf\u7559\u304c\u7dad\u6301\u304a\u3088\u3073\u60aa\u5316\u3057\u3001\u7cd6\u5c3f\u75c5\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u9ad8\u8840\u5727\u304c\u60aa\u5316\u3057\u307e\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u5869\u5206\uff08\u30ca\u30c8\u30ea\u30a6\u30e0\uff09\u306f1\u65e5\u306b\u3069\u308c\u304f\u3089\u3044\u7cf8\u7403\u4f53\u3067\u308d\u904e\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\uff1f1 \u65e5\u306b\u308d\u904e\u3055\u308c\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u306f\u591a\u304f\u898b\u7a4d\u3082\u308b\u3068 140mEq\/l\u00d7150 l\/day\uff1d21,000 mEq\u3001\u7d041200g\uff01\u3060\u305d\u3046\u3067\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u4ed6\u306e\u8ad6\u6587\u3067\u306f1\u65e5\u306b500g\u3092\u8d85\u3048\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u304c\u308d\u904e\u3055\u308c\u308b\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u6bce\u65e5\u9a5a\u7570\u7684\u306a\u91cf\u306e\u30ca\u30c8\u30ea\u30a6\u30e0\u304c\u308d\u904e\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u30ca\u30c8\u30ea\u30a6\u30e01200g\u3068\u3059\u308b\u3068\u98df\u5869\u306b\u63db\u7b97\u3059\u308b\u30683048g\u3001\u30ca\u30c8\u30ea\u30a6\u30e0500g\u3068\u3057\u3066\u3082\u98df\u58691270g\u3067\u3059\u30021\u65e5\u306b\u5869\u520610g\u6442\u53d6\u3057\u305f\u3068\u3053\u308d\u3067\u5927\u3057\u305f\u91cf\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n

\u308d\u904e\u3055\u308c\u305f\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u3046\u3061\u3001\u304a\u3088\u305d70\uff05\u306f\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3067\u518d\u5438\u53ce\u3055\u308c\u3001\u6b8b\u308a\u306e30\uff05\u304c\u30d8\u30f3\u30ec\u30eb\u30fc\u30d7\u3068\u3044\u3046\u5834\u6240\u306b\u5230\u9054\u3057\u3001\u3053\u3053\u3067\u30ca\u30c8\u30ea\u30a6\u30e0\u306f\u304a\u3088\u305d1\/6\u306e\u6fc3\u5ea6\u306b\u306a\u308b\u307e\u3067\u518d\u5438\u53ce\u3055\u308c\u3066\u3001\u304a\u3088\u305d5\uff05\uff08\u7d04 1000 mEq\uff1a60 g\uff09\u306e\u307f\u304c\u9060\u4f4d\u5c3f\u7d30\u7ba1\u4ee5\u964d\u306b\u9001\u3089\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u6700\u7d42\u7684\u306b\u5c3f\u4e2d\u306b\u306f 1000 mEq\uff08\u7d04 60 g\uff09\u8fd1\u304f\u7406\u8ad6\u7684\u306b\u306f\u6392\u6cc4\u304c\u53ef\u80fd\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u6b63\u5e38\u306a\u72b6\u614b\u3067\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u306e6%\u306e\u307f\u304cSGLT2\u7d4c\u7531\u3067\u518d\u5438\u53ce\u3055\u308c\u3001SGLT1\u7d4c\u7531\u3067\u306f\u307b\u3068\u3093\u3069\u518d\u5438\u53ce\u3055\u308c\u306a\u3044\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u5f8c\u3084\u7cd6\u5c3f\u75c5\u72b6\u614b\u3067\u8840\u7cd6\u5024\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3067\u518d\u5438\u53ce\u3055\u308c\u305f\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u6700\u592722.8%\u304cSGLT2\u306b\u3088\u308a\u4fdd\u6301\u3055\u308c\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u30022\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u6700\u5927SGLT2\u30d6\u30c9\u30a6\u7cd6\u8f38\u9001\u91cf\u306f500\uff5e600 g\/\u65e5\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u3001SGLT2\u306e\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u518d\u5438\u53ce\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u308d\u904e\u304c500g\u3068\u3059\u308b\u3068\u3001\u2009500\u2009g\/d\u00d7\u200970%\u00d722.8%\uff1d80g \/d\u3067\u3059\u3002\u30ca\u30c8\u30ea\u30a6\u30e0\u308d\u904e\u304c1200g\u3060\u3068\u3059\u308c\u30701200g\/d\u00d7\u200970%\u00d722.8%\uff1d192g \/d\u3067\u3059\u3002<\/p>\n

SGLT2 \u95be\u5024\u3092\u8d85\u3048\u305f\u5834\u5408\u306bSGLT1\u3067\u3082\u518d\u5438\u53ce\u304c\u884c\u308f\u308c\u308b\u3068\u8003\u3048\u308b\u3068\u3001\u9ad8\u8840\u7cd6\u306e\u72b6\u6cc1\u3067\u306f\u3001\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3067SGLT\u3067\u518d\u5438\u53ce\u3055\u308c\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u304c\u6700\u5927100\uff5e240g\u7a0b\u5ea6\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u3001\u307b\u3068\u3093\u3069\u5c3f\u4e2d\u6392\u6cc4\u304c\u306a\u304f\u306a\u308b\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u6050\u3089\u304f\u8a08\u7b97\u4e0a\u307b\u3069\u518d\u5438\u53ce\u306f\u306a\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3002<\/p>\n

\u305d\u3046\u3060\u3068\u3059\u308b\u3068\u3001\u5869\u5206\u5236\u9650\u3063\u3066\u306a\u3093\u306e\u305f\u3081\u3067\u3057\u3087\u3046\uff1f\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u518d\u5438\u53ce\u3001\u6392\u6cc4\u306f\u81ea\u52d5\u5236\u5fa1\u306e\u306f\u305a\u3067\u3059\u3002\u4eba\u9593\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u5869\u5206\u3092\u305f\u304f\u3055\u3093\u6442\u308c\u3070\u6392\u6cc4\u3092\u5897\u3084\u3057\u3001\u5869\u5206\u304c\u8db3\u308a\u306a\u3051\u308c\u3070\u518d\u5438\u53ce\u3092\u5897\u3084\u3059\u3060\u3051\u3067\u3059\u3002\u305d\u306e\u81ea\u52d5\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u7cd6\u8cea\u306b\u3088\u3063\u3066\u5d29\u3055\u308c\u3066\u3057\u307e\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3088\u308a\u5869\u5206\u306e\u904e\u5270\u306a\u518d\u5438\u53ce\u304c\u767a\u751f\u3057\u305f\u3060\u3051\u3067\u3059\u3002\u5869\u5206\u304c\u60aa\u3044\u306e\u3067\u306f\u306a\u304f\u3001\u7cd6\u8cea\u304c\u60aa\u3044\u306e\u3067\u3059\u3002SGLT2\u85ac\u306e\u5229\u70b9\u3092\u793a\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u7cd6\u8cea\u5236\u9650\u3067\u9054\u6210\u3067\u304d\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u9032\u884c\u3057\u3066\u3057\u307e\u3063\u305f\u7cd6\u5c3f\u75c5\u306e\u5834\u5408\u306b\u306fSGLT2\u85ac\u304c\u5fc5\u8981\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

SGLT2\u85ac\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u7cd6\u5c3f\u75c5\u85ac\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u69d8\u3005\u306a\u5229\u70b9\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6bd4\u8f03\u3059\u308b\u306e\u306f\u3042\u304f\u307e\u3067\u3053\u308c\u307e\u3067\u306e\u7cd6\u5c3f\u75c5\u85ac\u3067\u3059\u3002\u7cd6\u8cea\u5236\u9650\u306b\u306f\u6575\u3044\u307e\u305b\u3093\u3002\u6240\u8a6eSGLT2\u85ac\u306b\u3088\u308b1\u65e5\u306e\u30d6\u30c9\u30a6\u7cd6\u306e\u6392\u6cc4\u91cf\u306f60g\uff5e100g\u3067\u3059\u3002\u7cd6\u5c3f\u75c5\u306e\u72b6\u614b\u306b\u3082\u3088\u308a\u307e\u3059\u304c\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306e\u307e\u307e\u3067\u5341\u5206\u306a\u8840\u7cd6\u5024\u3001HbA1c\u306e\u4f4e\u4e0b\u306f\u5f97\u3089\u308c\u307e\u305b\u3093\u3002\uff08\u300cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306bSGLT2\u963b\u5bb3\u85ac\u3092\u52a0\u3048\u305f\u30891\u5e74\u5f8c\u3069\u3046\u306a\u308b\uff1f<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

\u672c\u5f53\u306b\u5fc5\u8981\u306a\u306e\u306f\u3001\u85ac\u3067\u3082\u5869\u5206\u5236\u9650\u3067\u3082\u306a\u304f\u3001\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002<\/p>\n

\u300cThe “discordant doppelganger dilemma”: SGLT2i mimics therapeutic carbohydrate restriction – food choice first over pharma?\u300d<\/span><\/p>\n

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