{"id":25929,"date":"2024-04-05T08:50:54","date_gmt":"2024-04-04T23:50:54","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=25929"},"modified":"2024-04-05T08:50:54","modified_gmt":"2024-04-04T23:50:54","slug":"ppi%ef%bc%88%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3%e3%83%9d%e3%83%b3%e3%83%97%e9%98%bb%e5%ae%b3%e8%96%ac%ef%bc%89%e3%81%a0%e3%81%a3%e3%81%a6%e8%85%8e%e6%a9%9f%e8%83%bd%e9%9a%9c%e5%ae%b3%e3%82%92","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=25929","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3060\u3063\u3066\u814e\u6a5f\u80fd\u969c\u5bb3\u3092\u8d77\u3053\u3059\u306e\u306b"},"content":{"rendered":"

\u30b5\u30d7\u30ea\u3084\u5065\u5eb7\u98df\u54c1\u304c\u5065\u5eb7\u88ab\u5bb3\u3092\u8d77\u3053\u3059\u3068\u5927\u9a12\u304e\u3067\u3059\u3002\u3057\u304b\u3057\u75c5\u9662\u3067\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u85ac\u306f\u5927\u4e08\u592b\u3067\u3059\u304b\uff1f<\/p>\n

\u4ee5\u524d\u306e\u8a18\u4e8b\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u814e\u81d3\u306b\u3082\u826f\u304f\u306a\u3044<\/a>\u300d\u300cPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u6162\u6027\u814e\u75be\u60a3\u3084\u672b\u671f\u814e\u4e0d\u5168\u3092\u5897\u52a0\u3055\u305b\u308b<\/a>\u300d\u306a\u3069\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001PPI\u306f\u814e\u6a5f\u80fd\u969c\u5bb3\u3082\u8d77\u3053\u3059\u85ac\u3067\u3059\u3002<\/p>\n

PPI\u306e\u814e\u6a5f\u80fd\u969c\u5bb3\u6027\u306e\u7814\u7a76\u306f\u4ed6\u306b\u3082\u3044\u3063\u3071\u3044\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u30ea\u30b9\u30af\uff08ARIC\uff09\u7814\u7a76\u306e\u53c2\u52a0\u800510,482\u4eba\u3092\u8ffd\u8de1\u8abf\u67fb\u3057\u305f\u7814\u7a76\u3067\u306f\u3001PPI\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u6162\u6027\u814e\u81d3\u75c5\u306e\u30ea\u30b9\u30af\u306f1.5\u500d\u3001\u6025\u6027\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u306f1.64\u500d\u3067\u3057\u305f\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n

\u5225\u306e\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\u3001\u8868\u306f\u3053\u306e\u8ad6\u6587\u3088\u308a\u6539\u5909\uff095,636\u4eba\u3092\u8ffd\u8de1\u8abf\u67fb\u3057\u305f\u7814\u7a76\u3067\u3001PPI\u4f7f\u7528\u8005\u306f\u975e\u4f7f\u7528\u8005\u3088\u308a\u3082\u9ad8\u3044\u6162\u6027\u814e\u81d3\u75c5\u30ea\u30b9\u30af\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\u8abf\u6574\u5f8c\u306eHR (95%CrI)<\/td>\n<\/tr>\n
PPI\u975e\u4f7f\u7528\u8005\u3068\u306e\u6bd4\u8f03<\/td>\n1.39 (1.15\u20131.61)<\/span><\/td>\n<\/tr>\n
\u3000\u7528\u91cf\u3002\u6a19\u6e96<\/td>\n1.33 (0.90\u20133.31)<\/td>\n<\/tr>\n
\u3000\u7528\u91cf\u3002\u9ad8\u7528\u91cf<\/td>\n2.21 (1.15\u20133.76)<\/span><\/td>\n<\/tr>\n
PPI \u66dd\u9732\u671f\u9593<\/td>\n—<\/td>\n<\/tr>\n
\u30001\u304b\u6708\u672a\u6e80<\/td>\n1.20 (0.50 \uff5e 3.51)<\/td>\n<\/tr>\n
\u30001\uff5e3\u30f6\u6708<\/td>\n1.22 (0.59\u20133.63)<\/td>\n<\/tr>\n
\u30003\uff5e6\u30f6\u6708<\/td>\n1.42 (1.11\u20132.11)<\/span><\/td>\n<\/tr>\n
\u3000> 6\u304b\u6708<\/td>\n1.61 (1.08\u20132.73)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001PPI\u975e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001PPI\u4f7f\u7528\u8005\u306e\u6162\u6027\u814e\u81d3\u75c5\u30ea\u30b9\u30af\u306f1.39\u500d\u3067\u3001\u9ad8\u7528\u91cf\u306ePPI\u3092\u4f7f\u3046\u30682.21\u500d\u306b\u3082\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306bPPI\u4f7f\u7528\u671f\u9593\u304c3\u304b\u6708\u4ee5\u4e0a\u306b\u306a\u308b\u3068\u6709\u610f\u306b\u6162\u6027\u814e\u81d3\u75c5\u30ea\u30b9\u30af\u304c\u4e0a\u304c\u308a\u30016\u304b\u6708\u4ee5\u4e0a\u3067\u306f1.61\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u3067\u306f\u3001\u3082\u3046\u4e00\u3064\u3001\u5c02\u9580\u5bb6\u5927\u597d\u304d\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u7d04260\u4e07\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f4\u4ef6\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u30685\u4ef6\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u3046\u3061534,003\u4eba (20.2%) \u304c PPI\u4f7f\u7528\u8005\u3067\u3057\u305f\u3002\u5206\u6790\u306e\u7d50\u679c\u3001PPI\u4f7f\u7528\u8005\u306f\u6025\u6027\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c1.44\u500d\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\u306e\u30ea\u30b9\u30af\u304c\u4f55\u30683.61\u500d\uff01\u3001\u6162\u6027\u814e\u81d3\u75c5\u304c1.36\u500d\u3001\u672b\u671f\u814e\u4e0d\u5168\u304c1.42\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u30b5\u30d7\u30ea\u3067\u814e\u6a5f\u80fd\u969c\u5bb3\u304c\u8d77\u304d\u308c\u3070\u81ea\u4e3b\u56de\u53ce\u3055\u308c\u307e\u3059\u304c\u3001\u85ac\u3067\u554f\u984c\u304c\u8d77\u304d\u3066\u3082\u3001\u6f2b\u7136\u3068\u51e6\u65b9\u3055\u308c\u7d9a\u3051\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u308b\u3067\u305d\u306e\u85ac\u304c\u539f\u56e0\u3067\u306f\u306a\u3044\u304b\u306e\u3088\u3046\u306b\u3002<\/p>\n

\u53ef\u9006\u7684\u3067\u4e00\u6642\u7684\u306a\u6df1\u523b\u3067\u306f\u306a\u3044\u75c7\u72b6\u3067\u3042\u308c\u3070\u526f\u4f5c\u7528\u3068\u3057\u3066\u3082\u826f\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u85ac\u3092\u98f2\u3093\u3067\u4ed6\u306e\u75be\u60a3\u3092\u60f9\u8d77\u3059\u308b\u3053\u3068\u306f\u526f\u4f5c\u7528\u3067\u306f\u306a\u304f\u5065\u5eb7\u88ab\u5bb3\u3067\u3059\u3002<\/p>\n

\u80c3\u9178\u3092\u6291\u3048\u308bPPI\u3092\u98f2\u3093\u3067\u814e\u6a5f\u80fd\u969c\u5bb3\u3092\u8d77\u3053\u3057\u305f\u308a\u3001\u75c7\u72b6\u306f\u7121\u3044\u306e\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u3068\u3044\u3046\u3060\u3051\u3067\u30b9\u30bf\u30c1\u30f3\u3092\u98f2\u3093\u3067\u7cd6\u5c3f\u75c5\u306b\u306a\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3001\u526f\u4f5c\u7528\u3067\u3059\u304b\uff1f\u526f\u4f5c\u7528\u3068\u3057\u3066\u53d7\u3051\u5165\u308c\u308b\u3079\u304d\u3067\u3059\u304b\uff1f<\/p>\n

 <\/p>\n

\u300cThe association between proton pump inhibitor use and the risk of adverse kidney outcomes: a systematic review and meta-analysis\u300d<\/span><\/p>\n

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