{"id":26215,"date":"2024-05-10T19:07:41","date_gmt":"2024-05-10T10:07:41","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=26215"},"modified":"2024-05-10T19:07:41","modified_gmt":"2024-05-10T10:07:41","slug":"%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%af%e5%8b%95%e8%84%88%e5%a3%81%e3%82%92%e5%ae%b9%e6%98%93%e3%81%ab%e9%80%9a%e9%81%8e","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=26215","title":{"rendered":"\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u52d5\u8108\u58c1\u3092\u5bb9\u6613\u306b\u901a\u904e\u3067\u304d\u308b\uff1f"},"content":{"rendered":"

\u591a\u304f\u306e\u5c02\u9580\u5bb6\u306f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u60aa\u7389\u3068\u8003\u3048\u3001LDL\u304c\u5c0f\u3055\u304f\u306a\u3063\u305fsdLDL\u306e\u65b9\u304c\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u304b\u3089\u52d5\u8108\u306e\u58c1\u3092\u901a\u904e\u3057\u3084\u3059\u3044\u306a\u3069\u3068\u8a00\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5148\u65e5\u306e\u8a18\u4e8b\u300c\u80a5\u6e80\u533b\u5b66\u5354\u4f1a\u3068\u5168\u7c73\u8102\u8cea\u5354\u4f1a\u306b\u3088\u308b\u5c02\u9580\u5bb6\u306e\u5171\u540c\u30ec\u30d3\u30e5\u30fc2024<\/a>\u300d\u306e\u30ec\u30d3\u30e5\u30fc\u306e\u4e2d\u3067\u3082\u3001\u30a6\u30bd\u304c\u3055\u3089\u3063\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300cRemnant lipoproteins may contain up to 4 times more cholesterol per particle than LDL particles, highlighting their atherogenic potential. Additionally, largely due to their small size, triglyceride-rich lipoprotein remnants (i.e., VLDL remnants, IDLs, and chylomicron remnants) readily penetrate the arterial wall. \u300d<\/span><\/p>\n

\u300c\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u3001LDL\u7c92\u5b50\u3088\u308a\u3082\u7c92\u5b50\u3042\u305f\u308a\u6700\u59274\u500d\u591a\u304f\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u751f\u6210\u306e\u53ef\u80fd\u6027\u304c\u5f37\u8abf\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u4e3b\u306b\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u305f\u3081\u3001\u4e2d\u6027\u8102\u80aa\u306b\u5bcc\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30e0\u30ca\u30f3\u30c8\uff08\u3064\u307e\u308a\u3001VLDL\u30ec\u30e0\u30ca\u30f3\u30c8\u3001IDL\u3001\u304a\u3088\u3073\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u30ec\u30e0\u30ca\u30f3\u30c8\uff09\u306f\u52d5\u8108\u58c1\u3092\u5bb9\u6613\u306b\u8cab\u901a\u3057\u307e\u3059\u3002\u300d<\/span><\/p>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u3082\u5c0f\u3055\u3044\u306e\u3067\u52d5\u8108\u58c1\u3092\u901a\u904e\u3057\u3084\u3059\u3044\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u8ad6\u6587\u306f\u3053\u308c<\/a>\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u5143\u306e\u8ad6\u6587\u3092\u8aad\u3093\u3067\u3082\u307b\u3068\u3093\u3069\u540c\u3058\u3053\u3068\u304c\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300cRemnant lipoproteins are cleared by the liver mainly via LDL receptor or penetrate arterial wall, thus contributing to the initiation and progression of atherosclerotic lesions. Unlike chylomicrons and VLDLs which do not penetrate the vessel wall due to their large size, and similarly to LDLs, LRTs remnants, due to the small size, easily pass through the arterial wall and are retained in the sub-endothelium, where they bind to the connective matrix and promote inflammation. \u300d<\/span><\/p>\n

\u300c\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4e3b\u306b LDL \u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u809d\u81d3\u306b\u3088\u3063\u3066\u9664\u53bb\u3055\u308c\u308b\u304b\u3001\u52d5\u8108\u58c1\u306b\u6d78\u900f\u3057\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u75c5\u5909\u306e\u958b\u59cb\u3068\u9032\u884c\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u30b5\u30a4\u30ba\u304c\u5927\u304d\u3044\u305f\u3081\u8840\u7ba1\u58c1\u3092\u900f\u904e\u3057\u306a\u3044\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3084 VLDL\u3068\u306f\u7570\u306a\u308a\u3001LDL\u3068\u540c\u69d8\u306b\u3001\u4e2d\u6027\u8102\u80aa\u306b\u5bcc\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u305f\u3081\u5bb9\u6613\u306b\u52d5\u8108\u58c1\u3092\u901a\u904e\u3057\u3001\u5185\u76ae\u4e0b\u306b\u4fdd\u6301\u3055\u308c\u3001\u305d\u3053\u3067\u7d50\u5408\u3057\u307e\u3059\u3002\u300d<\/span><\/p>\n

\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3084VLDL\u306f\u30b5\u30a4\u30ba\u304c\u5927\u304d\u3044\u306e\u3067\u52d5\u8108\u58c1\u306f\u901a\u8ca8\u3057\u306a\u3044\u3051\u308c\u3069\u3001\u305d\u308c\u304c\u30ec\u30e0\u30ca\u30f3\u30c8\u306b\u306a\u308b\u3068\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\u306a\u308b\u306e\u3067\u52d5\u8108\u58c1\u3092\u901a\u904e\u3059\u308b\u3068\u3044\u3046\u306e\u3067\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3069\u308c\u307b\u3069\u306e\u5927\u304d\u3055\u306a\u3093\u3067\u3057\u3087\u3046\u304b\uff1f\u5225\u306e\u8ad6\u6587\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u69d8\u3005\u306a\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5927\u304d\u3055\u3092\u8868\u3057\u305f\u3082\u306e\u3067\u3059\u3002CM\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3001CM-R\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u30ec\u30e0\u30ca\u30f3\u30c8\u3001VLDL-R\u306fVLDL\u30ec\u30e0\u30ca\u30f3\u30c8\u3067\u3059\u3002\u6a2a\u8ef8\u304c\u7c92\u5b50\u5f84\u3067\u3059\u3002\u6841\u9055\u3044\u306b\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306f\u5927\u304d\u3044\u306e\u3067\u3059\u304c\u3001\u4ee5\u524d\u306e\u7814\u7a76\u3067\u3001\u5927\u304d\u306a\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u304b\u3089\u751f\u6210\u3055\u308c\u308b\u307b\u3068\u3093\u3069\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u300c\u5927\u304d\u306a\u300dVLDL \u307b\u3069\u5c0f\u3055\u304f\u306a\u3089\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3088\u308a\u5927\u304d\u306a\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u307e\u305f\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u30ec\u30e0\u30ca\u30f3\u30c8\u304b\u3089\u306e\u5c0f\u3055\u306a\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u5f62\u6210\u306f\u9650\u3089\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u304a\u3088\u3073 VLDL\u7c92\u5b50\u304cLPL\uff08\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u30ea\u30d1\u30fc\u30bc\uff09\u306b\u3088\u3063\u3066\u52a0\u6c34\u5206\u89e3\u3055\u308c\u3001\u5178\u578b\u7684\u306a\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u7279\u5b9a\u3055\u308c\u308b\u4e2d\u9593\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff08IDL\uff09\u306a\u3069\u306e\u3088\u308a\u5c0f\u3055\u306a\u7c92\u5b50\u306b\u5909\u63db\u3055\u308c\u308b\u3068\u4e00\u822c\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u4e3b\u306b\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3067\u8a8d\u3081\u3089\u308c\u308b\u5927\u304d\u306aVLDL1\u306b\u7531\u6765\u3059\u308b\u5927\u304d\u306a\u30b5\u30a4\u30ba\u306eVLDL\u3067\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u306b\u306a\u3063\u3066\u3082\u7c92\u5b50\u30b5\u30a4\u30ba\u306f\u6bd4\u8f03\u7684\u5927\u304d\u3044\u307e\u307e\u3067\u3042\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001\u5927\u304d\u3055\u3067\u8003\u3048\u308b\u3068\u3001\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u30ec\u30e0\u30ca\u30f3\u30c8\u306fVLDL\u3088\u308a\u3082\u5927\u304d\u3044\u3053\u3068\u3055\u3048\u3042\u308a\u3001VLDL\u30ec\u30e0\u30ca\u30f3\u30c8\u3082\u3082\u3068\u3082\u3068\u5927\u304d\u306aVLDL\u3067\u3001\u305d\u308c\u307b\u3069\u5c0f\u3055\u304f\u306a\u3089\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u305d\u308c\u306f\u5927\u304d\u306a\u826f\u8cea\u306aLDL\u3088\u308a\u3082\u3082\u3063\u3068\u5927\u304d\u306a\u30b5\u30a4\u30ba\u3067\u3059\u3002<\/p>\n

\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3084VLDL\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u304c\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u304b\u3089\u52d5\u8108\u58c1\u3092\u901a\u904e\u3067\u304d\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u307b\u3068\u3093\u3069\u3069\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3082\u5bb9\u6613\u306b\u52d5\u8108\u58c1\u3092\u901a\u904e\u3067\u304d\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u305d\u3093\u306a\u3053\u3068\u304c\u3042\u308b\u308f\u3051\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u52d5\u8108\u58c1\u306f\u5927\u304d\u3055\u3067\u901a\u904e\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u304c\u6c7a\u307e\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u884c\u308f\u308c\u308b\u306f\u305a\u3067\u3059\u3002sdLDL\u3082\u5c0f\u3055\u3044\u304b\u3089\u901a\u904e\u3067\u304d\u308b\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u90fd\u5408\u306e\u826f\u3044\u4eee\u8aac\u3092\u6301\u3061\u51fa\u3057\u3066\u3001\u4f55\u3068\u304bLDL\u3092\u60aa\u8005\u306b\u3059\u308b\u305f\u3081\u306b\u5e73\u6c17\u3067\u30a6\u30bd\u3092\u3064\u3044\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n

sdLDL\u3082\u30ec\u30e0\u30ca\u30f3\u30c8\u3082\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3068\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3089\u304c\u60aa\u3055\u3092\u3059\u308b\u3068\u3044\u3046\u3088\u308a\u3082\u3001\u305d\u308c\u3089\u304c\u5897\u52a0\u3059\u308b\u72b6\u614b\u3001\u3064\u307e\u308a\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306a\u3069\u306e\u72b6\u614b\u304c\u554f\u984c\u306a\u306e\u3067\u3059\u3002<\/p>\n

\u5fc3\u8840\u7ba1\u75be\u60a3\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u3002<\/p>\n

\u300cRemnant Lipoproteins: A Subfraction of Plasma Triglyceride-Rich Lipoproteins Associated with Postprandial Hyperlipidemia\u300d<\/span><\/p>\n

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