{"id":26795,"date":"2024-07-02T15:52:06","date_gmt":"2024-07-02T06:52:06","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=26795"},"modified":"2024-07-02T15:52:06","modified_gmt":"2024-07-02T06:52:06","slug":"%e3%83%9e%e3%82%a6%e3%82%b9%e3%82%a6%e3%82%a9%e3%83%83%e3%82%b7%e3%83%a5%e3%81%af%e6%ad%a2%e3%82%81%e3%82%88%e3%81%86%e3%80%80%e3%81%9d%e3%81%ae4%e3%80%80%e9%99%a2%e5%86%85%e6%ad%bb%e4%ba%a1%e3%83%aa","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=26795","title":{"rendered":"\u30de\u30a6\u30b9\u30a6\u30a9\u30c3\u30b7\u30e5\u306f\u6b62\u3081\u3088\u3046\u3000\u305d\u306e4\u3000\u9662\u5185\u6b7b\u4ea1\u30ea\u30b9\u30af\u5897\u52a0"},"content":{"rendered":"<p>\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=26514\" target=\"_blank\" rel=\"noopener\">\u305d\u306e1<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=26574\" target=\"_blank\" rel=\"noopener\">\u305d\u306e2<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=26575\" target=\"_blank\" rel=\"noopener\">\u305d\u306e3<\/a>\u300d\u3067\u306f\u30de\u30a6\u30b9\u30a6\u30a9\u30c3\u30b7\u30e5\u3068\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u304c\u3093\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u66f8\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u901a\u5e38\u306e\u30de\u30a6\u30b9\u30a6\u30a9\u30c3\u30b7\u30e5\u3068\u306f\u3061\u3087\u3063\u3068\u9055\u3044\u307e\u3059\u304c\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3067\u3059\u3002<\/p>\n<p>\u5065\u5eb7\u306a\u4eba\u306e\u65e5\u5e38\u306e\u30de\u30a6\u30b9\u30a6\u30a9\u30c3\u30b7\u30e5\u306e\u4f7f\u7528\u3068\u6b7b\u4ea1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u5165\u9662\u4e2d\u3001\u7279\u306b\u96c6\u4e2d\u6cbb\u7642\u5ba4\uff08ICU\uff09\u3067\u306e\u53e3\u8154\u30b1\u30a2\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8a8d\u8b58\u3055\u308c\u3001\u4eba\u5de5\u547c\u5438\u5668\u95a2\u9023\u80ba\u708e\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u53e3\u8154\u30b1\u30a2\u304c\u63a8\u5968\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\uff08\u4eca\u306f\u3069\u3046\u304b\u308f\u304b\u308a\u307e\u305b\u3093\uff09<\/p>\n<p>\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u53e3\u8154\u30b1\u30a2\u3063\u3066\u672c\u5f53\u306b\u9662\u5185\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u52b9\u679c\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3044\u304f\u3064\u304b\u306e\u8ad6\u6587\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u3044\u308f\u3086\u308b\u3046\u304c\u3044\u3068\u3057\u3066\u306e\u30de\u30a6\u30b9\u30a6\u30a9\u30c3\u30b7\u30e5\u3068\u3044\u3046\u3088\u308a\u306f\u3001\u81ea\u5206\u3067\u53e3\u8154\u30b1\u30a2\u304c\u3067\u304d\u306a\u3044\u4eba\u306e\u305f\u3081\u306e\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u306e\u4f7f\u7528\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n<p>\u307e\u305a\u306f3630\u4eba\u306eICU\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f12\u4ef6\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24663255\/\" target=\"_blank\" rel=\"noopener\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u5fc3\u81d3\u624b\u8853\u3068\u975e\u5fc3\u81d3\u624b\u8853\u3068\u306b\u5206\u3051\u3066\u3044\u307e\u3059\u3002\u7121\u4f5c\u70ba\u306b\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u3092\u4f7f\u308f\u308c\u305f\u5fc3\u81d3\u624b\u8853\u60a3\u8005\u3067\u306f\u4e0b\u6c17\u9053\u611f\u67d3\u75c7\u304c\u6709\u610f\u306b\u5c11\u306a\u304f\u30010.56\u500d\u3067\u3057\u305f\u304c\u3001\u975e\u5fc3\u81d3\u624b\u8853\u60a3\u8005\u3067\u306f\u4eba\u5de5\u547c\u5438\u5668\u95a2\u9023\u80ba\u708e\u306e\u30ea\u30b9\u30af\u306b\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5fc3\u81d3\u624b\u8853\u3067\u306f\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u9593\u306b\u6b7b\u4ea1\u7387\u306e\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u975e\u5fc3\u81d3\u624b\u8853\u3067\u306f\u6b7b\u4ea1\u7387\u304c\u6709\u610f\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u304c1.13\u500d\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u4eba\u5de5\u547c\u5438\u5668\u306e\u5e73\u5747\u671f\u9593\u307e\u305f\u306f\u96c6\u4e2d\u6cbb\u7642\u5ba4\u5728\u9662\u671f\u9593\u306b\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u5225\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24687313\/\" target=\"_blank\" rel=\"noopener\">\u3053\u306e\u8ad6\u6587<\/a>\u53c2\u7167\uff09\u5fc3\u81d3\u624b\u8853\u3084\u809d\u81d3\u79fb\u690d\u306a\u3069\u3092\u9664\u3044\u305f\u3001\u4e00\u822cICU\u306e2618\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f11\u4ef6\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u53e3\u8154\u30b1\u30a2\u3067\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u3092\u4f7f\u3046\u3068\u6b7b\u4ea1\u3059\u308b\u53ef\u80fd\u6027\u304c1.25\u500d\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306e\u7814\u7a76\u3067\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27428482\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09\u5c11\u306a\u304f\u3068\u30823\u65e5\u9593\u306e\u4eba\u5de5\u547c\u5438\u5668\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b5539\u4eba\u304c\u5bfe\u8c61\u3067\u3059\u3002\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u306e\u4f7f\u7528\u306b\u3088\u308a\u4eba\u5de5\u547c\u5438\u5668\u6b7b\u4ea1\u7387\u304c\u4e0a1.63\u500d\u4e0a\u6607\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u5225\u306e\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29744564\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09\u3053\u306e\u7d50\u679c\u306f\u9a5a\u304d\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u306fICU\u60a3\u8005\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u75c5\u9662\u5168\u4f53\u306e\u4e00\u822c\u306e\u5165\u9662\u60a3\u800582,274\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u3046\u3061\u300111,139\u4eba\u304c\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u53e3\u8154\u30b1\u30a2\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u53e3\u8154\u30b1\u30a2\u306f\u3001\u81ea\u7acb\u3057\u305f\u60a3\u8005\u306b\u306f\u3046\u304c\u3044\u3068\u5410\u304d\u51fa\u3057\u6cd5\u3092\u3001\u4ecb\u52a9\u304c\u5fc5\u8981\u306a\u60a3\u8005\u306b\u306f\u770b\u8b77\u5e2b\u304c\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u3092\u6d78\u3057\u305f\u30ac\u30fc\u30bc\u3067\u53e3\u8154\u3092\u6d17\u6d44\u3057\u3001\u4e00\u822c\u75c5\u68df\u3067\u306f1\u65e52\u56de\u3001ICU\u3067\u306f1\u65e53\u56de\u9069\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u66dd\u9732\u306f\u3001\u305d\u308c\u305e\u308c\u4f4e\u66dd\u9732\uff08\u2264 300mg\uff09\u307e\u305f\u306f\u9ad8\u66dd\u9732\uff08&gt; 300mg\uff09\u306b\u5206\u3051\u307e\u3057\u305f\u3002300mg\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u306f\u30010.12%\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u306e\u6a19\u6e96\u30dc\u30c8\u30eb250mL\u306e\u5185\u5bb9\u91cf\u306b\u76f8\u5f53\u3057\u3001\u53e3\u8154\u30b1\u30a21\u56de\u3042\u305f\u308a\u306b\u4f7f\u7528\u3055\u308c\u308b\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u6eb6\u6db2\u306e\u5e73\u5747\u91cf\u306f\u7d0415 mL\u3067\u3042\u308b\u305f\u3081\u30011\u65e53\u56de\u306e\u53e3\u8154\u30b1\u30a2\u3067300mg\u3092\u8d85\u3048\u308b\u4f7f\u7528\u306f 5\uff5e6\u65e5\u3092\u8d85\u3048\u308b\u66dd\u9732\u6642\u9593\u306b\u306a\u308a\u307e\u3059\u3002\uff08\u8868\u306f\u3053\u306e\u8ad6\u6587\u3088\u308a\u6539\u5909\uff09\uff09<\/p>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" style=\"width: 73.1533%; height: 129px;\" frame=\"hsides\" rules=\"groups\">\n<thead>\n<tr>\n<th style=\"width: 50.5618%;\" colspan=\"2\" align=\"left\"><\/th>\n<th style=\"width: 49.3314%;\" align=\"left\">\u30aa\u30c3\u30ba\u6bd4<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 99.8932%;\" colspan=\"3\" align=\"left\">\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u53e3\u8154\u30b1\u30a2<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50.5618%;\" colspan=\"2\" align=\"left\">\u00a0\u306a\u3057\uff080 mg\uff09<\/td>\n<td style=\"width: 49.3314%;\" align=\"left\">1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50.5618%;\" colspan=\"2\" align=\"left\">\u00a0\u4f4e\uff08\u2264 300 mg\uff09<\/td>\n<td style=\"width: 49.3314%;\" align=\"left\">2.61 (2.32\u20132.92)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50.5618%;\" colspan=\"2\" align=\"left\">\u00a0\u9ad8\uff08&gt; 300 mg\uff09<\/td>\n<td style=\"width: 49.3314%;\" align=\"left\">2.73 (2.35\u20133.16)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u3092\u4f7f\u3063\u3066\u306a\u3044\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4f4e\u30ec\u30d9\u30eb\u306e\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u66dd\u9732\uff08\u7d2f\u7a4d\u6295\u4e0e\u91cf\u2264300 mg\uff09\u3067\u306f\u6b7b\u4ea1\u3059\u308b\u53ef\u80fd\u6027\u306f2.61\u500d\u3001\u3068\u9ad8\u30ec\u30d9\u30eb\u306e\u66dd\u9732\uff08\u7d2f\u7a4d\u6295\u4e0e\u91cf&gt; 300 mg\uff09\u3067\u306f2.73\u500d\u3067\u3057\u305f\u3002<\/p>\n<div class=\"caption\">\n<p>\u4e0b\u306e\u8868\u306f\u6b7b\u4ea1\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5f93\u3063\u3066\u7d30\u5206\u5316\u3055\u308c\u305f\u60a3\u8005\u306e\u6b7b\u4ea1\u7387\u3068\u306e\u95a2\u9023\u3067\u3059\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" style=\"width: 99.8519%;\" frame=\"hsides\" rules=\"groups\">\n<thead>\n<tr>\n<th style=\"width: 21.4351%;\" colspan=\"2\" align=\"left\"><\/th>\n<th style=\"width: 26.528%;\" align=\"left\">\u6b7b\u4ea1\u30ea\u30b9\u30af\u6975\u3081\u3066\u91cd\u5ea6\uff08\u30ab\u30c6\u30b4\u30ea\u30fc4\uff09<\/th>\n<th style=\"width: 26.0078%;\" align=\"left\">\u6b7b\u4ea1\u30ea\u30b9\u30af\u91cd\u5ea6\uff08\u30ab\u30c6\u30b4\u30ea\u30fc3\uff09<\/th>\n<th style=\"width: 25.8778%;\" align=\"left\">\u6b7b\u4ea1\u30ea\u30b9\u30af\u8efd\u5ea6\/\u4e2d\u7b49\u5ea6\uff08\u30ab\u30c6\u30b4\u30ea\u30fc1\u304a\u3088\u30732\uff09<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 99.8487%;\" colspan=\"5\" align=\"left\">\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u53e3\u8154\u30b1\u30a2<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.4351%;\" colspan=\"2\" align=\"left\">\u306a\u3057\uff080 mg\uff09<\/td>\n<td style=\"width: 26.528%;\" align=\"left\">1<\/td>\n<td style=\"width: 26.0078%;\" align=\"left\">1<\/td>\n<td style=\"width: 25.8778%;\" align=\"left\">1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.4351%;\" colspan=\"2\" align=\"left\">\u00a0\u4f4e\uff08\u2264 300 mg\uff09<\/td>\n<td style=\"width: 26.528%;\" align=\"left\">1.13 (0.90\u20131.41)<\/td>\n<td style=\"width: 26.0078%;\" align=\"left\"><span style=\"color: #ff0000;\">2.33 (1.96\u20132.78)<\/span><\/td>\n<td style=\"width: 25.8778%;\" align=\"left\"><span style=\"color: #ff0000;\">5.50 (4.51\u20136.71)<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.4351%;\" colspan=\"2\" align=\"left\">\u00a0\u9ad8\uff08&gt; 300 mg\uff09<\/td>\n<td style=\"width: 26.528%;\" align=\"left\">1.14 (0.90\u20131.44)<\/td>\n<td style=\"width: 26.0078%;\" align=\"left\"><span style=\"color: #ff0000;\">3.11 (2.45\u20133.92)<\/span><\/td>\n<td style=\"width: 25.8778%;\" align=\"left\"><span style=\"color: #ff0000;\">4.97 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