{"id":26872,"date":"2024-07-11T17:13:23","date_gmt":"2024-07-11T08:13:23","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=26872"},"modified":"2024-07-11T17:13:23","modified_gmt":"2024-07-11T08:13:23","slug":"ppi%ef%bc%88%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3%e3%83%9d%e3%83%b3%e3%83%97%e9%98%bb%e5%ae%b3%e8%96%ac%ef%bc%89%e3%81%af%e5%b0%8f%e8%85%b8%e3%82%92%e6%90%8d%e5%82%b7%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=26872","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u5c0f\u8178\u3092\u640d\u50b7\u3059\u308b"},"content":{"rendered":"

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\u307e\u305a\u306f\u3001\u5065\u5eb7\u306a\u4eba\u3092\u4f7f\u3063\u305f\u4eba\u4f53\u5b9f\u9a13\u7684\u7814\u7a76\u304b\u3089\u3002\u5bfe\u8c61\u306f57\u4eba\u306e\u5065\u5eb7\u306a\u4eba\u3067\u3059\u3002\u75c5\u6c17\u3067\u3082\u306a\u3044\u306e\u306b\u85ac\u3092\u98f2\u307e\u3055\u308c\u307e\u3059\u3002NSAIDs\u306e\u4e2d\u306eCOX2\u963b\u5bb3\u5264\u30bb\u30ec\u30b3\u30ad\u30b7\u30d6\uff08200 mg\u30011\u65e52\u56de\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u30922\u9031\u9593\u6295\u4e0e\u3059\u308b\u7fa4\uff08COX-2+\u30d7\u30e9\u30bb\u30dc\u7fa4\uff09\u3068\u3001\u30bb\u30ec\u30b3\u30ad\u30b7\u30d6\u3068PPI\u30e9\u30d9\u30d7\u30e9\u30be\u30fc\u30eb\uff0820 mg\u30011\u65e51\u56de\uff09\u30922\u9031\u9593\u6295\u4e0e\u3059\u308b\u7fa4\uff08COX-2 + PPI\u7fa4\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u5f53\u3066\u307e\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u4eba\u306f\u3001\u7814\u7a76\u958b\u59cb\u6642\u306b\u30ab\u30d7\u30bb\u30eb\u5185\u8996\u93e1\u691c\u67fb\u3067\u8a55\u4fa1\u3055\u308c\u3001\u7814\u7a76\u958b\u59cb2\u9031\u9593\u5f8c\u306b\u518d\u5ea6\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u30ab\u30d7\u30bb\u30eb\u5185\u8996\u93e1\u4e0b\u3067\u89b3\u5bdf\u3055\u308c\u305f\u5c0f\u8178\u640d\u50b7\uff08\u6f70\u760d\u304a\u3088\u3073\u3073\u3089\u3093\uff09\u306e\u767a\u751f\u7387\u3068\u6570\u3092\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306fCOX-2+\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068COX-2 + PPI\u7fa4\u306b\u304a\u3051\u308b\u5c0f\u8178\u640d\u50b7\u306e\u767a\u751f\u7387\u3067\u3059\u3002COX-2 + PPI\u7fa4\u3067\u306f\u306a\u3093\u3068\u305f\u3063\u305f2\u9031\u9593\u306744\uff05\u3082\u5c0f\u8178\u640d\u50b7\u304c\u767a\u751f\u3057\u3066\u3044\u307e\u3059\u3002COX-2+\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u30662.67\u500d\u3082\u5c0f\u8178\u640d\u50b7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u5c0f\u8178\u306e\u7a7a\u8178\u3068\u56de\u8178\u306e\u90e8\u4f4d\u5225\u3067\u306e\u640d\u50b7\u767a\u751f\u7387\u3067\u3059\u3002\u5de6\u306e\u7a7a\u8178\u7c98\u819c\u640d\u50b7\u306f\u3059\u3079\u3066\u3073\u3089\u3093\u3067\u3042\u308a\u3001COX-2 + PPI\u7fa4\u3067\u306e\u307f\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u53f3\u306e\u56de\u8178\u7c98\u819c\u640d\u50b7\u306e\u767a\u751f\u7387\u306b\u306f 2 \u3064\u306e\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u6570\u5024\u7684\u306b\u306fCOX-2 + PPI\u7fa4\u306e\u65b9\u304c2\u500d\u4ee5\u4e0a\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\uff0837% vs 17%\uff09\u3002\u307e\u305f\u3001\u6f70\u760d\uff0822% \u3068 33%\uff09\u3084\u3073\u3089\u3093\uff0810% \u3068 13%\uff09\u306e\u767a\u751f\u7387\u306b\u3082\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u30b5\u30f3\u30d7\u30eb\u6570\u306f\u5c11\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u660e\u3089\u304b\u306bPPI\u306fNSAIDs\u6295\u4e0e\u306b\u3088\u308b\u5c0f\u8178\u640d\u50b7\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002\u6050\u3089\u304f\u5c0f\u8178\u306e\u8178\u5185\u7d30\u83cc\u53e2\u304c\u5927\u304d\u304f\u5909\u5316\u3059\u308b\u306e\u304c\u8981\u56e0\u306e\u4e00\u3064\u3067\u3057\u3087\u3046\u3002\u3082\u3061\u308d\u3093\u3001\u8ca7\u8840\u306b\u306a\u308b\u307b\u3069\u306e\u640d\u50b7\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u6f70\u760d\u3084\u3073\u3089\u3093\u304c\u5897\u52a0\u3057\u3066\u826f\u3044\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u3082\u3046\u4e00\u3064\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002PPI\u306e\u4e0b\u90e8\u6d88\u5316\u7ba1\uff08\u5c0f\u8178\u3068\u5927\u8178\uff09\u51fa\u8840\u30ea\u30b9\u30af\u3092\u691c\u8a0e\u3057\u305f\u3059\u3079\u3066\u306e\u95a2\u9023\u7814\u7a76\u3092\u691c\u7d22\u3057\u305f\u3001341,063\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f12\u306e\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u3059\u3002<\/p>\n

\u305d\u306e\u7d50\u679c\u306f\u6b21\u306e\u3088\u3046\u3067\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u30a2\u30b9\u30d4\u30ea\u30f3\u307e\u305f\u306fNSAIDs\u4f7f\u7528\u8005\u3067\u306e\u3001PPI\u306b\u3088\u308b\u4e0b\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u306e\u53ef\u80fd\u6027\u3001\u30ea\u30b9\u30af\u3067\u3059\u3002\u4e0b\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u306e\u53ef\u80fd\u6027\u306f1.64\u500d\u306b\u306a\u308a\u3001\u30ea\u30b9\u30af\u306f6.55\u500d\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u5927\u8178\u51fa\u8840\u306e\u30ea\u30b9\u30af\u306fPPI\u306e\u4f7f\u7528\u3068\u95a2\u9023\u3057\u30016.55\u500d\u3067\u3057\u305f\u304c\u3001\u89e3\u6790\u306b\u542b\u307e\u308c\u3066\u3044\u305f\u306e\u306f1\u4ef6\u306e\u7814\u7a76\u306e\u307f\u3067\u3057\u305f\u3002<\/p>\n

\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u300112\u306e\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306a\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u591a\u304f\u304c\u65e5\u672c\u306e\u7814\u7a76\u306a\u306e\u3067\u3059\u3002\u3044\u304b\u306b\u65e5\u672c\u3067PPI\u304c\u904e\u5270\u306b\u4f7f\u308f\u308c\u3066\u3044\u308b\u304b\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n

PPI\u306f\u4e0a\u90e8\u6d88\u5316\u7ba1\u306e\u4fdd\u8b77\u306b\u306f\u6709\u7528\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u305d\u306e\u4ee3\u308f\u308a\u4e0b\u90e8\u6d88\u5316\u7ba1\u3092\u640d\u50b7\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u5b89\u6613\u306aPPI\u306e\u4f7f\u7528\u306f\u6b62\u3081\u305f\u65b9\u304c\u826f\u3044\u3067\u3057\u3087\u3046\u3002PPI\u306f\u30de\u30c3\u30c1\u30dd\u30f3\u30d7\u85ac\u306e\u4ee3\u8868\u3067\u3059\u3002PPI\u3067\u5f97\u3089\u308c\u308b\u6069\u6075\u3088\u308a\u3082\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u88ab\u308b\u6709\u5bb3\u306a\u526f\u4f5c\u7528\u306e\u65b9\u304c\u591a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u300cProton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug-Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial\u300d<\/span><\/p>\n

\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\u306f\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\u8a98\u767a\u6027\u5c0f\u8178\u969c\u5bb3\u306e\u767a\u751f\u7387\u3092\u5897\u52a0\u3055\u305b\u308b\uff1a\u30e9\u30f3\u30c0\u30e0\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u300cImpact of proton pump inhibitors on the risk of small bowel or colorectal bleeding: A systematic review and meta-analysis\u300d<\/span><\/p>\n

\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\u306e\u5c0f\u8178\u307e\u305f\u306f\u5927\u8178\u51fa\u8840\u30ea\u30b9\u30af\u3078\u306e\u5f71\u97ff\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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