{"id":26975,"date":"2024-08-09T12:27:04","date_gmt":"2024-08-09T03:27:04","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=26975"},"modified":"2024-08-09T12:27:04","modified_gmt":"2024-08-09T03:27:04","slug":"%e7%89%9b%e4%b9%b3%e3%81%a3%e3%81%a6%e5%8d%b1%e3%81%aa%e3%81%84%ef%bc%9f%e3%80%80%e3%81%9d%e3%81%ae3","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=26975","title":{"rendered":"\u725b\u4e73\u3063\u3066\u5371\u306a\u3044\uff1f\u3000\u305d\u306e3"},"content":{"rendered":"<p>\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=26764\" target=\"_blank\" rel=\"noopener\">\u305d\u306e1<\/a>\u300d\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=26992\" target=\"_blank\" rel=\"noopener\">\u305d\u306e2<\/a>\u300d\u306e\u7d9a\u304d\u3067\u3059\u3002\u524d\u56de\u306f\u69d8\u3005\u306a\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u591a\u304f\u306e\u75be\u60a3\u304a\u3088\u3073\u5168\u539f\u56e0\u6b7b\u4ea1\u3067\u725b\u4e73\u306f\u30ea\u30b9\u30af\u5897\u52a0\u3092\u793a\u3057\u3001\u307b\u3068\u3093\u3069\u306e\u7814\u7a76\u3067\u767a\u9175\u4e73\u306f\u30ea\u30b9\u30af\u6e1b\u5c11\u3092\u793a\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u66f8\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u4eca\u56de\u306f\u66f8\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u4eba\u9593\u304c\u725b\u4e73\u3092\u98f2\u3080\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u306f\u6050\u3089\u304f1\u4e07\u5e74\u524d\u304f\u3089\u3044\u3067\u3001\u51b7\u8535\u5eab\u3082\u306a\u3044\u6642\u4ee3\u3067\u306f\u3001\u767a\u9175\u306f\u81ea\u7136\u3068\u2f5c\u4e73\u306e\u4fdd\u5b58\u306e\u4e3b\u8981\u306a\u2f45\u6cd5\u3067\u3042\u3063\u305f\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u2f5c\u4e73\u306e\u4f4e\u6e29\u6bba\u83cc\u3068\u51b7\u8535\u304c\u5c0e\u2f0a\u3055\u308c\u308b\u524d\u306f\u3001\u5fc5\u7136\u7684\u306b\u767a\u9175\u3057\u3066\u3044\u305f\u3067\u3057\u3087\u3046\u3002200\u5e74\u307b\u3069\u524d\u306b\u51b7\u8535\u6280\u8853\u304c\u5e83\u307e\u308b\u3068\u3001 \u2fae\u767a\u9175\u4f4e\u6e29\u6bba\u83cc\u2f5c\u4e73\u306e\u2f24\u898f\u6a21\u306a\u6d41\u901a\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u98df\u4e8b\u30a2\u30f3\u30b1\u30fc\u30c8\u3068\u306f\u8a00\u3048\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u725b\u4e73\u306e\u7814\u7a76\u306f\u5927\u304d\u306a\u610f\u5473\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u2f00\u2f08\u5f53\u305f\u308a\u306e\u5e74\u9593\u2f5c\u4e73\u6d88\u8cbb\u91cf\u306f\u3001130.5\u30ea\u30c3\u30c8\u30eb\u3068\u3044\u3046\u2fae\u5e38\u306b\u2fbc\u3044\u6442\u53d6\u91cf\u3067\u3059\u3002\u4f1d\u7d71\u7684\u306b\u2fae\u767a\u9175\u4e73\u306e\u6442\u53d6\u91cf\u304c\u591a\u3044\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u6700\u8fd1\u306e3\u3064\u306e\u7814\u7a76\uff08<a href=\"https:\/\/www.mdpi.com\/2072-6643\/12\/5\/1393\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u3068<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002916522049243?via%3Dihub\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u3068<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25352269\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09\u306f\u3001\u2fae\u767a\u9175\u4e73\u306e\u6442\u53d6\u3068\u5168\u6b7b\u4ea1\u7387\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u2f64\u91cf\u4f9d\u5b58\u7684\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u767a\u9175\u3057\u3066\u3044\u306a\u3044\u725b\u4e73\u306f\u767a\u9175\u4e73\u3068\u4f55\u304c\u9055\u3046\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"26979\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=26979\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?fit=1508%2C786&amp;ssl=1\" data-orig-size=\"1508,786\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u725b\u4e73mTOR\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?fit=300%2C156&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?fit=640%2C334&amp;ssl=1\" class=\"alignnone size-full wp-image-26979\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?resize=640%2C334\" alt=\"\" width=\"640\" height=\"334\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?w=1508&amp;ssl=1 1508w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?resize=300%2C156&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?resize=1024%2C534&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?resize=768%2C400&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?resize=1170%2C610&amp;ssl=1 1170w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/db3df40a061dac3cd1b1eb6b1a1ddaa5.png?w=1280 1280w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u725b\u4e73\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3001\u4eba\u9593\u306e\u69d8\u3005\u306a\u4ee3\u8b1d\u3067\u3059\u304c\u3001\u3042\u307e\u308a\u7d30\u304b\u3044\u3053\u3068\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3057\u3001\u7701\u7565\u3057\u307e\u3059\u3002\u725b\u4e73\u306b\u542b\u307e\u308c\u308b\u725b\u4e73\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u30de\u30a4\u30af\u30edRNA\uff08miR\uff09\u3092\u5185\u5305\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u4f4e\u6e29\u6bba\u83cc\u3067\u306f\u58ca\u308c\u307e\u305b\u3093\u3002\u2f5c\u4e73\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3068\u305d\u306emiR\u306f\u6d88\u5316\u7ba1\u3067\u3082\u5206\u89e3\u306b\u62b5\u6297\u3057\u3001\u5168\u2f9d\u5faa\u74b0\u306b\u5230\u9054\u3057\u3066\u3055\u307e\u3056\u307e\u306a\u7d44\u7e54\u306b\u5206\u5e03\u3057\u307e<br \/>\n\u3059\u3002\u3082\u3057\u304b\u3057\u305f\u3089\u2f5c\u4e73\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3068miR\u306f\u4e73\u5150\u306e\u6210\u9577\u3001\u6210\u719f\u306b\u306f\u5229\u76ca\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u9577\u671f\u7684\u306b\u3001\u6210\u9577\u3057\u3066\u304b\u3089\u3082\u305a\u3063\u3068\u3053\u306e\u2f5c\u4e73\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3068miR\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u306f\u5065\u5eb7\u306b\u6709\u5bb3\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u2f5c\u4e73\u306e\u4e3b\u8981\u306amiR\u306fmiR-148a\u3068miR-21\u3001miR-29b\u3068miR-155\u3060\u305d\u3046\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3059\u3079\u3066\u2f08\u9593\u306e\u3082\u306e\u3068\u914d\u5217\u304c\u540c\u2f00\u3067\u3059\u3002\u3053\u306e\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0miR-148a\u3001miR-21\u3001miR-29b\u306f\u3001mTORC1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\uff4dTOR\u306e\u6d3b\u6027\u5316\u306f\u3001\u3053\u308c\u307e\u3067\u3082\u4f55\u5ea6\u3082\u66f8\u3044\u3066\u304d\u305f\u3088\u3046\u306b\u3001\u8001\u5316\u3084\u304c\u3093\u5316\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002\uff4dTOR\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306fAMPK\u306f\u6e1b\u5c11\u3057\u307e\u3059\u3002AMPK-\uff4dTOR\u7d4c\u8def\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002AMPK\u6e1b\u5c11\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6e1b\u5c11\u3067\u3059\u3002miR-21\u306fmTORC1\u3092\u6d3b\u6027\u5316\u3057\u3001\u6210\u2ed1\u3068\u540c\u5316\u3092\u4fc3\u9032\u3057\u3001\u6301\u7d9a\u7684\u306a\u7d30\u80de\u5897\u6b96\u3068\u304c\u3093\u306e\u6210\u2ed1\u3092\u4fc3\u9032\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002miR-155\u306fmTOR\u306e\u5206\u89e3\u3092\u6291\u5236\u3057\u3001miR-29b\u306fmTOR\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b BCAA\u306e\u7d30\u80de\u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>mTOR\u306f\u74b0\u5883\u304a\u3088\u3073\u7d30\u80de\u5185\u306e\u6804\u990a\u7d20\u3068\u6210\u2ed1\u56e0\u2f26\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u611f\u77e5\u3057\u3066\u7d71\u5408\u3057\u3001\u7d30\u80de\u306e\u6210\u2ed1\u3001\u5897\u6b96\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u6291\u5236\u3001\u500b\u3005\u306e\u7d30\u80de\u3084\u7d44\u7e54\u306b\u5fdc\u3058\u305f\u708e\u75c7\u306a\u3069\u306e\u57fa\u672c\u7684\u306a\u7d30\u80de\u304a\u3088\u3073\u2f63\u7269\u306e\u53cd\u5fdc\u3092\u8abf\u6574\u3057\u307e\u3059\u3002mTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u5897\u52a0\u306f\u5bff\u547d\u3092\u77ed\u7e2e\u3057\u3001\u7d30\u80de\u2f7c\u5316\u3084\u5e79\u7d30\u80de\u67af\u6e07\u306a\u3069\u306e\u2f7c\u5316\u95a2\u9023\u30d7\u30ed\u30bb\u30b9\u3092\u52a0\u901f\u3055\u305b\u307e\u3059\u3002\u6301\u7d9a\u7684\u306b\u5897\u52a0\u3057\u305fmTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u6162\u6027\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u306e\u3067\u3059\u304c\u3001\u2fae\u767a\u9175\u4e73\u306e\u6442\u53d6\u306b\u3088\u308a\u3001\u708e\u75c7\u8a98\u767a\u6027\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff08IL-6\uff09\u306e\u2f8e\u6e05\u30ec\u30d9\u30eb\u304c\u2f64\u91cf\u4f9d\u5b58\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u725b\u4e73\u306b\u542b\u307e\u308c\u308b\u4e73\u7cd6\u306f\u5206\u89e3\u3057\u3066\u30b0\u30eb\u30b3\u30fc\u30b9\u3068\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u306b\u5206\u304b\u308c\u307e\u3059\u304c\u3001\u2fae\u767a\u9175\u4e73\u306e\u6442\u53d6\u306b\u3088\u308b\u6162\u6027\u7684\u306a\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u66dd\u9732\u306f\u3001ROS\uff08\u6d3b\u6027\u9178\u7d20\uff09 \u3092\u4ecb\u3057\u305fmTOR\u306e\u904e\u5270\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u7834\u2fbb\u7d30\u80de\u8a98\u5c0e\u6027miR-148a\u306e\u767a\u73fe\u5897\u52a0\u306f\u3001\u2fbb\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3068\u2fbb\u7c97\u9b06\u75c7\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\uff08<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00508-016-1141-3\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u3068<a href=\"https:\/\/academic.oup.com\/jbmr\/article-abstract\/33\/3\/449\/7605545?redirectedFrom=fulltext\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u3082\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5897\u3084\u3059\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u9aa8\u306e\u5065\u5eb7\u306e\u305f\u3081\u306b\u725b\u4e73\u3092\u98f2\u3093\u3067\u3044\u308b\u3064\u3082\u308a\u3067\u3082\u3001\u9006\u52b9\u679c\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001miR-148a\u306f2\u578b\u7cd6\u5c3f\u75c5\u306b\u3082\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\uff08<a href=\"https:\/\/nutritionandmetabolism.biomedcentral.com\/articles\/10.1186\/s12986-019-0412-1\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u3067\u306f\u3001\u767a\u9175\u4e73\u306f\u3069\u3046\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"26978\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=26978\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?fit=1623%2C1015&amp;ssl=1\" data-orig-size=\"1623,1015\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u30e8\u30fc\u30b0\u30eb\u30c8mTOR\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?fit=300%2C188&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?fit=640%2C400&amp;ssl=1\" class=\"alignnone size-full wp-image-26978\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=640%2C400\" alt=\"\" width=\"640\" height=\"400\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?w=1623&amp;ssl=1 1623w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=300%2C188&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=1024%2C640&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=768%2C480&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=1536%2C961&amp;ssl=1 1536w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=1170%2C732&amp;ssl=1 1170w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?resize=350%2C220&amp;ssl=1 350w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/981cff7aba0c033b016f048d243c6839.png?w=1280 1280w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u767a\u9175\u4e73\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3001\u4eba\u9593\u306e\u69d8\u3005\u306a\u4ee3\u8b1d\u3067\u3059\u3002\u767a\u9175\u4e73\u3067\u306f\u69d8\u3005\u306a\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059miR\u3092\u5185\u5305\u3057\u305f\u2f5c\u4e73\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3001BCAA\u3084\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u4e73\u9178\u83cc\u304c\u8272\u3005\u3068\u4f5c\u7528\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u767a\u9175\u4e73\u3067\u306fmTOR\u306e\u6d3b\u6027\u5316\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u725b\u4e73\u304b\u3089\u306e\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u6442\u53d6\u91cf\u306f\u3001\u767a\u9175\u4e73\u304b\u3089\u6442\u53d6\u3059\u308b\u91cf\u3088\u308a\u3082\u304b\u306a\u308a\u591a\u304f\u306a\u308a\u307e\u3059\u3002\u30b3\u30c3\u30d71\u676f\u306e\u725b\u4e73\u306b\u542b\u307e\u308c\u308b\u4e73\u7cd6\u91cf\u306f\u7d045g \u306e\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u3078\u306e\u6162\u6027\u7684\u306a\u66dd\u9732\u306f\u5065\u5eb7\u306b\u6709\u5bb3\u3060\u3068\u8003\u3048\u3089\u308c\u3001\u52d5\u7269\u5b9f\u9a13\u7684\u306b\u306f\u3001\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u306e\u6dfb\u52a0\u306f\u8001\u5316\u306e\u78ba\u7acb\u3055\u308c\u305f\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u306f\u4f4e\u7528\u91cf\u3067\u3082\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u640d\u50b7\u3001\u6162\u6027\u708e\u75c7\u3001\u795e\u7d4c\u5909\u6027\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u4f4e\u4e0b\u3001\u907a\u4f1d\u5b50\u8ee2\u5199\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5bff\u547d\u306e\u77ed\u7e2e\u306a\u3069\u3001\u52d5\u7269\u306e\u81ea\u7136\u306a\u8001\u5316\u306b\u4f3c\u305f\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u4eba\u9593\u3068\u30de\u30a6\u30b9\u306f\u9055\u3046\u306e\u3067\u4e00\u6982\u306b\u306f\u8a00\u3048\u307e\u305b\u3093\u304c\u3001\u30de\u30a6\u30b9\u3067\u306f\u3001\u4eba\u9593\u306b\u304a\u3051\u308b\u725b\u4e731\uff5e2\u676f\u306b\u76f8\u5f53\u3059\u308b\u91cf\u306e\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u306b\u3088\u308a\u8001\u5316\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u725b\u4e73\u3068\u767a\u9175\u4e73\u306f\u4f3c\u3066\u975e\u306a\u308b\u3082\u306e\u3067\u3059\u3002\u4f4e\u6e29\u6bba\u83cc\u2f5c\u4e73\u306f\u2f7c\u5316\u306e\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308bmTOR\u306e\u6d3b\u6027\u5316\u3092\u6301\u7d9a\u7684\u306b\u4fc3\u9032\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u2fae\u767a\u9175\u306e\u2f5c\u4e73\u306f\u3001\u2f83\u7136\u306a\u2f7c\u5316\u3092\u4fc3\u9032\u3057\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u3044\u307e\u3060\u306b\u5b66\u6821\u3084\u75c5\u9662\u3067\u6bce\u65e5\u306e\u3088\u3046\u306b\u725b\u4e73\u304c\u63d0\u4f9b\u3055\u308c\u308b\u306e\u306f\u4e0d\u601d\u8b70\u3067\u3059\u3002\u3059\u3050\u306b\u3084\u3081\u308b\u3079\u304d\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u300cPasteurized non-fermented cow\u2019s milk but not fermented milk is a promoter of mTORC1-driven aging and increased mortality\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u4f4e\u6e29\u6bba\u83cc\u3055\u308c\u305f\u975e\u767a\u9175\u725b\u4e73\u306f\u3001\u767a\u9175\u4e73\u3068\u306f\u7570\u306a\u308a\u3001mTORC1\u306b\u3088\u308b\u8001\u5316\u3068\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u3092\u4fc3\u9032\u3059\u308b\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33571703\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u300c\u305d\u306e1\u300d\u300c\u305d\u306e2\u300d\u306e\u7d9a\u304d\u3067\u3059\u3002\u524d\u56de\u306f\u69d8\u3005\u306a\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u591a\u304f\u306e\u75be\u60a3\u304a\u3088\u3073\u5168\u539f\u56e0\u6b7b\u4ea1\u3067\u725b\u4e73\u306f\u30ea\u30b9\u30af\u5897\u52a0\u3092\u793a\u3057\u3001\u307b\u3068\u3093\u3069\u306e\u7814\u7a76\u3067\u767a\u9175\u4e73\u306f\u30ea\u30b9\u30af\u6e1b\u5c11\u3092\u793a\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u66f8\u304d\u307e\u3057\u305f\u3002 \u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u4eca\u56de\u306f\u66f8\u304d\u305f\u3044\u3068<\/p>\n","protected":false},"author":1,"featured_media":26983,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[150,153,10],"tags":[58,178],"class_list":["post-26975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diabetes","category-cancer","category-10","tag-cancer","tag-178","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/29654196_s.jpg?fit=640%2C427&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-715","jetpack-related-posts":[{"id":26992,"url":"https:\/\/promea2014.com\/blog\/?p=26992","url_meta":{"origin":26975,"position":0},"title":"\u725b\u4e73\u3063\u3066\u5371\u306a\u3044\uff1f\u3000\u305d\u306e2","author":"Dr.Shimizu","date":"2024\u5e747\u67088\u65e5","format":false,"excerpt":"\u300c\u725b\u4e73\u3063\u3066\u5371\u306a\u3044\uff1f\u3000\u305d\u306e1\u300d\u3067\u306f\u3001\u725b\u4e73\u3068\u767a\u9175\u4e73\u306eIGF-1\u542b\u6709\u91cf\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u66f8\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u725b\u4e73\u2026","rel":"","context":"\u7cd6\u5c3f\u75c5","block_context":{"text":"\u7cd6\u5c3f\u75c5","link":"https:\/\/promea2014.com\/blog\/?cat=150"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/26746618_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/26746618_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/07\/26746618_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":26764,"url":"https:\/\/promea2014.com\/blog\/?p=26764","url_meta":{"origin":26975,"position":1},"title":"\u725b\u4e73\u3063\u3066\u5371\u306a\u3044\uff1f\u3000\u305d\u306e1","author":"Dr.Shimizu","date":"2024\u5e746\u670824\u65e5","format":false,"excerpt":"\u3053\u308c\u307e\u3067\u306b\u79c1\u306e\u30d6\u30ed\u30b0\u3067\u516c\u958b\u3057\u305f\u8a18\u4e8b\u306f2000\u4ee5\u4e0a\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u6700\u521d\u306e\u3046\u3061\u306f\u4f55\u3092\u66f8\u3044\u305f\u304b\u3001\u3069\u3053\u306b\u66f8\u3044\u305f\u2026","rel":"","context":"\u304c\u3093","block_context":{"text":"\u304c\u3093","link":"https:\/\/promea2014.com\/blog\/?cat=153"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/06\/29419330_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/06\/29419330_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/06\/29419330_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":16614,"url":"https:\/\/promea2014.com\/blog\/?p=16614","url_meta":{"origin":26975,"position":2},"title":"\u725b\u4e73\u3067\u4e73\u304c\u3093\u30ea\u30b9\u30af\u306e\u4e0a\u6607\uff1f\u5973\u6027\u306f\u30d7\u30ed\u30c6\u30a4\u30f3\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u304b\u3082\u3057\u308c\u306a\u3044","author":"Dr.Shimizu","date":"2021\u5e748\u670813\u65e5","format":false,"excerpt":"\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u725b\u4e73\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u5927\u304d\u304f\u5897\u52a0\u3055\u305b\u308b\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u725b\u4e73\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u2026","rel":"","context":"\u304c\u3093","block_context":{"text":"\u304c\u3093","link":"https:\/\/promea2014.com\/blog\/?cat=153"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/4667551_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/4667551_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/08\/4667551_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":15722,"url":"https:\/\/promea2014.com\/blog\/?p=15722","url_meta":{"origin":26975,"position":3},"title":"\u725b\u4e73\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u5927\u304d\u304f\u5897\u52a0\u3055\u305b\u308b","author":"Dr.Shimizu","date":"2021\u5e744\u67089\u65e5","format":false,"excerpt":"\u5c0f\u3055\u3044\u9803\u3001\u80cc\u304c\u9ad8\u304f\u306a\u308a\u305f\u304f\u3066\u725b\u4e73\u3092\u305f\u304f\u3055\u3093\u98f2\u3093\u3067\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7d50\u679c\u7684\u306b\u306f\u4eca\u306f\u3061\u3093\u3061\u304f\u308a\u3093\u306e\u304a\u3058\u3055\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/04\/4609034_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/04\/4609034_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2021\/04\/4609034_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":18135,"url":"https:\/\/promea2014.com\/blog\/?p=18135","url_meta":{"origin":26975,"position":4},"title":"\u30d7\u30ed\u30c6\u30a4\u30f3\u6442\u53d6\u306f\u614e\u91cd\u306b","author":"Dr.Shimizu","date":"2022\u5e742\u67087\u65e5","format":false,"excerpt":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u5f71\u97ff\u3067\u69d8\u3005\u306a\u7523\u696d\u3001\u4f01\u696d\u304c\u6253\u6483\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5e74\u672b\u9803\u306b\u725b\u4e73\u306e\u6d88\u8cbb\u4f4e\u8ff7\u3067\u5728\u5eab\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/02\/23260002_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/02\/23260002_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/02\/23260002_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":19095,"url":"https:\/\/promea2014.com\/blog\/?p=19095","url_meta":{"origin":26975,"position":5},"title":"\u5927\u8c46\u98df\u54c1\u306e\u6442\u53d6\u3068\u3059\u3044\u81d3\u304c\u3093\u306e\u30ea\u30b9\u30af","author":"Dr.Shimizu","date":"2022\u5e746\u67083\u65e5","format":false,"excerpt":"\u30b3\u30e1\u30f3\u30c8\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002 \u79c1\u306f\u7cd6\u5c3f\u75c5\u3068\u4e73\u88fd\u54c1\u3001\u9d8f\u5375\u30a2\u30ec\u30eb\u30ae\u30fc\u3067\u3059\u3002\u73fe\u5728\u7cd6\u8cea\u5236\u9650\u306b\u3066\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u306f\u6b63\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/06\/22891802_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/06\/22891802_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/06\/22891802_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/26975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26975"}],"version-history":[{"count":5,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/26975\/revisions"}],"predecessor-version":[{"id":27356,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/26975\/revisions\/27356"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/media\/26983"}],"wp:attachment":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}