{"id":27675,"date":"2024-11-15T07:08:47","date_gmt":"2024-11-14T22:08:47","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=27675"},"modified":"2024-11-15T07:08:47","modified_gmt":"2024-11-14T22:08:47","slug":"ppi%ef%bc%88%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3%e3%83%9d%e3%83%b3%e3%83%97%e9%98%bb%e5%ae%b3%e8%96%ac%ef%bc%89%e3%81%af%e5%ad%90%e4%be%9b%e3%81%ae%e3%81%86%e3%81%a4%e3%82%84%e4%b8%8d%e5%ae%89","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=27675","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306f\u5b50\u4f9b\u306e\u3046\u3064\u3084\u4e0d\u5b89\u3092\u5897\u52a0\u3055\u305b\u308b"},"content":{"rendered":"

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u4e0d\u5b89\u3084\u3046\u3064\u75c5\u3068\u80c3\u98df\u9053\u9006\u6d41\u75c7\uff08\u9006\u6d41\u6027\u98df\u9053\u708e\uff09\u3068\u306e\u95a2\u9023\u6027<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u4e0d\u5b89\u3084\u3046\u3064\u75c5\u3068\u80c3\u98df\u9053\u9006\u6d41\u75c7\u306b\u306f\u95a2\u9023\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u80c3\u98df\u9053\u9006\u6d41\u75c7\u304c\u3042\u308b\u304b\u3089\u3068\u3044\u3063\u3066\u3001PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u4f59\u8a08\u306b\u3046\u3064\u3084\u4e0d\u5b89\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u3053\u3068\u306b\u3064\u3044\u3066\u3001\u307e\u305a\u306f\u5b50\u4f9b\u306b\u3064\u3044\u3066\u66f8\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u5b50\u4f9b\u306bPPI\u3092\u51e6\u65b9\u3059\u308b\u533b\u5e2b\u304c\u3044\u308b\u304b\u3068\u601d\u3046\u3068\u30be\u30c3\u3068\u3057\u307e\u3059\u3002\u3053\u308c\u304b\u3089\u6210\u9577\u3057\u305f\u308a\u3001\u5c06\u6765\u304c\u3042\u308b\u5b50\u4f9b\u306b\u3001\u3053\u3093\u306a\u526f\u4f5c\u7528\u306e\u591a\u3044\u85ac\u3092\u51e6\u65b9\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u30017\uff5e17\u6b73\u306e\u5c0f\u5150\u3067PPI\u3092\u958b\u59cb\u3057\u305f29,320\u4eba\u3068\u958b\u59cb\u3057\u306a\u304b\u3063\u305f29,320\u4eba\u3092\u5bfe\u8c61\u306b\u3001PPI\u306e\u4f7f\u7528\u3068\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u75c7\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u6027\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u4e21\u30b0\u30eb\u30fc\u30d7\u306e\u5e73\u5747\u5e74\u9f62\u306f11.9\u6b73\u3001\u5e73\u5747\u8ffd\u8de1\u671f\u9593\u306f1.6\u5e74\u3067\u3057\u305f\u3002<\/p>\n

\n

PPI\u4f7f\u7528\u3068\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306b\u95a2\u3059\u308b\u4e3b\u306a\u7d50\u679c\u3092\u4e0b\u306e\u8868\u306b\u793a\u3057\u307e\u3059\u3002\uff08\u767a\u751f\u7387\u306f1000\u4eba\u5e74\u5f53\u305f\u308a\u3067\u3059\uff09\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n<\/div>\n

\n\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\nPPI\u4f7f\u7528<\/th>\n\u975ePPI<\/th>\n\u767a\u751f\u7387\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee\uff0895% CI\uff09<\/th>\nHR (95% CI)<\/th>\n<\/tr>\n
\u767a\u751f\u7387<\/th>\n\u767a\u751f\u7387<\/th>\n<\/tr>\n<\/thead>\n
\u4e00\u6b21\u5206\u6790<\/td>\n20.4<\/td>\n7.8<\/td>\n12.61 (11.09\u201314.13)<\/td>\n2.61 (2.32\u20132.94)<\/span><\/td>\n<\/tr>\n
\u4e8c\u6b21\u5206\u6790<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u3046\u3064\u75c5\u307e\u305f\u306f\u4e0d\u5b89\u306e\u5b9a\u7fa9<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u3046\u3064\u75c5\u307e\u305f\u306f\u4e0d\u5b89\u75c7\u306e\u8a3a\u65ad<\/td>\n15.0<\/td>\n6.1<\/td>\n8.92 (7.61\u201310.23)<\/td>\n2.46 (2.15\u20132.82)<\/span><\/td>\n<\/tr>\n
\u3046\u3064\u75c5\u306e\u8a3a\u65ad<\/td>\n5.8<\/td>\n2.6<\/td>\n3.24 (2.41\u20134.06)<\/td>\n2.25 (1.82\u20132.79)<\/span><\/td>\n<\/tr>\n
\u4e0d\u5b89\u306e\u8a3a\u65ad<\/td>\n9.2<\/td>\n3.5<\/td>\n5.68 (4.66\u20136.70)<\/td>\n2.61 (2.19\u20133.12)<\/span><\/td>\n<\/tr>\n
\u6297\u3046\u3064\u85ac\u306e\u4f7f\u7528<\/td>\n5.4<\/td>\n1.7<\/td>\n3.69 (2.93\u20134.45)<\/td>\n3.15 (2.45\u20134.03)<\/span><\/td>\n<\/tr>\n
\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u767a\u75c7\u6642\u671f\uff08\u6cbb\u7642\u958b\u59cb\u5f8c\u306e\u65e5\u6570\uff09<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
1\uff5e30\u65e5<\/td>\n26.2<\/td>\n7.1<\/td>\n19.17 (11.87\u201326.47)<\/td>\n3.71 (2.17\u20136.34)<\/span><\/td>\n<\/tr>\n
31\uff5e90\u65e5<\/td>\n22.5<\/td>\n6.5<\/td>\n16.03 (11.19\u201320.86)<\/td>\n3.47 (2.33\u20135.18)<\/span><\/td>\n<\/tr>\n
91\uff5e180\u65e5<\/td>\n24.8<\/td>\n9.2<\/td>\n15.65 (11.34\u201319.95)<\/td>\n2.71 (2.04\u20133.60)<\/span><\/td>\n<\/tr>\n
181\uff5e365\u65e5<\/td>\n19.4<\/td>\n7.7<\/td>\n11.72 (8.91\u201314.54)<\/td>\n2.52 (2.00\u20133.16)<\/span><\/td>\n<\/tr>\n
366\uff5e730\u65e5<\/td>\n18.3<\/td>\n7.8<\/td>\n10.49 (8.24\u201312.74)<\/td>\n2.34 (1.94\u20132.82)<\/span><\/td>\n<\/tr>\n
\u500b\u3005\u306e\u85ac\u5264<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u30a8\u30bd\u30e1\u30d7\u30e9\u30be\u30fc\u30eb<\/td>\n19.7<\/td>\n7.4<\/td>\n12.29 (7.71\u201316.88)<\/td>\n2.66 (1.82\u20133.89)<\/span><\/td>\n<\/tr>\n
\u30aa\u30e1\u30d7\u30e9\u30be\u30fc\u30eb<\/td>\n20.9<\/td>\n7.9<\/td>\n13.00 (11.35\u201314.64)<\/td>\n2.65 (2.33\u20133.02)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

PPI\u3092\u958b\u59cb\u3057\u305f\u5b50\u4f9b\u306b\u304a\u3051\u308b\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u767a\u751f\u306f\u3001PPI\u975e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ea\u30b9\u30af\u304c2.61\u500d\u306b\u3082\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u6297\u3046\u3064\u85ac\u306e\u4f7f\u7528\u306e\u30ea\u30b9\u30af\u30823.15\u500d\u3067\u3057\u305f\u3002<\/p>\n

PPI\u958b\u59cb\u5f8c1\uff5e30\u65e5\u3067\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u767a\u751f\u30ea\u30b9\u30af\u306f3.71\u500d\u300131\uff5e90\u65e5\u3067\u306f3.47\u500d\u300191\uff5e180\u65e5\u3067\u306f2.71\u500d\u3001181\uff5e365\u65e5\u3067\u306f2.52\u500d\u3001366\uff5e730\u65e5\u3067\u306f2.34\u500d\u3067\u3057\u305f\u3002<\/p>\n

\n

\u4e0b\u306e\u8868\u306fPPI\u4f7f\u7528\u3068\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u3001PPI \u306e\u7d2f\u7a4d\u4f7f\u7528\u671f\u9593\u5225\u3067\u306e\u95a2\u9023\u6027\u3067\u3059\u3002<\/p>\n<\/div>\n

\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n
<\/th>\n\u767a\u751f\u7387<\/th>\n\u767a\u751f\u7387\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee(95% CI)<\/th>\nHR (95% CI)<\/th>\n<\/tr>\n<\/thead>\n
\u975ePPI\u4f7f\u7528<\/td>\n7.8<\/td>\n1<\/td>\n1<\/td>\n<\/tr>\n
\u226430\u65e5<\/td>\n16.2<\/td>\n8.38 (6.61\u201310.15)<\/td>\n2.02 (1.76\u20132.33)<\/span><\/td>\n<\/tr>\n
31\uff5e90\u65e5<\/td>\n22.9<\/td>\n15.04 (12.56\u201317.51)<\/td>\n2.85 (2.46\u20133.29)<\/span><\/td>\n<\/tr>\n
91\uff5e180\u65e5<\/td>\n31.7<\/td>\n23.87 (18.68\u201329.05)<\/td>\n3.89 (3.21\u20134.72)<\/span><\/td>\n<\/tr>\n
\u2265181\u65e5<\/td>\n31.0<\/td>\n23.15 (13.75\u201332.55)<\/td>\n3.81 (2.77\u20135.26)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u30ea\u30b9\u30af\u306f\u3001PPI\u306e\u7d2f\u7a4d\u4f7f\u7528\u671f\u9593\u304c\u9577\u304f\u306a\u308b\u306b\u3064\u308c\u3066\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u975e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u7d2f\u7a4d\u671f\u95931\uff5e30\u65e5\u30672.02\u500d\u300131\uff5e90\u65e5\u30672.85\u500d\u300191\uff5e180\u65e5\u3067\u306f3.89\u500d\u3001181\u65e5\u4ee5\u4e0a\u306e\u5834\u5408\u306f3.81\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u305d\u3057\u3066\u3001\u6050\u308d\u3057\u3044\u306e\u304c\u4e0b\u306e\u8868\u3067\u3059\u3002\u6cbb\u7642\u5f8c\u306ePPI\u306e\u4f7f\u7528\u3068\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/strong><\/td>\n\u767a\u751f\u7387<\/strong><\/td>\n\u767a\u751f\u7387\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee<\/strong> (95% CI)<\/strong><\/td>\n\u30cf\u30b6\u30fc\u30c9\u6bd4<\/strong>(95%CI)<\/strong><\/td>\n<\/tr>\n
\u975ePPI\u4f7f\u7528<\/td>\n7.8<\/td>\n1<\/td>\n1<\/td>\n<\/tr>\n
\u7d99\u7d9a\u4e2d\u306ePPI\u6cbb\u7642<\/td>\n31.3<\/td>\n23.54 (17.41-29.67)<\/td>\n4.48 (3.43-5.86)<\/span><\/td>\n<\/tr>\n
PPI\u306e\u4e2d\u6b62\u304b\u3089\u306e\u671f\u9593<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
1-90\u65e5<\/td>\n22.5<\/td>\n14.71 (10.98-18.43)<\/td>\n3.28 (2.55-4.21)<\/span><\/td>\n<\/tr>\n
91-180\u65e5<\/td>\n19.6<\/td>\n11.78 (8.10-15.46)<\/td>\n2.85 (2.18-3.72)<\/span><\/td>\n<\/tr>\n
181-365\u65e5<\/td>\n16.5<\/td>\n8.65 (6.01-11.29)<\/td>\n2.24 (1.79-2.80)<\/span><\/td>\n<\/tr>\n
366-730\u65e5<\/td>\n14.64<\/td>\n6.84 (4.62-9.07)<\/td>\n1.88 (1.55-2.29)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d99\u7d9a\u4e2d\u306ePPI\u6cbb\u7642\u3067\u306f\u3001\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u30ea\u30b9\u30af\u304c4.48\u500d\u3001\u305d\u3057\u3066PPI\u4e2d\u6b62\u5f8c1\uff5e90\u65e5\u3067\u306f3.28\u500d\u300191\uff5e180\u65e5\u3067\u306f2.85\u500d\u3001181\uff5e365\u65e5\u3067\u306f2.24\u3001366\uff5e730\u65e5\u3067\u306f1.88\u500d\u3067\u3057\u305f\u3002\u3064\u307e\u308a\u3001PPI\u3092\u4e2d\u6b62\u3057\u30661\u5e74\u4ee5\u4e0a\u305f\u3063\u3066\u3082\u6709\u610f\u306b\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u306e\u767a\u751f\u30ea\u30b9\u30af\u304c2\u500d\u8fd1\u304f\u3082\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n

PPI\u306b\u3088\u308b\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u306e\u767a\u751f\u306e\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3044\u304f\u3064\u304b\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5b9f\u969b\u306b\u306f\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001\u3053\u306ePPI\u3068\u3044\u3046\u85ac\u304c\u3001\u5b9f\u969b\u306b\u306f\u5b50\u4f9b\u306b\u3068\u3063\u3066\u306f\u6bd2\u306b\u306a\u308a\u3001\u8133\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u30ef\u30af\u30c1\u30f3\u306b\u3057\u3066\u3082\u85ac\u306b\u3057\u3066\u3082\u98df\u4e8b\u306b\u3057\u3066\u3082\u3001\u4f53\u306b\u5165\u308c\u308b\u3082\u306e\u306b\u306f\u3082\u3063\u3068\u614e\u91cd\u306b\u306a\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u3002\u5927\u4eba\u3067\u3055\u3048\u69d8\u3005\u306a\u5f71\u97ff\u304c\u3042\u308b\u306e\u3067\u3059\u304b\u3089\u3001\u5b50\u4f9b\u3067\u3042\u308c\u3070\u306a\u304a\u3055\u3089\u3067\u3059\u3002\u7279\u306b\u6210\u9577\u6bb5\u968e\u306e\u5b50\u4f9b\u306f\u5c0f\u3055\u306a\u5927\u4eba\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5927\u4eba\u4ee5\u4e0a\u306b\u8a08\u308a\u77e5\u308c\u306a\u3044\u30c0\u30e1\u30fc\u30b8\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u89aa\u306f\u3001\u5b50\u4f9b\u306b\u4f55\u3089\u304b\u306e\u75c7\u72b6\u304c\u51fa\u305f\u3068\u304d\u306b\u3001\u85ac\u306b\u983c\u308b\u524d\u306b\u3001\u81ea\u5206\u304c\u63d0\u4f9b\u3057\u3066\u3044\u308b\u98df\u4e8b\u306b\u307e\u305a\u76ee\u3092\u5411\u3051\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u98df\u4e8b\u304c\u751f\u7269\u5b66\u7684\u3001\u751f\u7406\u5b66\u7684\u306b\u4eba\u9593\u306b\u3068\u3063\u3066\u826f\u3044\u98df\u4e8b\u306a\u306e\u304b\u3092\u8003\u3048\u3066\u307f\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6804\u990a\u58eb\u3084\u533b\u5e2b\u306f\u98df\u4e8b\u306b\u95a2\u3057\u3066\u306f\u3042\u3066\u306b\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n

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\u300cProton pump inhibitor use and risk of depression and anxiety in children: nationwide cohort study\u300d<\/span><\/p>\n

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