{"id":27790,"date":"2024-10-10T18:19:13","date_gmt":"2024-10-10T09:19:13","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=27790"},"modified":"2024-10-10T18:19:13","modified_gmt":"2024-10-10T09:19:13","slug":"%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%a8%e9%ab%98%e8%a1%80%e5%9c%a7%e3%82%842%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%a8","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=27790","title":{"rendered":"\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u9ad8\u8840\u5727\u30842\u578b\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\u6027"},"content":{"rendered":"

\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u5584\u7389\u3001\u60aa\u7389\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3069\u308c\u3082\u540c\u3058\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3059\u3002\u9055\u3044\u306f\u305d\u308c\u3092\u904b\u3076\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u4e0d\u540d\u8a89\u306a\u547c\u3073\u65b9\u3092\u3055\u308c\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3082\u3061\u308d\u3093\u3001\u305d\u306e\u4e2d\u3067\u60aa\u3044\u3082\u306e\u304c\u3042\u308b\u3068\u3059\u308c\u3070\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u306f\u306a\u304fLDL\u3067\u3059\u3002<\/p>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u771f\u306e\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u60aa\u3044\u306e\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\uff08\u300c\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u9178\u5316LDL\u3068\u307b\u3068\u3093\u3069\u540c\u3058\uff1f<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

ApoC\u2162\u3068\u3044\u3046\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u306f\u4e2d\u6027\u8102\u80aa\u304c\u8c4a\u5bcc\u306a\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u304c\u809d\u81d3\u3067\u53d6\u308a\u8fbc\u307e\u308c\u308b\u306e\u3092\u4f4e\u4e0b\u3055\u305b\u3066\u3057\u307e\u3044\u307e\u3059\u3002ApoC\u2162\u304c\u591a\u304f\u306a\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3001\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8840\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\uff08\u300cApoC\u2162\u304c\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u95a2\u9023\u3057\u3066\u3044\u308b<\/a>\u300d\u53c2\u7167\uff09\u305d\u3057\u3066\u3001ApoC\u2162\u306f\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u5897\u52a0\u3057\u307e\u3059\u3002\u7cd6\u8cea\u306e\u4e2d\u3067\u3082\u679c\u7cd6\u304c\u6700\u3082\u5371\u967a\u3067\u3059\u3002\uff08\u300c\u679c\u7cd6\u306f\u30d6\u30c9\u30a6\u7cd6\u3088\u308a\u3082ApoCIII\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u308b<\/a>\u300d\u53c2\u7167\uff09\u679c\u7cd6\u306e\u6442\u53d6\u306f\u3001\u30d6\u30c9\u30a6\u7cd6\u306e\u6442\u53d6\u3068\u540c\u69d8\u306bChREBP-1\u304a\u3088\u3073SREBP-1\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u304c\u3001\u30d6\u30c9\u30a6\u7cd6\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u523a\u6fc0\u3057\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u679c\u7cd6\u6442\u53d6\u5f8c\u306eApoCIII\u767a\u73fe\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8ca0\u306e\u8abf\u6574\u304c\u50cd\u304b\u306a\u304f\u306a\u308a\u3001ApoCIII\u304c\u5927\u304d\u304f\u5897\u52a0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u300c\u4f4e\u8102\u8cea\u9ad8\u7cd6\u8cea\u306e\u98df\u4e8b\u306f\u7a7a\u8179\u6642\u3067\u3082\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6fc0\u5897\u3055\u305b\u308b<\/a>\u300d\u3067\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u4f4e\u8102\u8cea\u9ad8\u7cd6\u8cea\u3001\u3064\u307e\u308a\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5927\u304d\u304f\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u306f\u98df\u5f8c\u304b\u306a\u308a\u306e\u6642\u9593\u7d4c\u3063\u3066\u3082\u5927\u91cf\u306e\u6b8b\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u300c\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u98df\u5f8c12\u6642\u9593\u7d4c\u3063\u3066\u3082\u5927\u91cf\u306b\u6b8b\u3063\u3066\u3044\u308b<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u3092\u7c21\u5358\u306b\u77e5\u308b\u65b9\u6cd5\u306f\u3001\u4e2d\u6027\u8102\u80aa\u5024\u3092\u898b\u308c\u3070\u826f\u3044\u3067\u3059\u3002\u300c\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5897\u52a0\u306f\u9ad8\u4e2d\u6027\u8102\u80aa\u3092\u8868\u3057\u3066\u3044\u308b<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u3068\u3044\u3046\u3053\u3068\u306f\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u3053\u3068\u3092\u8868\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4e2d\u6027\u8102\u80aa\u3092\u975e\u5e38\u306b\u591a\u304f\u542b\u3093\u3060VLDL\u304b\u3089\u3067\u304d\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308c\u3070\u5f53\u7136\u3067\u3059\u3002<\/p>\n

\u3055\u3066\u3001\u524d\u7f6e\u304d\u304c\u9577\u304f\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u9ad8\u8840\u5727\u30012 \u578b\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\u6027\u3001\u304a\u3088\u3073\u305d\u306e2\u3064\u306e\u75be\u60a3\u306e\u4f75\u767a\u3068\u306e\u95a2\u9023\u6027\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

2005\uff5e2018\u5e74\u306e\u30a2\u30e1\u30ea\u30ab\u306e\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\u306e17,749\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n\n\n
<\/th>\n\u8abf\u6574\u30e2\u30c7\u30eb3<\/strong><\/th>\n<\/tr>\n
<\/th>\nOR\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/strong><\/th>\n<\/tr>\n<\/thead>\n
\u2003\u9ad8\u8840\u5727<\/td>\n1.068(1.063,1.073)<\/td>\n<\/tr>\n
\u30002\u578b\u7cd6\u5c3f\u75c5<\/td>\n2.259(1.797,2.838)<\/td>\n<\/tr>\n
\u2003\u9ad8\u8840\u5727\u30682\u578b\u7cd6\u5c3f\u75c5<\/td>\n2.362(1.834,3.041)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
<\/div>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e1\u5358\u4f4d\uff081mmol\/L=38.7mg\/dL\uff09\u5897\u52a0\u3042\u305f\u308a\u306e\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u306f\u3001\u9ad8\u8840\u5727\u30671.068\u30012\u578b\u7cd6\u5c3f\u75c5\u30672.259\u3001\u4e21\u65b9\u306e\u4f75\u5b58\u30672.362\u3067\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306e\u6a2a\u8ef8\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u65e5\u672c\u306e\u5358\u4f4d\u306b\u3059\u308b\u306b\u306f38.7\u3092\u304b\u3051\u3066\u304f\u3060\u3055\u3044\uff09\u3067\u7e26\u8ef8\u304c\u75be\u60a3\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u3067\u3059\u3002A\u304c\u9ad8\u8840\u5727\u3001B\u304c2\u578b\u7cd6\u5c3f\u75c5\u3001C\u306f\u9ad8\u8840\u5727\u30682\u578b\u7cd6\u5c3f\u75c5\u306e\u5408\u4f75\u3067\u3059\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5897\u52a0\u3059\u308b\u306b\u3064\u308c\u3066\u75be\u60a3\u30ea\u30b9\u30af\u306f\u5f90\u3005\u306b\u5897\u52a0\u3057\u307e\u3059\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c0.5\u3061\u3087\u3044\u4ee5\u4e0a\u3060\u3068\u75be\u60a3\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u65e5\u672c\u306e\u5358\u4f4d\u3060\u306820mg\/dL\u4ee5\u4e0a\u304f\u3089\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n
<\/th>\n\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<200mg\/dL<\/strong><\/th>\nLDL-C<130mg\/dL<\/strong><\/th>\nHDL-C\u226540mg\/dL<\/strong><\/th>\n<\/tr>\n
<\/th>\nOR\uff0895%CI\uff09<\/strong><\/th>\nOR\uff0895%CI\uff09<\/strong><\/th>\nOR\uff0895%CI\uff09<\/strong><\/th>\n<\/tr>\n<\/thead>\n
\u9ad8\u8840\u5727<\/td>\n2.085(1.565,2.777)<\/span><\/td>\n1.984(1.572,2.504)<\/span><\/td>\n1.797(1.440,2.241)<\/span><\/td>\n<\/tr>\n
2\u578b\u7cd6\u5c3f\u75c5<\/td>\n2.481(1.920,3.206)<\/span><\/td>\n2.169(1.703,2.763)<\/span><\/td>\n2.431(1.828,3.232)<\/span><\/td>\n<\/tr>\n
\u9ad8\u8840\u5727\u30682\u578b\u7cd6\u5c3f\u75c5<\/td>\n3.186(2.319,4.376)<\/span><\/td>\n2.590(1.957,3.428)<\/span><\/td>\n2.412(1.813,3.209)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3044\u308f\u3086\u308b\u6b63\u5e38\u306e\u7bc4\u56f2\u306b\u3042\u308b\u5834\u5408\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u75be\u60a3\u306e\u95a2\u9023\u6027\u3067\u3059\u304c\u3001\u4e0d\u601d\u8b70\u306a\u3053\u3068\u306b\u9ad8\u8840\u5727\u3084\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u3042\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7cd6\u5c3f\u75c5\u3067\u306f\u6bd4\u8f03\u7684\u4f4e\u3044\u5024\u306a\u306e\u3067\u3001\u5f53\u7136\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u5c0f\u3055\u306a\u5371\u967a\u306asdLDL\u3068\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u708e\u75c7\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3057\u3001ApoC-III\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\u03b2\u3092\u523a\u6fc0\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u305d\u3046\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u3067\u3082\u708e\u75c7\u95a2\u9023\u6307\u6a19\uff08\u767d\u8840\u7403\u3001\u30ea\u30f3\u30d1\u7403\u3001\u5358\u7403\u3001\u597d\u4e2d\u7403\uff09\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u9ad8\u8840\u5727\u30842\u578b\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\u6027\u3092\u90e8\u5206\u7684\u306b\u5a92\u4ecb\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3046\u3061\u3001\u767d\u8840\u7403\u306e\u5a92\u4ecb\u52b9\u679c\u304c\u6700\u3082\u5927\u304d\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

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\u300cAssociation of remnant cholesterol with hypertension, type 2 diabetes, and their coexistence: the mediating role of inflammation-related indicators\u300d<\/span><\/p>\n

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