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rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\u3001\u56f3\u306f\u3053\u306e\u8ad6\u6587\u3088\u308a\u3001\u8868\u306f\u6539\u5909\uff0925,726\u4eba\u306e\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u8005\u3068\u540c\u6570\u306e\u975e\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u8005\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n<div class=\"tbl-box p\" tabindex=\"0\">\n<table class=\"content\" style=\"width: 52.1223%; height: 150px;\" frame=\"hsides\" rules=\"groups\">\n<colgroup span=\"1\">\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/><\/colgroup>\n<thead>\n<tr>\n<th style=\"width: 147px;\" align=\"left\">\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u671f\u9593<\/th>\n<th style=\"width: 188px;\" align=\"center\">\u8abf\u6574\u30aa\u30c3\u30ba\u6bd4\uff0895% CI\uff09<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 147px;\" align=\"left\">\u20036\u304b\u6708\u672a\u6e80<\/td>\n<td style=\"width: 188px;\" align=\"center\">1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 147px;\" align=\"left\">\u20036\uff5e12\u304b\u6708<\/td>\n<td style=\"width: 188px;\" align=\"center\">2.57 (1.94\u20133.41)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 147px;\" align=\"left\">\u200312\uff5e18\u304b\u6708<\/td>\n<td style=\"width: 188px;\" align=\"center\">3.38 (2.45\u20134.66)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 147px;\" align=\"left\">\u200318\uff5e24\u304b\u6708<\/td>\n<td style=\"width: 188px;\" align=\"center\">6.29 (4.62\u20138.56)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 147px;\" align=\"left\">\u200324\u304b\u6708\u301c<\/td>\n<td style=\"width: 188px;\" align=\"center\">6.57 (5.29\u20138.16)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u671f\u9593\u304c\u5897\u52a0\u3059\u308b\u306b\u3064\u308c\u3066\u3001\u5e2f\u72b6\u75b1\u75b9\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u30016\u304b\u6708\u672a\u6e80\u3068\u6bd4\u8f03\u3059\u308b\u3068\u300124\u30ab\u6708\u4ee5\u4e0a\u3060\u30686.57\u500d\u306b\u3082\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"28535\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=28535\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg?fit=716%2C408&amp;ssl=1\" data-orig-size=\"716,408\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u30b9\u30bf\u30c1\u30f3\u5e2f\u72b6\u75b1\u75b9pone.0198263.g002\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg?fit=300%2C171&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg?fit=640%2C365&amp;ssl=1\" class=\"alignnone size-full wp-image-28535\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg?resize=640%2C365\" alt=\"\" width=\"640\" height=\"365\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg?w=716&amp;ssl=1 716w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/8e43e927055a63a0df504b62f908fa33.jpg?resize=300%2C171&amp;ssl=1 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u306e\u6709\u7121\u306b\u3088\u308b\u5e2f\u72b6\u75b1\u75b9\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3092\u793a\u3057\u3066\u3044\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u8005\u306f\u5e2f\u72b6\u75b1\u75b9\u306e\u30ea\u30b9\u30af\u304c1.53\u500d\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u30b9\u30bf\u30c1\u30f3\u306b\u95a2\u9023\u3059\u308b\u5e2f\u72b6\u75b1\u75b9\u306e\u30ea\u30b9\u30af\u306f\u7279\u306b\u9ad8\u9f62\u8005\u3067\u9ad8\u304f\u300170\u6b73\u4ee5\u4e0a\u3067\u306f1.39\u500d\u300160\u301c69\u6b73\u3067\u306f1.18\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u3082\u3046\u4e00\u3064\u3001\u30a2\u30b8\u30a2\u306e\u7814\u7a76\u3001\u53f0\u6e7e\u304b\u3089\u306e\u3082\u306e\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25864192\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\u3001\u56f3\u3082\u3053\u306e\u8ad6\u6587\u3088\u308a\uff09\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u800553,069\u2f08\u3001\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u60a3\u800553,069\u2f08\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"28552\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=28552\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png?fit=515%2C464&amp;ssl=1\" data-orig-size=\"515,464\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u30b9\u30bf\u30c1\u30f3\u5e2f\u72b6\u75b1\u75b91\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png?fit=300%2C270&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png?fit=515%2C464&amp;ssl=1\" class=\"alignnone size-full wp-image-28552\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png?resize=515%2C464\" alt=\"\" width=\"515\" height=\"464\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png?w=515&amp;ssl=1 515w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/cf4b889efab2d1b8480a22e445685558.png?resize=300%2C270&amp;ssl=1 300w\" sizes=\"auto, (max-width: 515px) 100vw, 515px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u306e\u6709\u7121\u306b\u3088\u308b\u3001\u5e2f\u72b6\u75b1\u75b9\u306e\u7d2f\u7a4d\u767a\u75c7\u7387\u3067\u3059\u3002\u70b9\u7dda\u306e\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u7fa4\u306e\u65b9\u304c\u767a\u75c7\u306f\u591a\u304f\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"28551\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=28551\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?fit=781%2C484&amp;ssl=1\" data-orig-size=\"781,484\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u30b9\u30bf\u30c1\u30f3\u5e2f\u72b6\u75b1\u75b92\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?fit=300%2C186&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?fit=640%2C397&amp;ssl=1\" class=\"alignnone size-full wp-image-28551\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?resize=640%2C397\" alt=\"\" width=\"640\" height=\"397\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?w=781&amp;ssl=1 781w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?resize=300%2C186&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2024\/12\/9df2d80145d76da8c99c85dd692bae6e.png?resize=768%2C476&amp;ssl=1 768w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u5168\u4f53\u3068\u3057\u3066\u306f\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u3067\u5e2f\u72b6\u75b1\u75b9\u30ea\u30b9\u30af\u304c1.21\u500d\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u5973\u6027\u30671.31\u500d\u3001\u7537\u6027\u30671.10\u500d\u3067\u3057\u305f\u3002\u5e74\u9f62\u3067\u306f20\uff5e49\u6b73\u30671.35\u500d\u300150\uff5e64\u6b73\u30671.33\u500d\u300165\u6b73\u4ee5\u4e0a\u3067\u306f1.24\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u3068\u5e2f\u72b6\u75b1\u75b9\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u6027\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e6\u4ef6\u306e\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30765397\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09\u306e\u7d50\u679c\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u306f\u5e2f\u72b6\u75b1\u75b9\u306e\u53ef\u80fd\u6027\u30921.18\u500d\u306b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u30a2\u30b8\u30a2\u3067\u306f1.26\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u3055\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u304c\u306a\u305c\u5e2f\u72b6\u75b1\u75b9\u3092\u5897\u52a0\u3055\u305b\u308b\u304b\uff1f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u304c\u3001\u6050\u3089\u304f\u306f\u30b9\u30bf\u30c1\u30f3\u304c\u514d\u75ab\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3089\u3060\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3044\u304f\u3064\u3082\u306e\u514d\u75ab\u7cfb\u306b\u76f4\u63a5\u7684\u3001\u9593\u63a5\u7684\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u4e00\u90e8\u3067\u3042\u308b\u306e\u3067\u3001\u305d\u308c\u3092\u4e0b\u3052\u3066\u3057\u307e\u3063\u3066\u306f\u4e0d\u90fd\u5408\u304c\u8d77\u304d\u308b\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u304c\u826f\u3044\u65b9\u306b\u50cd\u3044\u305f\u5074\u9762\u3092\u898b\u308c\u3070\u3001\u305d\u308c\u306f\u6297\u708e\u75c7\u4f5c\u7528\u3068\u8a00\u308f\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u60aa\u3044\u5f71\u97ff\u306f\u3001\u514d\u75ab\u306e\u6d3b\u6027\u5316\u3084\u514d\u75ab\u7d30\u80de\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u3067\u3082\u8a71\u984c\u306b\u306a\u308a\u307e\u3057\u305f\u3001\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u3067\u3059\u304c\u3001\u30b9\u30bf\u30c1\u30f3\u3082\u3053\u306eTreg\u3092\u5897\u52a0\u3055\u305b\u3066\u3057\u307e\u3046\u3088\u3046\u3067\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24222935\/\" target=\"_blank\" 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rel=\"noopener\">LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u3068\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u4e0b\u3059\u308b<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09<\/p>\n<p>\u4eba\u9593\u306e\u514d\u75ab\u6a5f\u80fd\u306f\u6a19\u6e96\u88c5\u5099\u3067\u3001\u3057\u304b\u3082\u305d\u308c\u306f\u81ea\u52d5\u64cd\u7e26\u3067\u3059\u3002\u305d\u3053\u306b\u4eba\u70ba\u7684\u306b\u4f55\u3089\u304b\u306e\u624b\u3092\u52a0\u3048\u308c\u3070\u3001\u4f55\u304b\u90fd\u5408\u306e\u60aa\u3044\u4e0d\u5177\u5408\u304c\u8d77\u304d\u3066\u3082\u4e0d\u601d\u8b70\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u5e2f\u72b6\u75b1\u75b9\u30ea\u30b9\u30af\u5897\u52a0\u306f\u3082\u306e\u3059\u3054\u304f\u9ad8\u3044\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30b9\u30bf\u30c1\u30f3\u3092\u98f2\u3093\u3067\u3044\u308b\u4eba\u306e\u6570\u306f\u3044\u307e\u3084\u81a8\u5927\u3067\u3059\u306e\u3067\u3001\u305d\u306e\u5f71\u97ff\u306f\u975e\u5e38\u306b\u5927\u304d\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u304c\u3082\u306e\u3059\u3054\u3044\u6570\u306b\u306e\u307c\u308a\u3001\u305d\u308c\u306b\u4f34\u3044\u5e2f\u72b6\u75b1\u75b9\u3082\u975e\u5e38\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u3082\u3046\u30b3\u30ed\u30ca\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u3059\u308b\u4eba\u306f\u3001\u4e00\u90e8\u306e\u60c5\u5831\u5f31\u8005\u306a\u3069\u306b\u9650\u3089\u308c\u3066\u304d\u305f\u3088\u3046\u306b\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u76f8\u5909\u308f\u3089\u305a\u5e2f\u72b6\u75b1\u75b9\u306f\u591a\u3044\u5370\u8c61\u3067\u3059\u3002 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