{"id":29761,"date":"2025-02-21T08:22:22","date_gmt":"2025-02-20T23:22:22","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=29761"},"modified":"2025-02-21T08:22:22","modified_gmt":"2025-02-20T23:22:22","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e6%8e%a5%e7%a8%ae%e5%be%8c%e3%81%8a%e3%82%88%e3%81%9d2%e5%b9%b4%e5%be%8c%e3%81%a7%e3%82%82%e4%bd%93%e5%86%85%e3%81%ab","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=29761","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u304a\u3088\u305d2\u5e74\u5f8c\u3067\u3082\u4f53\u5185\u306b\u5b58\u5728\u3059\u308b\u731b\u6bd2\u306e\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af"},"content":{"rendered":"

\u4eca\u5e74\u306e1\u6708\u306e\u5404\u90fd\u5e02\u306e\u6b7b\u4ea1\u6570\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u9a5a\u304f\u3079\u304d\u6b7b\u4ea1\u6570\u3060\u3063\u305f2023\u5e741\u6708\u3092\u306f\u308b\u304b\u306b\u8d85\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

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\u4eca\u56de\u306e\u7814\u7a76\u306f\u30a4\u30a7\u30fc\u30eb\u5927\u5b66\u304b\u3089\u51fa\u3066\u304d\u307e\u3057\u305f\u3002\uff08\u30d7\u30ec\u30d7\u30ea\u30f3\u30c8\u306a\u306e\u3067\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\uff09\u30a4\u30a7\u30fc\u30eb\u5927\u5b66\u306eLISTEN\u7814\u7a76\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u3082\u3046\u3001\u30c8\u30e9\u30f3\u30d7\u5927\u7d71\u9818\u306b\u306a\u3063\u3066\u3001\u691c\u95b2\u3084\u60c5\u5831\u64cd\u4f5c\u304c\u884c\u308f\u308c\u306a\u304f\u306a\u3063\u3066\u3001\u8272\u3005\u306a\u3053\u3068\u304c\u5674\u51fa\u3057\u3066\u3044\u308b\u611f\u3058\u3067\u3059\u3002<\/p>\n

\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u6162\u6027\u306e\u8870\u5f31\u72b6\u614b\u3092\u5831\u544a\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u4e00\u90e8\u3067\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u75c7\u5019\u7fa4\uff08PVS\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306fYale LISTEN\u7814\u7a76\u306b\u767b\u9332\u3055\u308c\u305f42\u4eba\u306ePVS\u306e\u4eba\u306822\u4eba\u306e\u5065\u5eb7\u306a\u5bfe\u7167\u7fa4\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

42\u4eba\u306ePVS\u53c2\u52a0\u8005\u304b\u3089\u5831\u544a\u3055\u308c\u305f\u6700\u3082\u983b\u7e41\u306a\u75c7\u72b6\u306f\u3001\u904e\u5ea6\u306e\u75b2\u52b4\uff0885%\uff09\u3001\u30c1\u30af\u30c1\u30af\u611f\u3068\u3057\u3073\u308c\uff0880%\uff09\u3001\u904b\u52d5\u4e0d\u8010\u6027\uff0880%\uff09\u3001\u982d\u304c\u307c\u3093\u3084\u308a\u3059\u308b\uff0877.5%\uff09\u3001\u96c6\u4e2d\u529b\u307e\u305f\u306f\u7126\u70b9\u5408\u308f\u305b\u306e\u56f0\u96e3\uff0872.5%\uff09\u3001\u5bdd\u3064\u304d\u307e\u305f\u306f\u7761\u7720\u7dad\u6301\u306e\u56f0\u96e3\uff0870%\uff09\u3001\u795e\u7d4c\u969c\u5bb3\uff0870%\uff09\u3001\u7b4b\u8089\u75db\uff0870%\uff09\u3001\u4e0d\u5b89\uff0865%\uff09\u3001\u8033\u9cf4\u308a\uff0860%\uff09\u3001\u707c\u71b1\u611f\uff0857.5%\uff09\u3067\u3057\u305f\u3002<\/p>\n

PVS\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u3046\u3061\u3001\u305d\u308c\u305e\u308c15\u2f08 (35.7%) \u306810\u2f08 (45.5%) \u304c\u904e\u53bb\u306b1\u56de\u4ee5\u4e0a\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u611f\u67d3\u6b74\u304c\u3042\u308b\u3068\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u611f\u67d3\u6b74\u3092\u3055\u3089\u306b\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u3001\u6297N\u6297\u4f53\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002PVS\u7fa4\u306e\u3046\u306126\u2f08\uff0861.9%\uff09\u304c\u6297N\u6297\u4f53\u967d\u6027\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u5bfe\u7167\u7fa4\u3067\u306f10\u2f08\uff0845.5%\uff09\u3067\u3057\u305f\u3002\u611f\u67d3\u6b74\u3092\u2f83\u2f30\u7533\u544a\u3057\u305f\u5404\u7fa4\u304b\u30891\u2f08\u306e\u53c2\u52a0\u8005\u306f\u3001\u9670\u6027\u306e\u691c\u67fb\u7d50\u679c\u3067\u3057\u305f\u3002<\/p>\n

\u2f83\u2f30\u7533\u544a\u3068\u691c\u67fb\u7d50\u679c\u306e\u4e21\u2f45\u306b\u57fa\u3065\u3044\u3066\u30012\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3055\u3089\u306b4\u3064\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002\u611f\u67d3\u6b74\u306e\u306a\u3044PVS\uff08PVS-I\u3001n = 15\uff09\u3001\u611f\u67d3\u6b74\u306e\u3042\u308bPVS \uff08 PVS +I\u3001n = 27\uff09\u3001\u611f\u67d3\u6b74\u306e\u306a\u3044\u5bfe\u7167\uff08Control-I\u3001n = 11 \uff09\u3001\u611f\u67d3\u6b74\u306e\u3042\u308b\u5bfe\u7167\uff08Control+I\u3001n = 11\uff09\u3067\u3059\u3002<\/p>\n

\u4e88\u60f3\u901a\u308a\u3001\u611f\u67d3\u3057\u3066\u3044\u306a\u3044PVS-I\u304a\u3088\u3073Control-I\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u691c\u51fa\u3055\u308c\u305f\u6297N IgG\u6297\u4f53\u30ec\u30d9\u30eb\u304c\u306f\u308b\u304b\u306b\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

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PVS\u7fa4\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u2f50\u8f03\u3057\u3066\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u56de\u6570\u304c\u6709\u610f\u306b\u5c11\u306a\u304f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u56de\u6570\u306e\u4e2d\u592e\u5024\u306fPVS 2\u56de\u3001\u5bfe\u7167\u7fa44\u56de\u3067\u3057\u305f\u3002\u6050\u3089\u304f\u30ef\u30af\u30c1\u30f3\u306e\u526f\u4f5c\u7528\u304c\u51fa\u305f\u305f\u3081\u306b\u305d\u308c\u4ee5\u4e0a\u306e\u63a5\u7a2e\u3092\u3057\u306a\u304f\u306a\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u3002\u6700\u3082\u6700\u8fd1\u306e\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u2f47\u6570\u306e\u4e2d\u592e\u5024\u306f\u3001\u5bfe\u7167\u7fa4\u306e199\u2f47\u3068\u2f50\u8f03\u3057\u3066\u3001PVS\u7fa4\u3067\u6709\u610f\u306b\u2fbc\u304f\u3001585\u2f47\u3067\u3057\u305f\u3002<\/p>\n

\u4e0a\u306e\u56f3\u306eF\u306b\u793a\u3059\u3088\u3046\u306b\u3001PVS\u3092\u8d77\u3053\u3057\u305f\u30ef\u30af\u30c1\u30f3\u306e85\uff05\u306f1\u56de\u76ee\uff0845\uff05\uff09\u307e\u305f\u306f2\u56de\u76ee\uff0840\uff05\uff09\u306e\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u3082\u306e\u3067\u3057\u305f\u3002<\/p>\n

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PVS\u7fa4\u3067\u306f\u3001CD4\u7d30\u80de\u306e\u4f4e\u4e0b\uff08\u514d\u75ab\u4e0d\u5168\uff1f\uff09\u3001TNF\u03b1+ \u304a\u3088\u3073 CD8 T \u7d30\u80de\u306e\u5897\u52a0\uff08\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff1f\uff09\u3092\u8a8d\u3081\u3001\u3055\u3089\u306b\u3001EBV\uff08EB\u30a6\u30a4\u30eb\u30b9\uff09\u306e\u6162\u6027\u611f\u67d3\u306e\u518d\u6d3b\u6027\u5316\u306e\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u5faa\u74b0\u2f8e\u4e2d\u306e\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u306fPVS\u306e\u53c2\u52a0\u8005\u306e\u2f00\u90e8\u306b\u306e\u307f\u3055\u307e\u3056\u307e\u306a\u6fc3\u5ea6\u3067\u691c\u51fa\u3055\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001\u5bfe\u7167\u7fa4\u3067\u306f\u4e3b\u306b\u30bc\u30ed\u5024\u3068\u2fae\u30bc\u30ed\u5024\u306e\u2f06\u5cf0\u6027\u5206\u5e03\u3092\u2f70\u3057\u305f\u3002\u691c\u51fa\u53ef\u80fd\u306a\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u306f\u300126\u2f47\u304b\u3089709\u2f47\u306e\u7bc4\u56f2\u3067\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002PVS-I\u7fa4\u3068PVS+I\u7fa4\u306e\u4e21\u2f45\u3067\u3001Control-I\u7fa4\u3068\u2f50\u8f03\u3057\u3066\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u30ec\u30d9\u30eb\u304c\u6709\u610f\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u7279\u306b\u3001PVS -I \u30b0\u30eb\u30fc\u30d7\u3067\u691c\u51fa\u3055\u308c\u305f\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304b\u3089600\u301c700 \u2f47\u3092\u8d85\u3048\u308b\u7bc4\u56f2\u3067\u3042\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f (NI-1 \u304a\u3088\u3073 NI-5 )\u3002\u3053\u308c\u306f\u3001\u2ed1\u671f\u306b\u308f\u305f\u308b\u6297\u539f\u306e\u6301\u7d9a\u304c\u60a3\u8005\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3051\u308b PVS\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u2f70\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001PVS+I\u30b0\u30eb\u30fc\u30d7\u306e\u53c2\u52a0\u8005\u306e\u307b\u3068\u3093\u3069\u306f\u3001 2\u4f8b\u3092\u9664\u3044\u3066\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc\u611f\u67d3\u3092\u7d4c\u9a13\u3057\u3066\u304a\u308a\u3001 PVS\u306e\u75c7\u72b6\u306f\u611f\u67d3\u524d\u306b\u59cb\u307e\u3063\u3066\u3044\u305f\u3053\u3068\u3092\u2f70\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

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