{"id":30038,"date":"2025-09-24T08:30:40","date_gmt":"2025-09-23T23:30:40","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=30038"},"modified":"2025-09-24T08:30:40","modified_gmt":"2025-09-23T23:30:40","slug":"%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3%e3%83%9d%e3%83%b3%e3%83%97%e9%98%bb%e5%ae%b3%e8%96%ac%ef%bc%88ppi%ef%bc%89%e3%81%a8%e8%86%9d%e9%96%a2%e7%af%80%e7%bd%ae%e6%8f%9b%e8%a1%93%e3%81%ae%e3%83%aa","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=30038","title":{"rendered":"\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u3068\u819d\u95a2\u7bc0\u7f6e\u63db\u8853\u306e\u30ea\u30b9\u30af"},"content":{"rendered":"<p>\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306f\u3001\u75db\u307f\u306e\u7de9\u548c\u306e\u305f\u3081\u306b\u93ae\u75db\u85ac\u306eNSAIDs\u3092\u98f2\u3093\u3067\u3044\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u306e\u526f\u4f5c\u7528\u4e88\u9632\u306e\u305f\u3081\u306b\u3001\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u3092\u98f2\u3093\u3067\u3044\u308b\u4eba\u306f\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u307e\u305f\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3082\u80c3\u98df\u9053\u9006\u6d41\uff08\u9006\u6d41\u6027\u98df\u9053\u708e\uff09\u306f\u3069\u3061\u3089\u3082\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u306e\u3067\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306f\u305d\u308c\u3067PPI\u3092\u98f2\u3093\u3067\u3044\u308b\u3053\u3068\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002PPI\u306f\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306e\u4f4e\u4e0b\u3092\u8d77\u3053\u3059\u306e\u3067\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306e\u9032\u884c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u8840\u4e2d\u306e\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u6fc3\u5ea6\u304c\u4e00\u756a\u4f4e\u3044\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u4e00\u756a\u9ad8\u3044\u7fa4\u3067\u306f\u3001\u30ec\u30f3\u30c8\u30b2\u30f3\u4e0a\u3067\u819d\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306e\u53ef\u80fd\u6027\u304c0.72\u500d\u3068\u4f4e\u304f\u306a\u308a\u307e\u3057\u305f\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26034158\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30a4\u30ae\u30ea\u30b9\u306eHealth Improvement Network\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u60a3\u8005\uff0850\u6b73\u4ee5\u4e0a\uff09\u3092\u5bfe\u8c61\u306b\u3001PPI\u307e\u305f\u306fH2\u30d6\u30ed\u30c3\u30ab\u30fc\uff08\u5236\u9178\u85ac\uff09\u3092\u958b\u59cb\u3057\u305f\u60a3\u8005\u30675\u5e74\u9593\u306e\u819d\u95a2\u7bc0\u7f6e\u63db\u8853\u306e\u30ea\u30b9\u30af\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"30162\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=30162\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?fit=2560%2C1634&amp;ssl=1\" data-orig-size=\"2560,1634\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Zeng, ChaoNeogi, TuhinaChan, And&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?fit=300%2C191&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?fit=640%2C408&amp;ssl=1\" class=\"alignnone wp-image-30162 size-large\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003.jpg?resize=640%2C408\" alt=\"\" width=\"640\" height=\"408\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?resize=1024%2C653&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?resize=300%2C191&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?resize=768%2C490&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?resize=1536%2C980&amp;ssl=1 1536w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?resize=2048%2C1307&amp;ssl=1 2048w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?resize=1170%2C747&amp;ssl=1 1170w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?w=1280 1280w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0003-scaled.jpg?w=1920 1920w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"30161\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=30161\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?fit=2560%2C1634&amp;ssl=1\" data-orig-size=\"2560,1634\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Zeng, ChaoNeogi, TuhinaChan, And&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?fit=300%2C191&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?fit=640%2C408&amp;ssl=1\" class=\"alignnone wp-image-30161 size-large\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004.jpg?resize=640%2C408\" alt=\"\" width=\"640\" height=\"408\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?resize=1024%2C653&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?resize=300%2C191&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?resize=768%2C490&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?resize=1536%2C980&amp;ssl=1 1536w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?resize=2048%2C1307&amp;ssl=1 2048w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?resize=1170%2C747&amp;ssl=1 1170w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?w=1280 1280w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0004-scaled.jpg?w=1920 1920w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"30160\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=30160\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?fit=2560%2C1634&amp;ssl=1\" data-orig-size=\"2560,1634\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Zeng, ChaoNeogi, TuhinaChan, And&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?fit=300%2C191&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?fit=640%2C408&amp;ssl=1\" class=\"alignnone wp-image-30160 size-large\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005.jpg?resize=640%2C408\" alt=\"\" width=\"640\" height=\"408\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?resize=1024%2C653&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?resize=300%2C191&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?resize=768%2C490&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?resize=1536%2C980&amp;ssl=1 1536w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?resize=2048%2C1307&amp;ssl=1 2048w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?resize=1170%2C747&amp;ssl=1 1170w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?w=1280 1280w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0005-scaled.jpg?w=1920 1920w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"30115\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=30115\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?fit=2560%2C1634&amp;ssl=1\" data-orig-size=\"2560,1634\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Zeng, ChaoNeogi, TuhinaChan, And&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?fit=300%2C191&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?fit=640%2C408&amp;ssl=1\" class=\"alignnone wp-image-30115 size-large\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8.jpg?resize=640%2C408\" alt=\"\" width=\"640\" height=\"408\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?resize=1024%2C653&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?resize=300%2C191&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?resize=768%2C490&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?resize=1536%2C980&amp;ssl=1 1536w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?resize=2048%2C1307&amp;ssl=1 2048w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?resize=1170%2C747&amp;ssl=1 1170w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?w=1280 1280w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/a7f76ed69f14886b44e16d7abac598c8-scaled.jpg?w=1920 1920w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007-scaled.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"30159\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=30159\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007-scaled.jpg?fit=2560%2C1615&amp;ssl=1\" data-orig-size=\"2560,1615\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Zeng, ChaoNeogi, TuhinaChan, And&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Proton Pump Inhibitor Therapy and Risk of Knee Replacement Surge\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007-scaled.jpg?fit=300%2C189&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007-scaled.jpg?fit=640%2C404&amp;ssl=1\" class=\"alignnone wp-image-30159 size-large\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007.jpg?resize=640%2C404\" alt=\"\" width=\"640\" height=\"404\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007-scaled.jpg?resize=1024%2C646&amp;ssl=1 1024w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/03\/PPInihms-1777162-f0007-scaled.jpg?resize=300%2C189&amp;ssl=1 300w, 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640px\" 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